Dyslipidemia in Kidney Disorders: Perspectives on Mitochondria Homeostasis and Therapeutic Opportunities

Pemafibrate, a New Selective PPARα Modulator: Drug Concept and Its Clinical Applications for Dyslipidemia and Metabolic Diseases

(2020) Shizuya Yamashita et al.   Current Atherosclerosis Reports

The Role and Function of HDL in Patients with Chronic Kidney Disease and the Risk of Cardiovascular Disease

(2020) Jacek Rysz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Efficacy of a mitochondrion-targeting agent for reducing the level of urinary protein in rats with puromycin aminonucleoside-induced minimal-change nephrotic syndrome

(2020) Yuko Fujii et al.   PLoS One

The Role of PGC-1α and Mitochondrial Biogenesis in Kidney Diseases

(2020) Miguel Fontecha-Barriuso et al.   Biomolecules

Lipotoxicity and Diabetic Nephropathy: Novel Mechanistic Insights and Therapeutic Opportunities

(2020) Lucas Opazo-Ríos et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ADCK4 Deficiency Destabilizes the Coenzyme Q Complex, Which Is Rescued by 2,4-Dihydroxybenzoic Acid Treatment

(2020) Eugen Widmeier et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Eicosapentaenoic acid attenuates renal lipotoxicity by restoring autophagic flux

(2020) Takeshi Yamamoto et al.   Autophagy

The Vicious Cycle of Renal Lipotoxicity and Mitochondrial Dysfunction

(2020) Mengyuan Ge et al.   Frontiers in Physiology

CoQ10 ameliorates mitochondrial dysfunction in diabetic nephropathy through mitophagy

(2019) Jia Sun et al.   JOURNAL OF ENDOCRINOLOGY

DHHC4 and DHHC5 Facilitate Fatty Acid Uptake by Palmitoylating and Targeting CD36 to the Plasma Membrane

(2019) Juan Wang et al.   Cell Reports

Lipid Accumulation and Chronic Kidney Disease

(2019) Zhibo Gai et al.   Nutrients

Niacin: an old lipid drug in a new NAD+ dress

(2019) Mario Romani et al.   JOURNAL OF LIPID RESEARCH

Proximal Tubular Cell–Specific Ablation of Carnitine Acetyltransferase Causes Tubular Disease and Secondary Glomerulosclerosis

(2019) Claudia Kruger et al.   DIABETES

Cholesterol-Lowering Agents

(2019) Robert S. Rosenson et al.   CIRCULATION RESEARCH

Advanced oxidation protein products promote lipotoxicity and tubulointerstitial fibrosis via CD36/β-catenin pathway in diabetic nephropathy

(2019) Xiao Li et al.   ANTIOXIDANTS & REDOX SIGNALING

Alterations of Fatty Acid Profile May Contribute to Dyslipidemia in Chronic Kidney Disease by Influencing Hepatocyte Metabolism

(2019) Aleksandra Czumaj et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The triglyceride synthesis enzymes DGAT1 and DGAT2 have distinct and overlapping functions in adipocytes

(2019) Chandramohan Chitraju et al.   JOURNAL OF LIPID RESEARCH

Anaerobic Glycolysis Maintains the Glomerular Filtration Barrier Independent of Mitochondrial Metabolism and Dynamics

(2019) Paul T. Brinkkoetter et al.   Cell Reports

Allosteric, transcriptional and post-translational control of mitochondrial energy metabolism

(2019) Qutuba G. Karwi et al.   BIOCHEMICAL JOURNAL

ATP-binding cassette A1 deficiency causes cardiolipin-driven mitochondrial dysfunction in podocytes

(2019) G. Michelle Ducasa et al.   JOURNAL OF CLINICAL INVESTIGATION

Lipotoxicity in Kidney, Heart, and Skeletal Muscle Dysfunction

(2019) Hiroshi Nishi et al.   Nutrients

Proximal tubule cyclophilin D regulates fatty acid oxidation in cisplatin-induced acute kidney injury

