The Mitochondrial Unfoldase-Peptidase Complex ClpXP Controls Bioenergetics Stress and Metastasis

ClpX stimulates the mitochondrial unfolded protein response (UPRmt) in mammalian cells

(2015) Natalie Al-Furoukh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Inhibition of the Mitochondrial Protease ClpP as a Therapeutic Strategy for Human Acute Myeloid Leukemia

(2015) Alicia Cole et al.   CANCER CELL

An Adaptor Hierarchy Regulates Proteolysis during a Bacterial Cell Cycle

(2015) Kamal Kishore Joshi et al.   CELL

Proteostasis control by the unfolded protein response

(2015) Claudio Hetz et al.   NATURE CELL BIOLOGY

PI3K therapy reprograms mitochondrial trafficking to fuel tumor cell invasion

(2015) M. Cecilia Caino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Survivin promotes oxidative phosphorylation, subcellular mitochondrial repositioning, and tumor cell invasion

(2015) Dayana B. Rivadeneira et al.   Science Signaling

Endoplasmic Reticulum Stress-Activated Cell Reprogramming in Oncogenesis

(2015) E. Chevet et al.   Cancer Discovery

Survivin promotes oxidative phosphorylation, subcellular mitochondrial repositioning, and tumor cell invasion

(2015) Dayana B. Rivadeneira et al.   Science Signaling

Dynamics of the ClpP serine protease: A model for self-compartmentalized proteases

(2014) Kaiyin Liu et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Organismal proteostasis: role of cell-nonautonomous regulation and transcellular chaperone signaling

(2014) P. van Oosten-Hawle et al.   GENES & DEVELOPMENT

Who controls the ATP supply in cancer cells? Biochemistry lessons to understand cancer energy metabolism

(2014) Rafael Moreno-Sánchez et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Rab5 is required in metastatic cancer cells for Caveolin-1-enhanced Rac1 activation, migration and invasion

(2014) J. Diaz et al.   JOURNAL OF CELL SCIENCE

TRAP1 Regulates Proliferation, Mitochondrial Function, and Has Prognostic Significance in NSCLC

(2014) Jackeline Agorreta et al.   MOLECULAR CANCER RESEARCH

Structural Asymmetry in the Closed State of Mitochondrial Hsp90 (TRAP1) Supports a Two-Step ATP Hydrolysis Mechanism

(2014) Laura A. Lavery et al.   MOLECULAR CELL

Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

(2014) Andrea Viale et al.   NATURE

PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis

(2014) Valerie S. LeBleu et al.   NATURE CELL BIOLOGY

Deletion of the Mitochondrial Chaperone TRAP-1 Uncovers Global Reprogramming of Metabolic Networks

(2014) Sofia Lisanti et al.   Cell Reports

Overcoming Intrinsic Multidrug Resistance in Melanoma by Blocking the Mitochondrial Respiratory Chain of Slow-Cycling JARID1Bhigh Cells

(2013) Alexander Roesch et al.   CANCER CELL

Loss of mitochondrial peptidase Clpp leads to infertility, hearing loss plus growth retardation via accumulation of CLPX, mtDNA and inflammatory factors

(2013) S. Gispert et al.   HUMAN MOLECULAR GENETICS

Metabolic stress regulates cytoskeletal dynamics and metastasis of cancer cells

(2013) M. Cecilia Caino et al.   JOURNAL OF CLINICAL INVESTIGATION

Activated ClpP kills persisters and eradicates a chronic biofilm infection

(2013) B. P. Conlon et al.   NATURE

Drosophila Trap1 protects against mitochondrial dysfunction in a PINK1/parkin model of Parkinson’s disease

(2013) A C Costa et al.   Cell Death & Disease

Control of Tumor Bioenergetics and Survival Stress Signaling by Mitochondrial HSP90s

(2012) Young Chan Chae et al.   CANCER CELL

Aberrant Overexpression of the Cell Polarity Module Scribble in Human Cancer

(2011) Valentina Vaira et al.   AMERICAN JOURNAL OF PATHOLOGY

TRAP-1, the mitochondrial Hsp90

(2011) Dario C. Altieri et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

ClpXP, an ATP-powered unfolding and protein-degradation machine

(2011) Tania A. Baker et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Exploiting the mitochondrial unfolded protein response for cancer therapy in mice and human cells

(2011) Markus D. Siegelin et al.   JOURNAL OF CLINICAL INVESTIGATION

Molecular chaperones in protein folding and proteostasis

(2011) F. Ulrich Hartl et al.   NATURE

Survivin and IAP proteins in cell-death mechanisms

(2010) Dario C. Altieri   BIOCHEMICAL JOURNAL

The mitochondrial UPR - protecting organelle protein homeostasis

(2010) C. M. Haynes et al.   JOURNAL OF CELL SCIENCE

Targeting mitochondria for cancer therapy

(2010) Simone Fulda et al.   NATURE REVIEWS DRUG DISCOVERY

HSP90 at the hub of protein homeostasis: emerging mechanistic insights

(2010) Mikko Taipale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE