Exosomal PD-L1: New Insights Into Tumor Immune Escape Mechanisms and Therapeutic Strategies
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Title
Exosomal PD-L1: New Insights Into Tumor Immune Escape Mechanisms and Therapeutic Strategies
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Journal
Frontiers in Cell and Developmental Biology
Volume 8, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2020-10-15
DOI
10.3389/fcell.2020.569219
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Note: Only part of the references are listed.- Homogeneous, Low-volume, Efficient, and Sensitive Quantitation of Circulating Exosomal PD-L1 for Cancer Diagnosis and Immunotherapy Response Prediction
- (2020) Mengjiao Huang et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- The abscopal effect 67 years later: from a side story to center stage
- (2020) Sandra Demaria et al. BRITISH JOURNAL OF RADIOLOGY
- Current issues and perspectives in PD-1 blockade cancer immunotherapy
- (2020) Kenji Chamoto et al. International Journal of Clinical Oncology
- Radiotherapy‐immunotherapy combinations: perspectives and challenges
- (2020) Michele Mondini et al. Molecular Oncology
- A comparison of methods for the isolation and separation of extracellular vesicles from protein and lipid particles in human serum
- (2020) K. Brennan et al. Scientific Reports
- Extracellular Vesicles in Glioblastoma Tumor Microenvironment
- (2020) Anuroop Yekula et al. Frontiers in Immunology
- The Clinical Significance of Soluble Programmed Cell Death-Ligand 1 (sPD-L1) in Patients With Gliomas
- (2020) Shujun Liu et al. Frontiers in Oncology
- Tracking the evolution of circulating exosomal-PD-L1 to monitor melanoma patients
- (2020) Marine Cordonnier et al. Journal of Extracellular Vesicles
- Small molecule inhibitors targeting the PD-1/PD-L1 signaling pathway
- (2020) Qian Wu et al. ACTA PHARMACOLOGICA SINICA
- PD-L1 and PD-L2 expression in the tumor microenvironment including peritumoral tissue in primary central nervous system lymphoma
- (2020) Motomasa Furuse et al. BMC CANCER
- Immune suppression caused by PD-L2 expression on tumor cells in gastric cancer
- (2020) Yuko Nakayama et al. Gastric Cancer
- Extracellular Vesicles and Tumor-Immune Escape: Biological Functions and Clinical Perspectives
- (2020) Stefania Raimondo et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- PD-L1/PD-1 axis as a potent therapeutic target in breast cancer
- (2020) Shima Bastaki et al. LIFE SCIENCES
- Dendritic cells dictate responses to PD-L1 blockade cancer immunotherapy
- (2020) Maud Mayoux et al. Science Translational Medicine
- The Biogenesis, Biology, and Clinical Significance of Exosomal PD-L1 in Cancer
- (2020) Yanyan Tang et al. Frontiers in Immunology
- High Expression of PD-L1 and PD-L2 in Ophthalmic Sebaceous Carcinoma: The Case for a Clinical Trial of Checkpoint Inhibitors
- (2020) Natalie Wolkow et al. AMERICAN JOURNAL OF OPHTHALMOLOGY
- Immune Checkpoint Inhibitor-Induced Inflammatory Arthritis: Identification and Management
- (2020) Sandra G. Williams et al. Expert Review of Clinical Immunology
- Severe immune-related hepatitis induced by immune checkpoint inhibitors: Clinical features and management proposal
- (2020) Marie-Léa Gauci et al. Clinics and Research in Hepatology and Gastroenterology
- Soluble programmed death-ligand 1 rather than PD-L1 on tumor cells effectively predicts metastasis and prognosis in soft tissue sarcomas
- (2020) Kunihiro Asanuma et al. Scientific Reports
- GATA2 Regulates Constitutive PD-L1 and PD-L2 Expression in Brain Tumors
- (2020) Yujie Fu et al. Scientific Reports
- Pembrolizumab‐induced pancytopenia in a patient with squamous cell lung cancer
- (2020) Yuriko Ueki et al. Thoracic Cancer
- Exosomal cargos modulate autophagy in recipient cells via different signaling pathways
- (2020) Mehdi Hassanpour et al. Cell and Bioscience
- Advances on immune-related adverse events associated with immune checkpoint inhibitors
- (2020) Yong Fan et al. Frontiers of Medicine
- Programmed cell death-ligand 2: A neglected but important target in the immune response to cancer?
- (2020) Cinzia Solinas et al. Translational Oncology
- PD-L1 expression in breast cancer: expression in subtypes and prognostic significance: a systematic review
- (2019) Elisabeth Specht Stovgaard et al. BREAST CANCER RESEARCH AND TREATMENT
- Role of the tumor microenvironment in PD-L1/PD-1-mediated tumor immune escape
- (2019) Xianjie Jiang et al. Molecular Cancer
- PD-1 and PD-L1 in cancer immunotherapy: clinical implications and future considerations
- (2019) Yongshuai Jiang et al. Human Vaccines & Immunotherapeutics
- Exosomes: biogenesis, biologic function and clinical potential
- (2019) Yuan Zhang et al. Cell and Bioscience
- Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade
- (2019) Brian C. Miller et al. NATURE IMMUNOLOGY
- Insluin and epithelial growth factor (EGF) promote programmed death ligand 1(PD-L1) production and transport in colon cancer stem cells
- (2019) Mingshui Chen et al. BMC CANCER
- Exosomal PD-L1 Retains Immunosuppressive Activity and is Associated with Gastric Cancer Prognosis
- (2019) Yibo Fan et al. ANNALS OF SURGICAL ONCOLOGY
- Exosomes in cancer development, metastasis, and immunity
- (2019) Lin Zhang et al. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
- Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory
- (2019) Mauro Poggio et al. CELL
- Immune suppression by PD-L2 against spontaneous and treatment-related antitumor immunity
- (2019) Hiroyoshi Nishikawa et al. CLINICAL CANCER RESEARCH
- Exosome-Mediated Metastasis: Communication from a Distance
- (2019) Inbal Wortzel et al. DEVELOPMENTAL CELL
- The role of extracellular vesicles from different origin in the microenvironment of head and neck cancers
- (2019) Changqing Xie et al. Molecular Cancer
- PD-1-expressing B cells suppress CD4+ and CD8+ T cells via PD-1/PD-L1-dependent pathway
- (2019) Xufu Wang et al. MOLECULAR IMMUNOLOGY
- Restriction of PD-1 function by cis-PD-L1/CD80 interactions is required for optimal T cell responses
- (2019) Daisuke Sugiura et al. SCIENCE
- Circulating exosomes measure responses to therapy in head and neck cancer patients treated with cetuximab, ipilimumab, and IMRT
- (2019) Marie-Nicole Theodoraki et al. OncoImmunology
- Removal of N-Linked Glycosylation Enhances PD-L1 Detection and Predicts Anti-PD-1/PD-L1 Therapeutic Efficacy
- (2019) Heng-Huan Lee et al. CANCER CELL
- c-Met and PD-L1 on Circulating Exosomes as Diagnostic and Prognostic Markers for Pancreatic Cancer
- (2019) Alexander Lux et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Understanding and overcoming the resistance of cancer to PD-1/PD-L1 blockade
- (2019) Amy L. Shergold et al. PHARMACOLOGICAL RESEARCH
- Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma
- (2019) Malgorzata Czystowska-Kuzmicz et al. Nature Communications
- The biology of extracellular vesicles: The known unknowns
- (2019) Leonid Margolis et al. PLOS BIOLOGY
- Functions of Exosomes in the Triangular Relationship between the Tumor, Inflammation, and Immunity in the Tumor Microenvironment
- (2019) Tiantian Wang et al. Journal of Immunology Research
- Immunomodulatory Effect of MSC on B Cells Is Independent of Secreted Extracellular Vesicles
- (2019) Laura Carreras-Planella et al. Frontiers in Immunology
- T Cell Dysfunction in Cancer Immunity and Immunotherapy
- (2019) Anliang Xia et al. Frontiers in Immunology
- Circulating Tumor Cell PD-L1 Expression as Biomarker for Therapeutic Efficacy of Immune Checkpoint Inhibition in NSCLC
- (2019) Kloten et al. Cells
- Molecular testing strategies in non-small cell lung cancer: optimizing the diagnostic journey
- (2019) Jeffrey P. Gregg et al. Translational Lung Cancer Research
- PD-L1 and PD-L2 expression correlated genes in non-small-cell lung cancer
- (2019) Trine Vilsbøll Larsen et al. Cancer Communications
- Plasma Levels of Soluble PD-L1 Correlate With Tumor Regression in Patients With Lung and Gastric Cancer Treated With Immune Checkpoint Inhibitors
- (2019) KIYOHIRO ANDO et al. ANTICANCER RESEARCH
- The Clinical Significance of Soluble PD-1 and PD-L1 in Lung Cancer
- (2019) Taher Abu Hejleh et al. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
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- (2019) Dong Ha Kim et al. EXPERIMENTAL AND MOLECULAR MEDICINE
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- (2019) Sandra Martinez-Morilla et al. LABORATORY INVESTIGATION
- The functions and clinical application potential of exosomes derived from adipose mesenchymal stem cells: a comprehensive review
- (2019) Pengyu Hong et al. Stem Cell Research & Therapy
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- (2019) Haotian Liao et al. Frontiers in Oncology
- The Clinicopathological and Prognostic Value of PD-L1 Expression in Cholangiocarcinoma: A Meta-Analysis
- (2019) Gang Xu et al. Frontiers in Oncology
- DNA analysis of low- and high-density fractions defines heterogeneous subpopulations of small extracellular vesicles based on their DNA cargo and topology
- (2019) Elisa Lázaro-Ibáñez et al. Journal of Extracellular Vesicles
- The clinicopathological and prognostic significance of PD-L1 expression assessed by immunohistochemistry in lung cancer: a meta-analysis of 50 studies with 11,383 patients
- (2019) Huijuan Li et al. Translational Lung Cancer Research
- Establishment of humanized tumor microenvironment mouse models based on the injection of peripheral blood mononuclear cells and IFN-γ to evaluate the efficacy of PD-L1/PD-1-targeted immunotherapy
- (2019) Xiuyun Lin et al. CANCER BIOLOGY & THERAPY
- Beyond tumor mutational burden: potential and limitations in using exosomes to predict response to immunotherapy
- (2019) Jennifer Crow et al. EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
- Tumor-derived extracellular vesicles: molecular parcels that enable regulation of the immune response in cancer
- (2019) Colin Sheehan et al. JOURNAL OF CELL SCIENCE
- Exosomes: New insights into cancer mechanisms
- (2019) Reza Sahebi et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Clinical significance of PD-L1 expression in serum-derived exosomes in NSCLC patients
- (2019) Chuling Li et al. Journal of Translational Medicine
- The role of exosomal PD-L1 in tumor progression and immunotherapy
- (2019) Feiting Xie et al. Molecular Cancer
- Mechanisms Controlling PD-L1 Expression in Cancer
- (2019) Jong-Ho Cha et al. MOLECULAR CELL
- Inhibitory receptors and ligands beyond PD-1, PD-L1 and CTLA-4: breakthroughs or backups
- (2019) Lawrence P. Andrews et al. NATURE IMMUNOLOGY
- A high-affinity human PD-1/PD-L2 complex informs avenues for small-molecule immune checkpoint drug discovery
- (2019) Shaogeng Tang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mechanisms of immune-related adverse events during the treatment of cancer with immune checkpoint inhibitors
- (2019) Sophia C Weinmann et al. RHEUMATOLOGY
- Soluble PD-L1 generated by endogenous retroelement exaptation is a receptor antagonist
- (2019) Kevin W Ng et al. eLife
- Soluble immune checkpoint-related proteins as predictors of tumor recurrence, survival, and T cell phenotypes in clear cell renal cell carcinoma patients
- (2019) Qinchuan Wang et al. Journal for ImmunoTherapy of Cancer
- The role of PD-L1 expression as a predictive biomarker: an analysis of all US Food and Drug Administration (FDA) approvals of immune checkpoint inhibitors
- (2019) Andrew A. Davis et al. Journal for ImmunoTherapy of Cancer
- Soluble Programmed Death Receptor Ligands sPD-L1 and sPD-L2 as Liquid Biopsy Markers for Prognosis and Platinum Response in Epithelial Ovarian Cancer
- (2019) Paul Buderath et al. Frontiers in Oncology
- Large and small extracellular vesicles released by glioma cells in vitro and in vivo
- (2019) Anudeep Yekula et al. Journal of Extracellular Vesicles
- Biomarker for personalized immunotherapy
- (2019) Si-Yang Liu et al. Translational Lung Cancer Research
- Abscopal Effect Following Immunotherapy and Combined Stereotactic Body Radiation Therapy in Recurrent Metastatic Head and Neck Squamous Cell Carcinoma: A Report of Two Cases and Literature Review
- (2019) Jonathan S. Choi et al. ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
- Personalized detection of circling exosomal PD-L1 based on Fe3O4@TiO2 isolation and SERS immunoassay
- (2019) Yuanfeng Pang et al. BIOSENSORS & BIOELECTRONICS
- Proteolytic processing of PD-L1 by ADAM proteases in breast cancer cells
- (2019) Yeni Romero et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory Receptor CD28 While Repressing the Inhibitory PD-1 and CTLA-4 Pathways
- (2019) Yunlong Zhao et al. IMMUNITY
- A Tumor-Specific Super-Enhancer Drives Immune Evasion by Guiding Synchronous Expression of PD-L1 and PD-L2
- (2019) Yuanpei Xu et al. Cell Reports
- Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation
- (2019) Zhaogang Yang et al. Nature Biomedical Engineering
- Inhibiting extracellular vesicles formation and release: a review of EV inhibitors
- (2019) Mariadelva Catalano et al. Journal of Extracellular Vesicles
- Heterogeneity of PD-L1 Expression and Relationship with Biology of NSCLC
- (2018) MARIA BASSANELLI et al. ANTICANCER RESEARCH
- nSMase2 (Type 2-Neutral Sphingomyelinase) Deficiency or Inhibition by GW4869 Reduces Inflammation and Atherosclerosis in Apoe−/−MiceHighlights
- (2018) Tom Lallemand et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Exosome biogenesis, bioactivities and functions as new delivery systems of natural compounds
- (2018) Ammad Ahmad Farooqi et al. BIOTECHNOLOGY ADVANCES
- PD-L1 mRNA expression in plasma-derived exosomes is associated with response to anti-PD-1 antibodies in melanoma and NSCLC
- (2018) Marzia Del Re et al. BRITISH JOURNAL OF CANCER
- Exosome-Mediated Regulation of Tumor Immunology
- (2018) Naohiro Seo et al. CANCER SCIENCE
- Exosomal PD-L1 harbors active defense function to suppress T cell killing of breast cancer cells and promote tumor growth
- (2018) Yi Yang et al. CELL RESEARCH
- Separation of plasma-derived exosomes into CD3(+) and CD3(-) fractions allows for association of immune cell and tumour cell markers with disease activity in HNSCC patients
- (2018) M.-N. Theodoraki et al. CLINICAL AND EXPERIMENTAL IMMUNOLOGY
- Immune Checkpoint Inhibitors and Cardiac Toxicity: An Emerging Issue
- (2018) Gilda Varricchi et al. CURRENT MEDICINAL CHEMISTRY
- Regulation and Function of the PD-L1 Checkpoint
- (2018) Chong Sun et al. IMMUNITY
- Soluble PD-L1 with PD-1-binding capacity exists in the plasma of patients with non-small cell lung cancer
- (2018) Masahiro Takeuchi et al. IMMUNOLOGY LETTERS
- Poly(I:C) enhanced anti-cervical cancer immunities induced by dendritic cells-derived exosomes
- (2018) Shisheng Chen et al. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
- Optimal management of immune-related adverse events resulting from treatment with immune checkpoint inhibitors: a review and update
- (2018) Hiroki Nagai et al. International Journal of Clinical Oncology
- Tumor-derived exosomes: Potential biomarker or therapeutic target in breast cancer?
- (2018) AmirReza Hesari et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Host expression of PD-L1 determines efficacy of PD-L1 pathway blockade–mediated tumor regression
- (2018) Heng Lin et al. JOURNAL OF CLINICAL INVESTIGATION
- PD-L1 on host cells is essential for PD-L1 blockade–mediated tumor regression
- (2018) Haidong Tang et al. JOURNAL OF CLINICAL INVESTIGATION
- Single-Exosome-Counting Immunoassays for Cancer Diagnostics
- (2018) Chunchen Liu et al. NANO LETTERS
- Shedding light on the cell biology of extracellular vesicles
- (2018) Guillaume van Niel et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- OUP accepted manuscript
- (2018) NEUROSURGERY
- Genetic, transcriptional and post-translational regulation of the programmed death protein ligand 1 in cancer: biology and clinical correlations
- (2018) Ioannis Zerdes et al. ONCOGENE
- Role of PD-1 during effector CD8 T cell differentiation
- (2018) Eunseon Ahn et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Triggered recruitment of ESCRT machinery promotes endolysosomal repair
- (2018) Michael L. Skowyra et al. SCIENCE
- The ESCRT machinery: When function follows form
- (2018) Maximilian Fürthauer SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Endosomal “sort” of signaling control: The role of ESCRT machinery in regulation of receptor-mediated signaling pathways
- (2018) Ewelina Szymanska et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- The role of extracellular vesicles when innate meets adaptive
- (2018) Tom Groot Kormelink et al. Seminars in Immunopathology
- Integrin and PD-1 Ligand Expression on Circulating Extracellular Vesicles in Systemic Inflammatory Response Syndrome and Sepsis
- (2018) Eiji Kawamoto et al. SHOCK
- Immunosuppression of Human Adipose-Derived Stem Cells on T-cell Subsets via the Reduction of NF-kappaB Activation Mediated by PD-L1/PD-1 and Gal-9/TIM-3 Pathways
- (2018) Kaijian Zhou et al. STEM CELLS AND DEVELOPMENT
- Immunological Mechanisms Responsible for Radiation-Induced Abscopal Effect
- (2018) María E. Rodríguez-Ruiz et al. TRENDS IN IMMUNOLOGY
- ALIX Regulates Tumor-Mediated Immunosuppression by Controlling EGFR Activity and PD-L1 Presentation
- (2018) James Monypenny et al. Cell Reports
- PD-L1 binds to B7-1 only in cis on the same cell surface
- (2018) Apoorvi Chaudhri et al. Cancer Immunology Research
- Biomarkers for Clinical Benefit of Immune Checkpoint Inhibitor Treatment—A Review From the Melanoma Perspective and Beyond
- (2018) Kristina Buder-Bakhaya et al. Frontiers in Immunology
- Predictive role of plasmatic biomarkers in advanced non-small cell lung cancer treated by nivolumab
- (2018) Adrien Costantini et al. OncoImmunology
- Sensitive detection of exosomal proteins via a compact surface plasmon resonance biosensor for cancer diagnosis
- (2018) Chang Liu et al. ACS Sensors
- Incidence of Endocrine Dysfunction Following the Use of Different Immune Checkpoint Inhibitor Regimens
- (2018) Romualdo Barroso-Sousa et al. JAMA Oncology
- Immune evasion mediated by PD-L1 on glioblastoma-derived extracellular vesicles
- (2018) Franz L. Ricklefs et al. Science Advances
- M1 Macrophage-Derived Nanovesicles Potentiate the Anticancer Efficacy of Immune Checkpoint Inhibitors
- (2018) Yeon Woong Choo et al. ACS Nano
- Contribution of NK cells to immunotherapy mediated by PD-1/PD-L1 blockade
- (2018) Joy Hsu et al. JOURNAL OF CLINICAL INVESTIGATION
- Abscopal effect of radiotherapy combined with immune checkpoint inhibitors
- (2018) Yang Liu et al. Journal of Hematology & Oncology
- Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response
- (2018) Gang Chen et al. NATURE
- Efficacy of PD-1 or PD-L1 inhibitors and PD-L1 expression status in cancer: meta-analysis
- (2018) Xian Shen et al. BMJ-British Medical Journal
- Immune-Related Adverse Events in Cancer Patients Treated With Immune Checkpoint Inhibitors
- (2018) Sabina Sandigursky et al. Current Rheumatology Reports
- Anti-PD-1/PD-L1 Therapy for Non-Small-Cell Lung Cancer: Toward Personalized Medicine and Combination Strategies
- (2018) Hongshu Sui et al. Journal of Immunology Research
- Soluble PD-L1 Expression in Circulation as a Predictive Marker for Recurrence and Prognosis in Gastric Cancer: Direct Comparison of the Clinical Burden Between Tissue and Serum PD-L1 Expression
- (2018) Tsunehiko Shigemori et al. ANNALS OF SURGICAL ONCOLOGY
- What is the blood concentration of extracellular vesicles? Implications for the use of extracellular vesicles as blood-borne biomarkers of cancer
- (2018) Kasper Bendix Johnsen et al. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
- The correlation and prognostic value of serum levels of soluble programmed death protein 1 (sPD-1) and soluble programmed death-ligand 1 (sPD-L1) in patients with hepatocellular carcinoma
- (2018) Boyang Chang et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- M2 Macrophage-Derived Exosomes Promote Cell Migration and Invasion in Colon Cancer
- (2018) Jingqin Lan et al. CANCER RESEARCH
- Dysfunctional CD8 T Cells Form a Proliferative, Dynamically Regulated Compartment within Human Melanoma
- (2018) Hanjie Li et al. CELL
- Immune-related adverse events of immune checkpoint inhibitors: a brief review
- (2018) G. Myers Current Oncology
- Differential regulation of PD-L1 expression by immune and tumor cells in NSCLC and the response to treatment with atezolizumab (anti–PD-L1)
- (2018) Marcin Kowanetz et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Antitumor Activity of Combinations of Cytotoxic Chemotherapy and Immune Checkpoint Inhibitors Is Model-Dependent
- (2018) Chloé Grasselly et al. Frontiers in Immunology
- PD-1 in human NK cells: evidence of cytoplasmic mRNA and protein expression
- (2018) Francesca R. Mariotti et al. OncoImmunology
- Soluble immune checkpoints in cancer: production, function and biological significance
- (2018) Daqian Gu et al. Journal for ImmunoTherapy of Cancer
- PD-1/ PD-L1 blockade as a novel treatment for colorectal cancer
- (2018) Neda Yaghoubi et al. BIOMEDICINE & PHARMACOTHERAPY
- Neurological adverse events associated with immune checkpoint inhibitors: Review of the literature
- (2017) S. Cuzzubbo et al. EUROPEAN JOURNAL OF CANCER
- Inflammatory cytokines IL-17 and TNF-α up-regulate PD-L1 expression in human prostate and colon cancer cells
- (2017) Xun Wang et al. IMMUNOLOGY LETTERS
- PD-L1 expression as a predictive biomarker in advanced non-small-cell lung cancer: updated survival data
- (2017) Pedro N Aguiar et al. Immunotherapy
- Regulation of programmed-death ligand in the human head and neck squamous cell carcinoma microenvironment is mediated through matrix metalloproteinase-mediated proteolytic cleavage
- (2017) Mayuko Hira-Miyazawa et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- PD-L1
- (2017) Anthousa Kythreotou et al. JOURNAL OF CLINICAL PATHOLOGY
- Melanoma subtypes demonstrate distinct PD-L1 expression profiles
- (2017) Genevieve J Kaunitz et al. LABORATORY INVESTIGATION
- PD-L1 expression in advanced NSCLC: Insights into risk stratification and treatment selection from a systematic literature review
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- High plasma levels of soluble programmed cell death ligand 1 are prognostic for reduced survival in advanced lung cancer
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- Prognostic significance of PD-L1 in solid tumor
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- Quantitative Mass Spectrometry Analysis of PD-L1 Protein Expression,N-glycosylation and Expression Stoichiometry with PD-1 and PD-L2 in Human Melanoma
- (2017) Carlos A. Morales-Betanzos et al. MOLECULAR & CELLULAR PROTEOMICS
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- (2017) Sydney R. Gordon et al. NATURE
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- (2017) Moh’d Khushman et al. PANCREAS
- Why the need and how to approach the functional diversity of extracellular vesicles
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- Proliferation of PD-1+ CD8 T cells in peripheral blood after PD-1–targeted therapy in lung cancer patients
- (2017) Alice O. Kamphorst et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- (2017) Enfu Hui et al. SCIENCE
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- (2017) Liliane Christ et al. TRENDS IN BIOCHEMICAL SCIENCES
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- (2017) Brian T. Maybruck et al. Journal for ImmunoTherapy of Cancer
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- (2016) Sangeeta Goswami et al. CANCER JOURNAL
- Communication by Extracellular Vesicles: Where We Are and Where We Need to Go
- (2016) Mercedes Tkach et al. CELL
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- (2016) Y Olmos et al. CURRENT OPINION IN CELL BIOLOGY
- Cancer Treatment with Anti-PD-1/PD-L1 Agents: Is PD-L1 Expression a Biomarker for Patient Selection?
- (2016) Lucia Festino et al. DRUGS
- PD-L1 (B7-H1) expression and the immune tumor microenvironment in primary and metastatic breast carcinomas
- (2016) Ashley Cimino-Mathews et al. HUMAN PATHOLOGY
- Lag-3, Tim-3, and TIGIT: Co-inhibitory Receptors with Specialized Functions in Immune Regulation
- (2016) Ana C. Anderson et al. IMMUNITY
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- Identification of Neutrophil Exocytosis Inhibitors (Nexinhibs), Small Molecule Inhibitors of Neutrophil Exocytosis and Inflammation
- (2016) Jennifer L. Johnson et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2016) Rong Xu et al. JOURNAL OF CLINICAL INVESTIGATION
- The biology and function of exosomes in cancer
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- (2016) Antoni Ribas et al. JOURNAL OF EXPERIMENTAL MEDICINE
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- (2016) Hui Yu et al. Journal of Thoracic Oncology
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- (2016) Takehito Shukuya et al. Journal of Thoracic Oncology
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- (2016) Ryan Newton et al. NATURE IMMUNOLOGY
- Reverse-topology membrane scission by the ESCRT proteins
- (2016) Johannes Schöneberg et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: Mechanisms, response biomarkers, and combinations
- (2016) Weiping Zou et al. Science Translational Medicine
- Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challenges
- (2016) Dinh Ha et al. Acta Pharmaceutica Sinica B
- PD-1 Blunts the Function of Ovarian Tumor–Infiltrating Dendritic Cells by Inactivating NF-κB
- (2015) Lavakumar Karyampudi et al. CANCER RESEARCH
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- (2015) Willem Stoorvogel CELL RESEARCH
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- (2015) Kathleen M. Mahoney et al. CLINICAL THERAPEUTICS
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- (2015) Alessandra Lo Cicero et al. CURRENT OPINION IN CELL BIOLOGY
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- (2015) Lara Milane et al. JOURNAL OF CONTROLLED RELEASE
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- (2015) Nan Chen et al. Journal of Thoracic Oncology
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- (2015) S. P. Patel et al. MOLECULAR CANCER THERAPEUTICS
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- (2015) Edjah K. Nduom et al. NEURO-ONCOLOGY
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- (2015) Daniel Enderle et al. PLoS One
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- (2015) Jordan M. Chinai et al. TRENDS IN PHARMACOLOGICAL SCIENCES
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- (2015) Colette Dezutter-Dambuyant et al. OncoImmunology
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- (2014) Marina Colombo et al. Annual Review of Cell and Developmental Biology
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- (2014) Suya Dai et al. CELLULAR IMMUNOLOGY
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- (2014) J. M. Taube et al. CLINICAL CANCER RESEARCH
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- (2014) Joanna Kowal et al. CURRENT OPINION IN CELL BIOLOGY
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- (2014) Santosh Phuyal et al. FEBS Journal
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- (2014) Liufu Deng et al. JOURNAL OF CLINICAL INVESTIGATION
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- (2014) Tamás Matusek et al. NATURE
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- (2014) Michael B. Dinkins et al. NEUROBIOLOGY OF AGING
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- (2014) Jason Madore et al. Pigment Cell & Melanoma Research
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- (2014) Eleni Anastasiadou et al. SCIENCE
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- (2013) David B. Page et al. Annual Review of Medicine
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- (2013) Fatemeh Momen-Heravi et al. BIOLOGICAL CHEMISTRY
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- (2013) M. Nishino et al. CLINICAL CANCER RESEARCH
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- (2013) Xiaoxiao Cheng et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2013) Daniela F Quail et al. NATURE MEDICINE
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- (2013) J. Couzin-Frankel SCIENCE
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- (2013) Christin Bissig et al. TRENDS IN CELL BIOLOGY
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- (2013) E. A. Akbay et al. Cancer Discovery
- The ESCRT machinery
- (2012) Oliver Schmidt et al. CURRENT BIOLOGY
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- (2012) Tadashi Yokosuka et al. JOURNAL OF EXPERIMENTAL MEDICINE
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- (2012) James H. Hurley et al. NATURE CELL BIOLOGY
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- (2012) Maria Francesca Baietti et al. NATURE CELL BIOLOGY
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- (2012) Michael A. Postow et al. NEW ENGLAND JOURNAL OF MEDICINE
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- (2012) N. Patsoukis et al. Science Signaling
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- (2011) J. L. Hood et al. CANCER RESEARCH
- The ESCRT Pathway
- (2011) William M. Henne et al. DEVELOPMENTAL CELL
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- (2011) Christian Steidl et al. NATURE
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- (2010) Jeremy Carlton BIOCHEMICAL SOCIETY TRANSACTIONS
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- (2010) J.-J. Park et al. BLOOD
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- (2009) Melanie A. Ruffner et al. EUROPEAN JOURNAL OF IMMUNOLOGY
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- (2009) James L. Riley IMMUNOLOGICAL REVIEWS
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- (2009) Matias Ostrowski et al. NATURE CELL BIOLOGY
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- (2008) Maaike S. Pols et al. EXPERIMENTAL CELL RESEARCH
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- (2008) Manish J. Butte et al. MOLECULAR IMMUNOLOGY
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- (2008) Johan Skog et al. NATURE CELL BIOLOGY
- Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes
- (2008) K. Trajkovic et al. SCIENCE
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