(2019) Hee-Seong Jang et al.   KIDNEY INTERNATIONAL

Renal lipid metabolism and lipotoxicity in diabetes

(2019) Laongdao Thongnak et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Berberine protects against diabetic kidney disease via promoting PGC‐1α‐regulated mitochondrial energy homeostasis

(2019) Xin Qin et al.   BRITISH JOURNAL OF PHARMACOLOGY

Crosstalk Between Lipids and Mitochondria in Diabetic Kidney Disease

(2019) G. Michelle Ducasa et al.   Current Diabetes Reports

Exploration and Development of PPAR Modulators in Health and Disease: An Update of Clinical Evidence

(2019) Cheng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

GCN5L1 controls renal lipotoxicity through regulating acetylation of fatty acid oxidation enzymes

(2019) Tingting Lv et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Podocyte lipotoxicity in diabetic kidney disease

(2019) Hiroshi Nishi et al.   KIDNEY INTERNATIONAL

NAD+ homeostasis in renal health and disease

(2019) Kenneth M. Ralto et al.   Nature Reviews Nephrology

Lipid-modifying therapy in chronic kidney disease: Pathophysiological and clinical considerations

(2019) Gunnar H. Heine et al.   PHARMACOLOGY & THERAPEUTICS

Pro-renin receptor suppresses mitochondrial biogenesis and function via AMPK/SIRT-1/ PGC-1α pathway in diabetic kidney

(2019) Safia Akhtar et al.   PLoS One

Lipid Deposition in Kidney Diseases: Interplay Among Redox, Lipid Mediators, and Renal Impairment

(2018) Hua Su et al.   ANTIOXIDANTS & REDOX SIGNALING

Novel Hypolipidaemic Drugs: Mechanisms Of Action And Main Metabolic Effects

(2018) Theodosios D. Filippatos et al.   Current Vascular Pharmacology

Chronic Supplementation With a Mitochondrial Antioxidant (MitoQ) Improves Vascular Function in Healthy Older AdultsNovelty and Significance

(2018) Matthew J. Rossman et al.   HYPERTENSION

Maintenance of Kidney Metabolic Homeostasis by PPAR Gamma

(2018) Patricia Corrales et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Fasting-induced JMJD3 histone demethylase epigenetically activates mitochondrial fatty acid β-oxidation

(2018) Sunmi Seok et al.   JOURNAL OF CLINICAL INVESTIGATION

Impairment of PPARαand the Fatty Acid Oxidation Pathway Aggravates Renal Fibrosis during Aging

(2018) Ki Wung Chung et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Sirtuins in Renal Health and Disease

(2018) Marina Morigi et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

HDL in CKD—The Devil Is in the Detail

(2018) Florian Kronenberg   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Phosphorylation of Acetyl-CoA Carboxylase by AMPK Reduces Renal Fibrosis and Is Essential for the Anti-Fibrotic Effect of Metformin

(2018) Mardiana Lee et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Mito-TEMPO Alleviates Renal Fibrosis by Reducing Inflammation, Mitochondrial Dysfunction, and Endoplasmic Reticulum Stress

(2018) Yuqing Liu et al.   Oxidative Medicine and Cellular Longevity

Mitochondrial Dysfunction and Signaling in Diabetic Kidney Disease: Oxidative Stress and Beyond

(2018) Nicole Bernadette Flemming et al.   SEMINARS IN NEPHROLOGY

The Role of Peroxisome Proliferator-Activated Receptor γ Coactivator 1α (PGC-1α) in Kidney Disease

(2018) Szu-Yuan Li et al.   SEMINARS IN NEPHROLOGY

Structural properties of apolipoprotein A-I mimetic peptides that promote ABCA1-dependent cholesterol efflux

(2018) Rafique M. Islam et al.   Scientific Reports

Berberine Protects Against Palmitate-Induced Apoptosis in Tubular Epithelial Cells by Promoting Fatty Acid Oxidation

