Mitochondria-Targeted Antioxidants SkQ1 and MitoTEMPO Failed to Exert a Long-Term Beneficial Effect in Murine Polymicrobial Sepsis

N-Acetylcysteine Attenuates Diabetic Myocardial Ischemia Reperfusion Injury through Inhibiting Excessive Autophagy

(2017) Sheng Wang et al.   MEDIATORS OF INFLAMMATION

Mitochondria-meditated pathways of organ failure upon inflammation

(2017) Andrey V. Kozlov et al.   Redox Biology

Selective scavenging of intra-mitochondrial superoxide corrects diclofenac-induced mitochondrial dysfunction and gastric injury: A novel gastroprotective mechanism independent of gastric acid suppression

(2016) Somnath Mazumder et al.   BIOCHEMICAL PHARMACOLOGY

The novel mitochondria-targeted antioxidant SkQ1 modulates angiogenesis and inflammatory micromilieu in a murine orthotopic model of pancreatic cancer

(2016) Alexandr V. Bazhin et al.   INTERNATIONAL JOURNAL OF CANCER

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Effects of the mitochondria-targeted antioxidant SkQ1 on lifespan of rodents

(2016) Vladimir N. Anisimov et al.   Aging-US

Shorter Duration of Post-Operative Antibiotics for Cecal Ligation and Puncture Does Not Increase Inflammation or Mortality

(2016) Kendra N. Iskander et al.   PLoS One

Vicious Inducible Nitric Oxide Synthase-Mitochondrial Reactive Oxygen Species Cycle Accelerates Inflammatory Response and Causes Liver Injury in Rats

(2015) Adelheid Weidinger et al.   ANTIOXIDANTS & REDOX SIGNALING

Randomized, Placebo-Controlled Trial of Acetaminophen for the Reduction of Oxidative Injury in Severe Sepsis

(2015) David R. Janz et al.   CRITICAL CARE MEDICINE

Effects of the Mitochondria-Targeted Antioxidant Mitoquinone in Murine Acute Pancreatitis

(2015) Wei Huang et al.   MEDIATORS OF INFLAMMATION

Refinement of Animal Models of Sepsis and Septic Shock

(2015) Elliot Lilley et al.   SHOCK

Mitochondria-targeted antioxidants prevent TNFα-induced endothelial cell damage

(2014) I. I. Galkin et al.   BIOCHEMISTRY-MOSCOW

Reactive oxygen species, heat stress and oxidative-induced mitochondrial damage. A review

(2014) Imen Belhadj Slimen et al.   INTERNATIONAL JOURNAL OF HYPERTHERMIA

Systemic inhibition and liver-specific over-expression of PAI-1 failed to improve survival in all-inclusive populations or homogenous cohorts of CLP mice

(2014) P. Raeven et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Abandon the Mouse Research Ship? Not Just Yet!

(2014) Marcin F. Osuchowski et al.   SHOCK

Tissue damage control in disease tolerance

(2014) Miguel P. Soares et al.   TRENDS IN IMMUNOLOGY

NLRP3 inflammasome contributes to inflammation after intracerebral hemorrhage

(2013) Qingyi Ma et al.   ANNALS OF NEUROLOGY

Antioxidants that protect mitochondria reduce interleukin-6 and oxidative stress, improve mitochondrial function, and reduce biochemical markers of organ dysfunction in a rat model of acute sepsis

(2013) D.A. Lowes et al.   BRITISH JOURNAL OF ANAESTHESIA

Possible biomarkers of early mortality in peritonitis-induced sepsis rats

(2013) Mei-Hui Liao et al.   JOURNAL OF SURGICAL RESEARCH

A Randomized Trial of Glutamine and Antioxidants in Critically Ill Patients

(2013) Daren Heyland et al.   NEW ENGLAND JOURNAL OF MEDICINE

Sepsis: Multiple Abnormalities, Heterogeneous Responses, and Evolving Understanding

