α-Synuclein increases β-amyloid secretion by promoting β-/γ-secretase processing of APP
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Title
α-Synuclein increases β-amyloid secretion by promoting β-/γ-secretase processing of APP
Authors
Keywords
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Journal
PLoS One
Volume 12, Issue 2, Pages e0171925
Publisher
Public Library of Science (PLoS)
Online
2017-02-11
DOI
10.1371/journal.pone.0171925
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Related references
Note: Only part of the references are listed.- Neuropathology of Autosomal Dominant Alzheimer Disease in the National Alzheimer Coordinating Center Database
- (2016) John M. Ringman et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Implication of Alpha-Synuclein Phosphorylation at S129 in Synucleinopathies: What Have We Learned in the Last Decade?
- (2016) Abid Oueslati Journal of Parkinsons Disease
- Non-Amyloid-β Component of Human α-Synuclein Oligomers Induces Formation of New Aβ Oligomers: Insight into the Mechanisms That Link Parkinson’s and Alzheimer’s Diseases
- (2015) Yoav Atsmon-Raz et al. ACS Chemical Neuroscience
- CSF β-Amyloid 1-42 Predicts Progression to Cognitive Impairment in Newly Diagnosed Parkinson Disease
- (2015) Mark Terrelonge et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- Amyloid deposition in Parkinson's disease and cognitive impairment: A systematic review
- (2015) Myria Petrou et al. MOVEMENT DISORDERS
- Inhibition of amyloid-β plaque formation by α-synuclein
- (2015) Teresa Bachhuber et al. NATURE MEDICINE
- Transcriptional Regulation of BACE1 by NFAT3 Leads to Enhanced Amyloidogenic Processing
- (2015) Zhengrong Mei et al. NEUROCHEMICAL RESEARCH
- Amyloid-β and α-synuclein cerebrospinal fluid biomarkers and cognition in early Parkinson's disease
- (2015) Ane Løvli Stav et al. PARKINSONISM & RELATED DISORDERS
- Immunotherapy in Parkinson’s Disease: Micromanaging Alpha-Synuclein Aggregation
- (2015) Sonia George et al. Journal of Parkinsons Disease
- Associations between Cerebrospinal Fluid Biomarkers and Cognition in Early Untreated Parkinson’s Disease
- (2015) Ragnhild E. Skogseth et al. Journal of Parkinsons Disease
- APP and APLP2 interact with the synaptic release machinery and facilitate transmitter release at hippocampal synapses
- (2015) Tomas Fanutza et al. eLife
- α-Synuclein as a ferrireductase
- (2015) David R. Brown BIOCHEMICAL SOCIETY TRANSACTIONS
- Iron increases APP translation and amyloid-beta production in the retina
- (2014) Lucie Y. Guo et al. EXPERIMENTAL EYE RESEARCH
- Tau protein, beta-amyloid1–42 and clusterin CSF levels in the differential diagnosis of Parkinsonian syndrome with dementia
- (2014) Hana Přikrylová Vranová et al. JOURNAL OF THE NEUROLOGICAL SCIENCES
- α-Synuclein interacts with the switch region of Rab8a in a Ser129 phosphorylation-dependent manner
- (2014) Guowei Yin et al. NEUROBIOLOGY OF DISEASE
- CSF A 42 predicts early-onset dementia in Parkinson disease
- (2014) G. Alves et al. NEUROLOGY
- CSF biomarkers and clinical progression of Parkinson disease
- (2014) S. Hall et al. NEUROLOGY
- Phosphorylation Modulates Clearance of Alpha-Synuclein Inclusions in a Yeast Model of Parkinson's Disease
- (2014) Sandra Tenreiro et al. PLoS Genetics
- Systematic Comparison of the Effects of Alpha-synuclein Mutations on Its Oligomerization and Aggregation
- (2014) Diana F. Lázaro et al. PLoS Genetics
- FOXO3 determines the accumulation of α-synuclein and controls the fate of dopaminergic neurons in the substantia nigra
- (2013) Emilda Pino et al. HUMAN MOLECULAR GENETICS
- Altered APP Carboxyl-Terminal Processing Under Ferrous Iron Treatment in PC12 Cells
- (2013) Chi Hyun Kim et al. KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
- Counter-regulation of alpha- and beta-synuclein expression at the transcriptional level
- (2013) Josephine A. Wright et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- Ser129D mutant alpha-synuclein induces earlier motor dysfunction while S129A results in distinctive pathology in a rat model of Parkinson's disease
- (2013) Fabia Febbraro et al. NEUROBIOLOGY OF DISEASE
- α-Synuclein and Mitochondria: Partners in Crime?
- (2013) Ken Nakamura Neurotherapeutics
- TOM40 Mediates Mitochondrial Dysfunction Induced by α-Synuclein Accumulation in Parkinson’s Disease
- (2013) Andreas Bender et al. PLoS One
- Mild Oxidative Stress Induces Redistribution of BACE1 in Non-Apoptotic Conditions and Promotes the Amyloidogenic Processing of Alzheimer’s Disease Amyloid Precursor Protein
- (2013) Jiang-Li Tan et al. PLoS One
- Gadd153 and NF-κB Crosstalk Regulates 27-Hydroxycholesterol-Induced Increase in BACE1 and β-Amyloid Production in Human Neuroblastoma SH-SY5Y Cells
- (2013) Gurdeep Marwarha et al. PLoS One
- Synucleins Antagonize Endoplasmic Reticulum Function to Modulate Dopamine Transporter Trafficking
- (2013) Adam W. Oaks et al. PLoS One
- Polo-like kinase 2 regulates selective autophagic -synuclein clearance and suppresses its toxicity in vivo
- (2013) A. Oueslati et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Nigrostriatal overabundance of α-synuclein leads to decreased vesicle density and deficits in dopamine release that correlate with reduced motor activity
- (2012) Meret Nora Gaugler et al. ACTA NEUROPATHOLOGICA
- Neuropathologic substrates of Parkinson disease dementia
- (2012) David J. Irwin et al. ANNALS OF NEUROLOGY
- Locally Resolved Membrane Binding Affinity of the N-Terminus of α-Synuclein
- (2012) Marta Robotta et al. BIOCHEMISTRY
- Oxidative stress increases BACE1 protein levels through activation of the PKR-eIF2α pathway
- (2012) François Mouton-Liger et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Phosphorylation of α-Synuclein Protein at Ser-129 Reduces Neuronal Dysfunction by Lowering Its Membrane Binding Property inCaenorhabditis elegans
- (2012) Tomoki Kuwahara et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cross-seeding effects of amyloid β-protein and α-synuclein
- (2012) Kenjiro Ono et al. JOURNAL OF NEUROCHEMISTRY
- Systematic Mutagenesis of -Synuclein Reveals Distinct Sequence Requirements for Physiological and Pathological Activities
- (2012) J. Burre et al. JOURNAL OF NEUROSCIENCE
- BACE1 is at the crossroad of a toxic vicious cycle involving cellular stress and β-amyloid production in Alzheimer’s disease
- (2012) Linda Chami et al. Molecular Neurodegeneration
- Intranasal deferoxamine reverses iron-induced memory deficits and inhibits amyloidogenic APP processing in a transgenic mouse model of Alzheimer's disease
- (2012) Chuang Guo et al. NEUROBIOLOGY OF AGING
- Prion protein expression alters APP cleavage without interaction with BACE-1
- (2012) Patrick C. McHugh et al. NEUROCHEMISTRY INTERNATIONAL
- Reciprocal Induction Between α-Synuclein and β-Amyloid in Adult Rat Neurons
- (2012) Shohreh Majd et al. NEUROTOXICITY RESEARCH
- Examining the mechanisms that link β-amyloid and α-synuclein pathologies
- (2012) Samuel E Marsh et al. Alzheimers Research & Therapy
- N-terminal deletion does not affect α-synuclein membrane binding, self-association and toxicity in human neuroblastoma cells, unlike yeast
- (2011) Katherina Vamvaca et al. JOURNAL OF NEUROCHEMISTRY
- Proteolytic processing of Alzheimer’s β-amyloid precursor protein
- (2011) Han Zhang et al. JOURNAL OF NEUROCHEMISTRY
- Authentically Phosphorylated -Synuclein at Ser129 Accelerates Neurodegeneration in a Rat Model of Familial Parkinson's Disease
- (2011) H. Sato et al. JOURNAL OF NEUROSCIENCE
- Alpha-Synuclein Is a Cellular Ferrireductase
- (2011) Paul Davies et al. PLoS One
- Activation of PKR Causes Amyloid ß-Peptide Accumulation via De-Repression of BACE1 Expression
- (2011) Gerard ILL-Raga et al. PLoS One
- Amyloid Precursor Protein Is Trafficked and Secreted via Synaptic Vesicles
- (2011) Teja W. Groemer et al. PLoS One
- Selective Translational Control of the Alzheimer Amyloid Precursor Protein Transcript by Iron Regulatory Protein-1
- (2010) Hyun-Hee Cho et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Copper binding regulates intracellular alpha-synuclein localisation, aggregation and toxicity
- (2010) Xiaoyan Wang et al. JOURNAL OF NEUROCHEMISTRY
- Synergistic Interactions between A , Tau, and -Synuclein: Acceleration of Neuropathology and Cognitive Decline
- (2010) L. K. Clinton et al. JOURNAL OF NEUROSCIENCE
- α-Synuclein Delays Endoplasmic Reticulum (ER)-to-Golgi Transport in Mammalian Cells by Antagonizing ER/Golgi SNAREs
- (2010) Nandhakumar Thayanidhi et al. MOLECULAR BIOLOGY OF THE CELL
- α-synuclein induced synapse damage is enhanced by amyloid-β1-42
- (2010) Clive Bate et al. Molecular Neurodegeneration
- α-Synuclein Aggregation and Ser-129 Phosphorylation-dependent Cell Death in Oligodendroglial Cells
- (2009) Christine L. Kragh et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The First N-terminal Amino Acids of α-Synuclein Are Essential for α-Helical Structure Formation In Vitro and Membrane Binding in Yeast
- (2009) Katherina Vamvaca et al. JOURNAL OF MOLECULAR BIOLOGY
- α-Synuclein S129 Phosphorylation Mutants Do Not Alter Nigrostriatal Toxicity in a Rat Model of Parkinson Disease
- (2009) Nikolaus R. McFarland et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Synaptic NMDA Receptor Activation Stimulates -Secretase Amyloid Precursor Protein Processing and Inhibits Amyloid- Production
- (2009) S. E. Hoey et al. JOURNAL OF NEUROSCIENCE
- Cortical α-synuclein load is associated with amyloid-β plaque burden in a subset of Parkinson’s disease patients
- (2008) Tammaryn Lashley et al. ACTA NEUROPATHOLOGICA
- Mitochondrial association of alpha-synuclein causes oxidative stress
- (2008) M. S. Parihar et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Proteomics Analysis Identifies Phosphorylation-dependent α-Synuclein Protein Interactions
- (2008) Melinda A. McFarland et al. MOLECULAR & CELLULAR PROTEOMICS
- Evidence that γ-secretase mediates oxidative stress-induced β-secretase expression in Alzheimer's disease
- (2008) Dong-Gyu Jo et al. NEUROBIOLOGY OF AGING
- α-Synuclein enhances secretion and toxicity of amyloid beta peptides in PC12 cells
- (2008) Anna Kazmierczak et al. NEUROCHEMISTRY INTERNATIONAL
- Phosphorylation of the Translation Initiation Factor eIF2α Increases BACE1 Levels and Promotes Amyloidogenesis
- (2008) Tracy O'Connor et al. NEURON
- Mechanisms of Hybrid Oligomer Formation in the Pathogenesis of Combined Alzheimer's and Parkinson's Diseases
- (2008) Igor F. Tsigelny et al. PLoS One
- The phosphorylation state of Ser-129 in human -synuclein determines neurodegeneration in a rat model of Parkinson disease
- (2008) O. S. Gorbatyuk et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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