The Compromised Intestinal Barrier Induced by Mycotoxins

Toxicity of mycotoxins in vivo on vertebrate organisms: A review

(2020) A. Cimbalo et al.   FOOD AND CHEMICAL TOXICOLOGY

Comparative toxicokinetics of Fusarium mycotoxins in pigs and humans

(2020) Wim Schelstraete et al.   FOOD AND CHEMICAL TOXICOLOGY

Selenium-rich yeast attenuates ochratoxin A-induced small intestinal injury in broiler chickens by activating the Nrf2 pathway and inhibiting NF-KB activation

(2020) Cui Tong et al.   Journal of Functional Foods

A Structural Study on the Listeria Monocytogenes Internalin A—Human E-cadherin Interaction: A Molecular Tool to Investigate the Effects of Missense Mutations

(2020) Luca Dellafiora et al.   Toxins

Lactobacillus rhamnosus GG supplementation modulates the gut microbiota to promote butyrate production, protecting against deoxynivalenol exposure in nude mice

(2020) Ruqin Lin et al.   BIOCHEMICAL PHARMACOLOGY

Mycotoxin toxicity and residue in animal products: Prevalence, consumer exposure and reduction strategies – A review

(2020) Moyosore Joseph Adegbeye et al.   TOXICON

Crossing the Intestinal Barrier via Listeria Adhesion Protein and Internalin A

(2019) Rishi Drolia et al.   TRENDS IN MICROBIOLOGY

Modulation of Mucin (MUC2, MUC5AC and MUC5B) mRNA Expression and Protein Production and Secretion in Caco-2/HT29-MTX Co-Cultures Following Exposure to Individual and Combined Aflatoxin M1 and Ochratoxin A

(2019) Xin Huang et al.   Toxins

Modulation of Intestinal Epithelial Permeability and Mucin mRNA (MUC2, MUC5AC, and MUC5B) Expression and Protein Secretion in Caco-2/HT29-MTX Co-cultures Exposed to Aflatoxin M1, Ochratoxin A, and Zearalenone Individually or Collectively

(2019) ChenQing Wu et al.   TOXICOLOGY LETTERS

Transcriptome analysis revealed that aflatoxin M1 could cause cell cycle arrest in differentiated Caco-2 cells

(2019) X.Y. Bao et al.   TOXICOLOGY IN VITRO

Enteroids: Promising in Vitro Models for Studies of Intestinal Physiology and Nutrition in Farm Animals

(2019) Yue-Bang Yin et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Determination of multiple mycotoxins in paired plasma and urine samples to assess human exposure in Nanjing, China

(2019) Kai Fan et al.   ENVIRONMENTAL POLLUTION

Probiotic Bacillus subtilis CW14 reduces disruption of the epithelial barrier and toxicity of ochratoxin A to Caco-2 cells

(2019) Mengxue Peng et al.   FOOD AND CHEMICAL TOXICOLOGY

The characteristics, occurrence, and toxicological effects of patulin

(2019) Iman Saleh et al.   FOOD AND CHEMICAL TOXICOLOGY

Hydrolyzed fumonisin B1 induces less inflammatory responses than fumonisin B1 in the co-culture model of porcine intestinal epithelial and immune cells

(2019) Min Jeong Gu et al.   TOXICOLOGY LETTERS

Acute exposure to deoxynivalenol inhibits porcine enteroid activity via suppression of the Wnt/β-catenin pathway

(2019) Xiang-Guang Li et al.   TOXICOLOGY LETTERS

Assessment of the efficacy of a grape seed waste in counteracting the changes induced by aflatoxin B1 contaminated diet on performance, plasma, liver and intestinal tissues of pigs after weaning

(2019) Ionelia Taranu et al.   TOXICON

Tests of intestinal mucosal hyperpermeability: Many diseases, many biomarkers and a bright future

(2019) Dominic-Luc Webb   Best Practice & Research Clinical Gastroenterology

Metagenomic analysis of gut microbiota alteration in a mouse model exposed to mycotoxin deoxynivalenol

(2019) Jun-Jie Wang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Comparative transcriptome analysis reveals the different roles between hepatopancreas and intestine of Litopenaeus vannamei in immune response to aflatoxin B1 (AFB1) challenge

(2019) Yilong Wang et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY

Deoxynivalenol induced apoptosis and inflammation of IPEC-J2 cells by promoting ROS production

(2019) Ruifen Kang et al.   ENVIRONMENTAL POLLUTION

Eugenol protects against citrinin-induced cytotoxicity and oxidative damages in cultured human colorectal HCT116 cells

