CD36 in chronic kidney disease: novel insights and therapeutic opportunities

Critical residues and motifs for homodimerization of the first transmembrane domain of the plasma membrane glycoprotein CD36

(2017) Peng Wei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kidney triglyceride accumulation in the fasted mouse is dependent upon serum free fatty acids

(2017) Diego Scerbo et al.   JOURNAL OF LIPID RESEARCH

Insights into binding of S100 proteins to scavenger receptors: class B scavenger receptor CD36 binds S100A12 with high affinity

(2016) Christoph Tondera et al.   AMINO ACIDS

Effects of Porphyromonas gingivalis lipopolysaccharide on the expression of key genes involved in cholesterol metabolism in macrophages

(2016) Fen Liu et al.   Archives of Medical Science

LPA/PKD-1-FoxO1 Signaling Axis Mediates Endothelial Cell CD36 Transcriptional Repression and Proangiogenic and Proarteriogenic ReprogrammingHighlights

(2016) Bin Ren et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The role of CD36 in the regulation of myocardial lipid metabolism

(2016) Ty T. Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Post-translational modifications of CD36 (SR-B2): Implications for regulation of myocellular fatty acid uptake

(2016) Joost J.F.P. Luiken et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

TSC2 N-terminal lysine acetylation status affects to its stability modulating mTORC1 signaling and autophagy

(2016) Ana García-Aguilar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Renal amyloidosis

(2016) Jason Kidd et al.   CURRENT PROBLEMS IN CANCER

Inhibition of Macrophage CD36 Expression and Cellular Oxidized Low Density Lipoprotein (oxLDL) Accumulation by Tamoxifen

(2016) Miao Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synthetic Amphipathic Helical Peptides Targeting CD36 Attenuate Lipopolysaccharide-Induced Inflammation and Acute Lung Injury

(2016) Alexander V. Bocharov et al.   JOURNAL OF IMMUNOLOGY

Antagonism of scavenger receptor CD36 by 5A peptide prevents chronic kidney disease progression in mice independent of blood pressure regulation

(2016) Ana Carolina P. Souza et al.   KIDNEY INTERNATIONAL

Advanced glycation end products increase lipids accumulation in macrophages through upregulation of receptor of advanced glycation end products: increasing uptake, esterification and decreasing efflux of cholesterol

(2016) Lei Xu et al.   Lipids in Health and Disease

Targeting metastasis-initiating cells through the fatty acid receptor CD36

(2016) Gloria Pascual et al.   NATURE

Thrombospondin 1 Deficiency Ameliorates the Development of Adriamycin-Induced Proteinuric Kidney Disease

(2016) Hasiyeti Maimaitiyiming et al.   PLoS One

AMPK: An Energy-Sensing Pathway with Multiple Inputs and Outputs

(2016) D. Grahame Hardie et al.   TRENDS IN CELL BIOLOGY

Effective CKD Care in European Countries: Challenges and Opportunities for Health Policy

(2015) Aminu K. Bello et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

The Macrophage Phagocytic Receptor CD36 Promotes Fibrogenic Pathways on Removal of Apoptotic Cells during Chronic Kidney Injury

(2015) Subramaniam Pennathur et al.   AMERICAN JOURNAL OF PATHOLOGY

CD36 is involved in high glucose-induced epithelial to mesenchymal transition in renal tubular epithelial cells

(2015) Yanjuan Hou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Interaction of thrombospondin1 and CD36 contributes to obesity-associated podocytopathy

(2015) Wenpeng Cui et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The Evolving Understanding of the Contribution of Lipid Metabolism to Diabetic Kidney Disease

(2015) Krisztian Stadler et al.   Current Diabetes Reports

Ca2+Binding/Permeation via Calcium Channel, CaV1.1, Regulates the Intracellular Distribution of the Fatty Acid Transport Protein, CD36, and Fatty Acid Metabolism

(2015) Dimitra K. Georgiou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Soluble CD36 in plasma and urine: A plausible prognostic marker for diabetic nephropathy

(2015) Thomas Michael Shiju et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Deletion of Lkb1 in Renal Tubular Epithelial Cells Leads to CKD by Altering Metabolism

(2015) S. H. Han et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

CD36/SR-B2-TLR2 Dependent Pathways Enhance Porphyromonas gingivalis Mediated Atherosclerosis in the Ldlr KO Mouse Model

(2015) Paul M. Brown et al.   PLoS One

Is plasma soluble CD36 associated with cardiovascular risk factors in early onset coronary artery disease patients?

