Reverse-topology membrane scission by the ESCRT proteins

The ESCRT machinery: new roles at new holes

(2016) Y Olmos et al.   CURRENT OPINION IN CELL BIOLOGY

Novel ESCRT functions in cell biology: spiraling out of control?

(2016) Coen Campsteijn et al.   CURRENT OPINION IN CELL BIOLOGY

ALIX and ESCRT-I/II function as parallel ESCRT-III recruiters in cytokinetic abscission

(2016) Liliane Christ et al.   JOURNAL OF CELL BIOLOGY

Meiotic Clade AAA ATPases: Protein Polymer Disassembly Machines

(2016) Nicole Monroe et al.   JOURNAL OF MOLECULAR BIOLOGY

A non-canonical ESCRT pathway, including histidine domain phosphotyrosine phosphatase (HD-PTP), is used for down-regulation of virally ubiquitinated MHC class I

(2015) M. D. J. Parkinson et al.   BIOCHEMICAL JOURNAL

The VPS-20 subunit of the endosomal sorting complex ESCRT-III exhibits an open conformation in the absence of upstream activation

(2015) Amber L. Schuh et al.   BIOCHEMICAL JOURNAL

Bud-Neck Scaffolding as a Possible Driving Force in ESCRT-Induced Membrane Budding

(2015) Moritz Mercker et al.   BIOPHYSICAL JOURNAL

Relaxation of Loaded ESCRT-III Spiral Springs Drives Membrane Deformation

(2015) Nicolas Chiaruttini et al.   CELL

ESCRT Filaments as Spiral Springs

(2015) Lars-Anders Carlson et al.   DEVELOPMENTAL CELL

ESCRTs are everywhere

(2015) J. H. Hurley   EMBO JOURNAL

Evidence for a Nonendosomal Function of the Saccharomyces cerevisiae ESCRT-III-Like Protein Chm7

(2015) I. Bauer et al.   GENETICS

Distinct Mechanisms of Recognizing Endosomal Sorting Complex Required for Transport III (ESCRT-III) Protein IST1 by Different Microtubule Interacting and Trafficking (MIT) Domains

(2015) Emily Z. Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Binding of Substrates to the Central Pore of the Vps4 ATPase Is Autoinhibited by the Microtubule Interacting and Trafficking (MIT) Domain and Activated by MIT Interacting Motifs (MIMs)

(2015) Han Han et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing

(2015) Marina Vietri et al.   NATURE

Vps4 disassembles an ESCRT-III filament by global unfolding and processive translocation

(2015) Bei Yang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Negative membrane curvature catalyzes nucleation of endosomal sorting complex required for transport (ESCRT)-III assembly

(2015) Il-Hyung Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evidence that the endosomal sorting complex required for transport-II (ESCRT-II) is required for efficient human immunodeficiency virus-1 (HIV-1) production

(2015) Bo Meng et al.   Retrovirology

Structure and membrane remodeling activity of ESCRT-III helical polymers

(2015) J. McCullough et al.   SCIENCE

Asymmetric ring structure of Vps4 required for ESCRT-III disassembly

(2015) Christophe Caillat et al.   Nature Communications

Vps4 disassembles an ESCRT-III filament by global unfolding and processive translocation

(2015) Bei Yang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

An ESCRT module is required for neuron pruning

(2015) Nicolas Loncle et al.   Scientific Reports

Super-Resolution Imaging of ESCRT-Proteins at HIV-1 Assembly Sites

(2015) Jens Prescher et al.   PLoS Pathogens

Vps4 Stimulatory Element of the Cofactor Vta1 Contacts the ATPase Vps4 α7 and α9 to Stimulate ATP Hydrolysis

(2014) Brian A. Davies et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural analysis and modeling reveals new mechanisms governing ESCRT-III spiral filament assembly

(2014) Qing-Tao Shen et al.   JOURNAL OF CELL BIOLOGY

Inhibition of ESCRT-II–CHMP6 interactions impedes cytokinetic abscission and leads to cell death

(2014) Inna Goliand et al.   MOLECULAR BIOLOGY OF THE CELL

Distribution of ESCRT Machinery at HIV Assembly Sites Reveals Virus Scaffolding of ESCRT Subunits

(2014) S. B. Van Engelenburg et al.   SCIENCE

Electron Tomography of HIV-1 Infection in Gut-Associated Lymphoid Tissue

(2014) Mark S. Ladinsky et al.   PLoS Pathogens

Membrane Fission Reactions of the Mammalian ESCRT Pathway

(2013) John McCullough et al.   Annual Review of Biochemistry

Virus Budding and the ESCRT Pathway

(2013) Jörg Votteler et al.   Cell Host & Microbe

Recruitment of UBPY and ESCRT Exchange Drive HD-PTP-Dependent Sorting of EGFR to the MVB

(2013) Nazim Ali et al.   CURRENT BIOLOGY

The Yeast Alix Homolog Bro1 Functions as a Ubiquitin Receptor for Protein Sorting into Multivesicular Endosomes

(2013) Natasha Pashkova et al.   DEVELOPMENTAL CELL

Structure-based in silico identification of ubiquitin-binding domains provides insights into the ALIX-V:ubiquitin complex and retrovirus budding

(2013) Tal Keren-Kaplan et al.   EMBO JOURNAL

Relief of Autoinhibition Enhances Vta1 Activation of Vps4 via the Vps4 Stimulatory Element

(2013) Andrew P. Norgan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An ESCRT–spastin interaction promotes fission of recycling tubules from the endosome

(2013) Rachel Allison et al.   JOURNAL OF CELL BIOLOGY

The Oligomeric State of the Active Vps4 AAA ATPase

(2013) Nicole Monroe et al.   JOURNAL OF MOLECULAR BIOLOGY

Electron cryotomography of ESCRT assemblies and dividing Sulfolobus cells suggests that spiraling filaments are involved in membrane scission

(2013) Megan J. Dobro et al.   MOLECULAR BIOLOGY OF THE CELL

Knowing when to cut and run: mechanisms that control cytokinetic abscission

(2013) Monica Agromayor et al.   TRENDS IN CELL BIOLOGY

The Endosomal Sorting Complex ESCRT-II Mediates the Assembly and Architecture of ESCRT-III Helices

(2012) William Mike Henne et al.   CELL

ESCRT-III CHMP2A and CHMP3 form variable helical polymersin vitroand act synergistically during HIV-1 budding

(2012) Grégory Effantin et al.   CELLULAR MICROBIOLOGY

ALIX Is a Lys63-Specific Polyubiquitin Binding Protein that Functions in Retrovirus Budding

(2012) Dara P. Dowlatshahi et al.   DEVELOPMENTAL CELL

In vitro reconstitution of the ordered assembly of the endosomal sorting complex required for transport at membrane-bound HIV-1 Gag clusters

(2012) L.-A. Carlson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Solution Structure of the ESCRT-I and -II Supercomplex: Implications for Membrane Budding and Scission

(2012) Evzen Boura et al.   STRUCTURE

Membrane-Elasticity Model of Coatless Vesicle Budding Induced by ESCRT Complexes

(2012) Bartosz Różycki et al.   PLoS Computational Biology

ESCRT-III Protein Requirements for HIV-1 Budding

(2011) Eiji Morita et al.   Cell Host & Microbe

The ESCRT Pathway

(2011) William M. Henne et al.   DEVELOPMENTAL CELL

Charged Multivesicular Body Protein 2B (CHMP2B) of the Endosomal Sorting Complex Required for Transport-III (ESCRT-III) Polymerizes into Helical Structures Deforming the Plasma Membrane

(2011) Gilles Bodon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of the Retroviral Budding Factor ALIX

(2011) Q. Zhai et al.   JOURNAL OF VIROLOGY

Live-cell visualization of dynamics of HIV budding site interactions with an ESCRT component

(2011) Viola Baumgärtel et al.   NATURE CELL BIOLOGY

Dynamics of ESCRT protein recruitment during retroviral assembly

(2011) Nolwenn Jouvenet et al.   NATURE CELL BIOLOGY

Host factors involved in retroviral budding and release

(2011) Juan Martin-Serrano et al.   NATURE REVIEWS MICROBIOLOGY

Dynamics of endosomal sorting complex required for transport (ESCRT) machinery during cytokinesis and its role in abscission

(2011) N. Elia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cortical Constriction During Abscission Involves Helices of ESCRT-III-Dependent Filaments

(2011) J. Guizetti et al.   SCIENCE

Structural Basis for ESCRT-III CHMP3 Recruitment of AMSH

(2011) Julianna Solomons et al.   STRUCTURE

SAXS Ensemble Refinement of ESCRT-III CHMP3 Conformational Transitions

(2011) Bartosz Różycki et al.   STRUCTURE

How Ubiquitin Functions with ESCRTs

(2011) S. Brookhart Shields et al.   TRAFFIC

ESCRT-II coordinates the assembly of ESCRT-III filaments for cargo sorting and multivesicular body vesicle formation

(2010) David Teis et al.   EMBO JOURNAL

Activation of Human VPS4A by ESCRT-III Proteins Reveals Ability of Substrates to Relieve Enzyme Autoinhibition

(2010) Samuel A. Merrill et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular mechanism of multivesicular body biogenesis by ESCRT complexes

(2010) Thomas Wollert et al.   NATURE

Membrane budding and scission by the ESCRT machinery: it's all in the neck

(2010) James H. Hurley et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural Role of the Vps4-Vta1 Interface in ESCRT-III Recycling

(2010) Dong Yang et al.   STRUCTURE

Structure and Function of the ESCRT-II-III Interface in Multivesicular Body Biogenesis

(2009) Young Jun Im et al.   DEVELOPMENTAL CELL

Structural Basis of Ist1 Function and Ist1–Did2 Interaction in the Multivesicular Body Pathway and Cytokinesis

(2009) Junyu Xiao et al.   MOLECULAR BIOLOGY OF THE CELL

Membrane scission by the ESCRT-III complex

(2009) Thomas Wollert et al.   NATURE

Structural basis for ESCRT-III protein autoinhibition

(2009) Monika Bajorek et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Membrane Buckling Induced by Curved Filaments

(2009) Martin Lenz et al.   PHYSICAL REVIEW LETTERS

Three-Dimensional Structure of AAA ATPase Vps4: Advancing Structural Insights into the Mechanisms of Endosomal Sorting and Enveloped Virus Budding

(2009) Michael John Landsberg et al.   STRUCTURE

A Crescent-Shaped ALIX Dimer Targets ESCRT-III CHMP4 Filaments

(2009) Ricardo Pires et al.   STRUCTURE

Computational Model of Membrane Fission Catalyzed by ESCRT-III

(2009) Gur Fabrikant et al.   PLoS Computational Biology

Structural Basis of Vta1 Function in the Multivesicular Body Sorting Pathway

(2008) Junyu Xiao et al.   DEVELOPMENTAL CELL

ESCRT-III Family Members Stimulate Vps4 ATPase Activity Directly or via Vta1

(2008) Ishara F. Azmi et al.   DEVELOPMENTAL CELL

Ordered Assembly of the ESCRT-III Complex on Endosomes Is Required to Sequester Cargo during MVB Formation

(2008) David Teis et al.   DEVELOPMENTAL CELL

MIT Domainia

(2008) James H. Hurley et al.   DEVELOPMENTAL CELL

Two Distinct Modes of ESCRT-III Recognition Are Required for VPS4 Functions in Lysosomal Protein Targeting and HIV-1 Budding

(2008) Collin Kieffer et al.   DEVELOPMENTAL CELL

Integrated Structural Model and Membrane Targeting Mechanism of the Human ESCRT-II Complex

(2008) Young Jun Im et al.   DEVELOPMENTAL CELL

Plasma membrane deformation by circular arrays of ESCRT-III protein filaments

(2008) Phyllis I. Hanson et al.   JOURNAL OF CELL BIOLOGY

Biochemical and Structural Studies of Yeast Vps4 Oligomerization

(2008) Malgorzata D. Gonciarz et al.   JOURNAL OF MOLECULAR BIOLOGY

Cryo-EM Structure of Dodecameric Vps4p and Its 2:1 Complex with Vta1p

(2008) Zhiheng Yu et al.   JOURNAL OF MOLECULAR BIOLOGY

Vacuolar Protein Sorting: Two Different Functional States of the AAA-ATPase Vps4p

(2008) Claudia Hartmann et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural Basis for Autoinhibition of ESCRT-III CHMP3

(2008) Suman Lata et al.   JOURNAL OF MOLECULAR BIOLOGY

Novel Interactions of ESCRT-III with LIP5 and VPS4 and their Implications for ESCRT-III Disassembly

(2008) Soomin Shim et al.   MOLECULAR BIOLOGY OF THE CELL

ALIX-CHMP4 interactions in the human ESCRT pathway

(2008) J. McCullough et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Helical Structures of ESCRT-III Are Disassembled by VPS4

(2008) S. Lata et al.   SCIENCE