Iron–sulfur cluster biogenesis and trafficking in mitochondria

In vitro characterization of a novel Isu homologue from Drosophila melanogaster for de novo FeS-cluster formation

(2017) Stephen P. Dzul et al.   Metallomics

Evolutionary conservation and in vitro reconstitution of microsporidian iron–sulfur cluster biosynthesis

(2017) Sven-A. Freibert et al.   Nature Communications

The Relationship between Environmental Dioxygen and Iron-Sulfur Proteins Explored at the Genome Level

(2017) Claudia Andreini et al.   PLoS One

Real-Time Kinetic Probes Support Monothiol Glutaredoxins As Intermediate Carriers in Fe–S Cluster Biosynthetic Pathways

(2016) James N. Vranish et al.   ACS Chemical Biology

Discoveries, metabolic roles and diseases of mitochondrial carriers: A review

(2016) Ferdinando Palmieri et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Disease-Causing SDHAF1 Mutations Impair Transfer of Fe-S Clusters to SDHB

(2016) Nunziata Maio et al.   Cell Metabolism

A Eukaryote without a Mitochondrial Organelle

(2016) Anna Karnkowska et al.   CURRENT BIOLOGY

Architecture of the Yeast Mitochondrial Iron-Sulfur Cluster Assembly Machinery

(2016) Wasantha Ranatunga et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Architecture of the Human Mitochondrial Iron-Sulfur Cluster Assembly Machinery

(2016) Oleksandr Gakh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mammalian Fe–S proteins: definition of a consensus motif recognized by the co-chaperone HSC20

(2016) N. Maio et al.   Metallomics

Structure of mammalian respiratory complex I

(2016) Jiapeng Zhu et al.   NATURE

Structural/Functional Properties of Human NFU1, an Intermediate [4Fe-4S] Carrier in Human Mitochondrial Iron-Sulfur Cluster Biogenesis

(2016) Kai Cai et al.   STRUCTURE

Mitochondrial Bol1 and Bol3 function as assembly factors for specific iron-sulfur proteins

(2016) Marta A Uzarska et al.   eLife

Role of Nfu1 and Bol3 in iron-sulfur cluster transfer to mitochondrial clients

(2016) Andrew Melber et al.   eLife

The mitochondrial acyl carrier protein (ACP) coordinates mitochondrial fatty acid synthesis with iron sulfur cluster biogenesis

(2016) Jonathan G Van Vranken et al.   eLife

How Is Fe-S Cluster Formation Regulated?

(2015) Erin L. Mettert et al.   Annual Review of Microbiology

The Human Iron–Sulfur Assembly Complex Catalyzes the Synthesis of [2Fe-2S] Clusters on ISCU2 That Can Be Transferred to Acceptor Molecules

(2015) Nicholas G. Fox et al.   BIOCHEMISTRY

Emerging critical roles of Fe–S clusters in DNA replication and repair

(2015) Jill O. Fuss et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Genetic approaches of the Fe–S cluster biogenesis process in bacteria: Historical account, methodological aspects and future challenges

(2015) Béatrice Py et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The roles of glutaredoxins ligating Fe–S clusters: Sensing, transfer or repair functions?

(2015) Jérémy Couturier et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

IscS from Archaeoglobus fulgidus has no desulfurase activity but may provide a cysteine ligand for [Fe 2 S 2 ] cluster assembly

(2015) Adrien Pagnier et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Assembly of Fe/S proteins in bacterial systems

(2015) B. Blanc et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease

(2015) D.J.R. Lane et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Ferredoxin, in conjunction with NADPH and ferredoxin-NADP reductase, transfers electrons to the IscS/IscU complex to promote iron–sulfur cluster assembly

(2015) Robert Yan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

The role of mitochondria and the CIA machinery in the maturation of cytosolic and nuclear iron–sulfur proteins

(2015) Roland Lill et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Mapping Key Residues of ISD11 Critical for NFS1-ISD11 Subcomplex Stability

(2015) Prasenjit Prasad Saha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional implications of the interaction between HscB and IscU in the biosynthesis of FeS clusters

(2015) Stefania Iametti et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Mutation of the iron-sulfur cluster assembly gene IBA57 causes fatal infantile leukodystrophy

(2015) François-Guillaume Debray et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Fe/S protein assembly gene IBA57 mutation causes hereditary spastic paraplegia

(2015) A. Lossos et al.   NEUROLOGY

Mammalian frataxin directly enhances sulfur transfer of NFS1 persulfide to both ISCU and free thiols

(2015) Aubérie Parent et al.   Nature Communications

Turning Saccharomyces cerevisiae into a Frataxin-Independent Organism

(2015) Heeyong Yoon et al.   PLoS Genetics

Human Frataxin Activates Fe–S Cluster Biosynthesis by Facilitating Sulfur Transfer Chemistry

(2014) Jennifer Bridwell-Rabb et al.   BIOCHEMISTRY

H2S and its role in redox signaling

(2014) Omer Kabil et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Mammalian Fe–S cluster biogenesis and its implication in disease

(2014) Lena K. Beilschmidt et al.   BIOCHIMIE

Mitochondrial iron–sulfur protein biogenesis and human disease

(2014) Oliver Stehling et al.   BIOCHIMIE

Fe-S Cluster Biogenesis in Isolated Mammalian Mitochondria

(2014) Alok Pandey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and Spectroscopic Insights into BolA-Glutaredoxin Complexes

(2014) Thomas Roret et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Overlapping Binding Sites of the Frataxin Homologue Assembly Factor and the Heat Shock Protein 70 Transfer Factor on the Isu Iron-Sulfur Cluster Scaffold Protein

(2014) Mateusz Manicki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Formation of [4Fe-4S] Clusters in the Mitochondrial Iron–Sulfur Cluster Assembly Machinery

(2014) Diego Brancaccio et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mammalian iron–sulphur proteins: novel insights into biogenesis and function

(2014) Tracey A. Rouault   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The LYR protein subunit NB4M/NDUFA6 of mitochondrial complex I anchors an acyl carrier protein and is essential for catalytic activity

(2014) H. Angerer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional reconstitution of mitochondrial Fe/S cluster synthesis on Isu1 reveals the involvement of ferredoxin

(2014) Holger Webert et al.   Nature Communications

Arabidopsis thaliana Nfu2 Accommodates [2Fe-2S] or [4Fe-4S] Clusters and Is Competent for in Vitro Maturation of Chloroplast [2Fe-2S] and [4Fe-4S] Cluster-Containing Proteins

(2013) Huanyao Gao et al.   BIOCHEMISTRY

Highly divergent mitochondrion-related organelles in anaerobic parasitic protozoa

(2013) Takashi Makiuchi et al.   BIOCHIMIE

Viperin is an iron-sulfur protein that inhibits genome synthesis of tick-borne encephalitis virus via radical SAM domain activity

(2013) Arunkumar S. Upadhyay et al.   CELLULAR MICROBIOLOGY

Frataxin Directly Stimulates Mitochondrial Cysteine Desulfurase by Exposing Substrate-binding Sites, and a Mutant Fe-S Cluster Scaffold Protein with Frataxin-bypassing Ability Acts Similarly

(2013) Alok Pandey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ferredoxin Competes with Bacterial Frataxin in Binding to the Desulfurase IscS

(2013) Robert Yan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Binding of the Chaperone Jac1 Protein and Cysteine Desulfurase Nfs1 to the Iron-Sulfur Cluster Scaffold Isu Protein Is Mutually Exclusive

(2013) Julia Majewska et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Frataxin: a protein in search for a function

(2013) Annalisa Pastore et al.   JOURNAL OF NEUROCHEMISTRY

The mitochondrial Hsp70 chaperone Ssq1 facilitates Fe/S cluster transfer from Isu1 to Grx5 by complex formation

(2013) Marta A. Uzarska et al.   MOLECULAR BIOLOGY OF THE CELL

Chaperone machines for protein folding, unfolding and disaggregation

(2013) Helen Saibil   NATURE REVIEWS MOLECULAR CELL BIOLOGY

(IscS-IscU)2Complex Structures Provide Insights into Fe2S2Biogenesis and Transfer

(2012) Elodie N. Marinoni et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Persulfide formation on mitochondrial cysteine desulfurase: enzyme activation by a eukaryote-specific interacting protein and Fe–S cluster synthesis

(2012) Alok Pandey et al.   BIOCHEMICAL JOURNAL

Spectroscopic and Functional Characterization of Iron–Sulfur Cluster-Bound Forms of Azotobacter vinelandiiNifIscA

(2012) Daphne T. Mapolelo et al.   BIOCHEMISTRY

Monothiol CGFS Glutaredoxins and BolA-like Proteins: [2Fe-2S] Binding Partners in Iron Homeostasis

(2012) Haoran Li et al.   BIOCHEMISTRY

Spectroscopic and Functional Characterization of Iron-Bound Forms of Azotobacter vinelandiiNifIscA

