Exosomes derived from miR-92a-3p-overexpressing human mesenchymal stem cells enhance chondrogenesis and suppress cartilage degradation via targeting WNT5A

MSC exosomes mediate cartilage repair by enhancing proliferation, attenuating apoptosis and modulating immune reactivity

(2018) Shipin Zhang et al.   BIOMATERIALS

Exosomal microRNA-21-5p Mediates Mesenchymal Stem Cell Paracrine Effects on Human Cardiac Tissue ContractilityNovelty and Significance

(2018) Joshua Mayourian et al.   CIRCULATION RESEARCH

Mesenchymal Stromal/stem Cell-derived Extracellular Vesicles Promote Human Cartilage Regeneration In Vitro

(2018) Lucienne A. Vonk et al.   Theranostics

Wnt5a induces catabolic signaling and matrix metalloproteinase production in human articular chondrocytes

(2017) G. Huang et al.   OSTEOARTHRITIS AND CARTILAGE

MicroRNA-92a-3p regulates the expression of cartilage-specific genes by directly targeting histone deacetylase 2 in chondrogenesis and degradation

(2017) G. Mao et al.   OSTEOARTHRITIS AND CARTILAGE

A novel Wnt pathway inhibitor, SM04690, for the treatment of moderate to severe osteoarthritis of the knee: results of a 24-week, randomized, controlled, phase 1 study

(2017) Y. Yazici et al.   OSTEOARTHRITIS AND CARTILAGE

MSC exosome as a cell-free MSC therapy for cartilage regeneration: Implications for osteoarthritis treatment

(2017) Wei Seong Toh et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Comparison of exosomes secreted by induced pluripotent stem cell-derived mesenchymal stem cells and synovial membrane-derived mesenchymal stem cells for the treatment of osteoarthritis

(2017) Yu Zhu et al.   Stem Cell Research & Therapy

Exosomes derived from miR-140-5p-overexpressing human synovial mesenchymal stem cells enhance cartilage tissue regeneration and prevent osteoarthritis of the knee in a rat model

(2017) Shi-Cong Tao et al.   Theranostics

Osteoarthritis: toward a comprehensive understanding of pathological mechanism

(2017) Di Chen et al.   Bone Research

Intra-articular therapies for osteoarthritis

(2016) Shirley P. Yu et al.   EXPERT OPINION ON PHARMACOTHERAPY

MicroRNA-320 regulates matrix metalloproteinase-13 expression in chondrogenesis and interleukin-1β-induced chondrocyte responses

(2016) F. Meng et al.   OSTEOARTHRITIS AND CARTILAGE

Exosomes derived from human embryonic mesenchymal stem cells promote osteochondral regeneration

(2016) S. Zhang et al.   OSTEOARTHRITIS AND CARTILAGE

Silencing of Wnt5a prevents interleukin-1β-induced collagen type II degradation in rat chondrocytes

(2016) Shiping Shi et al.   Experimental and Therapeutic Medicine

Human Endothelial Colony-Forming Cells Protect against Acute Kidney Injury

(2015) Dylan Burger et al.   AMERICAN JOURNAL OF PATHOLOGY

The WNT system: background and its role in bone

(2015) U. H. Lerner et al.   JOURNAL OF INTERNAL MEDICINE

Osteoarthritis

(2015) S Glyn-Jones et al.   LANCET

Advances in Mesenchymal Stem Cell-based Strategies for Cartilage Repair and Regeneration

(2014) Wei Seong Toh et al.   Stem Cell Reviews and Reports

Exosomes/miRNAs as mediating cell-based therapy of stroke

(2014) Hongqi Xin et al.   Frontiers in Cellular Neuroscience

MicroRNA-92a Upholds Bmp Signaling by Targeting noggin3 during Pharyngeal Cartilage Formation

(2013) Guozhu Ning et al.   DEVELOPMENTAL CELL

Dual functions for WNT5A during cartilage development and in disease

(2013) Sara Hosseini-Farahabadi et al.   MATRIX BIOLOGY

Osteoarthritis: A disease of the joint as an organ

(2012) Richard F. Loeser et al.   ARTHRITIS AND RHEUMATISM

The role of microRNA-23b in the differentiation of MSC into chondrocyte by targeting protein kinase A signaling

(2012) Onju Ham et al.   BIOMATERIALS

Cartilage development and degeneration: a Wnt Wnt situation

(2012) Katherine Ann Staines et al.   CELL BIOCHEMISTRY AND FUNCTION

Noncanonical WNT-5A signaling regulates TGF-β-induced extracellular matrix production by airway smooth muscle cells

(2012) Kuldeep Kumawat et al.   FASEB JOURNAL

Wnt5a-Ror2 signaling between osteoblast-lineage cells and osteoclast precursors enhances osteoclastogenesis

(2012) Kazuhiro Maeda et al.   NATURE MEDICINE

Wnt signaling in cartilage development and degeneration

(2011) Jang-Soo Chun et al.   BMB Reports

Requirement of the NF-κB pathway for induction of Wnt-5A by interleukin-1β in condylar chondrocytes of the temporomandibular joint: functional crosstalk between the Wnt-5A and NF-κB signaling pathways

(2010) Xian-Peng Ge et al.   OSTEOARTHRITIS AND CARTILAGE

Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury

(2010) Ruenn Chai Lai et al.   Stem Cell Research

Role of Wnt-5A in interleukin-1β-induced matrix metalloproteinase expression in rabbit temporomandibular joint condylar chondrocytes

(2009) Xianpeng Ge et al.   ARTHRITIS AND RHEUMATISM

Origins and Mechanisms of miRNAs and siRNAs

(2009) Richard W. Carthew et al.   CELL

Mechanisms involved in the therapeutic properties of mesenchymal stem cells

(2009) Lindolfo da Silva Meirelles et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Mesenchymal stem cell secretes microparticles enriched in pre-microRNAs

(2009) Tian Sheng Chen et al.   NUCLEIC ACIDS RESEARCH

The Interleukin 1β Pathway in the Pathogenesis of Osteoarthritis

(2008) Massoud Daheshia et al.   JOURNAL OF RHEUMATOLOGY