p66Shc as a switch in bringing about contrasting responses in cell growth: implications on cell proliferation and apoptosis

Canonical Wnt Signaling Induces Vascular Endothelial Dysfunction via p66 Shc -Regulated Reactive Oxygen Species

(2014) Ajit Vikram et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

P66Shc mediates increased platelet activation and aggregation in hypercholesterolemia

(2014) Santosh Kumar et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Role of SNTA1 in Rac1 activation, modulation of ROS generation and migratory potential of human breast cancer cells

(2014) H F Bhat et al.   BRITISH JOURNAL OF CANCER

Aiolos Promotes Anchorage Independence by Silencing p66Shc Transcription in Cancer Cells

(2014) Xichuan Li et al.   CANCER CELL

The mitochondrial reactive oxygen species regulator p66Shc controls PDGF-induced signaling and migration through protein tyrosine phosphatase oxidation

(2014) Jeroen Frijhoff et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Adaptor Proteins p66Shc and Grb2 Regulate the Activation of the GTPases ARF1 and ARF6 in Invasive Breast Cancer Cells

(2014) Eric Haines et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evidence for a novel antioxidant function and isoform-specific regulation of the human p66Shc gene

(2014) Masaki Miyazawa et al.   MOLECULAR BIOLOGY OF THE CELL

p66Shc longevity protein regulates the proliferation of human ovarian cancer cells

(2014) Sakthivel Muniyan et al.   MOLECULAR CARCINOGENESIS

The Expression of p66Shc Protein in Benign, Premalignant, and Malignant Gastrointestinal Lesions

(2014) Ganglei Liu et al.   PATHOLOGY & ONCOLOGY RESEARCH

Prooxidant Properties of p66shc Are Mediated by Mitochondria in Human Cells

(2014) Evgeny R. Galimov et al.   PLoS One

The Adaptor Protein p66Shc Inhibits mTOR-Dependent Anabolic Metabolism

(2014) M. A. Soliman et al.   Science Signaling

Feedback loop between p66Shc and Nrf2 promotes lung cancer progression

(2013) Wei Du et al.   CANCER LETTERS

Downregulated adaptor protein p66Shcmitigates autophagy process by low nutrient and enhances apoptotic resistance in human lung adenocarcinoma A549 cells

(2013) Zhichao Zheng et al.   FEBS Journal

SHetA2 interference with mortalin binding to p66shc and p53 identified using drug-conjugated magnetic microspheres

(2013) Doris Mangiaracina Benbrook et al.   INVESTIGATIONAL NEW DRUGS

β-Amyloid-evoked Apoptotic Cell Death is Mediated Through MKK6–p66shc Pathway

(2013) Muneesa Bashir et al.   NEUROMOLECULAR MEDICINE

The P66Shc/Mitochondrial Permeability Transition Pore Pathway Determines Neurodegeneration

(2013) Costanza Savino et al.   Oxidative Medicine and Cellular Longevity

Oxidative Stress in Cardiovascular Diseases and Obesity: Role of p66Shc and Protein Kinase C

(2013) Elena De Marchi et al.   Oxidative Medicine and Cellular Longevity

Reactive oxygen species induced by p66Shc longevity protein mediate nongenomic androgen action via tyrosine phosphorylation signaling to enhance tumorigenicity of prostate cancer cells

(2012) Suresh Veeramani et al.   FREE RADICAL BIOLOGY AND MEDICINE

The effect of p66shc protein on the resistance of the RKO colon cancer cell line to oxidative stress

(2012) E. R. Galimov et al.   MOLECULAR BIOLOGY

The p66Shcknockout mice are short lived under natural condition

(2011) Marco Giorgio et al.   AGING CELL

Steroids Up-Regulate p66Shc Longevity Protein in Growth Regulation by Inhibiting Its Ubiquitination

(2011) Santosh Kumar et al.   PLoS One

P66shc and its downstream Eps8 and Rac1 proteins are upregulated in esophageal cancers

(2010) Muneesa Bashir et al.   Cell Communication and Signaling

p66Shc, oxidative stress and aging: Importing a lifespan determinant into mitochondria

(2010) Paolo Pinton et al.   CELL CYCLE

p66Shc restrains Ras hyperactivation and suppresses metastatic behavior

(2010) Z Ma et al.   ONCOGENE

Roles for Growth Factors in Cancer Progression

(2010) Esther Witsch et al.   PHYSIOLOGY

A novel role of Shc adaptor proteins in steroid hormone-regulated cancers

(2008) Syed Mahfuzul Alam et al.   ENDOCRINE-RELATED CANCER

p66shcInhibits Pro-survival Epidermal Growth Factor Receptor/ERK Signaling during Severe Oxidative Stress in Mouse Renal Proximal Tubule Cells

(2008) Istvan Arany et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p66Shc-generated Oxidative Signal Promotes Fat Accumulation

(2008) Ina Berniakovich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Signaling through ShcA Is Required for Transforming Growth Factor  - and Neu/ErbB-2-Induced Breast Cancer Cell Motility and Invasion

(2008) J. J. Northey et al.   MOLECULAR AND CELLULAR BIOLOGY

Mitochondrial redox signaling by p66Shc is involved in regulating androgenic growth stimulation of human prostate cancer cells

(2008) S Veeramani et al.   ONCOGENE