VDAC1 and the TSPO: Expression, Interactions, and Associated Functions in Health and Disease States

Regulation of permeability transition pore opening in mitochondria by external NAD(H)

(2019) Ekaterina S. Kharechkina et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Calcium and regulation of the mitochondrial permeability transition

(2018) Valentina Giorgio et al.   CELL CALCIUM

VDAC1 functions in Ca 2+ homeostasis and cell life and death in health and disease

(2018) Varda Shoshan-Barmatz et al.   CELL CALCIUM

Transcriptional regulation of Translocator protein (18 kDa) (TSPO) in microglia requires Pu.1, Ap1 and Sp factors

(2018) Khalid Rashid et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

TSPO upregulation in bipolar disorder and concomitant downregulation of mitophagic proteins and NLRP3 inflammasome activation

(2018) Giselli Scaini et al.   NEUROPSYCHOPHARMACOLOGY

Classical and Novel TSPO Ligands for the Mitochondrial TSPO Can Modulate Nuclear Gene Expression: Implications for Mitochondrial Retrograde Signaling

(2017) Nasra Yasin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Photoaffinity labeling with cholesterol analogues precisely maps a cholesterol-binding site in voltage-dependent anion channel-1

(2017) Melissa M. Budelier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protonation state of glutamate 73 regulates the formation of a specific dimeric association of mVDAC1

(2017) Lucie A. Bergdoll et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structural characterization reveals novel oligomeric interactions of human voltage-dependent anion channel 1

(2017) Toshiaki Hosaka et al.   PROTEIN SCIENCE

A role for TSPO in mitochondrial Ca2+ homeostasis and redox stress signaling

(2017) Jemma Gatliff et al.   Cell Death & Disease

Oxidative Stress-Mediated Atherosclerosis: Mechanisms and Therapies

(2017) Xinyu Yang et al.   Frontiers in Physiology

The Mitochondrial Voltage-Dependent Anion Channel 1, Ca2+ Transport, Apoptosis, and Their Regulation

(2017) Varda Shoshan-Barmatz et al.   Frontiers in Oncology

Neuroinflammation in Alzheimer's disease: Current evidence and future directions

(2016) Valeria Calsolaro et al.   Alzheimers & Dementia

A translocator protein 18 kDa ligand, Ro5-4864, inhibits ATP-induced NLRP3 inflammasome activation

(2016) Ji-Won Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Translocator Protein 18 kDa (TSPO): An Old Protein with New Functions?

(2016) Fei Li et al.   BIOCHEMISTRY

Reducing VDAC1 expression induces a non-apoptotic role for pro-apoptotic proteins in cancer cell differentiation

(2016) Tasleem Arif et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

VDAC1-interacting anion transport inhibitors inhibit VDAC1 oligomerization and apoptosis

(2016) Danya Ben-Hail et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Translocator Protein (TSPO) Affects Mitochondrial Fatty Acid Oxidation in Steroidogenic Cells

(2016) Lan N. Tu et al.   ENDOCRINOLOGY

TSPO is a REDOX regulator of cell mitophagy

(2015) Jemma Gatliff et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Structure of the mammalian TSPO/PBR protein

(2015) Mariusz Jaremko et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The mitochondrial voltage-dependent anion channel 1 in tumor cells

(2015) Varda Shoshan-Barmatz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Structural Integrity of the A147T Polymorph of Mammalian TSPO

(2015) Mariusz Jaremko et al.   CHEMBIOCHEM

From ATP to PTP and Back: A Dual Function for the Mitochondrial ATP Synthase

(2015) P. Bernardi et al.   CIRCULATION RESEARCH

A New Fungal Diterpene Induces VDAC1-dependent Apoptosis in Bax/Bak-deficient Cells

(2015) Li Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In Vivo Detection of Age- and Disease-Related Increases in Neuroinflammation by 18 F-GE180 TSPO MicroPET Imaging in Wild-Type and Alzheimer's Transgenic Mice

(2015) Bin Liu et al.   JOURNAL OF NEUROSCIENCE

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Minireview: Translocator Protein (TSPO) and Steroidogenesis: A Reappraisal

(2015) Vimal Selvaraj et al.   MOLECULAR ENDOCRINOLOGY

Structure and activity of tryptophan-rich TSPO proteins

(2015) Y. Guo et al.   SCIENCE

After all, plasmalemmal expression of type-1 VDAC can be understood. Phosphorylation, nitrosylation, and channel modulators work together in vertebrate cell volume regulation and either apoptotic pathway

(2015) Friedrich P. Thinnes   Frontiers in Physiology

A comprehensive review of the lipid cubic phase orin mesomethod for crystallizing membrane and soluble proteins and complexes

(2015) Martin Caffrey   Acta Crystallographica Section F-Structural Biology Communications

Genetic analysis of dTSPO, an outer mitochondrial membrane protein, reveals its functions in apoptosis, longevity, and Aβ42-induced neurodegeneration

(2014) Ran Lin et al.   AGING CELL

TSPO interacts with VDAC1 and triggers a ROS-mediated inhibition of mitochondrial quality control

(2014) Jemma Gatliff et al.   Autophagy

Tracking neuroinflammation in Alzheimer’s disease: the role of positron emission tomography imaging

(2014) Eduardo Zimmer et al.   Journal of Neuroinflammation

Opening up of plasmalemma type-1 VDAC to form apoptotic “find me signal” pathways is essential in early apoptosis — Evidence from the pathogenesis of cystic fibrosis resulting from failure of apoptotic cell clearance followed by sterile inflammation

(2014) Friedrich P. Thinnes   MOLECULAR GENETICS AND METABOLISM

A frequent, GxxxG-mediated, transmembrane association motif is optimized for the formation of interhelical C -H hydrogen bonds

(2014) B. K. Mueller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the Mitochondrial Translocator Protein in Complex with a Diagnostic Ligand

(2014)  ukasz Jaremko et al.   SCIENCE

Membrane protein structure determination — The next generation

(2013) Isabel Moraes et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Targeting of the Translocator Protein 18 kDa (TSPO): A Valuable Approach for Nuclear and Optical Imaging of Activated Microglia

(2013) Adriana Trapani et al.   BIOCONJUGATE CHEMISTRY

A TSPO ligand is protective in a mouse model of multiple sclerosis

(2013) Daniel J. Daugherty et al.   EMBO Molecular Medicine

Ligand for Translocator Protein Reverses Pathology in a Mouse Model of Alzheimer's Disease

(2013) A. M. Barron et al.   JOURNAL OF NEUROSCIENCE

Structure and Intrinsic Disorder in Protein Autoinhibition

(2013) Travis Trudeau et al.   STRUCTURE

ANT-VDAC1 interaction is direct and depends on ANT isoform conformation in vitro

(2012) Maya Allouche et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Structure-based analysis of VDAC1: N-terminus location, translocation, channel gating and association with anti-apoptotic proteins

(2012) Shay Geula et al.   BIOCHEMICAL JOURNAL

Transcriptional Regulation of Translocator Protein (Tspo) via a SINE B2-Mediated Natural Antisense Transcript in MA-10 Leydig Cells1

(2012) Jinjiang Fan et al.   BIOLOGY OF REPRODUCTION

Peripheral benzodiazepine receptor regulates vascular endothelial activations via suppression of the voltage-dependent anion channel-1

(2012) Hee Kyoung Joo et al.   FEBS LETTERS

Mediation of the Antiapoptotic Activity of Bcl-xL Protein upon Interaction with VDAC1 Protein

(2012) Nir Arbel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Radiation Dosimetry and Biodistribution of the TSPO Ligand 11C-DPA-713 in Humans

(2012) C. J. Endres et al.   JOURNAL OF NUCLEAR MEDICINE

The 18 kDa translocator protein influences angiogenesis, as well as aggressiveness, adhesion, migration, and proliferation of glioblastoma cells

(2012) Julia Bode et al.   Pharmacogenetics and Genomics

VDAC isoforms in mammals

(2011) Angela Messina et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Protein Kinase Cε Regulation of Translocator Protein (18 kDa)TspoGene Expression Is Mediated through a MAPK Pathway Targeting STAT3 and c-Jun Transcription Factors

(2010) Amani Batarseh et al.   BIOCHEMISTRY

Is mPTP the gatekeeper for necrosis, apoptosis, or both?

(2010) Kathleen W. Kinnally et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The mitochondria permeability transition pore complex in the brain with interacting proteins – promising targets for protection in neurodegenerative diseases

(2010) Tamara Azarashvili et al.   BIOLOGICAL CHEMISTRY

Crystal packing analysis of murine VDAC1 crystals in a lipidic environment reveals novel insights on oligomerization and orientation

(2010) Rachna Ujwal et al.   Channels

Atg8-family interacting motif crucial for selective autophagy

(2010) Nobuo N. Noda et al.   FEBS LETTERS

Intracellular Acidification Is Associated with Changes in Free Cytosolic Calcium and Inhibition of Action Potentials in Rat Trigeminal Ganglion

(2010) Sung-Min Hwang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oligomerization of the Mitochondrial Protein Voltage-Dependent Anion Channel Is Coupled to the Induction of Apoptosis

(2010) N. Keinan et al.   MOLECULAR AND CELLULAR BIOLOGY

VDAC, a multi-functional mitochondrial protein regulating cell life and death

(2010) Varda Shoshan-Barmatz et al.   MOLECULAR ASPECTS OF MEDICINE

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders

(2010) Rainer Rupprecht et al.   NATURE REVIEWS DRUG DISCOVERY

Three-Dimensional Structure of TspO by Electron Cryomicroscopy of Helical Crystals

(2010) Vladimir M. Korkhov et al.   STRUCTURE

Effect of peripheral benzodiazepine receptor (PBR/TSPO) ligands on opening of Ca2+-induced pore and phosphorylation of 3.5-kDa polypeptide in rat brain mitochondria

(2009) O. V. Krestinina et al.   BIOCHEMISTRY-MOSCOW

Translocator protein (18 kDa) TSPO: An emerging therapeutic target in neurotrauma

(2009) Vassilios Papadopoulos et al.   EXPERIMENTAL NEUROLOGY

The VDAC1 N-terminus is essential both for apoptosis and the protective effect of anti-apoptotic proteins

(2009) S. Abu-Hamad et al.   JOURNAL OF CELL SCIENCE

Initial Evaluation of 11C-DPA-713, a Novel TSPO PET Ligand, in Humans

(2009) C. J. Endres et al.   JOURNAL OF NUCLEAR MEDICINE

Neuroinflammation in Schizophrenia-Related Psychosis: A PET Study

(2009) J. Doorduin et al.   JOURNAL OF NUCLEAR MEDICINE

Structural and Functional Characterization of the Integral Membrane Protein VDAC-1 in Lipid Bilayer Nanodiscs

(2009) Thomas Raschle et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The structure and function of G-protein-coupled receptors

(2009) Daniel M. Rosenbaum et al.   NATURE

Comparison of [11C]-(R)-PK 11195 and [11C]PBR28, two radioligands for translocator protein (18 kDa) in human and monkey: Implications for positron emission tomographic imaging of this inflammation biomarker

(2009) William C. Kreisl et al.   NEUROIMAGE

Ala147Thr substitution in translocator protein is associated with adult separation anxiety in patients with depression

(2009) Barbara Costa et al.   PSYCHIATRIC GENETICS

Translocator Protein (18 kD) as Target for Anxiolytics Without Benzodiazepine-Like Side Effects

(2009) Rainer Rupprecht et al.   SCIENCE

Modulation of intracellular Ca2+ signalling in HeLa cells by the apoptotic cell death enhancer PK11195

(2008) Michelangelo Campanella et al.   BIOCHEMICAL PHARMACOLOGY

Approaching the structure of human VDAC1, a key molecule in mitochondrial cross-talk

(2008) Kornelius Zeth et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Uncovering the role of VDAC in the regulation of cell life and death

(2008) Varda Shoshan-Barmatz et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

VDAC activation by the 18 kDa translocator protein (TSPO), implications for apoptosis

(2008) Leo Veenman et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Voltage-dependent Anion Channel 1-based Peptides Interact with Hexokinase to Prevent Its Anti-apoptotic Activity

(2008) Laetitia Arzoine et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Translocator protein 18 kDa (TSPO): Molecular sensor of brain injury and repair

(2008) Ming-Kai Chen et al.   PHARMACOLOGY & THERAPEUTICS

Structure of the human voltage-dependent anion channel

(2008) M. Bayrhuber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The crystal structure of mouse VDAC1 at 2.3 A resolution reveals mechanistic insights into metabolite gating

(2008) R. Ujwal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Solution Structure of the Integral Human Membrane Protein VDAC-1 in Detergent Micelles

(2008) S. Hiller et al.   SCIENCE