(2015) Andrzej Krzystolik et al.   SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION

Palmitate induces ER calcium depletion and apoptosis in mouse podocytes subsequent to mitochondrial oxidative stress

(2015) S Xu et al.   Cell Death & Disease

CD36 Mediated Fatty Acid-Induced Podocyte Apoptosis via Oxidative Stress

(2015) Wei Hua et al.   PLoS One

Calcium signaling recruits substrate transporters GLUT4 and CD36 to the sarcolemma without increasing cardiac substrate uptake

(2014) Yeliz Angin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Circulating CD36 and oxLDL levels are associated with cardiovascular risk factors in young subjects

(2014) Luz E Ramos-Arellano et al.   BMC Cardiovascular Disorders

Regulation of AMPK Activation by CD36 Links Fatty Acid Uptake to β-Oxidation

(2014) Dmitri Samovski et al.   DIABETES

Oxidized high-density lipoprotein impairs the function of human renal proximal tubule epithelial cells through CD36

(2014) XIANG GAO et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Exosome poly-ubiquitin inhibits platelet activation, downregulates CD36 and inhibits pro-atherothombotic cellular functions

(2014) S. Srikanthan et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development

(2014) Hyun Mi Kang et al.   NATURE MEDICINE

Inflammatory Stress Increases Hepatic CD36 Translational Efficiency via Activation of the mTOR Signalling Pathway

(2014) Chuan Wang et al.   PLoS One

Circulating sCD36 is associated with unhealthy fat distribution and elevated circulating triglycerides in morbidly obese individuals

(2014) L Knøsgaard et al.   Nutrition & Diabetes

Fatty kidney: emerging role of ectopic lipid in obesity-related renal disease

(2014) Aiko P J de Vries et al.   Lancet Diabetes & Endocrinology

Lipid Droplet Accumulation Is Associated with an Increase in Hyperglycemia-Induced Renal Damage

(2013) Eva Kiss et al.   AMERICAN JOURNAL OF PATHOLOGY

Molecular Basis of Antiangiogenic Thrombospondin-1 Type 1 Repeat Domain Interactions With CD36

(2013) Philip A. Klenotic et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Thrombospondin 1 activates the macrophage Toll-like receptor 4 pathway

(2013) Yanzhang Li et al.   Cellular & Molecular Immunology

Macrophage ADAM17 Deficiency Augments CD36-Dependent Apoptotic Cell Uptake and the Linked Anti-Inflammatory Phenotype

(2013) Will S. Driscoll et al.   CIRCULATION RESEARCH

Inhibition of carnitine palymitoyltransferase1b induces cardiac hypertrophy and mortality in mice

(2013) K. R. Haynie et al.   DIABETES OBESITY & METABOLISM

Liver X receptors preserve renal glomerular integrity under normoglycaemia and in diabetes in mice

(2013) Monika Patel et al.   DIABETOLOGIA

Increased soluble CD36 is linked to advanced steatosis in nonalcoholic fatty liver disease

(2013) Carmelo García-Monzón et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

OxLDL-induced IL-1beta secretion promoting foam cells formation was mainly via CD36 mediated ROS production leading to NLRP3 inflammasome activation

(2013) Weiwei Liu et al.   INFLAMMATION RESEARCH

Carbamylated-Oxidized LDL: Proatherosclerotic Effects on Endothelial Cells and Macrophages

(2013) Eugene O. Apostolov et al.   Journal of Atherosclerosis and Thrombosis

Sulfo-N-succinimidyl Oleate (SSO) Inhibits Fatty Acid Uptake and Signaling for Intracellular Calcium via Binding CD36 Lysine 164

(2013) Ondrej Kuda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMPK, insulin resistance, and the metabolic syndrome

(2013) Neil B. Ruderman et al.   JOURNAL OF CLINICAL INVESTIGATION

Selenoprotein K is required for palmitoylation of CD36 in macrophages: implications in foam cell formation and atherogenesis

(2013) Svenja Meiler et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Altered renal lipid metabolism and renal lipid accumulation in human diabetic nephropathy

(2013) Michal Herman-Edelstein et al.   JOURNAL OF LIPID RESEARCH

Cardiomyocyte-specific ablation of CD36 improves post-ischemic functional recovery

(2013) Jeevan Nagendran et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Structure of LIMP-2 provides functional insights with implications for SR-BI and CD36

(2013) Dante Neculai et al.   NATURE

CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation

(2013) Frederick J Sheedy et al.   NATURE IMMUNOLOGY

Peroxisome Proliferator‐Activated Receptor‐γ in Capillary Endothelia Promotes Fatty Acid Uptake by Heart During Long‐Term Fasting

(2013) Kosaku Goto et al.   Journal of the American Heart Association

Responses of skeletal muscle lipid metabolism in rat gastrocnemius to hypothyroidism and iodothyronine administration: a putative role for FAT/CD36

(2012) Assunta Lombardi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Advanced Oxidation Protein Products Activate Intrarenal Renin–Angiotensin System via a CD36-Mediated, Redox-Dependent Pathway

(2012) Wei Cao et al.   ANTIOXIDANTS & REDOX SIGNALING

CD36 Ectodomain Phosphorylation Blocks Thrombospondin-1 Binding

(2012) Ling-Yun Chu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Advanced glycation end products induce a prothrombotic phenotype in mice via interaction with platelet CD36

(2012) W. Zhu et al.   BLOOD

EP 80317, a selective CD36 ligand, shows cardioprotective effects against post-ischaemic myocardial damage in mice

(2012) Valérie L. Bessi et al.   CARDIOVASCULAR RESEARCH

Muscle-Specific Deletion of Carnitine Acetyltransferase Compromises Glucose Tolerance and Metabolic Flexibility

(2012) Deborah M. Muoio et al.   Cell Metabolism

Lack of consistency between two commercial ELISAs and against an in-house ELISA for the detection of CD36 in human plasma

(2012) Simon Lykkeboe et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Plasma levels of soluble CD36, platelet activation, inflammation, and oxidative stress are increased in type 2 diabetic patients

(2012) Rossella Liani et al.   FREE RADICAL BIOLOGY AND MEDICINE

CD36 and Na/K-ATPase-α1 Form a Proinflammatory Signaling Loop in Kidney

(2012) David J. Kennedy et al.   HYPERTENSION

CD36 Protein Influences Myocardial Ca2+Homeostasis and Phospholipid Metabolism

(2012) Terri A. Pietka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of Liver X Receptor Inhibits Osteopontin and Ameliorates Diabetic Nephropathy

(2012) H. Tachibana et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Thrombospondin-1 plays a profibrotic and pro-inflammatory role during ureteric obstruction

(2012) Naïke Bige et al.   KIDNEY INTERNATIONAL

Vertebrate protein glycosylation: diversity, synthesis and function

(2012) Kelley W. Moremen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Accumulation of circulating advanced oxidation protein products is an independent risk factor for ischaemic heart disease in maintenance haemodialysis patients

(2012) QIUGEN ZHOU et al.   NEPHROLOGY

CD36 modulates proinflammatory cytokine responses to Plasmodium falciparum glycosylphosphatidylinositols and merozoites by dendritic cells

