The intestinal barrier as an emerging target in the toxicological assessment of mycotoxins
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Title
The intestinal barrier as an emerging target in the toxicological assessment of mycotoxins
Authors
Keywords
Mycotoxins, Tight junction proteins, Intestinal permeability, Mucosal inflammation
Journal
ARCHIVES OF TOXICOLOGY
Volume 91, Issue 3, Pages 1007-1029
Publisher
Springer Nature
Online
2016-07-15
DOI
10.1007/s00204-016-1794-8
References
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Note: Only part of the references are listed.- Protective Capacity of Resveratrol, a Natural Polyphenolic Compound, against Deoxynivalenol-Induced Intestinal Barrier Dysfunction and Bacterial Translocation
- (2016) Ka-Ho Ling et al. CHEMICAL RESEARCH IN TOXICOLOGY
- The mycotoxin deoxynivalenol facilitates allergic sensitization to whey in mice
- (2016) M Bol-Schoenmakers et al. Mucosal Immunology
- Interactive effects of dietary protein concentration and aflatoxin B1on performance, nutrient digestibility, and gut health in broiler chicks
- (2016) X. Chen et al. POULTRY SCIENCE
- Mycotoxins modify the barrier function of Caco-2 cells through differential gene expression of specific claudin isoforms: Protective effect of illite mineral clay
- (2016) Alejandro Romero et al. TOXICOLOGY
- Characterization of in vitro effects of patulin on intestinal epithelial and immune cells
- (2016) R. Assunção et al. TOXICOLOGY LETTERS
- Simultaneous determination of major type A and B trichothecenes, zearalenone and certain modified metabolites in Finnish cereal grains with a novel liquid chromatography-tandem mass spectrometric method
- (2015) Alexis V. Nathanail et al. ANALYTICAL AND BIOANALYTICAL CHEMISTRY
- In vivo toxicity studies of fusarium mycotoxins in the last decade: A review
- (2015) L. Escrivá et al. FOOD AND CHEMICAL TOXICOLOGY
- Impact of deoxynivalenol (DON) contaminated feed on intestinal integrity and immune response in swine
- (2015) Martin Lessard et al. FOOD AND CHEMICAL TOXICOLOGY
- Deoxynivalenol inhibits the expression by goblet cells of intestinal mucins through a PKR and MAP kinase dependent repression of the resistin-like molecule β
- (2015) Philippe Pinton et al. MOLECULAR NUTRITION & FOOD RESEARCH
- Wheat protein recognition pattern in tolerant and allergic children
- (2015) Steven Sievers et al. PEDIATRIC ALLERGY AND IMMUNOLOGY
- Patulin Induces Apoptosis through ROS-Mediated Endoplasmic Reticulum Stress Pathway
- (2015) Manel Boussabbeh et al. TOXICOLOGICAL SCIENCES
- Nivalenol induces oxidative stress and increases deoxynivalenol pro-oxidant effect in intestinal epithelial cells
- (2015) Marisanta Del Regno et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Nivalenol Has a Greater Impact than Deoxynivalenol on Pig Jejunum Mucosa in Vitro on Explants and in Vivo on Intestinal Loops
- (2015) Sophal Cheat et al. Toxins
- Food Contaminant Zearalenone and Its Metabolites Affect Cytokine Synthesis and Intestinal Epithelial Integrity of Porcine Cells
- (2015) Daniela Marin et al. Toxins
- Dual Effects Exerted in Vitro by Micromolar Concentrations of Deoxynivalenol on Undifferentiated Caco-2 Cells
- (2015) Gina Manda et al. Toxins
- Deoxynivalenol Impairs Weight Gain and Affects Markers of Gut Health after Low-Dose, Short-Term Exposure of Growing Pigs
- (2015) Arash Alizadeh et al. Toxins
- New insights into the organ-specific adverse effects of fumonisin B1: comparison between lung and liver
- (2014) Nicolas Loiseau et al. ARCHIVES OF TOXICOLOGY
- The mycotoxin patulin reacts with DNA bases with and without previous conjugation to GSH: implication for related α,β-unsaturated carbonyl compounds?
- (2014) Carolin Pfenning et al. ARCHIVES OF TOXICOLOGY
- Oxidative stress-mediated cytotoxicity and metabolism of T-2 toxin and deoxynivalenol in animals and humans: an update
- (2014) Qing-Hua Wu et al. ARCHIVES OF TOXICOLOGY
- Deoxynivalenol: signaling pathways and human exposure risk assessment—an update
- (2014) Zhonghong Wang et al. ARCHIVES OF TOXICOLOGY
- Toxicological interactions between the mycotoxins deoxynivalenol, nivalenol and their acetylated derivatives in intestinal epithelial cells
- (2014) Imourana Alassane-Kpembi et al. ARCHIVES OF TOXICOLOGY
- <italic>Bacillus subtilis</italic> Protects Porcine Intestinal Barrier from Deoxynivalenol via Improved Zonula Occludens-1 Expression
- (2014) Min Jeong Gu et al. ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES
- Intestinal permeability – a new target for disease prevention and therapy
- (2014) Stephan C Bischoff et al. BMC GASTROENTEROLOGY
- Wheat allergy in children - new tools for diagnostics
- (2014) M. J. Mäkelä et al. CLINICAL AND EXPERIMENTAL ALLERGY
- Deoxynivalenol: a trigger for intestinal integrity breakdown
- (2014) Peyman Akbari et al. FASEB JOURNAL
- Applicability of In Vitro Methods to Study Patulin Bioaccessibility and Its Effects on Intestinal Membrane Integrity
- (2014) Ricardo Assunção et al. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
- Toxic Effects of Maternal Zearalenone Exposure on Intestinal Oxidative Stress, Barrier Function, Immunological and Morphological Changes in Rats
- (2014) Min Liu et al. PLoS One
- The Mycotoxin Patulin Decreases Expression of Density-Enhanced Phosphatase-1 by Down-Regulating PPARγ in Human Colon Cancer Cells
- (2014) Akihiro Katsuyama et al. TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
- Public Health Impacts of Foodborne Mycotoxins
- (2014) Felicia Wu et al. Annual Review of Food Science and Technology
- Effect of Deoxynivalenol and Other Type B Trichothecenes on the Intestine: A Review
- (2014) Philippe Pinton et al. Toxins
- The emerging mycotoxin, enniatin B1, down-modulates the gastrointestinal toxicity of T-2 toxin in vitro on intestinal epithelial cells and ex vivo on intestinal explants
- (2013) Martine Kolf-Clauw et al. ARCHIVES OF TOXICOLOGY
- Intestinal Permeability Defects: Is It Time to Treat?
- (2013) Matthew A. Odenwald et al. Clinical Gastroenterology and Hepatology
- Trichothecenes: Structure-Toxic Activity Relationships
- (2013) Qinghua Wu et al. CURRENT DRUG METABOLISM
- Mycotoxins: Occurrence, toxicology, and exposure assessment
- (2013) S. Marin et al. FOOD AND CHEMICAL TOXICOLOGY
- Urinary analysis reveals high deoxynivalenol exposure in pregnant women from Croatia
- (2013) Bojan Šarkanj et al. FOOD AND CHEMICAL TOXICOLOGY
- The Role of Aflatoxins in Hepatocellular Carcinoma
- (2013) Hui-Chen Wu et al. Hepatitis Monthly
- Deoxynivalenol Impairs Hepatic and Intestinal Gene Expression of Selected Oxidative Stress, Tight Junction and Inflammation Proteins in Broiler Chickens, but Addition of an Adsorbing Agent Shifts the Effects to the Distal Parts of the Small Intestine
- (2013) Ann Osselaere et al. PLoS One
- New insights into mycotoxin mixtures: The toxicity of low doses of Type B trichothecenes on intestinal epithelial cells is synergistic
- (2013) Imourana Alassane-Kpembi et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Comparative study of deoxynivalenol, 3-acetyldeoxynivalenol, and 15-acetyldeoxynivalenol on intestinal transport and IL-8 secretion in the human cell line Caco-2
- (2013) Tomoyuki Kadota et al. TOXICOLOGY IN VITRO
- New insights into the human metabolism of the Fusarium mycotoxins deoxynivalenol and zearalenone
- (2013) Benedikt Warth et al. TOXICOLOGY LETTERS
- The food contaminant deoxynivalenol activates the mitogen activated protein kinases in the intestine: Interest of ex vivo models as an alternative to in vivo experiments
- (2013) Joelma Lucioli et al. TOXICON
- Aflatoxin B1-induced hepatocellular carcinoma in developing countries: Geographical distribution, mechanism of action and prevention
- (2013) ABDU SELIM HAMID et al. Oncology Letters
- Modulation of Intestinal Functions Following Mycotoxin Ingestion: Meta-Analysis of Published Experiments in Animals
- (2013) Bertrand Grenier et al. Toxins
- From the Gut to the Brain: Journey and Pathophysiological Effects of the Food-Associated Trichothecene Mycotoxin Deoxynivalenol
- (2013) Marc Maresca Toxins
- Toxicity of Ochratoxin A and Its Modulation by Antioxidants: A Review
- (2013) Valeria Sorrenti et al. Toxins
- Central Role of the Gut Epithelial Barrier in the Pathogenesis of Chronic Intestinal Inflammation: Lessons Learned from Animal Models and Human Genetics
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- Oral food challenge to wheat: a near-fatal anaphylaxis and review of 93 food challenges in children
- (2013) Antonella Cianferoni et al. World Allergy Organization Journal
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- (2012) Leslie H Jimison et al. ADVANCED MATERIALS
- A dynamic real-time method for monitoring epithelial barrier function in vitro
- (2012) Mingjiao Sun et al. ANALYTICAL BIOCHEMISTRY
- Zonulin, regulation of tight junctions, and autoimmune diseases
- (2012) Alessio Fasano Annals of the New York Academy of Sciences
- Ceramide synthases at the centre of sphingolipid metabolism and biology
- (2012) Thomas D. Mullen et al. BIOCHEMICAL JOURNAL
- Porcine intestinal epithelial barrier disruption by the Fusarium mycotoxins deoxynivalenol and T-2 toxin promotes transepithelial passage of doxycycline and paromomycin
- (2012) Joline Goossens et al. BMC Veterinary Research
- Regulation of intestinal epithelial permeability by tight junctions
- (2012) Takuya Suzuki CELLULAR AND MOLECULAR LIFE SCIENCES
- Population attributable risk of aflatoxin-related liver cancer: Systematic review and meta-analysis
- (2012) Yan Liu et al. EUROPEAN JOURNAL OF CANCER
- The mycotoxin patulin increases colonic epithelial permeability in vitro
- (2012) H.M. Mohan et al. FOOD AND CHEMICAL TOXICOLOGY
- Determinants of colonic barrier function in inflammatory bowel disease and potential therapeutics
- (2012) Nina A. Hering et al. JOURNAL OF PHYSIOLOGY-LONDON
- Nivalenol and Deoxynivalenol Affect Rat Intestinal Epithelial Cells: A Concentration Related Study
- (2012) Giuseppe Bianco et al. PLoS One
- Transgenerational toxicity of Zearalenone in pigs
- (2012) Eric J. Schoevers et al. REPRODUCTIVE TOXICOLOGY
- Toxicity of Deoxynivalenol and Its Acetylated Derivatives on the Intestine: Differential Effects on Morphology, Barrier Function, Tight Junction Proteins, and Mitogen-Activated Protein Kinases
- (2012) Philippe Pinton et al. TOXICOLOGICAL SCIENCES
- Ochratoxin A and Mitotic Disruption: Mode of Action Analysis of Renal Tumor Formation by Ochratoxin A
- (2012) Angela Mally TOXICOLOGICAL SCIENCES
- Assessment of human deoxynivalenol exposure using an LC–MS/MS based biomarker method
- (2012) Benedikt Warth et al. TOXICOLOGY LETTERS
- A Three-Year Survey on the Worldwide Occurrence of Mycotoxins in Feedstuffs and Feed
- (2012) Inês Rodrigues et al. Toxins
- Advances in Deoxynivalenol Toxicity Mechanisms: The Brain as a Target
- (2012) Marion Bonnet et al. Toxins
- Transport of Aflatoxin M1 in Human Intestinal Caco-2/TC7 Cells
- (2012) Francesca Caloni et al. Frontiers in Pharmacology
- Exposure measurement of aflatoxins and aflatoxin metabolites in human body fluids. A short review
- (2012) Yin-Hui Leong et al. Mycotoxin Research
- The Expression and the Cellular Distribution of the Tight Junction Proteins Are Altered in Irritable Bowel Syndrome Patients With Differences According to the Disease Subtype
- (2011) Nathalie Bertiaux-Vandaële et al. AMERICAN JOURNAL OF GASTROENTEROLOGY