(2019) Amal Salah et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Species-specific models in toxicology: in vitro epithelial barriers

(2019) A. Bertero et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Activation of the p38/MAPK pathway regulates autophagy in response to the CYPOR-dependent oxidative stress induced by zearalenone in porcine intestinal epithelial cells

(2019) Tongtong Shen et al.   FOOD AND CHEMICAL TOXICOLOGY

Hydrolyzed wheat gluten alleviates deoxynivalenol-induced intestinal injury by promoting intestinal stem cell proliferation and differentiation via upregulation of Wnt/β-catenin signaling in mice

(2019) Jia-yi Zhou et al.   FOOD AND CHEMICAL TOXICOLOGY

T-2 toxin inhibits the production of mucin via activating the IRE1/XBP1 pathway

(2019) Ruqin Lin et al.   TOXICOLOGY

Nontoxic concentrations of OTA aggravate DON-induced intestinal barrier dysfunction in IPEC-J2 cells via activation of NF-κB signaling pathway

(2019) Chen Ying et al.   TOXICOLOGY LETTERS

In vitro and in vivo effects of a mycotoxin, deoxynivalenol, and a trace metal, cadmium, alone or in a mixture on the intestinal barrier

(2019) Su Luo et al.   ENVIRONMENT INTERNATIONAL

Methionine and Its Hydroxyl Analogues Improve Stem Cell Activity To Eliminate Deoxynivalenol-Induced Intestinal Injury by Reactivating Wnt/β-Catenin Signaling

(2019) Jia-yi Zhou et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

A multi-endpoint approach to the combined toxic effects of patulin and ochratoxin a in human intestinal cells

(2019) Ricardo Assunção et al.   TOXICOLOGY LETTERS

Transcriptional profiling of zearalenone-induced inhibition of IPEC-J2 cell proliferation

(2019) Xin Wang et al.   TOXICON

The occurrence of mycotoxins in breast milk, fruit products and cereal-based infant formula: A review

(2019) Carolina Fernanda Sengling Cebin Coppa et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Effects of zearalenone-induced oxidative stress and Keap1–Nrf2 signaling pathway-related gene expression in the ileum and mesenteric lymph nodes of post-weaning gilts

(2019) Qun Cheng et al.   TOXICOLOGY

Wnt Signaling in 3D: Recent Advances in the Applications of Intestinal Organoids

(2019) Alessandra Merenda et al.   TRENDS IN CELL BIOLOGY

Recent advances on toxicity and determination methods of mycotoxins in foodstuffs

(2019) Yan Yang et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Transcriptome Analysis of Ochratoxin A-Induced Apoptosis in Differentiated Caco-2 Cells

(2019) Xue Yang et al.   Toxins

Effects of curcumin on performance, antioxidation, intestinal barrier and mitochondrial function in ducks fed corn contaminated with ochratoxin A

(2018) D. Ruan et al.   Animal

Short-term ingestion of deoxynivalenol in naturally contaminated feed alters piglet performance and gut hormone secretion

(2018) Ruonan Li et al.   ANIMAL SCIENCE JOURNAL

Aflatoxin B1 (AFB1) induced dysregulation of intestinal microbiota and damage of antioxidant system in pacific white shrimp ( Litopenaeus vannamei )

(2018) Yilong Wang et al.   AQUACULTURE

In vitro co-culture models to evaluate acute cytotoxicity of individual and combined mycotoxin exposures on Caco-2, THP-1 and HepaRG human cell lines

(2018) Marie-Caroline Smith et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Zearalenone (ZEA)-induced intestinal inflammation is mediated by the NLRP3 inflammasome

(2018) Wentao Fan et al.   CHEMOSPHERE

OTA induces intestinal epithelial barrier dysfunction and tight junction disruption in IPEC-J2 cells through ROS/Ca 2+ -mediated MLCK activation

(2018) Hong Wang et al.   ENVIRONMENTAL POLLUTION

Deoxynivalenol decreased the growth performance and impaired intestinal physical barrier in juvenile grass carp ( Ctenopharyngodon idella )

(2018) Chen Huang et al.   FISH & SHELLFISH IMMUNOLOGY

Mycotoxins in dry-cured meats: A review

(2018) Francisco Pizzolato Montanha et al.   FOOD AND CHEMICAL TOXICOLOGY

Application of porcine gastrointestinal organoid units as a potential in vitro tool for drug discovery and development

(2018) Adedamola Olayanju et al.   JOURNAL OF APPLIED TOXICOLOGY

Interactions of commensal and pathogenic microorganisms with the intestinal mucosal barrier

(2018) Eric C. Martens et al.   NATURE REVIEWS MICROBIOLOGY

Optimized procedures for generating an enhanced, near physiological 2D culture system from porcine intestinal organoids

(2018) B. van der Hee et al.   Stem Cell Research

Lactobacillus plantarum alleviate aflatoxins (B 1 and M 1 ) induced disturbances in the intestinal genes expression and DNA fragmentation in mice

(2018) Rania Jebali et al.   TOXICON

Lactoferrin inhibits aflatoxin B1- and aflatoxin M1-induced cytotoxicity and DNA damage in Caco-2, HEK, Hep-G2, and SK-N-SH cells

(2018) Nan Zheng et al.   TOXICON

Low Levels of Chito-Oligosaccharides Are Not Effective in Reducing Deoxynivalenol Toxicity in Swine Jejunal Explants

(2018) Juliana Gerez et al.   Toxins

Organoid and Enteroid Modeling of Salmonella Infection

(2018) Yuebang Yin et al.   Frontiers in Cellular and Infection Microbiology

Dietary Deoxynivalenol Contamination and Oral Lipopolysaccharide Challenge Alters the Cecal Microbiota of Broiler Chickens

(2018) Annegret Lucke et al.   Frontiers in Microbiology

Monitoring and evaluation of the interaction between deoxynivalenol and gut microbiota in Wistar rats by mass spectrometry-based metabolomics and next-generation sequencing

(2018) Eugènia Miró-Abella et al.   FOOD AND CHEMICAL TOXICOLOGY

Fusarium mycotoxins and in vitro species-specific approach with porcine intestinal and brain in vitro barriers: A review

(2018) A. Bertero et al.   FOOD AND CHEMICAL TOXICOLOGY

Transcriptional and Proteomic Analysis Revealed a Synergistic Effect of Aflatoxin M1 and Ochratoxin A Mycotoxins on the Intestinal Epithelial Integrity of Differentiated Human Caco-2 Cells

(2018) Yanan Gao et al.   JOURNAL OF PROTEOME RESEARCH

Isolation and characterization of the Bacillus cereus BC7 strain, which is capable of zearalenone removal and intestinal flora modulation in mice

(2018) Yue Wang et al.   TOXICON

Deoxynivalenol decreased intestinal immune function related to NF-κB and TOR signalling in juvenile grass carp (Ctenopharyngodon idella)

(2018) Chen Huang et al.   FISH & SHELLFISH IMMUNOLOGY

Beneficial effects of Saccharomyces cerevisiae RC016 in weaned piglets: in vivo and ex vivo analysis

(2018) G.R. Garcia et al.   Beneficial Microbes

Development and comparison of single-step solid phase extraction and QuEChERS clean-up for the analysis of 7 mycotoxins in fruits and vegetables during storage by UHPLC-MS/MS

(2018) Hao Dong et al.   FOOD CHEMISTRY

Contributions of intestinal epithelial barriers to health and disease

(2017) Wangsun Choi et al.   EXPERIMENTAL CELL RESEARCH

Food contact materials and gut health: Implications for toxicity assessment and relevance of high molecular weight migrants

(2017) Ksenia J. Groh et al.   FOOD AND CHEMICAL TOXICOLOGY

Co-occurrence of aflatoxins and ochratoxin A in dried fruits in Iran: Dietary exposure risk assessment

(2017) Ali Heshmati et al.   FOOD AND CHEMICAL TOXICOLOGY

Ochratoxin A-Induced Apoptosis of IPEC-J2 Cells through ROS-Mediated Mitochondrial Permeability Transition Pore Opening Pathway

(2017) Hong Wang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Effects of dietary inclusion of silymarin on performance, intestinal morphology and ileal bacterial count in aflatoxin-challenged broiler chicks

(2017) E. Jahanian et al.   JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION

Alterations in Intestinal Permeability: The Role of the “Leaky Gut” in Health and Disease

(2017) Amy Stieler Stewart et al.   JOURNAL OF EQUINE VETERINARY SCIENCE

Bentonite modified with zinc enhances aflatoxin B 1 adsorption and increase survival of fibroblasts (3T3) and epithelial colorectal adenocarcinoma cells (Caco-2)

(2017) Janaína Nones et al.   JOURNAL OF HAZARDOUS MATERIALS

Effect of yeast cell wall on the growth performance and gut health of broilers challenged with aflatoxin B1 and necrotic enteritis

(2017) N Liu et al.   POULTRY SCIENCE

Mycotoxin detoxifiers attenuate deoxynivalenol-induced pro-inflammatory barrier insult in porcine enterocytes as an in vitro evaluation model of feed mycotoxin reduction

(2017) Seong-Hwan Park et al.   TOXICOLOGY IN VITRO

The Food Contaminant Deoxynivalenol Exacerbates the Genotoxicity of Gut Microbiota

(2017) Delphine Payros et al.   mBio

Parallel Changes in Harvey-Bradshaw Index, TNFα, and Intestinal Fatty Acid Binding Protein in Response to Infliximab in Crohn’s Disease

(2017) Anas Kh. Al-Saffar et al.   Gastroenterology Research and Practice

Response of Intestinal Bacterial Flora to the Long-term Feeding of Aflatoxin B1 (AFB1) in Mice

(2017) et al.   Toxins

Modulation of Intestinal Epithelial Permeability in Differentiated Caco-2 Cells Exposed to Aflatoxin M1 and Ochratoxin A Individually or Collectively

(2017) Yanan Gao et al.   Toxins

WRN conditioned media is sufficient forin vitropropagation of intestinal organoids from large farm and small companion animals

(2017) Robin H. Powell et al.   Biology Open

The intestinal barrier as an emerging target in the toxicological assessment of mycotoxins

(2016) Peyman Akbari et al.   ARCHIVES OF TOXICOLOGY

Modeling Development and Disease with Organoids

(2016) Hans Clevers   CELL

Protective Capacity of Resveratrol, a Natural Polyphenolic Compound, against Deoxynivalenol-Induced Intestinal Barrier Dysfunction and Bacterial Translocation

(2016) Ka-Ho Ling et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Interleukin-1β Mediates β-Catenin-Driven Downregulation of Claudin-3 and Barrier Dysfunction in Caco2 Cells

(2016) R. J. Haines et al.   DIGESTIVE DISEASES AND SCIENCES

Zearalenone as an endocrine disruptor in humans

(2016) Karolina Kowalska et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Histological structure of duodenum in gilts receiving low doses of zearalenone and deoxynivalenol in feed

(2016) Bogdan Lewczuk et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Comparative in vitro cytotoxicity of modified deoxynivalenol on porcine intestinal epithelial cells

(2016) Nathan Broekaert et al.   FOOD AND CHEMICAL TOXICOLOGY

Aflatoxin M1 cytotoxicity against human intestinal Caco-2 cells is enhanced in the presence of other mycotoxins

(2016) Y.N. Gao et al.   FOOD AND CHEMICAL TOXICOLOGY

Effects of patulin and ascladiol on porcine intestinal mucosa: An ex vivo approach

(2016) Leila Maidana et al.   FOOD AND CHEMICAL TOXICOLOGY

Inflammation and the Intestinal Barrier: Leukocyte–Epithelial Cell Interactions, Cell Junction Remodeling, and Mucosal Repair

(2016) Anny-Claude Luissint et al.   GASTROENTEROLOGY

Intestinal Epithelial Toll-Like Receptor 4 Signaling Affects Epithelial Function and Colonic Microbiota and Promotes a Risk for Transmissible Colitis

(2016) Rishu Dheer et al.   INFECTION AND IMMUNITY

Intestinal barrier dysfunction in human necrotizing enterocolitis

(2016) Sarah A. Moore et al.   JOURNAL OF PEDIATRIC SURGERY

Effect of dietary supplementation of mannanoligosaccharides on growth performance, ileal microbial counts, and jejunal morphology in broiler chicks exposed to aflatoxins

(2016) E. Jahanian et al.   Livestock Science

The intestinal epithelial barrier: a therapeutic target?

(2016) Matthew A. Odenwald et al.   Nature Reviews Gastroenterology & Hepatology

TNFα/IFNγ Mediated Intestinal Epithelial Barrier Dysfunction Is Attenuated by MicroRNA-93 Downregulation of PTK6 in Mouse Colonic Epithelial Cells

(2016) Ricci J. Haines et al.   PLoS One

Effect of aflatoxin experimental ingestion andEimeiravaccine challenges on intestinal histopathology and immune cellular dynamic of broilers: applying an Intestinal Health Index

(2016) A. L. Kraieski et al.   POULTRY SCIENCE

Interactive effects of dietary protein concentration and aflatoxin B1on performance, nutrient digestibility, and gut health in broiler chicks

(2016) X. Chen et al.   POULTRY SCIENCE

Effects of maize naturally contaminated with aflatoxin B1on growth performance, intestinal morphology, and digestive physiology in ducks

(2016) G. D. Feng et al.   POULTRY SCIENCE

Individual and combined effects of deoxynivalenol and zearalenone on modulation of mucin expression on intestinal epithelial cells

(2016) K.K. Lo et al.   TOXICOLOGY LETTERS

Characterization of in vitro effects of patulin on intestinal epithelial and immune cells

(2016) R. Assunção et al.   TOXICOLOGY LETTERS

The mycotoxin zearalenone enhances cell proliferation, colony formation and promotes cell migration in the human colon carcinoma cell line HCT116

(2016) Haila Abassi et al.   TOXICOLOGY LETTERS

Lactobacillus rhamnosus GG modulates intestinal mucosal barrier and inflammation in mice following combined dietary exposure to deoxynivalenol and zearalenone

(2016) Murphy L.Y. Wan et al.   Journal of Functional Foods

Changes in serum cytokine levels, hepatic and intestinal morphology in aflatoxin B1-induced injury: modulatory roles of melatonin and flavonoid-rich fractions from Chromolena odorata

(2016) Fadeyemi Joseph Akinrinmade et al.   Mycotoxin Research

Mycotoxins as human carcinogens—the IARC Monographs classification

(2016) Vladimir Ostry et al.   Mycotoxin Research

Growth performance, serum biochemical profile, jejunal morphology, and the expression of nutrients transporter genes in deoxynivalenol (DON)- challenged growing pigs

(2015) Li Wu et al.   BMC Veterinary Research

The role of immunomodulators on intestinal barrier homeostasis in experimental models

(2015) Maria Emília Rabelo Andrade et al.   CLINICAL NUTRITION

Deoxynivalenol alone or in combination with nivalenol and zearalenone induce systemic histological changes in pigs

(2015) Juliana R. Gerez et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Modulation of the xenobiotic transformation system and inflammatory response by ochratoxin A exposure using a co-culture system of Caco-2 and HepG2 cells

(2015) C.A. González-Arias et al.   FOOD AND CHEMICAL TOXICOLOGY

Aflatoxin B1 and aflatoxin M1 induced cytotoxicity and DNA damage in differentiated and undifferentiated Caco-2 cells

(2015) J. Zhang et al.   FOOD AND CHEMICAL TOXICOLOGY

Impact of deoxynivalenol (DON) contaminated feed on intestinal integrity and immune response in swine

(2015) Martin Lessard et al.   FOOD AND CHEMICAL TOXICOLOGY

Mycotoxins Deoxynivalenol and Fumonisins Alter the Extrinsic Component of Intestinal Barrier in Broiler Chickens

(2015) Gunther Antonissen et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Effect of Glucan and Low Doses of T-2 Toxin on Mucin, IgA Expression and IgA+ Lymphocytes in the Intestine of Chickens

(2015) M. Levkut et al.   JOURNAL OF COMPARATIVE PATHOLOGY

Deoxynivalenol inhibits the expression by goblet cells of intestinal mucins through a PKR and MAP kinase dependent repression of the resistin-like molecule β

(2015) Philippe Pinton et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Claudin-related intestinal diseases

(2015) Christian Barmeyer et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Claudin switching: Physiological plasticity of the Tight Junction

(2015) Christopher T. Capaldo et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Patulin Induces Apoptosis through ROS-Mediated Endoplasmic Reticulum Stress Pathway

(2015) Manel Boussabbeh et al.   TOXICOLOGICAL SCIENCES

Aflatoxin B1Induced Compositional Changes in Gut Microbial Communities of Male F344 Rats

(2015) Jincheng Wang et al.   TOXICOLOGICAL SCIENCES

Dose-dependent lipid peroxidation induction on ex vivo intestine tracts exposed to chyme samples from fumonisins contaminated corn samples

(2015) A. Garbetta et al.   TOXICOLOGY IN VITRO

Cytotoxicity of the mycotoxins deoxynivalenol and ochratoxin A on Caco-2 cell line in presence of resveratrol

(2015) G. Cano-Sancho et al.   TOXICOLOGY IN VITRO

Exposure to zearalenone mycotoxin alters in vitro porcine intestinal epithelial cells by differential gene expression

(2015) Ionelia Taranu et al.   TOXICOLOGY LETTERS

Induction of pro-inflammatory gene expression by Escherichia coli and mycotoxin zearalenone contamination and protection by a Lactobacillus mixture in porcine IPEC-1 cells

(2015) Ionelia Taranu et al.   TOXICON

Mycotoxin mechanisms of action and health impact: ‘in vitro’ or ‘in vivo’ tests, that is the question

(2015) F. Cheli et al.   World Mycotoxin Journal

Fungal metabolites diversity in maize and associated human dietary exposures relate to micro-climatic patterns in Malawi

(2015) L. Matumba et al.   World Mycotoxin Journal

High-density lipoprotein contribute to G0-G1/S transition in Swiss NIH/3T3 fibroblasts

(2015) Fabrizio Angius et al.   Scientific Reports

Food Contaminant Zearalenone and Its Metabolites Affect Cytokine Synthesis and Intestinal Epithelial Integrity of Porcine Cells

(2015) Daniela Marin et al.   Toxins

Comparing Two Intestinal Porcine Epithelial Cell Lines (IPECs): Morphological Differentiation, Function and Metabolism

(2015) Constanze Nossol et al.   PLoS One

Toxic Mechanisms Induced by Fumonisin B1 Mycotoxin on Human Intestinal Cell Line

(2014) Fiorenza Minervini et al.   ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY

Microbial imbalance and intestinal pathologies: connections and contributions

(2014) Y. Yang et al.   Disease Models & Mechanisms

The effects of season and gender on the serum aflatoxins and ochratoxin A levels of healthy adult subjects from the Central Anatolia Region, Turkey

(2014) Suna Sabuncuoglu et al.   EUROPEAN JOURNAL OF NUTRITION

Mucus Layers in Inflammatory Bowel Disease

(2014) Malin E. V. Johansson   INFLAMMATORY BOWEL DISEASES

Targeted colonic claudin-2 expression renders resistance to epithelial injury, induces immune suppression and protects from colitis

(2014) R Ahmad et al.   Mucosal Immunology

Subversion of human intestinal mucosa innate immunity by a Crohn’s disease-associated E. coli

(2014) A Jarry et al.   Mucosal Immunology

Single and Combined Effects of Deoxynivalenol Mycotoxin and a Microbial Feed Additive on Lymphocyte DNA Damage and Oxidative Stress in Broiler Chickens

(2014) Wageha A. Awad et al.   PLoS One

Toxic Effects of Maternal Zearalenone Exposure on Intestinal Oxidative Stress, Barrier Function, Immunological and Morphological Changes in Rats

(2014) Min Liu et al.   PLoS One

The Mycotoxin Patulin Decreases Expression of Density-Enhanced Phosphatase-1 by Down-Regulating PPARγ in Human Colon Cancer Cells

(2014) Akihiro Katsuyama et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

Modulation of Mucin mRNA (MUC5AC and MUC5B) Expression and Protein Production and Secretion in Caco-2/HT29-MTX Co-cultures Following Exposure to Individual and Combined Fusarium Mycotoxins

(2014) Lam-Yim Murphy Wan et al.   TOXICOLOGICAL SCIENCES

Combination of Metagenomics and Culture-Based Methods to Study the Interaction Between Ochratoxin A and Gut Microbiota

(2014) Mingzhang Guo et al.   TOXICOLOGICAL SCIENCES

Are alterations of tight junctions at molecular and ultrastructural level different in duodenal biopsies of patients with celiac disease and Crohn's disease?

(2014) Pooja Goswami et al.   VIRCHOWS ARCHIV

Assessment of Multi-Mycotoxin Exposure in Southern Italy by Urinary Multi-Biomarker Determination

(2014) Michele Solfrizzo et al.   Toxins

Effect of Deoxynivalenol and Other Type B Trichothecenes on the Intestine: A Review

(2014) Philippe Pinton et al.   Toxins

Analysis of Individual and Combined Effects of Ochratoxin A and Zearalenone on HepG2 and KK-1 Cells with Mathematical Models

(2014) Yuzhe Li et al.   Toxins

Zearalenone, an Estrogenic Mycotoxin, Is an Immunotoxic Compound

(2014) Isis Hueza et al.   Toxins

The Effect of Experimental Fusarium Mycotoxicosis on Microbiota Diversity in Porcine Ascending Colon Contents

(2014) Małgorzata Piotrowska et al.   Toxins

Blowing on Embers: Commensal Microbiota and Our Immune System

(2014) Darina S. Spasova et al.   Frontiers in Immunology

Modulation of Porcine β-Defensins 1 and 2 upon Individual and Combined Fusarium Toxin Exposure in a Swine Jejunal Epithelial Cell Line

(2013) Murphy Lam-Yim Wan et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

The emerging mycotoxin, enniatin B1, down-modulates the gastrointestinal toxicity of T-2 toxin in vitro on intestinal epithelial cells and ex vivo on intestinal explants

(2013) Martine Kolf-Clauw et al.   ARCHIVES OF TOXICOLOGY

Ex vivo systems to study host–microbiota interactions in the gastrointestinal tract

(2013) Guus Roeselers et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Claudin-2 Regulates Colorectal Inflammation via Myosin Light Chain Kinase-Dependent Signaling

(2013) Masayuki Nishida et al.   DIGESTIVE DISEASES AND SCIENCES

Mucosal innate immune cells regulate both gut homeostasis and intestinal inflammation

(2013) Yosuke Kurashima et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Mycotoxins: Occurrence, toxicology, and exposure assessment

(2013) S. Marin et al.   FOOD AND CHEMICAL TOXICOLOGY

Bio-monitoring of mycotoxin exposure in Cameroon using a urinary multi-biomarker approach

(2013) Wilfred A. Abia et al.   FOOD AND CHEMICAL TOXICOLOGY

Metabolic fate of ochratoxin A as a coffee contaminant in a dynamic simulator of the human colon

(2013) Minale Ouethrani et al.   FOOD CHEMISTRY

Simultaneous determination of aflatoxin M1, ochratoxin A, zearalenone and α-zearalenol in milk by UHPLC–MS/MS

(2013) L.C. Huang et al.   FOOD CHEMISTRY

Evaluation of an Oral Subchronic Exposure of Deoxynivalenol on the Composition of Human Gut Microbiota in a Model of Human Microbiota-Associated Rats

(2013) Manuel J. Saint-Cyr et al.   PLoS One

Growing Self-Organizing Mini-Guts from a Single Intestinal Stem Cell: Mechanism and Applications

(2013) T. Sato et al.   SCIENCE

The food contaminant deoxynivalenol activates the mitogen activated protein kinases in the intestine: Interest of ex vivo models as an alternative to in vivo experiments

(2013) Joelma Lucioli et al.   TOXICON

Modulation of Intestinal Functions Following Mycotoxin Ingestion: Meta-Analysis of Published Experiments in Animals

(2013) Bertrand Grenier et al.   Toxins

Effect of Low Dose of Fumonisins on Pig Health: Immune Status, Intestinal Microbiota and Sensitivity to Salmonella

(2013) Christine Burel et al.   Toxins

Role of secretory IgA in infection and maintenance of homeostasis

(2012) Blaise Corthésy   AUTOIMMUNITY REVIEWS

Tumor-Induced CD8+ T-Cell Dysfunction in Lung Cancer Patients

(2012) Heriberto Prado-Garcia et al.   Clinical & Developmental Immunology

Immune modulatory effects of the foodborne contaminant citrinin in mice

(2012) Mohammad Rafiqul Islam et al.   FOOD AND CHEMICAL TOXICOLOGY

Quantitation of Mycotoxins in Food and Feed from Burkina Faso and Mozambique Using a Modern LC-MS/MS Multitoxin Method

(2012) Benedikt Warth et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Modulation of intestinal barrier by intestinal microbiota: Pathological and therapeutic implications

(2012) Jane M.M. Natividad et al.   PHARMACOLOGICAL RESEARCH

Nivalenol and Deoxynivalenol Affect Rat Intestinal Epithelial Cells: A Concentration Related Study

(2012) Giuseppe Bianco et al.   PLoS One

Deoxynivalenol as a contaminant of broiler feed: Intestinal development, absorptive functionality, and metabolism of the mycotoxin

(2012) A. W. Yunus et al.   POULTRY SCIENCE

A mitochondria-mediated apoptotic pathway induced by deoxynivalenol in human colon cancer cells

(2012) Yanna Ma et al.   TOXICOLOGY IN VITRO

In Vitro Gliadin Challenge: Diagnostic Accuracy and Utility for the Difficult Diagnosis of Celiac Disease

(2011) Raffaella Tortora et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

The use of a porcine intestinal cell model system for evaluating the food safety risk of Bacillus cereus probiotics and the implications for assessing enterotoxigenicity

(2011) MARTIN TRAPECAR et al.   APMIS

Alternative (non-animal) methods for cosmetics testing: current status and future prospects—2010

(2011) Sarah Adler et al.   ARCHIVES OF TOXICOLOGY

Chronic ingestion of deoxynivalenol and fumonisin, alone or in interaction, induces morphological and immunological changes in the intestine of piglets

(2011) Ana-Paula F. L. Bracarense et al.   BRITISH JOURNAL OF NUTRITION

Explant culture of gastrointestinal tissue: a review of methods and applications

(2011) Kevin J. Randall et al.   CELL BIOLOGY AND TOXICOLOGY

Patulin induces colorectal cancer cells apoptosis through EGR-1 dependent ATF3 up-regulation

(2011) Osong Kwon et al.   CELLULAR SIGNALLING

Enteric pathogen exploitation of the microbiota-generated nutrient environment of the gut

(2011) Kristie M Keeney et al.   CURRENT OPINION IN MICROBIOLOGY

Exposure assessment of mycotoxins in cow’s milk in Argentina

(2011) M.L. Signorini et al.   FOOD AND CHEMICAL TOXICOLOGY

Inflammation and Disruption of the Mucosal Architecture in Claudin-7–Deficient Mice

(2011) Lei Ding et al.   GASTROENTEROLOGY

Interleukin-6 (IL-6) Regulates Claudin-2 Expression and Tight Junction Permeability in Intestinal Epithelium

(2011) Takuya Suzuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Tight Junction Permeability by Intestinal Bacteria and Dietary Components

(2011) Dulantha Ulluwishewa et al.   JOURNAL OF NUTRITION

Intestinal homeostasis and its breakdown in inflammatory bowel disease

(2011) Kevin J. Maloy et al.   NATURE

Mucin dynamics and enteric pathogens

(2011) Michael A. McGuckin et al.   NATURE REVIEWS MICROBIOLOGY

Vulnerability of Polarised Intestinal Porcine Epithelial Cells to Mycotoxin Deoxynivalenol Depends on the Route of Application

(2011) Anne-Kathrin Diesing et al.   PLoS One

Correlation between the destruction of tight junction by patulin treatment and increase of phosphorylation of ZO-1 in Caco-2 human colon cancer cells

(2011) Tomoko Kawauchiya et al.   TOXICOLOGY LETTERS

ClC-2 regulates mucosal barrier function associated with structural changes to the villus and epithelial tight junction

(2010) Prashant K. Nighot et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Epithelial Myosin Light Chain Kinase Activation Induces Mucosal Interleukin-13 Expression to Alter Tight Junction Ion Selectivity

(2010) Christopher R. Weber et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Feasibility of the Ussing chamber technique for the determination of in vitro jejunal permeability of passively absorbed compounds in different animal species

(2010) E. NEIRINCKX et al.   JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS

Mycotoxin deoxynivalenol (DON) mediates biphasic cellular response in intestinal porcine epithelial cell lines IPEC-1 and IPEC-J2

(2010) Anne-Kathrin Diesing et al.   TOXICOLOGY LETTERS

Some food-associated mycotoxins as potential risk factors in humans predisposed to chronic intestinal inflammatory diseases

(2010) Marc Maresca et al.   TOXICON

Effects of feed-borne Fusarium mycotoxins and an organic mycotoxin adsorbent on immune cell dynamics in the jejunum of chickens infected with Eimeria maxima

(2010) George N. Girgis et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Toxicological mechanisms and potential health effects of deoxynivalenol and nivalenol

(2010) J. Pestka   World Mycotoxin Journal

TNFα up-regulates claudin-2 expression in epithelial HT-29/B6 cells via phosphatidylinositol-3-kinase signaling

(2009) J. Mankertz et al.   CELL AND TISSUE RESEARCH

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Do symbiotic bacteria subvert host immunity?

(2009) Lora V. Hooper   NATURE REVIEWS MICROBIOLOGY

Effect of aflatoxin culture on intestinal function and nutrient loss in laying hens

(2009) T. J. Applegate et al.   POULTRY SCIENCE

The food contaminant deoxynivalenol, decreases intestinal barrier permeability and reduces claudin expression

(2009) Philippe Pinton et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Development of a pig jejunal explant culture for studying the gastrointestinal toxicity of the mycotoxin deoxynivalenol: Histopathological analysis

(2009) Martine Kolf-Clauw et al.   TOXICOLOGY IN VITRO

Stem Cells, Self-Renewal, and Differentiation in the Intestinal Epithelium

(2008) Laurens G. van der Flier et al.   Annual Review of Physiology

Cytokine regulation of tight junctions

(2008) Christopher T. Capaldo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Impact of Deoxynivalenol on the Intestinal Microflora of Pigs

(2008) Yann Waché et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Changes in the expression of claudins in active ulcerative colitis

(2008) Tadayuki Oshima et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Both direct and indirect effects account for the pro-inflammatory activity of enteropathogenic mycotoxins on the human intestinal epithelium: Stimulation of interleukin-8 secretion, potentiation of interleukin-1β effect and increase in the transepithelial passage of commensal bacteria

(2007) Marc Maresca et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY