Identification of Neutrophil Exocytosis Inhibitors (Nexinhibs), Small Molecule Inhibitors of Neutrophil Exocytosis and Inflammation

Munc13-4 Is a Rab11-binding Protein That Regulates Rab11-positive Vesicle Trafficking and Docking at the Plasma Membrane

(2015) Jennifer L. Johnson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of Rab27a in the regulation of neutrophil function

(2014) Sergio D. Catz   CELLULAR MICROBIOLOGY

Drugging the undruggable RAS: Mission Possible?

(2014) Adrienne D. Cox et al.   NATURE REVIEWS DRUG DISCOVERY

Upregulation of the Rab27a-Dependent Trafficking and Secretory Mechanisms Improves Lysosomal Transport, Alleviates Endoplasmic Reticulum Stress, and Reduces Lysosome Overload in Cystinosis

(2013) J. L. Johnson et al.   MOLECULAR AND CELLULAR BIOLOGY

Inhibition of Neutrophil Exocytosis Ameliorates Acute Lung Injury in Rats

(2013) Silvia M. Uriarte et al.   SHOCK

Neutrophil Function: From Mechanisms to Disease

(2012) Borko Amulic et al.   Annual Review of Immunology

MUNC13-4 Protein Regulates the Oxidative Response and Is Essential for Phagosomal Maturation and Bacterial Killing in Neutrophils

(2012) Jlenia Monfregola et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vesicular trafficking through cortical actin during exocytosis is regulated by the Rab27a effector JFC1/Slp1 and the RhoA-GTPase–activating protein Gem-interacting protein

(2012) Jennifer L. Johnson et al.   MOLECULAR BIOLOGY OF THE CELL

Myeloperoxidase and oxidative stress in rheumatoid arthritis

(2012) L. K. Stamp et al.   RHEUMATOLOGY

Bioactivation of Drugs: Risk and Drug Design

(2011) John S. Walsh et al.   Annual Review of Pharmacology and Toxicology

Increased Survival and Reduced Neutrophil Infiltration of the Liver in Rab27a- but Not Munc13-4-Deficient Mice in Lipopolysaccharide-Induced Systemic Inflammation

(2011) Jennifer L. Johnson et al.   INFECTION AND IMMUNITY

Granule Exocytosis Contributes to Priming and Activation of the Human Neutrophil Respiratory Burst

(2011) S. M. Uriarte et al.   JOURNAL OF IMMUNOLOGY

Fas-mediated neutrophil apoptosis is accelerated by Bid, Bak, and Bax and inhibited by Bcl-2 and Mcl-1

(2011) Ben A. Croker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of Neutrophil Elastase Inhibitor (Sivelestat Sodium) in the Treatment of Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS): A Systematic Review and Meta-Analysis

(2010) Kentaro Iwata et al.   INTERNAL MEDICINE

Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps

(2010) Venizelos Papayannopoulos et al.   JOURNAL OF CELL BIOLOGY

Increased myeloperoxidase enzyme activity in plasma is an indicator of inflammation and onset of sepsis

(2010) Nikhil Kothari et al.   JOURNAL OF CRITICAL CARE

Synaptotagmin-mediated vesicle fusion regulates cell migration

(2010) Richard A Colvin et al.   NATURE IMMUNOLOGY

DNase I Inhibits a Late Phase of Reactive Oxygen Species Production in Neutrophils

(2009) Daniela B. Munafo et al.   Journal of Innate Immunity

Rab27a and Rab27b Regulate Neutrophil Azurophilic Granule Exocytosis and NADPH oxidase Activity by Independent Mechanisms

(2009) Jennifer L. Johnson et al.   TRAFFIC

Augmented inducible nitric oxide synthase expression and increased NO production reduce sepsis-induced lung injury and mortality in myeloperoxidase-null mice

(2008) Viktor Brovkovych et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The GDP-dependent Rab27a effector coronin 3 controls endocytosis of secretory membrane in insulin-secreting cell lines

(2008) T. Kimura et al.   JOURNAL OF CELL SCIENCE

Potent, Selective and Cell Penetrant Inhibitors of SF-1 by Functional Ultra-High-Throughput Screening

(2008) F. Madoux et al.   MOLECULAR PHARMACOLOGY

Elucidation of Rab27 Recruitment by Its Effectors: Structure of Rab27a Bound to Exophilin4/Slp2-a

(2008) Leonard M.G. Chavas et al.   STRUCTURE

Slp1 and Slp2-a Localize to the Plasma Membrane of CTL and Contribute to Secretion from the Immunological Synapse

(2008) Oliver Holt et al.   TRAFFIC

The Rab27a Effectors JFC1/Slp1 and Munc13-4 Regulate Exocytosis of Neutrophil Granules

(2008) Agnieszka A. Brzezinska et al.   TRAFFIC