- Chronic ingestion of deoxynivalenol and fumonisin, alone or in interaction, induces morphological and immunological changes in the intestine of piglets
- (2011) Ana-Paula F. L. Bracarense et al. BRITISH JOURNAL OF NUTRITION
- Explant culture of gastrointestinal tissue: a review of methods and applications
- (2011) Kevin J. Randall et al. CELL BIOLOGY AND TOXICOLOGY
- An Update on Direct Genotoxicity as a Molecular Mechanism of Ochratoxin A Carcinogenicity
- (2011) Annie Pfohl-Leszkowicz et al. CHEMICAL RESEARCH IN TOXICOLOGY
- A biomarker survey of urinary deoxynivalenol in China: the Shanghai Women's Health Study
- (2011) P.C. Turner et al. Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk Assessment
- Deoxynivalenol exposure assessment in a cohort of pregnant women from Bradford, UK
- (2011) S.J. Hepworth et al. Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk Assessment
- Deoxynivalenol transport across the human placental barrier
- (2011) Jeanette K.S. Nielsen et al. FOOD AND CHEMICAL TOXICOLOGY
- T-2 Toxin, a Trichothecene Mycotoxin: Review of Toxicity, Metabolism, and Analytical Methods
- (2011) Yanshen Li et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- Global quantification of mammalian gene expression control
- (2011) Björn Schwanhäusser et al. NATURE
- Zonulin and Its Regulation of Intestinal Barrier Function: The Biological Door to Inflammation, Autoimmunity, and Cancer
- (2011) Alessio Fasano PHYSIOLOGICAL REVIEWS
- Vulnerability of Polarised Intestinal Porcine Epithelial Cells to Mycotoxin Deoxynivalenol Depends on the Route of Application
- (2011) Anne-Kathrin Diesing et al. PLoS One
- The Mycotoxin Deoxynivalenol Potentiates Intestinal Inflammation by Salmonella Typhimurium in Porcine Ileal Loops
- (2011) Virginie Vandenbroucke et al. PLoS One
- Effects of zearalenone and its derivatives on porcine immune response
- (2011) Daniela E. Marin et al. TOXICOLOGY IN VITRO
- Correlation between the destruction of tight junction by patulin treatment and increase of phosphorylation of ZO-1 in Caco-2 human colon cancer cells
- (2011) Tomoko Kawauchiya et al. TOXICOLOGY LETTERS
- Current and Future Experimental Strategies for Structural Analysis of Trichothecene Mycotoxins—A Prospectus
- (2011) Roxanne A. Shank et al. Toxins
- Trichothecenes: From Simple to Complex Mycotoxins
- (2011) Susan P. McCormick et al. Toxins
- Deoxynivalenol: mechanisms of action, human exposure, and toxicological relevance
- (2010) James J. Pestka ARCHIVES OF TOXICOLOGY
- The MAPK cascades: Signaling components, nuclear roles and mechanisms of nuclear translocation
- (2010) Alexander Plotnikov et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Interaction between Food Substances and the Intestinal Epithelium
- (2010) Makoto SHIMIZU BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
- Loss of the Protein-Tyrosine Phosphatase DEP-1/PTPRJ Drives Meningioma Cell Motility
- (2010) Astrid Petermann et al. BRAIN PATHOLOGY
- The changing pattern of epidemiology in hepatocellular carcinoma
- (2010) Helena Nordenstedt et al. DIGESTIVE AND LIVER DISEASE
- Global Burden of Aflatoxin-Induced Hepatocellular Carcinoma: A Risk Assessment
- (2010) Yan Liu et al. ENVIRONMENTAL HEALTH PERSPECTIVES
- Effects of Aflatoxin B1 and Fumonisin B1 on the Viability and Induction of Apoptosis in Rat Primary Hepatocytes
- (2010) Deise H. B. Ribeiro et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Deoxynivalenol Impairs Porcine Intestinal Barrier Function and Decreases the Protein Expression of Claudin-4 through a Mitogen-Activated Protein Kinase-Dependent Mechanism
- (2010) Philippe Pinton et al. JOURNAL OF NUTRITION
- Absorption and metabolism of the mycotoxin zearalenone and the growth promotor zeranol in Caco-2 cells in vitro
- (2010) Erika Pfeiffer et al. MOLECULAR NUTRITION & FOOD RESEARCH
- Sequence signatures and mRNA concentration can explain two-thirds of protein abundance variation in a human cell line
- (2010) Christine Vogel et al. Molecular Systems Biology
- Deoxynivalenol affects in vitro intestinal epithelial cell barrier integrity through inhibition of protein synthesis
- (2010) Jacqueline Van De Walle et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Mycotoxin deoxynivalenol (DON) mediates biphasic cellular response in intestinal porcine epithelial cell lines IPEC-1 and IPEC-J2
- (2010) Anne-Kathrin Diesing et al. TOXICOLOGY LETTERS
- Some food-associated mycotoxins as potential risk factors in humans predisposed to chronic intestinal inflammatory diseases
- (2010) Marc Maresca et al. TOXICON
- Mucosal expression of claudins 2, 3 and 4 in proximal and distal part of duodenum in children with coeliac disease
- (2010) Dorottya Nagy Szakál et al. VIRCHOWS ARCHIV
- Biosynthesis and Toxicological Effects of Patulin
- (2010) Olivier Puel et al. Toxins
- Deoxynivalenol-Induced Proinflammatory Gene Expression: Mechanisms and Pathological Sequelae
- (2010) James J. Pestka Toxins
- Analysis of glutathione adducts of patulin by means of liquid chromatography (HPLC) with biochemical detection (BCD) and electrospray ionization tandem mass spectrometry (ESI-MS/MS)
- (2009) Nils Helge Schebb et al. ANALYTICAL AND BIOANALYTICAL CHEMISTRY
- Kinetic Cell-Based Morphological Screening: Prediction of Mechanism of Compound Action and Off-Target Effects
- (2009) Yama A. Abassi et al. CHEMISTRY & BIOLOGY
- Mycotoxins in Food and Feed: Present Status and Future Concerns
- (2009) Rajeev Bhat et al. COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY
- Intestinal barrier function: Molecular regulation and disease pathogenesis
- (2009) Katherine R. Groschwitz et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Oxidative stress induction by T-2 toxin causes DNA damage and triggers apoptosis via caspase pathway in human cervical cancer cells
- (2009) Manjari Chaudhari et al. TOXICOLOGY
- The food contaminant deoxynivalenol, decreases intestinal barrier permeability and reduces claudin expression
- (2009) Philippe Pinton et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Development of a pig jejunal explant culture for studying the gastrointestinal toxicity of the mycotoxin deoxynivalenol: Histopathological analysis
- (2009) Martine Kolf-Clauw et al. TOXICOLOGY IN VITRO
- ABCC1, ABCC2 and ABCC3 are implicated in the transepithelial transport of the myco-estrogen zearalenone and its major metabolites
- (2009) Bernadette Videmann et al. TOXICOLOGY LETTERS
- Intestinal barrier function is modulated by short-term exposure to fumonisin B1 in Ussing chambers
- (2009) Jean-Paul Lallès et al. VETERINARY RESEARCH COMMUNICATIONS
- The Caco-2 cell monolayer: usefulness and limitations
- (2008) Huadong Sun et al. Expert Opinion on Drug Metabolism & Toxicology
- Unique Role of Junctional Adhesion Molecule-A in Maintaining Mucosal Homeostasis in Inflammatory Bowel Disease
- (2008) Stefania Vetrano et al. GASTROENTEROLOGY
- Fumonisins, Trichothecenes and Zearalenone in Cereals
- (2008) Selma Yazar et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Zearalenone and Reproductive Function in Farm Animals
- (2008) Fiorenza Minervini et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets
- (2008) Masato Furuhashi et al. NATURE REVIEWS DRUG DISCOVERY
- The mycotoxin patulin, modulates tight junctions in caco-2 cells
- (2008) John McLaughlin et al. TOXICOLOGY IN VITRO
- Transmembrane proteins of tight junctions
- (2007) Hideki Chiba et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Both direct and indirect effects account for the pro-inflammatory activity of enteropathogenic mycotoxins on the human intestinal epithelium: Stimulation of interleukin-8 secretion, potentiation of interleukin-1β effect and increase in the transepithelial passage of commensal bacteria
- (2007) Marc Maresca et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
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