(2013) Kendra N. Iskander et al.   PHYSIOLOGICAL REVIEWS

The Role of Mitochondria-Derived Reactive Oxygen Species in Hyperthermia-Induced Platelet Apoptosis

(2013) Zhicheng Wang et al.   PLoS One

Protective effect of mitochondria-targeted antioxidants in an acute bacterial infection

(2013) E. Y. Plotnikov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Specific inhibition of mitochondrial oxidative stress suppresses inflammation and improves cardiac function in a rat pneumonia-related sepsis model

(2012) Qun S. Zang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

In vivo immunoregulatory properties of the novel mitochondria-targeted antioxidant SkQ1

(2012) Yuhui Yang et al.   MOLECULAR IMMUNOLOGY

Compartment-specific expression of plasminogen activator inhibitor-1 correlates with severity/outcome of murine polymicrobial sepsis

(2012) Pierre Raeven et al.   THROMBOSIS RESEARCH

Oxidative stress and mitochondrial dysfunction in sepsis

(2011) H.F. Galley   BRITISH JOURNAL OF ANAESTHESIA

Experimentally Approaching the ICU: Monitoring Outcome-Based Responses in the Two-Hit Mouse Model of Posttraumatic Sepsis

(2011) Susanne Drechsler et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Mitochondrial reactive oxygen species drive proinflammatory cytokine production: Figure 1.

(2011) Edwina Naik et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS)

(2011) Ariel C. Bulua et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Therapeutic Targeting of Mitochondrial Superoxide in Hypertension

(2010) Anna E. Dikalova et al.   CIRCULATION RESEARCH

A double-blind, placebo-controlled study to assess the mitochondria-targeted antioxidant MitoQ as a disease-modifying therapy in Parkinson's disease

(2010) Barry J. Snow et al.   MOVEMENT DISORDERS

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

UNTREATED TYPE 1 DIABETES INCREASES SEPSIS-INDUCED MORTALITY WITHOUT INDUCING A PRELETHAL CYTOKINE RESPONSE

(2010) Marcin F. Osuchowski et al.   SHOCK

INHIBITION OF NITRIC OXIDE SYNTHASE DURING SEPSIS

(2010) Wolfgang Stahl et al.   SHOCK

REPETITIVE LOW-VOLUME BLOOD SAMPLING METHOD AS A FEASIBLE MONITORING TOOL IN A MOUSE MODEL OF SEPSIS

(2010) Katrin M. Weixelbaumer et al.   SHOCK

Isolation of Mouse Peritoneal Cavity Cells

(2010) Avijit Ray et al.   Jove-Journal of Visualized Experiments

MitoQ administration prevents endotoxin-induced cardiac dysfunction

(2009) G. S. Supinski et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Phase II trial of CoQ10 for ALS finds insufficient evidence to justify phase III

(2009) Petra Kaufmann et al.   ANNALS OF NEUROLOGY

Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 1. Cationic plastoquinone derivatives: Synthesis and in vitro studies

(2009) Y. N. Antonenko et al.   BIOCHEMISTRY-MOSCOW

Stratification is the key: Inflammatory biomarkers accurately direct immunomodulatory therapy in experimental sepsis*

(2009) Marcin F. Osuchowski et al.   CRITICAL CARE MEDICINE

The effect of ulinastation on the small intestine injury and mast cell degranulation in a rat model of sepsis induced by CLP

(2009) Yi-Jing Zhang et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Antimycin A and lipopolysaccharide cause the leakage of superoxide radicals from rat liver mitochondria

(2008) Christina Piskernik et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mitochondrial complex III regulates hypoxic activation of HIF

(2008) T Klimova et al.   CELL DEATH AND DIFFERENTIATION

The mitochondria-targeted antioxidant MitoQ protects against organ damage in a lipopolysaccharide–peptidoglycan model of sepsis

(2008) Damon A. Lowes et al.   FREE RADICAL BIOLOGY AND MEDICINE