Systematic Surveys of Iron Homeostasis Mechanisms Reveal Ferritin Superfamily and Nucleotide Surveillance Regulation to be Modified by PINK1 Absence

Mechanisms of Mitochondrial Iron-Sulfur Protein Biogenesis

(2020) Roland Lill et al.   Annual Review of Biochemistry

Nrf2 and Ferroptosis: A New Research Direction for Neurodegenerative Diseases

(2020) Xiaohua Song et al.   Frontiers in Neuroscience

Molecular evidence of impaired iron metabolism and its association with Parkinson's disease progression

(2020) Haitao Chi et al.   3 Biotech

Cellular iron sensing and regulation: Nuclear IRP1 extends a classic paradigm

(2020) Anna Karen Hernández-Gallardo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Switching on Endogenous Metal Binding Proteins in Parkinson’s Disease

(2019) Fleur McLeary et al.   Cells

Iron in Neurodegeneration – Cause or Consequence?

(2019) Alain Ndayisaba et al.   Frontiers in Neuroscience

Dimeric ferrochelatase bridges ABCB7 and ABCB10 homodimers in an architecturally defined molecular complex required for heme biosynthesis

(2019) Nunziata Maio et al.   HAEMATOLOGICA

SerThr-PhosphoProteome of Brain from Aged PINK1-KO+A53T-SNCA Mice Reveals pT1928-MAP1B and pS3781-ANK2 Deficits, as Hub between Autophagy and Synapse Changes

(2019) Georg Auburger et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Intestinal infection triggers Parkinson’s disease-like symptoms in Pink1−/− mice

(2019) Diana Matheoud et al.   NATURE

Generation of an Atxn2-CAG100 knock-in mouse reveals N-acetylaspartate production deficit due to early Nat8l dysregulation

(2019) Nesli-Ece Sen et al.   NEUROBIOLOGY OF DISEASE

Interactions between iron and α-synuclein pathology in Parkinson's disease

(2019) Bingbing Chen et al.   FREE RADICAL BIOLOGY AND MEDICINE

MISTERMINATE Mechanistically Links Mitochondrial Dysfunction with Proteostasis Failure

(2019) Zhihao Wu et al.   MOLECULAR CELL

Programmed Cell-Death by Ferroptosis: Antioxidants as Mitigators

(2019) Kajarabille et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Glycogen branching enzyme controls cellular iron homeostasis via Iron Regulatory Protein 1 and mitoNEET

(2019) Nhan Huynh et al.   Nature Communications

Ubiquitination of ABCE1 by NOT4 in Response to Mitochondrial Damage Links Co-translational Quality Control to PINK1-Directed Mitophagy

(2018) Zhihao Wu et al.   Cell Metabolism

Loss of mitochondrial protease ClpP protects mice from diet‐induced obesity and insulin resistance

(2018) Shylesh Bhaskaran et al.   EMBO REPORTS

Levels of α- and β-synuclein regulate cellular susceptibility to toxicity from α-synuclein oligomers

(2018) Dafina M. Angelova et al.   FASEB JOURNAL

Acute loss of iron–sulfur clusters results in metabolic reprogramming and generation of lipid droplets in mammalian cells

(2018) Daniel R. Crooks et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Iron regulatory protein deficiency compromises mitochondrial function in murine embryonic fibroblasts

(2018) Huihui Li et al.   Scientific Reports

A Role for the Krebs Cycle Intermediate Citrate in Metabolic Reprogramming in Innate Immunity and Inflammation

(2018) Niamh C. Williams et al.   Frontiers in Immunology

Ameliorating mitochondrial dysfunction restores carbon ion-induced cognitive deficits via co-activation of NRF2 and PINK1 signaling pathway

(2018) Yang Liu et al.   Redox Biology

Mitochondrial Quality Control Mediated by PINK1 and PRKN: Links to Iron Metabolism and Tumor Immunity

(2018) Rui Kang et al.   Autophagy

PINK1 and PARK2 Suppress Pancreatic Tumorigenesis through Control of Mitochondrial Iron-Mediated Immunometabolism

(2018) Changfeng Li et al.   DEVELOPMENTAL CELL

Parkin and PINK1 mitigate STING-induced inflammation

(2018) Danielle A. Sliter et al.   NATURE

Artesunate-induced mitophagy alters cellular redox status

(2018) Jianbin Zhang et al.   Redox Biology

Iron‐induced energy supply deficiency and mitochondrial fragmentation in neurons

(2018) Xiao Tian Huang et al.   JOURNAL OF NEUROCHEMISTRY

Ferroptosis and Its Role in Diverse Brain Diseases

(2018) Abigail Weiland et al.   MOLECULAR NEUROBIOLOGY

STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

(2018) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Widespread Accumulation of Ribosome-Associated Isolated 3′ UTRs in Neuronal Cell Populations of the Aging Brain

(2018) Peter H. Sudmant et al.   Cell Reports

Metabolic Signature of Dietary Iron Overload in a Mouse Model

(2018) Chiara Volani et al.   Cells

The radical SAM protein HemW is a heme chaperone

(2017) Vera Haskamp et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reductions in the mitochondrial ABC transporter Abcb10 affect the transcriptional profile of heme biosynthesis genes

(2017) Alexandra Seguin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The iron chaperone poly(rC)-binding protein 2 forms a metabolon with the heme oxygenase 1/cytochrome P450 reductase complex for heme catabolism and iron transfer

(2017) Izumi Yanatori et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Iron–sulfur cluster biogenesis and trafficking in mitochondria

(2017) Joseph J. Braymer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Progression of pathology in PINK1-deficient mouse brain from splicing via ubiquitination, ER stress, and mitophagy changes to neuroinflammation

(2017) Sylvia Torres-Odio et al.   Journal of Neuroinflammation

DNA repair in the trinucleotide repeat disorders

(2017) Lesley Jones et al.   LANCET NEUROLOGY

Intracellular iron and heme trafficking and metabolism in developing erythroblasts

(2017) Martin D. Kafina et al.   Metallomics

The elemental role of iron in DNA synthesis and repair

(2017) Sergi Puig et al.   Metallomics

Alpha-synuclein ferrireductase activity is detectible in vivo , is altered in Parkinson's disease and increases the neurotoxicity of DOPAL

(2017) Jennifer S. McDowall et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Dietary antioxidants and risk of Parkinson's disease in two population-based cohorts

(2017) Fei Yang et al.   MOVEMENT DISORDERS

Antagonism of proteasome inhibitor-induced heme oxygenase-1 expression by PINK1 mutation

(2017) Xiang-Jun Sheng et al.   PLoS One

Activation of the mitochondrial unfolded protein response promotes longevity and dopamine neuron survival in Parkinson’s disease models

(2017) Jason F. Cooper et al.   Scientific Reports

α-Synuclein increases β-amyloid secretion by promoting β-/γ-secretase processing of APP

(2017) Hazel L. Roberts et al.   PLoS One

The Roles of NRF2 in Modulating Cellular Iron Homeostasis

(2017) Michael John Kerins et al.   ANTIOXIDANTS & REDOX SIGNALING

Synthesis, delivery and regulation of eukaryotic heme and Fe–S cluster cofactors

(2016) Dulmini P. Barupala et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

CISD1 inhibits ferroptosis by protection against mitochondrial lipid peroxidation

(2016) Hua Yuan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Molecular and cellular basis for the unique functioning of Nrf1, an indispensable transcription factor for maintaining cell homoeostasis and organ integrity

(2016) Y. Zhang et al.   BIOCHEMICAL JOURNAL

A Novel Role for Progesterone Receptor Membrane Component 1 (PGRMC1): A Partner and Regulator of Ferrochelatase

(2016) Robert B. Piel et al.   BIOCHEMISTRY

Mitochondrial ferritin suppresses MPTP-induced cell damage by regulating iron metabolism and attenuating oxidative stress

(2016) Lin-hao You et al.   BRAIN RESEARCH

Mammalian Fe–S proteins: definition of a consensus motif recognized by the co-chaperone HSC20

(2016) N. Maio et al.   Metallomics

Alpha-synuclein: relating metals to structure, function and inhibition

(2016) J. S. McDowall et al.   Metallomics

LRRK2 Expression Is Deregulated in Fibroblasts and Neurons from Parkinson Patients with Mutations in PINK1

(2016) Garikoitz Azkona et al.   MOLECULAR NEUROBIOLOGY

Mitochondrial and nuclear DNA matching shapes metabolism and healthy ageing

(2016) Ana Latorre-Pellicer et al.   NATURE

Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents

(2016) Dongryeol Ryu et al.   NATURE MEDICINE

Meta-analysis of brain iron levels of Parkinson’s disease patients determined by postmortem and MRI measurements

(2016) Jian-Yong Wang et al.   Scientific Reports

Differences in vulnerability of neurons and astrocytes to heme oxygenase-1 modulation: Implications for mitochondrial ferritin

(2016) Xiaojun Yu et al.   Scientific Reports

The Mitochondrial Unfoldase-Peptidase Complex ClpXP Controls Bioenergetics Stress and Metastasis

(2016) Jae Ho Seo et al.   PLOS BIOLOGY

The role of the ribosome in the regulation of longevity and lifespan extension

(2016) Alyson W. MacInnes   Wiley Interdisciplinary Reviews-RNA

Mitochondrial Bol1 and Bol3 function as assembly factors for specific iron-sulfur proteins

(2016) Marta A Uzarska et al.   eLife

Methyl-Arginine Profile of Brain from Aged PINK1-KO+A53T-SNCA Mice Suggests Altered Mitochondrial Biogenesis

(2016) Georg Auburger et al.   Parkinsons Disease

Iron–sulfur proteins responsible for RNA modifications

(2015) Satoshi Kimura et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease

(2015) D.J.R. Lane et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Biogenesis of cytosolic and nuclear iron–sulfur proteins and their role in genome stability

(2015) Viktoria Désirée Paul et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Identification of Genetic Factors that Modify Clinical Onset of Huntington’s Disease

(2015) Jong-Min Lee et al.   CELL

PINK1 and Parkin Control Localized Translation of Respiratory Chain Component mRNAs on Mitochondria Outer Membrane

(2015) Stephan Gehrke et al.   Cell Metabolism

Iron-Starvation-Induced Mitophagy Mediates Lifespan Extension upon Mitochondrial Stress in C. elegans

(2015) Alfonso Schiavi et al.   CURRENT BIOLOGY

Compartmentalization of iron between mitochondria and the cytosol and its regulation

(2015) Ulrich Mühlenhoff et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

The role of mitochondria and the CIA machinery in the maturation of cytosolic and nuclear iron–sulfur proteins

(2015) Roland Lill et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

The three ‘P’s of mitophagy: PARKIN, PINK1, and post-translational modifications

(2015) Thomas M. Durcan et al.   GENES & DEVELOPMENT

Mitochondrial iron supply is required for the developmental pulse of ecdysone biosynthesis that initiates metamorphosis in Drosophila melanogaster

(2015) Jose V. Llorens et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

A new role for α-synuclein in Parkinson's disease: Alteration of ER-mitochondrial communication

(2015) Cristina Guardia-Laguarta et al.   MOVEMENT DISORDERS

Endogenous Parkin Preserves Dopaminergic Substantia Nigral Neurons following Mitochondrial DNA Mutagenic Stress

(2015) Alicia M. Pickrell et al.   NEURON

Serum Ferritin Is Associated with Metabolic Syndrome and Red Meat Consumption

(2015) Avila Felipe et al.   Oxidative Medicine and Cellular Longevity

Cancer-Related NEET Proteins Transfer 2Fe-2S Clusters to Anamorsin, a Protein Required for Cytosolic Iron-Sulfur Cluster Biogenesis

(2015) Colin H. Lipper et al.   PLoS One

α-Synuclein as a ferrireductase

(2015) David R. Brown   BIOCHEMICAL SOCIETY TRANSACTIONS

NRF2 Regulates PINK1 Expression under Oxidative Stress Conditions

(2015) Hitoshi Murata et al.   PLoS One

Biology of ferritin in mammals: an update on iron storage, oxidative damage and neurodegeneration

(2014) Dario Finazzi et al.   ARCHIVES OF TOXICOLOGY

Mitochondrial iron–sulfur protein biogenesis and human disease

(2014) Oliver Stehling et al.   BIOCHIMIE

The paradox of mitochondrial dysfunction and extended longevity

(2014) Erin Munkácsy et al.   EXPERIMENTAL GERONTOLOGY

The active role of vitamin C in mammalian iron metabolism: Much more than just enhanced iron absorption!

(2014) Darius J.R. Lane et al.   FREE RADICAL BIOLOGY AND MEDICINE

Potentiation of neurotoxicity in double-mutant mice with Pink1 ablation and A53T-SNCA overexpression

(2014) Suzana Gispert et al.   HUMAN MOLECULAR GENETICS

Iron Regulatory Protein-1 Protects against Mitoferrin-1-deficient Porphyria

(2014) Jacky Chung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HBS1L-MYB intergenic variants modulate fetal hemoglobin via long-range MYB enhancers

(2014) Ralph Stadhouders et al.   JOURNAL OF CLINICAL INVESTIGATION

Metabolome and Proteome Profiling of Complex I Deficiency Induced by Rotenone

(2014) Ina Gielisch et al.   JOURNAL OF PROTEOME RESEARCH

Minimal, encapsulated proteomic-sample processing applied to copy-number estimation in eukaryotic cells

(2014) Nils A Kulak et al.   NATURE METHODS

Loss of PINK1 Impairs Stress-Induced Autophagy and Cell Survival

(2014) Dajana Parganlija et al.   PLoS One

PINK1 deficiency sustains cell proliferation by reprogramming glucose metabolism through HIF1

(2014) Raquel Requejo-Aguilar et al.   Nature Communications

Base Excision Repair Facilitates a Functional Relationship Between Guanine Oxidation and Histone Demethylation

(2013) Jianfeng Li et al.   ANTIOXIDANTS & REDOX SIGNALING

Loss of iron triggers PINK1/Parkin-independent mitophagy

(2013) George F G Allen et al.   EMBO REPORTS

Loss of mitochondrial peptidase Clpp leads to infertility, hearing loss plus growth retardation via accumulation of CLPX, mtDNA and inflammatory factors

(2013) S. Gispert et al.   HUMAN MOLECULAR GENETICS

Each Member of the Poly-r(C)-binding Protein 1 (PCBP) Family Exhibits Iron Chaperone Activity toward Ferritin

(2013) Sebastien Leidgens et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The ubiquitin ligase parkin mediates resistance to intracellular pathogens

(2013) Paolo S. Manzanillo et al.   NATURE

The Role of Mitochondria in Cellular Iron-Sulfur Protein Biogenesis: Mechanisms, Connected Processes, and Diseases

(2013) O. Stehling et al.   Cold Spring Harbor Perspectives in Biology

Iron modulates cell survival in a Ras- and MAPK-dependent manner in ovarian cells

(2013) K A Bauckman et al.   Cell Death & Disease

Human CLPP reverts the longevity phenotype of a fungal ClpP deletion strain

(2013) Fabian Fischer et al.   Nature Communications

Aconitase Causes Iron Toxicity in Drosophila pink1 Mutants

(2013) Giovanni Esposito et al.   PLoS Genetics

Mammalian iron metabolism and its control by iron regulatory proteins

(2012) Cole P. Anderson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mitochondria and Organismal Longevity

(2012) Ara B. Hwang et al.   CURRENT GENOMICS

Siderophore-mediated iron trafficking in humans is regulated by iron

(2012) Zhuoming Liu et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Iron–sulfur cluster synthesis, iron homeostasis and oxidative stress in Friedreich ataxia

(2012) Rachael A. Vaubel et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

The essential iron-sulfur protein Rli1 is an important target accounting for inhibition of cell growth by reactive oxygen species

(2012) Alawiah Alhebshi et al.   MOLECULAR BIOLOGY OF THE CELL

Primary Skin Fibroblasts as a Model of Parkinson's Disease

(2012) Georg Auburger et al.   MOLECULAR NEUROBIOLOGY

Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export

(2012) Peng Lei et al.   NATURE MEDICINE

Reduction of Mitoferrin Results in Abnormal Development and Extended Lifespan in Caenorhabditis elegans

(2012) Yaguang Ren et al.   PLoS One

Disruption of ATP-binding cassette B8 in mice leads to cardiomyopathy through a decrease in mitochondrial iron export

(2012) Y. Ichikawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of mitochondrial complex I inhibition on Fe–S cluster protein activity

(2011) Natalia P. Mena et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Genome-Wide association study identifies candidate genes for Parkinson's disease in an Ashkenazi Jewish population

(2011) Xinmin Liu et al.   BMC Medical Genetics

Iron accumulation and neurotoxicity in cortical cultures treated with holotransferrin

(2011) Jing Chen-Roetling et al.   FREE RADICAL BIOLOGY AND MEDICINE

Alpha- and beta-synuclein expression in Parkinson disease with and without dementia

(2011) Katrin Beyer et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Restriction of trophic factors and nutrients induces PARKIN expression

(2011) M. Klinkenberg et al.   NEUROGENETICS

What Genetics Tells us About the Causes and Mechanisms of Parkinson's Disease

(2011) Olga Corti et al.   PHYSIOLOGICAL REVIEWS

Correction: Alpha-Synuclein Is a Cellular Ferrireductase

(2011) Paul Davies et al.   PLoS One

Uncovering the roles of PINK1 and Parkin in mitophagy

(2010) Noriyuki Matsuda et al.   Autophagy

Iron in neuronal function and dysfunction

(2010) Gabriela A. Salvador   BIOFACTORS

Ferrochelatase forms an oligomeric complex with mitoferrin-1 and Abcb10 for erythroid heme biosynthesis

(2010) W. Chen et al.   BLOOD

Iron Regulatory Proteins Secure Mitochondrial Iron Sufficiency and Function

(2010) Bruno Galy et al.   Cell Metabolism

Cytochrome P450 regulation: the interplay between its heme and apoprotein moieties in synthesis, assembly, repair, and disposal

(2010) Maria Almira Correia et al.   DRUG METABOLISM REVIEWS

Long-lived mitochondrial (Mit) mutants of Caenorhabditis elegans utilize a novel metabolism

(2010) Jeffrey A. Butler et al.   FASEB JOURNAL

Structural Basis of Drug Binding to CYP46A1, an Enzyme That Controls Cholesterol Turnover in the Brain

(2010) Natalia Mast et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Decreased expression of Drp1 and Fis1 mediates mitochondrial elongation in senescent cells and enhances resistance to oxidative stress through PINK1

(2010) Sören Mai et al.   JOURNAL OF CELL SCIENCE

A Noncanonical Mechanism of Nrf2 Activation by Autophagy Deficiency: Direct Interaction between Keap1 and p62

(2010) A. Lau et al.   MOLECULAR AND CELLULAR BIOLOGY

Environmental Neurotoxic Pesticide Increases Histone Acetylation to Promote Apoptosis in Dopaminergic Neuronal Cells: Relevance to Epigenetic Mechanisms of Neurodegeneration

(2010) C. Song et al.   MOLECULAR PHARMACOLOGY

Extended lifespan of Drosophila parkin mutants through sequestration of redox-active metals and enhancement of anti-oxidative pathways

(2010) Nidhi Saini et al.   NEUROBIOLOGY OF DISEASE

Enhanced vulnerability of PARK6 patient skin fibroblasts to apoptosis induced by proteasomal stress

(2010) M. Klinkenberg et al.   NEUROSCIENCE

Iron and reactive oxygen species activity in parkinsonian substantia nigra

(2010) Anna Wypijewska et al.   PARKINSONISM & RELATED DISORDERS

Is there more to aging than mitochondrial DNA and reactive oxygen species?

(2009) Mikhail F. Alexeyev   FEBS Journal

Pantothenate kinase-associated neurodegeneration: insights from a Drosophila model

(2009) Z. Wu et al.   HUMAN MOLECULAR GENETICS

Ectopic localization of FOXO3a protein in Lewy bodies in Lewy body dementia and Parkinson's disease

(2009) Bo Su et al.   Molecular Neurodegeneration

Function and biogenesis of iron–sulphur proteins

(2009) Roland Lill   NATURE

Parkinson Phenotype in Aged PINK1-Deficient Mice Is Accompanied by Progressive Mitochondrial Dysfunction in Absence of Neurodegeneration

(2009) Suzana Gispert et al.   PLoS One

Abcb10 physically interacts with mitoferrin-1 (Slc25a37) to enhance its stability and function in the erythroid mitochondria

(2009) W. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dietary Iron Intake and Risk of Parkinson's Disease

(2008) G. Logroscino et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Parkinson patient fibroblasts show increased alpha-synuclein expression

(2008) Hans-Hermann Hoepken et al.   EXPERIMENTAL NEUROLOGY

Regulation of Mitochondrial Iron Import through Differential Turnover of Mitoferrin 1 and Mitoferrin 2

(2008) P. N. Paradkar et al.   MOLECULAR AND CELLULAR BIOLOGY

Analyzing real-time PCR data by the comparative CT method

(2008) Thomas D Schmittgen et al.   Nature Protocols

A Cytosolic Iron Chaperone That Delivers Iron to Ferritin

(2008) H. Shi et al.   SCIENCE

Sleep quality in a family with hereditary parkinsonism (PARK6)

(2007) I. Tuin et al.   SLEEP MEDICINE