Targeted mitochondrial therapy using MitoQ shows equivalent renoprotection to angiotensin converting enzyme inhibition but no combined synergy in diabetes

Mapping time-course mitochondrial adaptations in the kidney in experimental diabetes

(2016) M. T. Coughlan et al.   CLINICAL SCIENCE

Tapping into Mitochondria to Find Novel Targets for Diabetes Complications

(2016) Nicole B. Flemming et al.   CURRENT DRUG TARGETS

Deficiency in Apoptosis-Inducing Factor Recapitulates Chronic Kidney Disease via Aberrant Mitochondrial Homeostasis

(2016) Melinda T. Coughlan et al.   DIABETES

APOL1 Renal-Risk Variants Induce Mitochondrial Dysfunction

(2016) Lijun Ma et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Protection of mitochondria prevents high-fat diet–induced glomerulopathy and proximal tubular injury

(2016) Hazel H. Szeto et al.   KIDNEY INTERNATIONAL

Empagliflozin and Progression of Kidney Disease in Type 2 Diabetes

(2016) Christoph Wanner et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mitochondria–Power Players in Kidney Function?

(2016) Josephine M. Forbes   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Mass Spectrometry Imaging Reveals Elevated Glomerular ATP/AMP in Diabetes/obesity and Identifies Sphingomyelin as a Possible Mediator

(2016) Satoshi Miyamoto et al.   EBioMedicine

Once daily administration of the SGLT2 inhibitor, empagliflozin, attenuates markers of renal fibrosis without improving albuminuria in diabetic db/db mice

(2016) Linda A. Gallo et al.   Scientific Reports

A liquid chromatography–tandem mass spectrometry-based investigation of the lamellar interstitial metabolome in healthy horses and during experimental laminitis induction

(2015) C.E. Medina-Torres et al.   VETERINARY JOURNAL

Altered Mitochondrial Function, Mitochondrial DNA and Reduced Metabolic Flexibility in Patients With Diabetic Nephropathy

(2015) Anna Czajka et al.   EBioMedicine

Effects of insulin resistance on skeletal muscle growth and exercise capacity in type 2 diabetic mouse models

(2014) Joseph E. Ostler et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The mitochondria-targeted antioxidant MitoQ extends lifespan and improves healthspan of a transgenic Caenorhabditis elegans model of Alzheimer disease

(2014) Li Fang Ng et al.   FREE RADICAL BIOLOGY AND MEDICINE

Increased sensitivity to tryptophan bioavailability is a positive adaptation by the human strains ofChlamydia pneumoniae

(2014) Anu Chacko et al.   MOLECULAR MICROBIOLOGY

Changes in Diabetes-Related Complications in the United States, 1990–2010

(2014) Edward W. Gregg et al.   NEW ENGLAND JOURNAL OF MEDICINE

Deficiency in Mitochondrial Complex I Activity Due to Ndufs6 Gene Trap Insertion Induces Renal Disease

(2013) Josephine M. Forbes et al.   ANTIOXIDANTS & REDOX SIGNALING

Renal Hemodynamic Effect of Sodium-Glucose Cotransporter 2 Inhibition in Patients With Type 1 Diabetes Mellitus

(2013) David Z.I. Cherney et al.   CIRCULATION

AMPK dysregulation promotes diabetes-related reduction of superoxide and mitochondrial function

(2013) Laura L. Dugan et al.   JOURNAL OF CLINICAL INVESTIGATION

Kidney Disease and Increased Mortality Risk in Type 2 Diabetes

(2013) M. Afkarian et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Metabolomics Reveals Signature of Mitochondrial Dysfunction in Diabetic Kidney Disease

(2013) K. Sharma et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Mechanisms of Diabetic Complications

(2013) Josephine M. Forbes et al.   PHYSIOLOGICAL REVIEWS

Determinants of kidney oxygen consumption and their relationship to tissue oxygen tension in diabetes and hypertension

(2012) Peter Hansell et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Assessment of early diabetic renal changes with hyperpolarized [1-13C]pyruvate

(2012) Christoffer Laustsen et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Coenzyme Q10 prevents GDP-sensitive mitochondrial uncoupling, glomerular hyperfiltration and proteinuria in kidneys from db/db mice as a model of type 2 diabetes

(2012) M. Friederich Persson et al.   DIABETOLOGIA

Endothelial Cell and Platelet Bioenergetics: Effect of Glucose and Nutrient Composition

(2012) Brian D. Fink et al.   PLoS One

MitoQ Blunts Mitochondrial and Renal Damage during Cold Preservation of Porcine Kidneys

(2012) Nirmala Parajuli et al.   PLoS One

Acute and chronic effects of SGLT2 blockade on glomerular and tubular function in the early diabetic rat

(2011) Scott C. Thomson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Standards of Medical Care in Diabetes--2012

(2011)   DIABETES CARE

Ubiquinone (coenzyme Q10) prevents renal mitochondrial dysfunction in an experimental model of type 2 diabetes

(2011) Karly C. Sourris et al.   FREE RADICAL BIOLOGY AND MEDICINE

Animal and human studies with the mitochondria-targeted antioxidant MitoQ

(2010) Robin A.J. Smith et al.   Annals of the New York Academy of Sciences

The Mitochondria-Targeted Antioxidant Mitoquinone Protects against Cold Storage Injury of Renal Tubular Cells and Rat Kidneys

(2010) T. Mitchell et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Consequences of long-term oral administration of the mitochondria-targeted antioxidant MitoQ to wild-type mice

(2009) Sergio Rodriguez-Cuenca et al.   FREE RADICAL BIOLOGY AND MEDICINE

RAGE-Induced Cytosolic ROS Promote Mitochondrial Superoxide Generation in Diabetes

(2009) M. T. Coughlan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

A Mitochondrial Protein Compendium Elucidates Complex I Disease Biology

(2008) David J. Pagliarini et al.   CELL