Exosomes in diagnostic and therapeutic applications: biomarker, vaccine and RNA interference delivery vehicle

Early diagnostic value of survivin and its alternative splice variants in breast cancer

(2014) Salma Khan et al.   BMC CANCER

Biogenesis and secretion of exosomes

(2014) Joanna Kowal et al.   CURRENT OPINION IN CELL BIOLOGY

Extracellular vesicles as a platform for ‘liquid biopsy’ in glioblastoma patients

(2014) David R Santiago-Dieppa et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Improved vaccine efficacy of tumor exosome compared to tumor lysate loaded dendritic cells in mice

(2014) Xiaoyu Gu et al.   INTERNATIONAL JOURNAL OF CANCER

Increased Exosomal MicroRNA-21 and MicroRNA-146a Levels in the Cervicovaginal Lavage Specimens of Patients with Cervical Cancer

(2014) Jie Liu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Human Tumor-Derived Exosomes Down-Modulate NKG2D Expression

(2014) A. Clayton et al.   JOURNAL OF IMMUNOLOGY

Exosomes from Bronchoalveolar Fluid of Tolerized Mice Prevent Allergic Reaction

(2014) N. Prado et al.   JOURNAL OF IMMUNOLOGY

Bladder Cancer Exosomes Contain EDIL-3/Del1 and Facilitate Cancer Progression

(2014) Carla J. Beckham et al.   JOURNAL OF UROLOGY

Exosomes in human semen carry a distinctive repertoire of small non-coding RNAs with potential regulatory functions

(2014) L. Vojtech et al.   NUCLEIC ACIDS RESEARCH

Extracellular vesicles as modulators of cell-to-cell communication in the healthy and diseased brain

(2014) D. M. Pegtel et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Exosome Release and Low pH Belong to a Framework of Resistance of Human Melanoma Cells to Cisplatin

(2014) Cristina Federici et al.   PLoS One

Exosomes from Drug-Resistant Breast Cancer Cells Transmit Chemoresistance by a Horizontal Transfer of MicroRNAs

(2014) Wei-xian Chen et al.   PLoS One

Exosomes from bone marrow mesenchymal stem cells contain a microRNA that promotes dormancy in metastatic breast cancer cells

(2014) M. Ono et al.   Science Signaling

Mesenchymal stem cell-derived exosomes promote hepatic regeneration in drug-induced liver injury models

(2014) Cheau Tan et al.   Stem Cell Research & Therapy

Bacterial Outer Membrane Vesicles and Vaccine Applications

(2014) Reinaldo Acevedo et al.   Frontiers in Immunology

Functions and Therapeutic Roles of Exosomes in Cancer

(2014) Jacob A. Tickner et al.   Frontiers in Oncology

Bioinspired Exosome-Mimetic Nanovesicles for Targeted Delivery of Chemotherapeutics to Malignant Tumors

(2013) Su Chul Jang et al.   ACS Nano

Exosomes as a novel way of interneuronal communication

(2013) Mathilde Chivet et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Small RNA Transcriptomes of Two Types of Exosomes in Human Whole Saliva Determined by Next Generation Sequencing

(2013) Yuko Ogawa et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy

(2013) Yanhua Tian et al.   BIOMATERIALS

Exosomes are natural carriers of exogenous siRNA to human cells in vitro

(2013) Tatyana A Shtam et al.   Cell Communication and Signaling

Circulating p53-Responsive MicroRNAs Are Predictive Indicators of Heart Failure After Acute Myocardial Infarction

(2013) Sen Matsumoto et al.   CIRCULATION RESEARCH

CD2AP mRNA in urinary exosome as biomarker of kidney disease

(2013) Lin-Li Lv et al.   CLINICA CHIMICA ACTA

Exosomes carrying mycobacterial antigens can protect mice againstMycobacterium tuberculosisinfection

(2013) Yong Cheng et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Intracellular Interactome of Tetraspanin-enriched Microdomains Reveals Their Function as Sorting Machineries toward Exosomes

(2013) Daniel Perez-Hernandez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles

(2013) Marina Colombo et al.   JOURNAL OF CELL SCIENCE

Electroporation-induced siRNA precipitation obscures the efficiency of siRNA loading into extracellular vesicles

(2013) Sander A.A. Kooijmans et al.   JOURNAL OF CONTROLLED RELEASE

Dendritic Cell-Derived Exosomes Need To Activate Both T and B Cells To Induce Antitumor Immunity

(2013) T. I. Naslund et al.   JOURNAL OF IMMUNOLOGY

Immunization with Escherichia coli Outer Membrane Vesicles Protects Bacteria-Induced Lethality via Th1 and Th17 Cell Responses

(2013) O. Y. Kim et al.   JOURNAL OF IMMUNOLOGY

Diabetic nephropathy induces changes in the proteome of human urinary exosomes as revealed by label-free comparative analysis

(2013) Irene Zubiri et al.   Journal of Proteomics

Characterization and deep sequencing analysis of exosomal and non-exosomal miRNA in human urine

(2013) Lesley Cheng et al.   KIDNEY INTERNATIONAL

Extracellular vesicles: biology and emerging therapeutic opportunities

(2013) Samir EL Andaloussi et al.   NATURE REVIEWS DRUG DISCOVERY

Differential Expression of Exosomal microRNAs in Prefrontal Cortices of Schizophrenia and Bipolar Disorder Patients

(2013) Meredith G. Banigan et al.   PLoS One

Wilm's Tumor-1 Protein Levels in Urinary Exosomes from Diabetic Patients with or without Proteinuria

(2013) Anuradha Kalani et al.   PLoS One

Regulation of the Tumor Suppressor PTEN through Exosomes: A Diagnostic Potential for Prostate Cancer

(2013) Kathleen Gabriel et al.   PLoS One

Exosomal Signaling during Hypoxia Mediates Microvascular Endothelial Cell Migration and Vasculogenesis

(2013) Carlos Salomon et al.   PLoS One

Urinary Exosomal MicroRNAs in Incipient Diabetic Nephropathy

(2013) Federica Barutta et al.   PLoS One

Urinary Exosomes as a Source of Kidney Dysfunction Biomarker in Renal Transplantation

(2013) S. Alvarez et al.   TRANSPLANTATION PROCEEDINGS

Outer membrane vesicles derived from Bordetella parapertussis as an acellular vaccine against Bordetella parapertussis and Bordetella pertussis infection

(2013) D. Bottero et al.   VACCINE

Extracellular vesicles as mediators of neuron-glia communication

(2013) Carsten Frühbeis et al.   Frontiers in Cellular Neuroscience

Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs

(2013) Carolina Villarroya-Beltri et al.   Nature Communications

Exosomes released by human umbilical cord mesenchymal stem cells protect against cisplatin-induced renal oxidative stress and apoptosis in vivo and in vitro

(2013) Ying Zhou et al.   Stem Cell Research & Therapy

Monitoring the Rab27 associated exosome pathway using nanoparticle tracking analysis

(2012) Ying Zheng et al.   EXPERIMENTAL CELL RESEARCH

Exosomal RNA as biomarkers and the therapeutic potential of exosome vectors

(2012) Cecilia Lässer   EXPERT OPINION ON BIOLOGICAL THERAPY

The Phosphorylated Sodium Chloride Cotransporter in Urinary Exosomes Is Superior to Prostasin as a Marker for Aldosteronism

(2012) Nils van der Lubbe et al.   HYPERTENSION

Transfer of extracellular vesicles during immune cell-cell interactions

(2012) Cristina Gutiérrez-Vázquez et al.   IMMUNOLOGICAL REVIEWS

Membrane Vesicle Release in Bacteria, Eukaryotes, and Archaea: a Conserved yet Underappreciated Aspect of Microbial Life

(2012) Brooke L. Deatherage et al.   INFECTION AND IMMUNITY

Tissue factor–bearing exosome secretion from human mechanically stimulated bronchial epithelial cells in vitro and in vivo

(2012) Jin-Ah Park et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Immune Surveillance Properties of Human NK Cell-Derived Exosomes

(2012) L. Lugini et al.   JOURNAL OF IMMUNOLOGY

Identification and proteomic profiling of exosomes in human cerebrospinal fluid

(2012) Jonathan M Street et al.   Journal of Translational Medicine

Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells

(2012) Shin-ichiro Ohno et al.   MOLECULAR THERAPY

Syndecan–syntenin–ALIX regulates the biogenesis of exosomes

(2012) Maria Francesca Baietti et al.   NATURE CELL BIOLOGY

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

(2012) Héctor Peinado et al.   NATURE MEDICINE

Small RNA deep sequencing reveals a distinct miRNA signature released in exosomes from prion-infected neuronal cells

(2012) Shayne A. Bellingham et al.   NUCLEIC ACIDS RESEARCH

Deep sequencing of RNA from immune cell-derived vesicles uncovers the selective incorporation of small non-coding RNA biotypes with potential regulatory functions

(2012) Esther N. M. Nolte-’t Hoen et al.   NUCLEIC ACIDS RESEARCH

Plasma exosomes can deliver exogenous short interfering RNA to monocytes and lymphocytes

(2012) Jessica Wahlgren et al.   NUCLEIC ACIDS RESEARCH

Plasma-Derived Exosomal Survivin, a Plausible Biomarker for Early Detection of Prostate Cancer

(2012) Salma Khan et al.   PLoS One

Formation and release of arrestin domain-containing protein 1-mediated microvesicles (ARMMs) at plasma membrane by recruitment of TSG101 protein

(2012) J. F. Nabhan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation

(2012) Hina Kalra et al.   PLOS BIOLOGY

Dendritic cell exosomes directly kill tumor cells and activate natural killer cells via TNF superfamily ligands

(2012) Stephan Munich et al.   OncoImmunology

Exosomes as intercellular signalosomes and pharmacological effectors

(2011) Michel Record et al.   BIOCHEMICAL PHARMACOLOGY

Cell-derived vesicles exposing coagulant tissue factor in saliva

(2011) R. J. Berckmans et al.   BLOOD

Exosomes Released by Melanoma Cells Prepare Sentinel Lymph Nodes for Tumor Metastasis

(2011) J. L. Hood et al.   CANCER RESEARCH

Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles

(2011) Bence György et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Exosomes From Human CD34 + Stem Cells Mediate Their Proangiogenic Paracrine Activity

(2011) Susmita Sahoo et al.   CIRCULATION RESEARCH

The Roles of Tumor-Derived Exosomes in Cancer Pathogenesis

(2011) Chenjie Yang et al.   Clinical & Developmental Immunology

The Tetraspanin CD63 Regulates ESCRT-Independent and -Dependent Endosomal Sorting during Melanogenesis

(2011) Guillaume van Niel et al.   DEVELOPMENTAL CELL

Proteomic identification of exosomal LRG1: A potential urinary biomarker for detecting NSCLC

(2011) Yanyan Li et al.   ELECTROPHORESIS

Intercellular nanovesicle-mediated microRNA transfer: A mechanism of environmental modulation of hepatocellular cancer cell growth

(2011) Takayuki Kogure et al.   HEPATOLOGY

Role of exosomes released by chronic myelogenous leukemia cells in angiogenesis

(2011) Simona Taverna et al.   INTERNATIONAL JOURNAL OF CANCER

Human saliva, plasma and breast milk exosomes contain RNA: uptake by macrophages

(2011) Cecilia Lässer et al.   Journal of Translational Medicine

Body fluid derived exosomes as a novel template for clinical diagnostics

(2011) Sascha Keller et al.   Journal of Translational Medicine

Exosomes and the kidney: prospects for diagnosis and therapy of renal diseases

(2011) Bas W.M. van Balkom et al.   KIDNEY INTERNATIONAL

Treatment of Brain Inflammatory Diseases by Delivering Exosome Encapsulated Anti-inflammatory Drugs From the Nasal Region to the Brain

(2011) Xiaoying Zhuang et al.   MOLECULAR THERAPY

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy

(2011) Pyong-Gon Moon et al.   PROTEOMICS

Exosomes/microvesicles: mediators of cancer-associated immunosuppressive microenvironments

(2011) Douglas D. Taylor et al.   Seminars in Immunopathology

Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells

(2011) María Mittelbrunn et al.   Nature Communications

The Role of Placental Exosomes in Reproduction

(2010) Lucia Mincheva-Nilsson et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Biological Functions and Biogenesis of Secreted Bacterial Outer Membrane Vesicles

(2010) Adam Kulp et al.   Annual Review of Microbiology

Exosome secretion of dendritic cells is regulated by Hrs, an ESCRT-0 protein

(2010) Keiichi Tamai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Natural Killer Cell Cytotoxicity Is Suppressed by Exposure to the Human NKG2D Ligand MICA*008 That Is Shed by Tumor Cells in Exosomes

(2010) O. Ashiru et al.   CANCER RESEARCH

Vesicle-related microRNAs in plasma of nonsmall cell lung cancer patients and correlation with survival

(2010) J. Silva et al.   EUROPEAN RESPIRATORY JOURNAL

The road toward microRNA therapeutics

(2010) Anita G. Seto   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Secretory Mechanisms and Intercellular Transfer of MicroRNAs in Living Cells

(2010) Nobuyoshi Kosaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A–C

(2010) Chieh Hsu et al.   JOURNAL OF CELL BIOLOGY

Exosomes Containing Glycoprotein 350 Released by EBV-Transformed B Cells Selectively Target B Cells through CD21 and Block EBV Infection In Vitro

(2010) H. Vallhov et al.   JOURNAL OF IMMUNOLOGY

Updated Technology to Produce Highly Immunogenic Dendritic Cell-derived Exosomes of Clinical Grade

(2010) Sophie Viaud et al.   JOURNAL OF IMMUNOTHERAPY

Exosomes: Extracellular organelles important in intercellular communication

(2010) Suresh Mathivanan et al.   Journal of Proteomics

A Novel Nanoparticle Drug Delivery System: The Anti-inflammatory Activity of Curcumin Is Enhanced When Encapsulated in Exosomes

(2010) Dongmei Sun et al.   MOLECULAR THERAPY

Exosomes: immune properties and potential clinical implementations

(2010) Nathalie Chaput et al.   Seminars in Immunopathology

Exosomes in erythropoiesis

(2010) M. Vidal   TRANSFUSION CLINIQUE ET BIOLOGIQUE

Antigen-loaded exosomes alone induce Th1-type memory through a B cell-dependent mechanism

(2009) K. R. Qazi et al.   BLOOD

Claudin-containing exosomes in the peripheral circulation of women with ovarian cancer

(2009) Jianghong Li et al.   BMC CANCER

Exosomal MicroRNA: A Diagnostic Marker for Lung Cancer

(2009) Guilherme Rabinowits et al.   Clinical Lung Cancer

Microenvironmental pH Is a Key Factor for Exosome Traffic in Tumor Cells

(2009) Isabella Parolini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human Placenta Expresses and Secretes NKG2D Ligands via Exosomes that Down-Modulate the Cognate Receptor Expression: Evidence for Immunosuppressive Function

(2009) M. Hedlund et al.   JOURNAL OF IMMUNOLOGY

Can urinary exosomes act as treatment response markers in prostate cancer?

(2009) Paul J Mitchell et al.   Journal of Translational Medicine

Rab27a and Rab27b control different steps of the exosome secretion pathway

(2009) Matias Ostrowski et al.   NATURE CELL BIOLOGY

High Levels of Exosomes Expressing CD63 and Caveolin-1 in Plasma of Melanoma Patients

(2009) Mariantonia Logozzi et al.   PLoS One

Identification of extracellular δ-catenin accumulation for prostate cancer detection

(2009) Qun Lu et al.   PROSTATE

Exosomes are an effective vaccine against congenital toxoplasmosis in mice

(2009) Céline Beauvillain et al.   VACCINE

Blood diffusion and Th1-suppressive effects of galectin-9-containing exosomes released by Epstein-Barr virus-infected nasopharyngeal carcinoma cells

(2008) J. Klibi et al.   BLOOD

MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer

(2008) Douglas D. Taylor et al.   GYNECOLOGIC ONCOLOGY

Increased exosome production from tumour cell cultures using the Integra CELLine Culture System

(2008) J. Paul Mitchell et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Isolation and Identification of Potential Urinary Microparticle Biomarkers of Bladder Cancer

(2008) David M. Smalley et al.   JOURNAL OF PROTEOME RESEARCH

Urinary exosomal transcription factors, a new class of biomarkers for renal disease

(2008) Hua Zhou et al.   KIDNEY INTERNATIONAL

Phase I Clinical Trial of Autologous Ascites-derived Exosomes Combined With GM-CSF for Colorectal Cancer

(2008) Shengming Dai et al.   MOLECULAR THERAPY

Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

(2008) Johan Skog et al.   NATURE CELL BIOLOGY

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

(2008) K. Trajkovic et al.   SCIENCE

Exosome Function: From Tumor Immunology to Pathogen Biology

(2008) Jeffrey S. Schorey et al.   TRAFFIC