An Insulin-Responsive Sensor in the SIRT1 Disordered Region Binds DBC1 and PACS-2 to Control Enzyme Activity

Published 2018 View Full Article

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Title
An Insulin-Responsive Sensor in the SIRT1 Disordered Region Binds DBC1 and PACS-2 to Control Enzyme Activity
Authors
Keywords
nuclear magnetic resonance spectroscopy, NMR spectroscopy, small molecule sirtuin-activating compounds, STACs, 3-helix bundle, diet-induced obesity, liver, PGC-1alpha, PPARalpha, FGF21, AKT, PACS2
Journal
MOLECULAR CELL
Volume 72, Issue 6, Pages 985-998.e7
Publisher
Elsevier BV
Online
2018-11-08
DOI
10.1016/j.molcel.2018.10.007

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