Application of porcine gastrointestinal organoid units as a potential in vitro tool for drug discovery and development

Wnt/β-catenin promotes gastric fundus specification in mice and humans

(2017) Kyle W. McCracken et al.   NATURE

Long-term expansion of alveolar stem cells derived from human iPS cells in organoids

(2017) Yuki Yamamoto et al.   NATURE METHODS

A Scalable Approach for the Generation of Human Pluripotent Stem Cell-Derived Hepatic Organoids with Sensitive Hepatotoxicity Features

(2017) Malte Sgodda et al.   STEM CELLS AND DEVELOPMENT

Omnisphero: a high-content image analysis (HCA) approach for phenotypic developmental neurotoxicity (DNT) screenings of organoid neurosphere cultures in vitro

(2016) Martin R. Schmuck et al.   ARCHIVES OF TOXICOLOGY

A novel culture system for adult porcine intestinal crypts

(2016) Hassan A. Khalil et al.   CELL AND TISSUE RESEARCH

Stomach development, stem cells and disease

(2016) Tae-Hee Kim et al.   DEVELOPMENT

Gastrointestinal organoids: How they gut it out

(2016) Sebastian R. Merker et al.   DEVELOPMENTAL BIOLOGY

Dishing out mini-brains: Current progress and future prospects in brain organoid research

(2016) Iva Kelava et al.   DEVELOPMENTAL BIOLOGY

Microencapsulation of porcine thyroid cell organoids within a polymer microcapsule construct

(2016) Yipeng Yang et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Organoid Models of Human Gastrointestinal Development and Disease

(2016) Priya H. Dedhia et al.   GASTROENTEROLOGY

Pregnancy and the Patient with Inflammatory Bowel Disease

(2016) Ryan A. McConnell et al.   GASTROENTEROLOGY CLINICS OF NORTH AMERICA

Stem cell-derived models to improve mechanistic understanding and prediction of human drug-induced liver injury

(2016) Christopher Goldring et al.   HEPATOLOGY

Organoids: A historical perspective of thinking in three dimensions

(2016) Marina Simian et al.   JOURNAL OF CELL BIOLOGY

Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation

(2016) Laura Broutier et al.   Nature Protocols

Quantitative proteomic analyses of mammary organoids reveals distinct signatures after exposure to environmental chemicals

(2016) Katherine E. Williams et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Miniature Swine for Preclinical Modeling of Complexities of Human Disease for Translational Scientific Discovery and Accelerated Development of Therapies and Medical Devices

(2016) Dominic T. Schomberg et al.   TOXICOLOGIC PATHOLOGY

Generation and characterization of rat liver stem cell lines and their engraftment in a rat model of liver failure

(2016) Ewart W. Kuijk et al.   Scientific Reports

Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver

(2015) Meritxell Huch et al.   CELL

Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients

(2015) Marc van de Wetering et al.   CELL

Ascl2 Acts as an R-spondin/Wnt-Responsive Switch to Control Stemness in Intestinal Crypts

(2015) Jurian Schuijers et al.   Cell Stem Cell

Intestinal organoids: A model of intestinal fibrosis for evaluating anti-fibrotic drugs

(2015) Eva S. Rodansky et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

In Vitro Expansion of Human Gastric Epithelial Stem Cells and Their Responses to Bacterial Infection

(2015) Sina Bartfeld et al.   GASTROENTEROLOGY

Selenoprotein P influences colitis-induced tumorigenesis by mediating stemness and oxidative damage

(2015) Caitlyn W. Barrett et al.   JOURNAL OF CLINICAL INVESTIGATION

Nephron organoids derived from human pluripotent stem cells model kidney development and injury

(2015) Ryuji Morizane et al.   NATURE BIOTECHNOLOGY

Porcine models of digestive disease: the future of large animal translational research

(2015) Liara M. Gonzalez et al.   Translational Research

Intestinal organoids for assessing nutrient transport, sensing and incretin secretion

(2015) Tamara Zietek et al.   Scientific Reports

How to make an intestine

(2014) J. M. Wells et al.   DEVELOPMENT

Loss of Syntaxin 3 Causes Variant Microvillus Inclusion Disease

(2014) Caroline L. Wiegerinck et al.   GASTROENTEROLOGY

Mutations in Tetratricopeptide Repeat Domain 7A Result in a Severe Form of Very Early Onset Inflammatory Bowel Disease

(2014) Yaron Avitzur et al.   GASTROENTEROLOGY

A novel human gastric primary cell culture system for modellingHelicobacter pyloriinfection in vitro

(2014) Philipp Schlaermann et al.   GUT

Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche

(2014) Hayley Davis et al.   NATURE MEDICINE

Oncogenic transformation of diverse gastrointestinal tissues in primary organoid culture

(2014) Xingnan Li et al.   NATURE MEDICINE

Predictors of recurrence of Crohn’s disease after ileocolectomy: A review

(2014) Tara M Connelly   WORLD JOURNAL OF GASTROENTEROLOGY

Ex vivo culture of intestinal crypt organoids as a model system for assessing cell death induction in intestinal epithelial cells and enteropathy

(2014) T Grabinger et al.   Cell Death & Disease

Functional Repair of CFTR by CRISPR/Cas9 in Intestinal Stem Cell Organoids of Cystic Fibrosis Patients

(2013) Gerald Schwank et al.   Cell Stem Cell

Strategies for Improving Animal Models for Regenerative Medicine

(2013) Jose Cibelli et al.   Cell Stem Cell

TTC7A mutations disrupt intestinal epithelial apicobasal polarity

(2013) Amélie E. Bigorgne et al.   JOURNAL OF CLINICAL INVESTIGATION

In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration

(2013) Meritxell Huch et al.   NATURE

A functional CFTR assay using primary cystic fibrosis intestinal organoids

(2013) Johanna F Dekkers et al.   NATURE MEDICINE

Extremely rare cause of congenital diarrhea: Enteric anendocrinosis

(2013) Ersin Sayar et al.   PEDIATRICS INTERNATIONAL

Cell Lineage Identification and Stem Cell Culture in a Porcine Model for the Study of Intestinal Epithelial Regeneration

(2013) Liara M. Gonzalez et al.   PLoS One

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Real-time analysis of P-glycoprotein-mediated drug transport across primary intestinal epithelium three-dimensionally cultured in vitro

(2012) Tomohiro Mizutani et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Comparing predictive drug nephrotoxicity biomarkers in kidney 3-D primary organoid culture and immortalized cell lines

(2012) Anna I. Astashkina et al.   BIOMATERIALS

A 3-D organoid kidney culture model engineered for high-throughput nephrotoxicity assays

(2012) Anna I. Astashkina et al.   BIOMATERIALS

Low Incidence of DNA Sequence Variation in Human Induced Pluripotent Stem Cells Generated by Nonintegrating Plasmid Expression

(2012) Linzhao Cheng et al.   Cell Stem Cell

Explant culture of gastrointestinal tissue: a review of methods and applications

(2011) Kevin J. Randall et al.   CELL BIOLOGY AND TOXICOLOGY

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

(2011) Toshiro Sato et al.   GASTROENTEROLOGY

Increasing Incidence and Prevalence of the Inflammatory Bowel Diseases With Time, Based on Systematic Review

(2011) Natalie A. Molodecky et al.   GASTROENTEROLOGY

Lgr5+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro

(2010) Nick Barker et al.   Cell Stem Cell

Mouse atonal homolog 1 directs intestinal progenitors to secretory cell rather than absorptive cell fate

(2010) Kelli L. VanDussen et al.   DEVELOPMENTAL BIOLOGY

Mediators of Inflammation in Acute Kidney Injury

(2010) Ali Akcay et al.   MEDIATORS OF INFLAMMATION

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

(2010) Toshiro Sato et al.   NATURE

Vertebrate Endoderm Development and Organ Formation

(2009) Aaron M. Zorn et al.   Annual Review of Cell and Developmental Biology

Tissue-Engineered Small Intestine and Stomach Form from Autologous Tissue in a Preclinical Large Animal Model

(2009) Frédéric G. Sala et al.   JOURNAL OF SURGICAL RESEARCH

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Regeneration of the Gastric Mucosa and its Glands from Stem Cells

(2008) Werner Hoffmann   CURRENT MEDICINAL CHEMISTRY

Hepatic reconstruction from fetal porcine liver cells using a radial flow bioreactor

(2008) Yuji Ishii et al.   WORLD JOURNAL OF GASTROENTEROLOGY