Crosstalk Between Lipids and Mitochondria in Diabetic Kidney Disease

Abcc6 deficiency in mice leads to altered ABC transporter gene expression in metabolic active tissues

(2019) Bettina Ibold et al.   Lipids in Health and Disease

Aryl hydrocarbon receptor ligands increase ABC transporter activity and protein expression in killifish (Fundulus heteroclitus) renal proximal tubules

(2019) Anne Mahringer et al.   BIOLOGICAL CHEMISTRY

Small GTPase Arf6 regulates diabetes-induced cholesterol accumulation in podocytes

(2019) Jijia Hu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

ATP-binding cassette A1 deficiency causes cardiolipin-driven mitochondrial dysfunction in podocytes

(2019) G. Michelle Ducasa et al.   JOURNAL OF CLINICAL INVESTIGATION

SMPDL3b modulates insulin receptor signaling in diabetic kidney disease

(2019) A. Mitrofanova et al.   Nature Communications

Mitochondrial dysfunction in diabetic kidney disease

(2018) Josephine M. Forbes et al.   Nature Reviews Nephrology

Pramipexole and Fingolimod exert neuroprotection in a mouse model of Parkinson's disease by activation of sphingosine kinase 1 and Akt kinase

(2018) Joanna Motyl et al.   NEUROPHARMACOLOGY

The sphingosine 1-phosphate receptor 2 is shed in exosomes from breast cancer cells and is N-terminally processed to a short constitutively active form that promotes extracellular signal regulated kinase activation and DNA synthesis in fibroblasts

(2018) Ashref El Buri et al.   Oncotarget

The role of sphingosine-1-phosphate in inflammation and cancer progression

(2018) Masayuki Nagahashi et al.   CANCER SCIENCE

CD36 Promotes Podocyte Apoptosis by Activating the Pyrin Domain-Containing-3 (NLRP3) Inflammasome in Primary Nephrotic Syndrome

(2018) Xuejun Yang et al.   MEDICAL SCIENCE MONITOR

Pharmacological inhibition of serine palmitoyl transferase and sphingosine kinase-1/-2 inhibits Merkel Cell Carcinoma cell proliferation

(2018) Vishwanath Kumble Bhat et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Hydroxypropyl-β-cyclodextrin protects from kidney disease in experimental Alport syndrome and focal segmental glomerulosclerosis

(2018) Alla Mitrofanova et al.   KIDNEY INTERNATIONAL

The sphingosine kinase-1/sphingosine-1-phosphate axis in cancer: Potential target for anticancer therapy

(2018) Xiangjin Zheng et al.   PHARMACOLOGY & THERAPEUTICS

Sphingomyelinase-like phosphodiesterase 3b mediates radiation-induced damage of renal podocytes

(2017) Anis Ahmad et al.   FASEB JOURNAL

Sphingosine-1-phosphate lyase mutations cause primary adrenal insufficiency and steroid-resistant nephrotic syndrome

(2017) Rathi Prasad et al.   JOURNAL OF CLINICAL INVESTIGATION

Mutations in sphingosine-1-phosphate lyase cause nephrosis with ichthyosis and adrenal insufficiency

(2017) Svjetlana Lovric et al.   JOURNAL OF CLINICAL INVESTIGATION

Effect of Simvastatin on Lipid Accumulation and the Expression of CXCL16 and Nephrin in Podocyte Induced by Oxidized LDL

(2017) Li Wang et al.   JOURNAL OF INVESTIGATIVE SURGERY

Plasma metabolite profiles, cellular cholesterol efflux, and non-traditional cardiovascular risk in patients with CKD

(2017) Anjali Ganda et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The Role of Sphingosine-1-Phosphate and Ceramide-1-Phosphate in Inflammation and Cancer

(2017) Nitai C. Hait et al.   MEDIATORS OF INFLAMMATION

Sphingosine 1-Phosphate Receptor 1 Modulates CNTF-Induced Axonal Growth and Neuroprotection in the Mouse Visual System

(2017) Sandrine Joly et al.   NEURAL PLASTICITY

De novo Synthesis of Sphingolipids Is Defective in Experimental Models of Huntington's Disease

(2017) Alba Di Pardo et al.   Frontiers in Neuroscience

Angiotensin II induces cholesterol accumulation and injury in podocytes

(2017) Yingjie Yang et al.   Scientific Reports

Glomerular Endothelial Mitochondrial Dysfunction Is Essential and Characteristic of Diabetic Kidney Disease Susceptibility

(2016) Haiying Qi et al.   DIABETES

Plasma Triglycerides and HDL-C Levels Predict the Development of Diabetic Kidney Disease in Subjects With Type 2 Diabetes: The AMD Annals Initiative

(2016) Giuseppina T. Russo et al.   DIABETES CARE

Mitochondrial Fission Increases Apoptosis and Decreases Autophagy in Renal Proximal Tubular Epithelial Cells Treated with High Glucose

(2016) Wen-Chin Lee et al.   DNA AND CELL BIOLOGY

Local TNF causes NFATc1-dependent cholesterol-mediated podocyte injury

(2016) Christopher E. Pedigo et al.   JOURNAL OF CLINICAL INVESTIGATION

Dynamin-Related Protein 1 Deficiency Improves Mitochondrial Fitness and Protects against Progression of Diabetic Nephropathy

(2016) B. A. Ayanga et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Endothelial Sphingosine 1-Phosphate Receptor-1 Mediates Protection and Recovery from Acute Kidney Injury

(2016) H. M. Perry et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Sphingosine Kinase 2 Deficiency Attenuates Kidney Fibrosis via IFN- γ

(2016) Amandeep Bajwa et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Protection of mitochondria prevents high-fat diet–induced glomerulopathy and proximal tubular injury

(2016) Hazel H. Szeto et al.   KIDNEY INTERNATIONAL

Diabetes Dyslipidemia

(2016) Jonathan D. Schofield et al.   Diabetes Therapy

Diabetes Dyslipidemia

(2016) Jonathan D. Schofield et al.   Diabetes Therapy

Inflammatory stress exacerbates lipid accumulation and podocyte injuries in diabetic nephropathy

(2015) Yang Zhang et al.   ACTA DIABETOLOGICA

Dysregulation of low-density lipoprotein receptor contributes to podocyte injuries in diabetic nephropathy

(2015) Yang Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

CD36 is involved in high glucose-induced epithelial to mesenchymal transition in renal tubular epithelial cells

(2015) Yanjuan Hou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Activation of sphingosine kinase 2 by endoplasmic reticulum stress ameliorates hepatic steatosis and insulin resistance in mice

(2015) Su-Yeon Lee et al.   HEPATOLOGY

The Lipid-Modifying Enzyme SMPDL3B Negatively Regulates Innate Immunity

(2015) Leonhard X. Heinz et al.   Cell Reports

CD36 Mediated Fatty Acid-Induced Podocyte Apoptosis via Oxidative Stress

(2015) Wei Hua et al.   PLoS One

CerS2 Haploinsufficiency Inhibits β-Oxidation and Confers Susceptibility to Diet-Induced Steatohepatitis and Insulin Resistance

(2014) Suryaprakash Raichur et al.   Cell Metabolism

Ceramide Kinase Contributes to Proliferation but not to Prostaglandin E2 Formation in Renal Mesangial Cells and Fibroblasts

(2014) Oleksandr Pastukhov et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Sphingomyelinase-Like Phosphodiesterase 3b Expression Levels Determine Podocyte Injury Phenotypes in Glomerular Disease

(2014) T.-H. Yoo et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes

(2014) Rachel J. Perry et al.   NATURE

Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development

(2014) Hyun Mi Kang et al.   NATURE MEDICINE

Modulation of sphingosine-1-phosphate and apolipoprotein M levels in the plasma, liver and kidneys in streptozotocin-induced diabetic mice

(2014) Takahiro Nojiri et al.   Journal of Diabetes Investigation

Free Fatty Acids and Their Metabolism Affect Function and Survival of Podocytes

(2014) Jonas Sieber et al.   Frontiers in Endocrinology

Susceptibility of Podocytes to Palmitic Acid Is Regulated by Stearoyl-CoA Desaturases 1 and 2

(2013) Jonas Sieber et al.   AMERICAN JOURNAL OF PATHOLOGY

Functional role of cardiolipin in mitochondrial bioenergetics

(2013) Giuseppe Paradies et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

First-in-class cardiolipin-protective compound as a therapeutic agent to restore mitochondrial bioenergetics

(2013) Hazel H Szeto   BRITISH JOURNAL OF PHARMACOLOGY

Targeting mitochondrial cardiolipin and the cytochromec/cardiolipin complex to promote electron transport and optimize mitochondrial ATP synthesis

(2013) A V Birk et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cyclodextrin Protects Podocytes in Diabetic Kidney Disease

(2013) S. Merscher-Gomez et al.   DIABETES

Altered renal lipid metabolism and renal lipid accumulation in human diabetic nephropathy

(2013) Michal Herman-Edelstein et al.   JOURNAL OF LIPID RESEARCH

Hepatopoietin Cn reduces ethanol-induced hepatoxicity via sphingosine kinase 1 and sphingosine 1-phosphate receptors

(2013) Yang Liu et al.   JOURNAL OF PATHOLOGY

Evidence for Cardiolipin Binding Sites on the Membrane-Exposed Surface of the Cytochrome bc1

(2013) Clement Arnarez et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Metabolomics Reveals Signature of Mitochondrial Dysfunction in Diabetic Kidney Disease

(2013) K. Sharma et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Cardiolipin Effects on Membrane Structure and Dynamics

(2013) Joseph D. Unsay et al.   LANGMUIR

Oxidative Stress and Cell Senescence Combine to Cause Maximal Renal Tubular Epithelial Cell Dysfunction and Loss in an in vitro Model of Kidney Disease

(2013) David M. Small et al.   NEPHRON EXPERIMENTAL NEPHROLOGY

Plasma Sphingosine-1-Phosphate Is Elevated in Obesity

(2013) Greg M. Kowalski et al.   PLoS One

Lipids of mitochondria

(2013) Susanne E. Horvath et al.   PROGRESS IN LIPID RESEARCH

Mechanisms of Mitochondrial Fission and Fusion

(2013) A. M. van der Bliek et al.   Cold Spring Harbor Perspectives in Biology

Identification of cardiolipin binding sites on cytochrome c oxidase at the entrance of proton channels

(2013) C. Arnarez et al.   Scientific Reports

Regulatory Pathways for ATP-binding Cassette Transport Proteins in Kidney Proximal Tubules

(2012) Rosalinde Masereeuw et al.   AAPS Journal

Cellular and molecular mechanisms of mitochondrial function

(2012) Laura D. Osellame et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Overexpression of Sphingosine Kinase 1 Prevents Ceramide Accumulation and Ameliorates Muscle Insulin Resistance in High-Fat Diet-Fed Mice

(2012) C. R. Bruce et al.   DIABETES

The Sphingosine-1-Phosphate Analog FTY720 Reduces Muscle Ceramide Content and Improves Glucose Tolerance in High Fat-Fed Male Mice

(2012) Clinton R. Bruce et al.   ENDOCRINOLOGY

Arrangement of the Respiratory Chain Complexes inSaccharomyces cerevisiaeSupercomplex III2IV2Revealed by Single Particle Cryo-Electron Microscopy

(2012) Eugenia Mileykovskaya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphatidylethanolamine and Cardiolipin Differentially Affect the Stability of Mitochondrial Respiratory Chain Supercomplexes

(2012) Lena Böttinger et al.   JOURNAL OF MOLECULAR BIOLOGY

Spontaneously diabetic Ins2+/Akita:apoE-deficient mice exhibit exaggerated hypercholesterolemia and atherosclerosis

(2011) John Y. Jun et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Making heads or tails of phospholipids in mitochondria

(2011) Christof Osman et al.   JOURNAL OF CELL BIOLOGY

Hyperglycemic Ins2AkitaLdlr−/−mice show severely elevated lipid levels and increased atherosclerosis: a model of type 1 diabetic macrovascular disease

(2011) Changcheng Zhou et al.   JOURNAL OF LIPID RESEARCH

Conservation of Lipid Functions in Cytochrome bc Complexes

(2011) S. Saif Hasan et al.   JOURNAL OF MOLECULAR BIOLOGY

Effects of atorvastatin on progression of diabetic nephropathy and local RAGE and soluble RAGE expressions in rats

(2011) Lin Lu et al.   Journal of Zhejiang University-SCIENCE B

Chronic sphingosine 1-phosphate 1 receptor activation attenuates early-stage diabetic nephropathy independent of lymphocytes

(2011) Alaa S. Awad et al.   KIDNEY INTERNATIONAL

Conditioning for hematopoietic transplantation activates the complement cascade and induces a proteolytic environment in bone marrow: a novel role for bioactive lipids and soluble C5b-C9 as homing factors

(2011) C H Kim et al.   LEUKEMIA

Polymorphisms of the MDR1 and MIF genes in children with nephrotic syndrome

(2011) Hyun Jin Choi et al.   PEDIATRIC NEPHROLOGY

Rituximab Targets Podocytes in Recurrent Focal Segmental Glomerulosclerosis

(2011) A. Fornoni et al.   Science Translational Medicine

The complexity of cardiolipin in health and disease

(2011) Steven M. Claypool et al.   TRENDS IN BIOCHEMICAL SCIENCES

Diabetic Nephropathy Is Accelerated by Farnesoid X Receptor Deficiency and Inhibited by Farnesoid X Receptor Activation in a Type 1 Diabetes Model

(2010) X. X. Wang et al.   DIABETES

Circulating sphingolipid biomarkers in models of type 1 diabetes

(2010) Todd E. Fox et al.   JOURNAL OF LIPID RESEARCH

Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2

(2010) Sergio E. Alvarez et al.   NATURE

Mitochondrial fusion and fission in cell life and death

(2010) Benedikt Westermann   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial Dysfunction in Diabetes: From Molecular Mechanisms to Functional Significance and Therapeutic Opportunities

(2009) William I. Sivitz et al.   ANTIOXIDANTS & REDOX SIGNALING

Structure and function of mitochondrial supercomplexes

(2009) Natalya V. Dudkina et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Cardiolipin acts as a mitochondrial signalling platform to launch apoptosis

(2009) Zachary T. Schug et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Sphingosine 1-phosphate increases glucose uptake through trans-activation of insulin receptor

(2009) Elena Rapizzi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Diabetes reduces the cholesterol exporter ABCA1 in mouse macrophages and kidneys

(2009) Chongren Tang et al.   JOURNAL OF LIPID RESEARCH

An update on the lipid nephrotoxicity hypothesis

(2009) Xiong Z. Ruan et al.   Nature Reviews Nephrology

Simvastatin Reverses Podocyte Injury but not Mesangial Expansion in Early Stage Type 2 Diabetes Mellitus

(2009) P. Wei et al.   RENAL FAILURE

Cellular functions of cardiolipin in yeast

(2008) Amit S. Joshi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Oxidative Stress as a Major Culprit in Kidney Disease in Diabetes

(2008) J. M. Forbes et al.   DIABETES

Intracellular Lipid Accumulation in Liver and Muscle and the Insulin Resistance Syndrome

(2008) Cristina Lara-Castro et al.   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Cardiolipin provides an essential activating platform for caspase-8 on mitochondria

(2008) Francois Gonzalvez et al.   JOURNAL OF CELL BIOLOGY

The translocator maintenance protein Tam41 is required for mitochondrial cardiolipin biosynthesis

(2008) Stephan Kutik et al.   JOURNAL OF CELL BIOLOGY

The breast cancer resistance protein transporter ABCG2 is expressed in the human kidney proximal tubule apical membrane

(2007) M. Huls et al.   KIDNEY INTERNATIONAL