(2012) Daphne T. Mapolelo et al.   BIOCHEMISTRY

The role of mitochondria in cellular iron–sulfur protein biogenesis and iron metabolism

(2012) Roland Lill et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Monothiol glutaredoxins and A-type proteins: partners in Fe–S cluster trafficking

(2012) Daphne T. Mapolelo et al.   DALTON TRANSACTIONS

Monothiol Glutaredoxins Function in Storing and Transporting [Fe2S2] Clusters Assembled on IscU Scaffold Proteins

(2012) Priyanka Shakamuri et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The human mitochondrial ISCA1, ISCA2, and IBA57 proteins are required for [4Fe-4S] protein maturation

(2012) Alex D. Sheftel et al.   MOLECULAR BIOLOGY OF THE CELL

Molecular organization, biochemical function, cellular role and evolution of NfuA, an atypical Fe-S carrier

(2012) Béatrice Py et al.   MOLECULAR MICROBIOLOGY

Mutations in Iron-Sulfur Cluster Scaffold Genes NFU1 and BOLA3 Cause a Fatal Deficiency of Multiple Respiratory Chain and 2-Oxoacid Dehydrogenase Enzymes

(2011) Jessie M. Cameron et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A Fatal Mitochondrial Disease Is Associated with Defective NFU1 Function in the Maturation of a Subset of Mitochondrial Fe-S Proteins

(2011) Aleix Navarro-Sastre et al.   AMERICAN JOURNAL OF HUMAN GENETICS

TheE. coliMonothiol Glutaredoxin GrxD Forms Homodimeric and Heterodimeric FeS Cluster Containing Complexes

(2011) N. Yeung et al.   BIOCHEMISTRY

Facilitated Transfer of IscU–[2Fe2S] Clusters by Chaperone-Mediated Ligand Exchange

(2011) Francesco Bonomi et al.   BIOCHEMISTRY

Both human ferredoxins 1 and 2 and ferredoxin reductase are important for iron-sulfur cluster biogenesis

(2011) Yanbo Shi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Specialized Function of Yeast Isa1 and Isa2 Proteins in the Maturation of Mitochondrial [4Fe-4S] Proteins

(2011) Ulrich Mühlenhoff et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Monothiol glutaredoxin Grx5 interacts with Fe–S scaffold proteins Isa1 and Isa2 and supports Fe–S assembly and DNA integrity in mitochondria of fission yeast

(2010) Kyoung-Dong Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The crystal structure of human GLRX5: iron–sulfur cluster co-ordination, tetrameric assembly and monomer activity

(2010) Catrine Johansson et al.   BIOCHEMICAL JOURNAL

Mitochondrial fatty acid synthesis and respiration

(2010) J. Kalervo Hiltunen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Cytosolic Monothiol Glutaredoxins Function in Intracellular Iron Sensing and Trafficking via Their Bound Iron-Sulfur Cluster

(2010) Ulrich Mühlenhoff et al.   Cell Metabolism

Co-evolution-driven switch of J-protein specificity towards an Hsp70 partner

(2010) Sebastian Pukszta et al.   EMBO REPORTS

The HSP70 chaperone machinery: J proteins as drivers of functional specificity

(2010) Harm H. Kampinga et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Humans possess two mitochondrial ferredoxins, Fdx1 and Fdx2, with distinct roles in steroidogenesis, heme, and Fe/S cluster biosynthesis

(2010) A. D. Sheftel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural bases for the interaction of frataxin with the central components of iron–sulphur cluster assembly

(2010) Filippo Prischi et al.   Nature Communications

Structural Basis for Fe–S Cluster Assembly and tRNA Thiolation Mediated by IscS Protein–Protein Interactions

(2010) Rong Shi et al.   PLOS BIOLOGY

Human Ind1, an Iron-Sulfur Cluster Assembly Factor for Respiratory Complex I

(2009) A. D. Sheftel et al.   MOLECULAR AND CELLULAR BIOLOGY

Function and biogenesis of iron–sulphur proteins

(2009) Roland Lill   NATURE

The other nanotech

(2009)   Nature Nanotechnology

The iron–sulphur protein Ind1 is required for effective complex I assembly

(2008) Katrine Bych et al.   EMBO JOURNAL

A Proposed Role for theAzotobacter vinelandiiNfuA Protein as an Intermediate Iron-Sulfur Cluster Carrier

(2008) Sibali Bandyopadhyay et al.   JOURNAL OF BIOLOGICAL CHEMISTRY