(2018) Jiye Sun et al.   MEDICAL SCIENCE MONITOR

Urine Sediment Examination in the Diagnosis and Management of Kidney Disease: Core Curriculum 2019

(2018) Corey Cavanaugh et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

De novo NAD+ biosynthetic impairment in acute kidney injury in humans

(2018) Ali Poyan Mehr et al.   NATURE MEDICINE

Peroxisomes can oxidize medium- and long-chain fatty acids through a pathway involving ABCD3 and HSD17B4

(2018) Sara Violante et al.   FASEB JOURNAL

The protein acetylase GCN5L1 modulates hepatic fatty acid oxidation activity via acetylation of the mitochondrial β-oxidation enzyme HADHA

(2018) Dharendra Thapa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

De novo NAD+ synthesis enhances mitochondrial function and improves health

(2018) Elena Katsyuba et al.   NATURE

Lipid management in patients with chronic kidney disease

(2018) Charles J. Ferro et al.   Nature Reviews Nephrology

Metabolic requirements of the nephron

(2018) Kasey Cargill et al.   PEDIATRIC NEPHROLOGY

Functional and molecular studies in primary carnitine deficiency

(2017) Marta Frigeni et al.   HUMAN MUTATION

Kidney triglyceride accumulation in the fasted mouse is dependent upon serum free fatty acids

(2017) Diego Scerbo et al.   JOURNAL OF LIPID RESEARCH

Kidney Proximal Tubule Lipoapoptosis Is Regulated by Fatty Acid Transporter-2 (FATP2)

(2017) Shenaz Khan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Pharmacologic Approaches to Improve Mitochondrial Function in AKI and CKD

(2017) Hazel H. Szeto   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The hallmarks of mitochondrial dysfunction in chronic kidney disease

(2017) Daniel L. Galvan et al.   KIDNEY INTERNATIONAL

Dyslipidaemia in nephrotic syndrome: mechanisms and treatment

(2017) Shipra Agrawal et al.   Nature Reviews Nephrology

Mitochondrial energetics in the kidney

(2017) Pallavi Bhargava et al.   Nature Reviews Nephrology

Role of NAD+ and mitochondrial sirtuins in cardiac and renal diseases

(2017) Kathleen A. Hershberger et al.   Nature Reviews Nephrology

CD36 in chronic kidney disease: novel insights and therapeutic opportunities

(2017) Xiaochun Yang et al.   Nature Reviews Nephrology

Mitochondria-Targeted Antioxidants SkQ1 and MitoTEMPO Failed to Exert a Long-Term Beneficial Effect in Murine Polymicrobial Sepsis

(2017) Pia Rademann et al.   Oxidative Medicine and Cellular Longevity

Peroxisomal Dysfunction in Age-Related Diseases

(2017) Cynthia M. Cipolla et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Targeted mitochondrial therapy using MitoQ shows equivalent renoprotection to angiotensin converting enzyme inhibition but no combined synergy in diabetes

(2017) Micheal S. Ward et al.   Scientific Reports

The Biochemistry and Physiology of Mitochondrial Fatty Acid β-Oxidation and Its Genetic Disorders

(2016) Sander M. Houten et al.   Annual Review of Physiology

Regulation of the subcellular trafficking of CD36, a major determinant of cardiac fatty acid utilization

(2016) Jan F.C. Glatz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Post-translational modifications of CD36 (SR-B2): Implications for regulation of myocellular fatty acid uptake

(2016) Joost J.F.P. Luiken et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Combined defects in oxidative phosphorylation and fatty acid  -oxidation in mitochondrial disease

(2016) A. Nsiah-Sefaa et al.   BIOSCIENCE REPORTS

Lipotoxicity as a trigger factor of renal disease

(2016) Adriana Izquierdo-Lahuerta et al.   JOURNAL OF NEPHROLOGY

High-Fat Diet–Induced Lysosomal Dysfunction and Impaired Autophagic Flux Contribute to Lipotoxicity in the Kidney

(2016) Takeshi Yamamoto et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Mitochondria Protection after Acute Ischemia Prevents Prolonged Upregulation of IL-1βand IL-18 and Arrests CKD

(2016) Hazel H. Szeto et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Mitochondrial Pathology and Glycolytic Shift during Proximal Tubule Atrophy after Ischemic AKI

(2016) R. Lan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Disorders of lipid metabolism in nephrotic syndrome: mechanisms and consequences

(2016) Nosratola D. Vaziri   KIDNEY INTERNATIONAL

Protection of mitochondria prevents high-fat diet–induced glomerulopathy and proximal tubular injury

(2016) Hazel H. Szeto et al.   KIDNEY INTERNATIONAL

Antagonism of scavenger receptor CD36 by 5A peptide prevents chronic kidney disease progression in mice independent of blood pressure regulation

(2016) Ana Carolina P. Souza et al.   KIDNEY INTERNATIONAL

PGC1α drives NAD biosynthesis linking oxidative metabolism to renal protection

(2016) Mei T. Tran et al.   NATURE

Mitochondria-Targeted Antioxidants: Future Perspectives in Kidney Ischemia Reperfusion Injury

(2016) Aleksandra Kezic et al.   Oxidative Medicine and Cellular Longevity

Dyslipidemia in patients with chronic kidney disease

(2016) Matthew R. Hager et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Modified Lipids and Lipoproteins in Chronic Kidney Disease: A New Class of Uremic Toxins

(2016) Nans Florens et al.   Toxins

The Macrophage Phagocytic Receptor CD36 Promotes Fibrogenic Pathways on Removal of Apoptotic Cells during Chronic Kidney Injury

(2015) Subramaniam Pennathur et al.   AMERICAN JOURNAL OF PATHOLOGY

Acetyl Coenzyme A: A Central Metabolite and Second Messenger

(2015) Federico Pietrocola et al.   Cell Metabolism

NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus

(2015) Carles Cantó et al.   Cell Metabolism

The Evolving Understanding of the Contribution of Lipid Metabolism to Diabetic Kidney Disease

(2015) Krisztian Stadler et al.   Current Diabetes Reports

Acetyl-CoA and the regulation of metabolism: mechanisms and consequences

(2015) Lei Shi et al.   CURRENT OPINION IN CELL BIOLOGY

Ca2+Binding/Permeation via Calcium Channel, CaV1.1, Regulates the Intracellular Distribution of the Fatty Acid Transport Protein, CD36, and Fatty Acid Metabolism

(2015) Dimitra K. Georgiou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Defining the Apoptotic Trigger

(2015) Evan S. O'Brien et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sirtuin and metabolic kidney disease

(2015) Shu Wakino et al.   KIDNEY INTERNATIONAL

NAD+ in aging, metabolism, and neurodegeneration

(2015) E. Verdin   SCIENCE

Protection against renal ischemia–reperfusion injury in vivo by the mitochondria targeted antioxidant MitoQ

(2015) Anna J. Dare et al.   Redox Biology

CD36 Mediated Fatty Acid-Induced Podocyte Apoptosis via Oxidative Stress

(2015) Wei Hua et al.   PLoS One

Niacin receptor activation improves human microvascular endothelial cell angiogenic function during lipotoxicity

(2014) Jennifer M. Hughes-Large et al.   ATHEROSCLEROSIS

Homeostasis, the Milieu Interieur, and the Wisdom of the Nephron

(2014) M. P. Hoenig et al.   Clinical Journal of the American Society of Nephrology

Berberine decreases cholesterol levels in rats through multiple mechanisms, including inhibition of cholesterol absorption

(2014) Yanwen Wang et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development

(2014) Hyun Mi Kang et al.   NATURE MEDICINE

Lipid biology of the podocyte—new perspectives offer new opportunities

(2014) Alessia Fornoni et al.   Nature Reviews Nephrology

Mitochondrial and cellular mechanisms for managing lipid excess

(2014) Miguel A. Aon et al.   Frontiers in Physiology

Metabolism, Energetics, and Lipid Biology in the Podocyte – Cellular Cholesterol-Mediated Glomerular Injury

(2014) Sandra Merscher et al.   Frontiers in Endocrinology

Free Fatty Acids and Their Metabolism Affect Function and Survival of Podocytes

(2014) Jonas Sieber et al.   Frontiers in Endocrinology

Targeting mitochondrial cardiolipin and the cytochromec/cardiolipin complex to promote electron transport and optimize mitochondrial ATP synthesis

(2013) A V Birk et al.   BRITISH JOURNAL OF PHARMACOLOGY

ADCK4 mutations promote steroid-resistant nephrotic syndrome through CoQ10 biosynthesis disruption

(2013) Shazia Ashraf et al.   JOURNAL OF CLINICAL INVESTIGATION

Altered renal lipid metabolism and renal lipid accumulation in human diabetic nephropathy

(2013) Michal Herman-Edelstein et al.   JOURNAL OF LIPID RESEARCH

The Nrf2 pathway in the progression of renal disease

(2013) C. Zoja et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Primary coenzyme Q10 (CoQ10) deficiencies and related nephropathies

(2013) Fatih Ozaltin   PEDIATRIC NEPHROLOGY

Mitochondrial Dysfunction and Lipid Homeostasis

(2012) Joseph Vamecq et al.   CURRENT DRUG METABOLISM

CD36 and Na/K-ATPase-α1 Form a Proinflammatory Signaling Loop in Kidney

(2012) David J. Kennedy et al.   HYPERTENSION

Dysfunctional High-Density Lipoprotein in Patients on Chronic Hemodialysis

(2012) Suguru Yamamoto et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

FAT/CD36 is located on the outer mitochondrial membrane, upstream of long-chain acyl-CoA synthetase, and regulates palmitate oxidation

(2011) Brennan K. Smith et al.   BIOCHEMICAL JOURNAL

Cellular pathophysiology of ischemic acute kidney injury

(2011) Joseph V. Bonventre et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondrial Biogenesis in Kidney Disease

(2011) J. M. Weinberg   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Prevention of diabetic nephropathy in Ins2+/−AkitaJmice by the mitochondria-targeted therapy MitoQ

(2010) Balu K. Chacko et al.   BIOCHEMICAL JOURNAL

Optimal micronutrients delay mitochondrial decay and age-associated diseases

(2010) Bruce N. Ames   MECHANISMS OF AGEING AND DEVELOPMENT

Role of oxidized low density lipoproteins and free fatty acids in the pathogenesis of glomerulopathy and tubulointerstitial lesions in type 2 diabetes

(2010) R. Nosadini et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

PGC-1α, SIRT1 and AMPK, an energy sensing network that controls energy expenditure

(2009) Carles Cantó et al.   CURRENT OPINION IN LIPIDOLOGY

Peroxisome proliferator-activated receptors and renal diseases

(2009) Jing Wu   Frontiers in Bioscience-Landmark

CD36 Regulates Oxidative Stress and Inflammation in Hypercholesterolemic CKD

(2009) D. M. Okamura et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Cellular fatty acid uptake: a pathway under construction

(2009) Xiong Su et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Monocarboxylate transporter (MCT)-1 is up-regulated by PPARα

(2008) Bettina König et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

A mitochondria-targeted nitroxide is reduced to its hydroxylamine by ubiquinol in mitochondria

(2008) Jan Trnka et al.   FREE RADICAL BIOLOGY AND MEDICINE

Niacin inhibits surface expression of ATP synthase β chain in HepG2 cells: implications for raising HDL

(2008) Lin-Hua Zhang et al.   JOURNAL OF LIPID RESEARCH

Fat redistribution and adipocyte transformation in uninephrectomized rats

(2008) Hai-Lu Zhao et al.   KIDNEY INTERNATIONAL

Mesangial matrix-activated monocytes express functional scavenger receptors and accumulate intracellular lipid

(2008) E. U. Rahman et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Fatty acid‐binding protein as marker for renal injury

(2008) Maurice M. A. L. Pelsers   SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION