Bcl-2 and IP3 compete for the ligand-binding domain of IP3Rs modulating Ca2+ signaling output

Breast Cancer Targeting through Inhibition of the Endoplasmic Reticulum-Based Apoptosis Regulator Nrh/BCL2L10

(2018) Adrien Nougarede et al.   CANCER RESEARCH

Cryo-EM reveals ligand induced allostery underlying InsP3R channel gating

(2018) Guizhen Fan et al.   CELL RESEARCH

IP3-mediated gating mechanism of the IP3receptor revealed by mutagenesis and X-ray crystallography

(2017) Kozo Hamada et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The apoptotic members CD95, BclxL and Bcl-2 cooperate to promote cell migration by inducing Ca2+ flux from the endoplasmic reticulum to mitochondria

(2016) A Fouqué et al.   CELL DEATH AND DIFFERENTIATION

Highly Sensitive Measurement of Inositol 1,4,5-Trisphosphate by Using a New Fluorescent Ligand and Ligand Binding Domain Combination

(2016) Tai Oura et al.   CHEMBIOCHEM

Bcl-2 proteins and calcium signaling: complexity beneath the surface

(2016) T Vervliet et al.   ONCOGENE

Defining the stoichiometry of inositol 1,4,5-trisphosphate binding required to initiate Ca2+release

(2016) Kamil J. Alzayady et al.   Science Signaling

The trans-membrane domain of Bcl-2α, but not its hydrophobic cleft, is a critical determinant for efficient IP3 receptor inhibition

(2016) Hristina Ivanova et al.   Oncotarget

IRBIT controls apoptosis by interacting with the Bcl-2 homolog, Bcl2l10, and by promoting ER-mitochondria contact

(2016) Benjamin Bonneau et al.   eLife

Defining the stoichiometry of inositol 1,4,5-trisphosphate binding required to initiate Ca2+release

(2016) Kamil J. Alzayady et al.   Science Signaling

Regulation of the ryanodine receptor by anti-apoptotic Bcl-2 is independent of its BH3-domain-binding properties

(2015) Tim Vervliet et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibition of Pro-Apoptotic BAX by a Noncanonical Interaction Mechanism

(2015) Lauren A. Barclay et al.   MOLECULAR CELL

Gating machinery of InsP3R channels revealed by electron cryomicroscopy

(2015) Guizhen Fan et al.   NATURE

Synergistic killing of human small cell lung cancer cells by the Bcl-2-inositol 1,4,5-trisphosphate receptor disruptor BIRD-2 and the BH3-mimetic ABT-263

(2015) E F Greenberg et al.   Cell Death & Disease

Bcl-2 regulation of the inositol 1,4,5-trisphosphate receptor and calcium signaling in normal and malignant lymphocytes: Potential new target for cancer treatment

(2014) Edward F. Greenberg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

ZDOCK server: interactive docking prediction of protein-protein complexes and symmetric multimers

(2014) B. G. Pierce et al.   BIOINFORMATICS

Bcl-2 binds to and inhibits ryanodine receptors

(2014) T. Vervliet et al.   JOURNAL OF CELL SCIENCE

The Bcl-2 Homolog Nrz Inhibits Binding of IP3 to Its Receptor to Control Calcium Signaling During Zebrafish Epiboly

(2014) B. Bonneau et al.   Science Signaling

Imaging intraorganellar Ca2+ at subcellular resolution using CEPIA

(2014) Junji Suzuki et al.   Nature Communications

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

(2013) Andrew J Souers et al.   NATURE MEDICINE

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

(2013) Peter E. Czabotar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Alpha-Helical Destabilization of the Bcl-2-BH4-Domain Peptide Abolishes Its Ability to Inhibit the IP3 Receptor

(2013) Giovanni Monaco et al.   PLoS One

Profiling of the Bcl-2/Bcl-XL-binding sites on type 1 IP3 receptor

(2012) Giovanni Monaco et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Differential regulation of the InsP3receptor type-1 and -2 single channel properties by InsP3, Ca2+and ATP

(2012) Larry E. Wagner II et al.   JOURNAL OF PHYSIOLOGY-LONDON

Structural and functional conservation of key domains in InsP3 and ryanodine receptors

(2012) Min-Duk Seo et al.   NATURE

Selective regulation of IP3-receptor-mediated Ca2+ signaling and apoptosis by the BH4 domain of Bcl-2 versus Bcl-Xl

(2011) G Monaco et al.   CELL DEATH AND DIFFERENTIATION

Apo and InsP3-bound crystal structures of the ligand-binding domain of an InsP3 receptor

(2011) Chun-Chi Lin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Apoptosis Protection by Mcl-1 and Bcl-2 Modulation of Inositol 1,4,5-Trisphosphate Receptor-dependent Ca2+Signaling

(2010) Emily F. Eckenrode et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FiberDock: a web server for flexible induced-fit backbone refinement in molecular docking

(2010) E. Mashiach et al.   NUCLEIC ACIDS RESEARCH

Control of mitochondrial apoptosis by the Bcl-2 family

(2009) J. K. Brunelle et al.   JOURNAL OF CELL SCIENCE

The BH4 domain of Bcl-2 inhibits ER calcium release and apoptosis by binding the regulatory and coupling domain of the IP3 receptor

(2009) Y.-P. Rong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting Bcl-2 based on the interaction of its BH4 domain with the inositol 1,4,5-trisphosphate receptor

(2008) Yi-Ping Rong et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Bcl-2 suppresses Ca2+ release through inositol 1,4,5-trisphosphate receptors and inhibits Ca2+ uptake by mitochondria without affecting ER calcium store content

(2008) C. Jane Hanson et al.   CELL CALCIUM

Targeting Bcl-2-IP3 Receptor Interaction to Reverse Bcl-2's Inhibition of Apoptotic Calcium Signals

(2008) Yi-Ping Rong et al.   MOLECULAR CELL

Bcl-2 Protein Family Members: Versatile Regulators of Calcium Signaling in Cell Survival and Apoptosis

(2007) Yiping Rong et al.   Annual Review of Physiology