(2012) S. KUMAR et al.   PARASITE IMMUNOLOGY

High Glucose Increases Mesangial Lipid Accumulation via Impaired Cholesterol Transporters

(2012) K.H. Song et al.   TRANSPLANTATION PROCEEDINGS

Proteomic Analysis of Lysine Acetylation Sites in Rat Tissues Reveals Organ Specificity and Subcellular Patterns

(2012) Alicia Lundby et al.   Cell Reports

Interactions between CD36 and global intestinal alkaline phosphatase in mouse small intestine and effects of high-fat diet

(2011) Matthew Lynes et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Protein palmitoylation and subcellular trafficking

(2011) Clara Aicart-Ramos et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Lysophosphatidic acid suppresses endothelial cell CD36 expression and promotes angiogenesis via a PKD-1-dependent signaling pathway

(2011) B. Ren et al.   BLOOD

α M β 2 Integrin Activation Prevents Alternative Activation of Human and Murine Macrophages and Impedes Foam Cell Formation

(2011) Valentin P. Yakubenko et al.   CIRCULATION RESEARCH

Hepatic fatty acid translocase CD36 upregulation is associated with insulin resistance, hyperinsulinaemia and increased steatosis in non-alcoholic steatohepatitis and chronic hepatitis C

(2011) M. E. Miquilena-Colina et al.   GUT

High-Density Lipoprotein Inhibits the Uptake of Modified Low- Density Lipoprotein and the Expression of CD36 and FcγRI

(2011) Márcia Dias Teixeira Carvalho et al.   Journal of Atherosclerosis and Thrombosis

Parkin reinvents itself to regulate fatty acid metabolism by tagging CD36

(2011) Nada A. Abumrad et al.   JOURNAL OF CLINICAL INVESTIGATION

Parkin is a lipid-responsive regulator of fat uptake in mice and mutant human cells

(2011) Kye-Young Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Plasma sCD36 is associated with markers of atherosclerosis, insulin resistance and fatty liver in a nondiabetic healthy population

(2011) A. Handberg et al.   JOURNAL OF INTERNAL MEDICINE

Contraction-induced skeletal muscle FAT/CD36 trafficking and FA uptake is AMPK independent

(2011) J. Jeppesen et al.   JOURNAL OF LIPID RESEARCH

Post-translational modifications, a key process in CD36 function: Lessons from the spontaneously hypertensive rat heart

(2011) Benjamin Lauzier et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The putative diabetic plasma marker, soluble CD36, is non-cleaved, non-soluble and entirely associated with microparticles

(2011) M. J. ALKHATATBEH et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

CD9 Tetraspanin Interacts with CD36 on the Surface of Macrophages: A Possible Regulatory Influence on Uptake of Oxidized Low Density Lipoprotein

(2011) Wenxin Huang et al.   PLoS One

Dyslipidemia in Human Kidney Transplant Recipients Receiving Cyclosporine and Tacrolimus is Associated With Different Expression of CD36 on Peripheral Blood Monocytes

(2011) Y. Jiang et al.   TRANSPLANTATION PROCEEDINGS

Palmitoylation of CD36/FAT regulates the rate of its post-transcriptional processing in the endoplasmic reticulum

(2010) Rick F. Thorne et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Atherogenic Lipids and Lipoproteins Trigger CD36-TLR2-Dependent Apoptosis in Macrophages Undergoing Endoplasmic Reticulum Stress

(2010) Tracie A. Seimon et al.   Cell Metabolism

Serum soluble CD36, assessed by a novel monoclonal antibody-based sandwich ELISA, predicts cardiovascular mortality in dialysis patients

(2010) Michal Chmielewski et al.   CLINICA CHIMICA ACTA

Oxidized high-density lipoprotein enhances inflammatory activity in rat mesangial cells

(2010) Miao Zhang et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

CD36 Is a Novel Serum Amyloid A (SAA) Receptor Mediating SAA Binding and SAA-induced Signaling in Human and Rodent Cells

(2010) Irina N. Baranova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Soluble CD36 (sCD36) Clusters with Markers of Insulin Resistance, and High sCD36 Is Associated with Increased Type 2 Diabetes Risk

(2010) A. Handberg et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

oxHDL decreases the expression of CD36 on human macrophages through PPARγ and p38 MAP kinase dependent mechanisms

(2010) Jingyi Ren et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Membrane Fatty Acid Transporters as Regulators of Lipid Metabolism: Implications for Metabolic Disease

(2010) Jan F. C. Glatz et al.   PHYSIOLOGICAL REVIEWS

Receptor of Advanced Glycation End Products (RAGE) Positively Regulates CD36 Expression and Reactive Oxygen Species Production in Human Monocytes in Diabetes

(2009) A. Xanthis et al.   ANGIOLOGY

Pleiotropic effect of pyridoxamine on diabetic complications via CD36 expression in KK-Ay/Ta mice

(2009) Maki Murakoshi et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Glucagon-Like Peptide-2 Increases Intestinal Lipid Absorption and Chylomicron Production via CD36

(2009) Joanne Hsieh et al.   GASTROENTEROLOGY

p53 Acetylation Is Crucial for Its Transcription-independent Proapoptotic Functions

(2009) Hirohito Yamaguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Human Scavenger Receptor CD36

(2009) Sarah J. Hoosdally et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CD36 Regulates Oxidative Stress and Inflammation in Hypercholesterolemic CKD

(2009) D. M. Okamura et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Knockdown of Human N -Terminal Acetyltransferase Complex C Leads to p53-Dependent Apoptosis and Aberrant Human Arl8b Localization

(2009) K. K. Starheim et al.   MOLECULAR AND CELLULAR BIOLOGY

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

(2009) Cameron R Stewart et al.   NATURE IMMUNOLOGY

An update on the lipid nephrotoxicity hypothesis

(2009) Xiong Z. Ruan et al.   Nature Reviews Nephrology

Soluble CD36 Ectodomain Binds Negatively Charged Diacylglycerol Ligands and Acts as a Co-Receptor for TLR2

(2009) Maximiliano J. Jimenez-Dalmaroni et al.   PLoS One

CD36, a Scavenger Receptor Involved in Immunity, Metabolism, Angiogenesis, and Behavior

(2009) R. L. Silverstein et al.   Science Signaling

Characterization of Hepatic Mitochondrial Injury Induced by Fatty Acid Oxidation Inhibitors

(2009) Alison E.M. Vickers   TOXICOLOGIC PATHOLOGY

Advanced Glycation End-Product of Low Density Lipoprotein Activates the Toll-Like 4 Receptor Pathway Implications for Diabetic Atherosclerosis

(2008) Conrad P. Hodgkinson et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Proatherogenic high-density lipoprotein, vascular inflammation, and mimetic peptides

(2008) Roger Yu et al.   Current Atherosclerosis Reports

Opposite Regulation of CD36 Ubiquitination by Fatty Acids and Insulin

(2008) Jill Smith et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcriptional Regulation of Fatty Acid Translocase/CD36 Expression by CCAAT/Enhancer-binding Protein α

(2008) Liping Qiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of catalase in monocytic differentiation of U937 cells by TPA: hydrogen peroxide as a second messenger

(2008) T Yamamoto et al.   LEUKEMIA

Soluble CD36 in Plasma Is Increased in Patients With Symptomatic Atherosclerotic Carotid Plaques and Is Related to Plaque Instability

(2008) Aase Handberg et al.   STROKE

Hepatic Fatty Acid Transporter Cd36 Is a Common Target of LXR, PXR, and PPARγ in Promoting Steatosis

(2007) Jie Zhou et al.   GASTROENTEROLOGY

Modulation of CD36 protein expression by AGEs and insulin in aortic VSMCs from diabetic and non-diabetic rats

(2006) Cristina de Oliveira Silva et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES