Alternative (non-animal) methods for cosmetics testing: current status and future prospects—2010

TOX 21: New Dimensions of Toxicity Testing

(2012) Charles W. Schmidt   ENVIRONMENTAL HEALTH PERSPECTIVES

An engineered 3D blood-testis barrier model for the assessment of reproductive toxicity potential

(2010) A. Legendre et al.   BIOMATERIALS

Metabolic flux determination in perfused livers by mass balance analysis: Effect of fasting

(2010) Mehmet A. Orman et al.   BIOTECHNOLOGY AND BIOENGINEERING

Development of a zebrafish embryo teratogenicity assay and quantitative prediction model

(2010) Kimberly C. Brannen et al.   BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY

In vitro developmental toxicology assays: A review of the state of the science of rodent and zebrafish whole embryo culture and embryonic stem cell assays

(2010) Karen Augustine-Rauch et al.   BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS

T-cell recognition of chemicals, protein allergens and drugs: towards the development of in vitro assays

(2010) Stefan F. Martin et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Rapid and Simple Kinetics Screening Assay for Electrophilic Dermal Sensitizers Using Nitrobenzenethiol

(2010) Itai Chipinda et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Global QSAR models of skin sensitisers for regulatory purposes

(2010) Qasim Chaudhry et al.   Chemistry Central Journal

New public QSAR model for carcinogenicity

(2010) Natalja Fjodorova et al.   Chemistry Central Journal

A review of the electrophilic reaction chemistry involved in covalent DNA binding

(2010) S. J. Enoch et al.   CRITICAL REVIEWS IN TOXICOLOGY

Non-animal sensitization testing: State-of-the-art

(2010) Rob J. Vandebriel et al.   CRITICAL REVIEWS IN TOXICOLOGY

Alternatives to the carcinogenicity bioassay:in silicomethods, and thein vitroandin vivomutagenicity assays

(2010) Romualdo Benigni et al.   Expert Opinion on Drug Metabolism & Toxicology

Estrogenic in vitro assay on mouse embryonic Leydig cells

(2010) Gina Lasala et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Biokinetic Modeling andin Vitro–in VivoExtrapolations

(2010) Bas J. Blaauboer   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

Toxicity Testing in the 21st Century: A Vision and a Strategy

(2010) Daniel Krewski et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

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(2010) Miguel Lopez-Lazaro   MOLECULAR MEDICINE

Further analysis of Ames-negative rodent carcinogens that are only genotoxic in mammalian cells in vitro at concentrations exceeding 1 mM, including retesting of compounds of concern

(2010) D. Kirkland et al.   MUTAGENESIS

Gene expression profiling in primary mouse hepatocytes discriminates true from false-positive genotoxic compounds

(2010) K. Mathijs et al.   MUTAGENESIS

Analysis of published data for top concentration considerations in mammalian cell genotoxicity testing

(2010) James M. Parry et al.   MUTAGENESIS

A pre-validation transferability study of the GreenScreen HC GADD45a-GFP assay with a metabolic activation system (S9)

(2010) Nicholas Billinton et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

International prevalidation studies of the EpiDerm™ 3D human reconstructed skin micronucleus (RSMN) assay: Transferability and reproducibility

(2010) Marilyn J. Aardema et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Characterizing and predicting carcinogenicity and mode of action using conventional and toxicogenomics methods

(2010) Michael D. Waters et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Identification of toxicological biomarkers of di(2-ethylhexyl) phthalate in proteins secreted by HepG2 cells using proteomic analysis

(2010) Seonyoung Choi et al.   PROTEOMICS

Exposure-based waiving under REACH

(2010) Theo Vermeire et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Evaluation of inhalation TTC values with the database RepDose

(2010) S.E. Escher et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

In silico approaches to predicting cancer potency for risk assessment of genotoxic impurities in drug substances

(2010) Joel P. Bercu et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

A tiered approach to the use of alternatives to animal testing for the safety assessment of cosmetics: Genotoxicity. A COLIPA analysis

(2010) Stefan Pfuhler et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Transcriptomics analysis of retinoic acid embryotoxicity in rat postimplantation whole embryo culture

(2010) Mirjam Luijten et al.   REPRODUCTIVE TOXICOLOGY

In vitro-Ishikawa cell test for assessing tissue-specific chemical effects on human endometrium

(2010) W.R. Schaefer et al.   REPRODUCTIVE TOXICOLOGY

Proteome profiling of mouse embryonic stem cells to define markers for cell differentiation and embryotoxicity

(2010) Ahmed M. Osman et al.   REPRODUCTIVE TOXICOLOGY

Assessment of a robust model protocol with accelerated throughput for a human recombinant full length estrogen receptor-α binding assay: Protocol optimization and intralaboratory assay performance as initial steps towards validation

(2010) Alexius Freyberger et al.   REPRODUCTIVE TOXICOLOGY

Transferability and inter-laboratory variability assessment of the in vitro bovine oocyte maturation (IVM) test within ReProTect

(2010) Alberto M. Luciano et al.   REPRODUCTIVE TOXICOLOGY

The assessment of estrogenic or anti-estrogenic activity of chemicals by the human stably transfected estrogen sensitive MELN cell line: Results of test performance and transferability

(2010) H. Witters et al.   REPRODUCTIVE TOXICOLOGY

Optimization and prevalidation of the in vitro ERα CALUX method to test estrogenic and antiestrogenic activity of compounds

(2010) Bart van der Burg et al.   REPRODUCTIVE TOXICOLOGY

Placental transport and in vitro effects of Bisphenol A

(2010) Thit J. Mørck et al.   REPRODUCTIVE TOXICOLOGY

The ReProTect Feasibility Study, a novel comprehensive in vitro approach to detect reproductive toxicants

(2010) Barbara Schenk et al.   REPRODUCTIVE TOXICOLOGY

An abbreviated protocol for multilineage neural differentiation of murine embryonic stem cells and its perturbation by methyl mercury

(2010) P.T. Theunissen et al.   REPRODUCTIVE TOXICOLOGY

Optimization and prevalidation of the in vitro AR CALUX method to test androgenic and antiandrogenic activity of compounds

(2010) Bart van der Burg et al.   REPRODUCTIVE TOXICOLOGY

Incorporating Human Dosimetry and Exposure into High-Throughput In Vitro Toxicity Screening

(2010) Daniel M. Rotroff et al.   TOXICOLOGICAL SCIENCES

Embryotoxicant-Specific Transcriptomic Responses in Rat Postimplantation Whole-Embryo Culture

(2010) Joshua F. Robinson et al.   TOXICOLOGICAL SCIENCES

Toxicogenomics Applied to In Vitro Carcinogenicity Testing with Balb/c 3T3 Cells Revealed a Gene Signature Predictive of Chemical Carcinogens

(2010) Astrid Rohrbeck et al.   TOXICOLOGICAL SCIENCES

Monolayer cultivation of osteoprogenitors shortens duration of the embryonic stem cell test while reliably predicting developmental osteotoxicity

(2010) Nicole I. zur Nieden et al.   TOXICOLOGY

PBPK modelling of inter-individual variability in the pharmacokinetics of environmental chemicals

(2010) Frédéric Y. Bois et al.   TOXICOLOGY

Classification of sensitizing and irritative potential in a combined in-vitro assay

(2010) Reinhard Wanner et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Predicting human developmental toxicity of pharmaceuticals using human embryonic stem cells and metabolomics

(2010) Paul R. West et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Performance of a novel keratinocyte-based reporter cell line to screen skin sensitizers in vitro

(2010) Roger Emter et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Maintenance and characterization of lymphocytes in human long term bone marrow cultures to study immunotoxicity

(2010) M. Carfí et al.   TOXICOLOGY IN VITRO

Xenobiotic metabolism gene expression in the EpiDerm™ in vitro 3D human epidermis model compared to human skin

(2010) T. Hu et al.   TOXICOLOGY IN VITRO

Gene markers in dendritic cells unravel pieces of the skin sensitization puzzle

(2010) Nathalie Lambrechts et al.   TOXICOLOGY LETTERS

Cytotoxicity and genotoxicity in human lung epithelial A549 cells caused by airborne volatile organic compounds emitted from pine wood and oriented strand boards

(2010) Richard Gminski et al.   TOXICOLOGY LETTERS

Trends in microdosing and other exploratory human pharmacokinetic studies for early drug development

(2010) Berend Oosterhuis   Bioanalysis

A Review of Imaging Agent Development

(2009) Eric D. Agdeppa et al.   AAPS Journal

Modelling and PBPK Simulation in Drug Discovery

(2009) Hannah M. Jones et al.   AAPS Journal

Effector and regulatory mechanisms in allergic contact dermatitis

(2009) M. Vocanson et al.   ALLERGY

Automated soft agar assay for the high-throughput screening of anticancer compounds

(2009) René Thierbach et al.   ANALYTICAL BIOCHEMISTRY

Feasibility study to support a threshold of sensitization concern concept in risk assessment based on human data

(2009) Detlef Keller et al.   ARCHIVES OF TOXICOLOGY

Evaluation of a microfluidic based cell culture platform with primary human hepatocytes for the prediction of hepatic clearance in human

(2009) P. Chao et al.   BIOCHEMICAL PHARMACOLOGY

Effect of human patient plasma ex vivo treatment on gene expression and progenitor cell activation of primary human liver cells in multi-compartment 3D perfusion bioreactors for extra-corporeal liver support

(2009) Eva Schmelzer et al.   BIOTECHNOLOGY AND BIOENGINEERING

Finding transcriptomics biomarkers for in vivo identification of (non-)genotoxic carcinogens using wild-type and Xpa/p53 mutant mouse models

(2009) Martijs J. Jonker et al.   CARCINOGENESIS

Report and Recommendations of the Workshop of the European Centre for the Validation of Alternative Methods for Drug-Induced Cardiotoxicity

(2009) Tina C. Stummann et al.   Cardiovascular Toxicology

Kinetic Glutathione Chemoassay To Quantify Thiol Reactivity of Organic ElectrophilesApplication to α,β-Unsaturated Ketones, Acrylates, and Propiolates

(2009) Alexander Böhme et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Cutaneous Metabolic Activation of Carvoxime, a Self-Activating, Skin-Sensitizing Prohapten

(2009) Hagen Ott et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Experimental Reactivity Parameters for Toxicity Modeling: Application to the Acute Aquatic Toxicity of SN2 Electrophiles toTetrahymena pyriformis

(2009) David W. Roberts et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Cytometric analysis for drug-induced steatosis in HepG2 cells

(2009) M. Teresa Donato et al.   CHEMICO-BIOLOGICAL INTERACTIONS

An Expert System Approach to the Assessment of Hepatotoxic Potential

(2009) Carol A. Marchant et al.   CHEMISTRY & BIODIVERSITY

In vitro assessment of AhR-mediated activities of TCDD in mixture with humic substances

(2009) M. Bittner et al.   CHEMOSPHERE

Read-across to rank skin sensitization potential: subcategories for the Michael acceptor domain

(2009) Terry Wayne Schultz et al.   CONTACT DERMATITIS

Application of Key Events Analysis to Chemical Carcinogens and Noncarcinogens

(2009) Alan R. Boobis et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

The Potential of Embryonic Stem Cells Combined with -omics Technologies as Model Systems for Toxicology

(2009) J. Winkler et al.   CURRENT MEDICINAL CHEMISTRY

The human repeated insult patch test in the 21st century: A commentary

(2009) David A. Basketter   Cutaneous and Ocular Toxicology

Methyldibromoglutaronitrile: skin sensitization and quantitative risk assessment

(2009) David A. Basketter   Cutaneous and Ocular Toxicology

Brain drug targeting: a computational approach for overcoming blood–brain barrier

(2009) Ahmad Reza Mehdipour et al.   DRUG DISCOVERY TODAY

A Framework for Assessing Inter-individual Variability in Pharmacokinetics Using Virtual Human Populations and Integrating General Knowledge of Physical Chemistry, Biology, Anatomy, Physiology and Genetics: A Tale of ‘Bottom-Up’ vs ‘Top-Down’ Recognition of Covariates

(2009) Masoud Jamei et al.   Drug Metabolism and Pharmacokinetics

Metabolic bioactivation and drug-related adverse effects: current status and future directions from a pharmaceutical research perspective

(2009) Wei Tang et al.   DRUG METABOLISM REVIEWS

TLR2-activated human langerhans cells promote Th17 polarization via IL-1β, TGF-β and IL-23

(2009) Ehsan Aliahmadi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Discovery of estrogen receptor modulators: a review of virtual screening and SAR efforts

(2009) Xue Xu et al.   Expert Opinion on Drug Discovery

New cytochrome P450 mechanisms: implications for understanding molecular basis for drug toxicity at the level of the cytochrome

(2009) Narasimhulu Shakunthala   Expert Opinion on Drug Metabolism & Toxicology

Developmental expression of drug metabolizing enzymes and transporter proteins in human placenta and fetal tissues

(2009) Päivi Myllynen et al.   Expert Opinion on Drug Metabolism & Toxicology

Effects of pharmaceuticals and other active chemicals at biological targets: mechanisms, interactions, and integration into PB-PK/PD models

(2009) Jaime Kapitulnik et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Critical analysis of the SCCNFP/SCCP safety assessment of cosmetic ingredients (2000–2006)

(2009) M. Pauwels et al.   FOOD AND CHEMICAL TOXICOLOGY

Refining the threshold of toxicological concern (TTC) for risk prioritization of trace chemicals in food

(2009) Susan Felter et al.   FOOD AND CHEMICAL TOXICOLOGY

Exposure based waiving: The application of the toxicological threshold of concern (TTC) to inhalation exposure for aerosol ingredients in consumer products

(2009) P. Carthew et al.   FOOD AND CHEMICAL TOXICOLOGY

4.7 Biological modeling as a method for data evaluation and integration in toxicology

(2009) HA Barton   HUMAN & EXPERIMENTAL TOXICOLOGY

Additive SMILES-Based Carcinogenicity Models: Probabilistic Principles in the Search for Robust Predictions

(2009) Andrey Toropov et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Updating the skin sensitizationin vitrodata assessment paradigm in 2009

(2009) David A. Basketter et al.   JOURNAL OF APPLIED TOXICOLOGY

Image analysis and automatic classification of transformed foci

(2009) C. URANI et al.   JOURNAL OF MICROSCOPY

Development of a novel method for predicting human volume of distribution at steady-state of basic drugs and comparative assessment with existing methods

(2009) Patrick Poulin et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Modification of cell-surface thiols elicits activation of human monocytic cell line THP-1: Possible involvement in effect of haptens 2,4-dinitrochlorobenzene and nickel sulfate

(2009) Morihiko Hirota et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Intralaboratory and interlaboratory evaluation of the EpiDerm™ 3D human reconstructed skin micronucleus (RSMN) assay

(2009) Ting Hu et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

How to assess the mutagenic potential of cosmetic products without animal tests?

(2009) Günter Speit   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Further development of the EpiDerm™ 3D reconstructed human skin micronucleus (RSMN) assay

(2009) Greg C. Mun et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Mechanisms of non-genotoxic carcinogens and importance of a weight of evidence approach

(2009) Lya G. Hernández et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Application of toxicokinetics to improve chemical risk assessment: Implications for the use of animals

(2009) Stuart Creton et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

A framework for using structural, reactivity, metabolic and physicochemical similarity to evaluate the suitability of analogs for SAR-based toxicological assessments

(2009) Shengde Wu et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Early gene expression changes during embryonic stem cell differentiation into cardiomyocytes and their modulation by monobutyl phthalate

(2009) Dorien A.M. van Dartel et al.   REPRODUCTIVE TOXICOLOGY

Development of a screening assay to identify teratogenic and embryotoxic chemicals using the zebrafish embryo

(2009) Ingrid W.T. Selderslaghs et al.   REPRODUCTIVE TOXICOLOGY

Assessment of a recombinant androgen receptor binding assay: Initial steps towards validation☆

(2009) Alexius Freyberger et al.   REPRODUCTIVE TOXICOLOGY

Screening for (anti)androgenic properties using a standard operation protocol based on the human stably transfected androgen sensitive PALM cell line. First steps towards validation

(2009) A. Freyberger et al.   REPRODUCTIVE TOXICOLOGY

ReProGlo: A new stem cell-based reporter assay aimed to predict embryotoxic potential of drugs and chemicals

(2009) Frederik Uibel et al.   REPRODUCTIVE TOXICOLOGY

Integrating (Q)SAR models, expert systems and read-across approaches for the prediction of developmental toxicity

(2009) M. Hewitt et al.   REPRODUCTIVE TOXICOLOGY

Using chemical categories to fill data gaps in hazard assessment

(2009) K. van Leeuwen et al.   SAR AND QSAR IN ENVIRONMENTAL RESEARCH

A Human Stem Cell-Based Model for Identifying Adverse Effects of Organic and Inorganic Chemicals on the Developing Nervous System

(2009) Leonora Buzanska et al.   STEM CELLS

A Data-Based Assessment of Alternative Strategies for Identification of Potential Human Cancer Hazards

(2009) Alan R. Boobis et al.   TOXICOLOGIC PATHOLOGY

Oxidative Stress and Oxidative Damage in Carcinogenesis

(2009) James E. Klaunig et al.   TOXICOLOGIC PATHOLOGY

Toxicity Testing in the 21st Century: Using the New Toxicity Testing Paradigm to Create a Taxonomy of Adverse Effects

(2009) Kim Boekelheide et al.   TOXICOLOGICAL SCIENCES

Endless Possibilities: Stem Cells and the Vision for Toxicology Testing in the 21st Century

(2009) Robert E. Chapin et al.   TOXICOLOGICAL SCIENCES

Embryonic Stem Cell Test Remastered: Comparison between the Validated EST and the New Molecular FACS-EST for Assessing Developmental Toxicity In Vitro

(2009) Roland Buesen et al.   TOXICOLOGICAL SCIENCES

The Nrf2-Keap1-ARE Toxicity Pathway as a Cellular Sensor for Skin Sensitizers—Functional Relevance and a Hypothesis on Innate Reactions to Skin Sensitizers

(2009) Andreas Natsch   TOXICOLOGICAL SCIENCES

Investigation of Peptide Reactivity of Pro-hapten Skin Sensitizers Using a Peroxidase-Peroxide Oxidation System

(2009) G. Frank Gerberick et al.   TOXICOLOGICAL SCIENCES

Reactivity Profiling: Covalent Modification of Single Nucleophile Peptides for Skin Sensitization Risk Assessment

(2009) Maja Aleksic et al.   TOXICOLOGICAL SCIENCES

Characterization and Interlaboratory Comparison of a Gene Expression Signature for Differentiating Genotoxic Mechanisms

(2009) Heidrun Ellinger-Ziegelbauer et al.   TOXICOLOGICAL SCIENCES

Discrimination of a transformation phenotype in Syrian golden hamster embryo (SHE) cells using ATR-FTIR spectroscopy

(2009) Michael J. Walsh et al.   TOXICOLOGY

Stem cell-derived hepatocytes and their use in toxicology

(2009) Christiane Guguen-Guillouzo et al.   TOXICOLOGY

Progress on the development of human in vitro dendritic cell based assays for assessment of the sensitizing potential of a compound

(2009) G. Galvão dos Santos et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Human health safety evaluation of cosmetics in the EU: A legally imposed challenge to science

(2009) M. Pauwels et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Transcriptomics-based identification of developmental toxicants through their interference with cardiomyocyte differentiation of embryonic stem cells

(2009) Dorien A.M. van Dartel et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Effects and uptake of gold nanoparticles deposited at the air–liquid interface of a human epithelial airway model

(2009) C. Brandenberger et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Safety assessment of personal care products/cosmetics and their ingredients

(2009) Gerhard J. Nohynek et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Evaluation of changes of cell-surface thiols as a new biomarker for in vitro sensitization test

(2009) Mie Suzuki et al.   TOXICOLOGY IN VITRO

Use of IL-18 production in a human keratinocyte cell line to discriminate contact sensitizers from irritants and low molecular weight respiratory allergens

(2009) Emanuela Corsini et al.   TOXICOLOGY IN VITRO

The immediate early genes, c-fos, c-jun and AP-1, are early markers of platinum analogue toxicity in human proximal tubular cell primary cultures

(2009) Richard David Wainford et al.   TOXICOLOGY IN VITRO

The influence of modes of action and physicochemical properties of chemicals on the correlation between in vitro and acute fish toxicity data

(2009) Nynke I. Kramer et al.   TOXICOLOGY IN VITRO

Characterization and hepatic differentiation of skin-derived precursors from adult foreskin by sequential exposure to hepatogenic cytokines and growth factors reflecting liver development

(2009) Joery De Kock et al.   TOXICOLOGY IN VITRO

Inter-laboratory comparison of human renal proximal tubule (HK-2) transcriptome alterations due to Cyclosporine A exposure and medium exhaustion

(2009) Paul Jennings et al.   TOXICOLOGY IN VITRO

Comparison of gene expression profiles in BALB/c 3T3 transformed foci exposed to tumor promoting agents

(2009) Lin Ao et al.   TOXICOLOGY IN VITRO

Comparison of a novel CXCL12/CCL5 dependent migration assay with CXCL8 secretion and CD86 expression for distinguishing sensitizers from non-sensitizers using MUTZ-3 Langerhans cells

(2009) Krista Ouwehand et al.   TOXICOLOGY IN VITRO

Effects of plasticizers and their mixtures on estrogen receptor and thyroid hormone functions

(2009) Mandana Ghisari et al.   TOXICOLOGY LETTERS

Comparison of in vitro hormone activities of selected phthalates using reporter gene assays

(2009) Ouxi Shen et al.   TOXICOLOGY LETTERS

From known knowns to known unknowns: predictingin vivodrug metabolites

(2009) Olavi Pelkonen et al.   Bioanalysis

Formation of Structural Categories to Allow for Read-Across for Teratogenicity

(2009) Steven J. Enoch et al.   Quantitative structure-activity relationships & combinatorial science

The end of the era of generosity? Global health amid economic crisis

(2009) Kammerle Schneider et al.   Philosophy Ethics and Humanities in Medicine

Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation

(2008) Ulrich M. Zanger et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Inhibition and induction of human cytochrome P450 enzymes: current status

(2008) Olavi Pelkonen et al.   ARCHIVES OF TOXICOLOGY

Microvalve-assisted patterning platform for measuring cellular dynamics based on 3D cell culture

(2008) Minseok S. Kim et al.   BIOTECHNOLOGY AND BIOENGINEERING

A novel system for evaluation of drug mixtures for potential efficacy in treating multidrug resistant cancers

(2008) Daniel A. Tatosian et al.   BIOTECHNOLOGY AND BIOENGINEERING

Assessment of the Embryonic Stem Cell Test and application and use in the pharmaceutical industry

(2008) Jennifer A. Paquette et al.   BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY

Advances in Chemical Carcinogenesis: A Historical Review and Prospective

(2008) L. A. Loeb et al.   CANCER RESEARCH

The relationship between CD86/CD54 expression and THP-1 cell viability in an in vitro skin sensitization test – human cell line activation test (h-CLAT)

(2008) Hitoshi Sakaguchi et al.   CELL BIOLOGY AND TOXICOLOGY

Prediction of non-genotoxic carcinogenesis in rats using changes in gene expression following acute dosing

(2008) Paul Nioi et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Local Kinetics and Dynamics of Xenobiotics

(2008) Olavi Pelkonen et al.   CRITICAL REVIEWS IN TOXICOLOGY

IPCS Framework for Analyzing the Relevance of a Noncancer Mode of Action for Humans

(2008) Alan R. Boobis et al.   CRITICAL REVIEWS IN TOXICOLOGY

Methods for Predicting In Vivo Pharmacokinetics Using Data from In Vitro Assays

(2008) J. Houston et al.   CURRENT DRUG METABOLISM

Cause and Consequences of Genetic and Epigenetic Alterations in Human Cancer

(2008) B. Sadikovic et al.   CURRENT GENOMICS

Development of a ModifiedIn vitroSkin Absorption Method to Study the Epidermal/Dermal Disposition of a Contact Allergen in Human Skin

(2008) Ruth U. Pendlington et al.   Cutaneous and Ocular Toxicology

Preclinical assessment of cardiac toxicity

(2008) Ralf Kettenhofen et al.   DRUG DISCOVERY TODAY

Computational toxicology in drug development

(2008) Wolfgang Muster et al.   DRUG DISCOVERY TODAY

Liquid chromatography–mass spectrometry in in vitro drug metabolite screening

(2008) Ari Tolonen et al.   DRUG DISCOVERY TODAY

Computational Toxicology of Chloroform: Reverse Dosimetry Using Bayesian Inference, Markov Chain Monte Carlo Simulation, and Human Biomonitoring Data

(2008) Michael A. Lyons et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Profiling Chemicals Based on Chronic Toxicity Results from the U.S. EPA ToxRef Database

(2008) Matthew T. Martin et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Phthalates Impair Germ Cell Development in the Human Fetal Testis in Vitro without Change in Testosterone Production

(2008) Romain Lambrot et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

IN VITRO THYROID HORMONE–DISRUPTING ACTIVITY IN EFFLUENTS AND SURFACE WATERS IN THAILAND

(2008) Akinori Ishihara et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

CXCL12 is essential for migration of activated Langerhans cells from epidermis to dermis

(2008) Krista Ouwehand et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Human cytochromes P450 in the metabolism of drugs: new molecular models of enzyme–substrate interactions

(2008) David FV Lewis et al.   Expert Opinion on Drug Metabolism & Toxicology

Whole body physiologically-based pharmacokinetic models: their use in clinical drug development

(2008) Andrea N Edginton et al.   Expert Opinion on Drug Metabolism & Toxicology

An update on metabolism studies using human hepatocytes in primary culture

(2008) María José Gómez-Lechón et al.   Expert Opinion on Drug Metabolism & Toxicology

Comparison of the skin sensitizing potential of unsaturated compounds as assessed by the murine local lymph node assay (LLNA) and the guinea pig maximization test (GPMT)

(2008) R. Kreiling et al.   FOOD AND CHEMICAL TOXICOLOGY

Improving the applicability of (Q)SARs for percutaneous penetration in regulatory risk assessment

(2008) T Bouwman et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

An improved protocol for primary culture of cardiomyocyte from neonatal mice

(2008) P. Sreejit et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

Predictivity of QSAR

(2008) Romualdo Benigni et al.   Journal of Chemical Information and Modeling

Modeling Oral Rat Chronic Toxicity

(2008) Paolo Mazzatorta et al.   Journal of Chemical Information and Modeling

Depletion of Human Peripheral Blood Lymphocytes in CD25+ Cells Allows for the Sensitive In Vitro Screening of Contact Allergens

(2008) Marc Vocanson et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Validation of a Rapid Equilibrium Dialysis Approach for the Measurement of Plasma Protein Binding

(2008) Nigel J. Waters et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Placental Passage of Benzoic acid, Caffeine, and Glyphosate in an Ex Vivo Human Perfusion System

(2008) Tina Mose et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Characterization of drug metabolites and cytotoxicity assay simultaneously using an integrated microfluidic device

(2008) Bo Ma et al.   LAB ON A CHIP

Detection of potential (anti)progestagenic endocrine disruptors using a recombinant human progesterone receptor binding and transactivation assay

(2008) Gunda Viswanath et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Assessment of the genotoxicity of S9-generated metabolites using the GreenScreen HC GADD45a-GFP assay

(2008) C. Jagger et al.   MUTAGENESIS

ECVAM retrospective validation of in vitro micronucleus test (MNT)

(2008) R. Corvi et al.   MUTAGENESIS

Interlaboratory assessment of the GreenScreen HC GADD45a-GFP genotoxicity screening assay: An enabling study for independent validation as an alternative method

(2008) Nicholas Billinton et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Syrian hamster embryo (SHE) cell transformation assay with conditioned media (without X-ray irradiated feeder layer) using 2,4-diaminotoluene, 2,6-diaminotoluene and chloral hydrate

(2008) Kamala Pant et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

The hen's egg test for micronucleus induction (HET-MN): Novel analyses with a series of well-characterized substances support the further evaluation of the test system

(2008) Thorsten Wolf et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Recommended lists of genotoxic and non-genotoxic chemicals for assessment of the performance of new or improved genotoxicity tests: A follow-up to an ECVAM workshop

(2008) David Kirkland et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Evaluation of the ability of a battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens

(2008) David Kirkland et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Improving prediction of chemical carcinogenicity by considering multiple mechanisms and applying toxicogenomic approaches

(2008) Kathryn Z. Guyton et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Application of in vitro neurotoxicity testing for regulatory purposes: Symposium III summary and research needs

(2008) Anna K. Bal-Price et al.   NEUROTOXICOLOGY

Epigenomics and breast cancer

(2008) Pang-Kuo Lo et al.   PHARMACOGENOMICS

The Dermal Sensitisation Threshold—A TTC approach for allergic contact dermatitis

(2008) R.J. Safford   REGULATORY TOXICOLOGY AND PHARMACOLOGY

REACH, non-testing approaches and the urgent need for a change in mind set

(2008) G. Schaafsma et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

QSAR models for reproductive toxicity and endocrine disruption in regulatory use – a preliminary investigation†

(2008) G.E. Jensen et al.   SAR AND QSAR IN ENVIRONMENTAL RESEARCH

Prediction of chemical toxicity with local support vector regression and activity-specific kernels

(2008) A. Maunz et al.   SAR AND QSAR IN ENVIRONMENTAL RESEARCH

Identification of mechanisms of toxic action for skin sensitisation using a SMARTS pattern based approach

(2008) S.J. Enoch et al.   SAR AND QSAR IN ENVIRONMENTAL RESEARCH

Toxmatch–a new software tool to aid in the development and evaluation of chemically similar groups

(2008) G. Patlewicz et al.   SAR AND QSAR IN ENVIRONMENTAL RESEARCH

Skin Irritation and Sensitization: Mechanisms and New Approaches for Risk Assessment

(2008) D. Basketter et al.   SKIN PHARMACOLOGY AND PHYSIOLOGY

In Vitro Differentiation of Embryonic and Adult Stem Cells into Hepatocytes: State of the Art

(2008) Sarah Snykers et al.   STEM CELLS

Filling the Concept with Data: Integrating Data from Different In Vitro and In Silico Assays on Skin Sensitizers to Explore the Battery Approach for Animal-Free Skin Sensitization Testing

(2008) Andreas Natsch et al.   TOXICOLOGICAL SCIENCES

Nonanimal Alternatives for Skin Sensitization: Letter to the Editor

(2008) David W. Roberts et al.   TOXICOLOGICAL SCIENCES

Interlaboratory Evaluation of Genomic Signatures for Predicting Carcinogenicity in the Rat

(2008) Mark R. Fielden et al.   TOXICOLOGICAL SCIENCES

Development of a New Screening Assay to Identify Proteratogenic Substances using Zebrafish Danio rerio Embryo Combined with an Exogenous Mammalian Metabolic Activation System (mDarT)

(2008) François Busquet et al.   TOXICOLOGICAL SCIENCES

A toxicogenomics approach for early assessment of potential non-genotoxic hepatocarcinogenicity of chemicals in rats

(2008) Takeki Uehara et al.   TOXICOLOGY

Hazard assessment of methylmercury toxicity to neuronal induction in embryogenesis using human embryonic stem cells

(2008) Tina C. Stummann et al.   TOXICOLOGY

Microarray analysis in rat liver slices correctly predicts in vivo hepatotoxicity

(2008) M ELFERINK et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Development of an in vitro test battery for assessing chemical effects on bovine germ cells under the ReProTect umbrella

(2008) Giovanna Lazzari et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

A cell-based in vitro alternative to identify skin sensitizers by gene expression

(2008) Jef Hooyberghs et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Quantitative Interpretation of Human Biomonitoring Data

(2008) Harvey J. Clewell et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Automated analysis of contractility in the embryonic stem cell test, a novel approach to assess embryotoxicity

(2008) Annelieke K. Peters et al.   TOXICOLOGY IN VITRO

New strategy for alerting central nervous system toxicity: Integration of blood–brain barrier toxicity and permeability in neurotoxicity assessment

(2008) Dorothée Hallier-Vanuxeem et al.   TOXICOLOGY IN VITRO

Potential method to determine irritant potency in vitro – Comparison of two reconstructed epidermal culture models with different barrier competency

(2008) S.W. Spiekstra et al.   TOXICOLOGY IN VITRO

Reconstruction of three-dimensional human skin model composed of dendritic cells, keratinocytes and fibroblasts utilizing a handy scaffold of collagen vitrigel membrane

(2008) T. Uchino et al.   TOXICOLOGY IN VITRO

The contribution of in vitro toxicity data in hazard and risk assessment: Current limitations and future perspectives

(2008) Bas J. Blaauboer   TOXICOLOGY LETTERS

High throughput adjustable 96-well plate assay for androgen receptor binding: A practical approach for EDC screening using the chimpanzee AR☆

(2008) P HARTIG et al.   TOXICOLOGY LETTERS

The Threshold of Toxicological Concern (TTC) in risk assessment

(2008) I.C. Munro et al.   TOXICOLOGY LETTERS

Application of toxicogenomics to study mechanisms of genotoxicity and carcinogenicity

(2008) Heidrun Ellinger-Ziegelbauer et al.   TOXICOLOGY LETTERS

Combined Use of MC4PC, MDL-QSAR, BioEpisteme, Leadscope PDM, and Derek for Windows Software to Achieve High-Performance, High-Confidence, Mode of Action–Based Predictions of Chemical Carcinogenesis in Rodents

(2008) Edwin J. Matthews et al.   TOXICOLOGY MECHANISMS AND METHODS

(Q)SARs for Predicting Effects Relating to Reproductive Toxicity

(2008) Mark T. D. Cronin et al.   Quantitative structure-activity relationships & combinatorial science

The Possible Impact of Human Embryonic Stem Cells on Safety Pharmacological and Toxicological Assessments in Drug Discovery and Drug Development

(2008) Tina Stummann et al.   Current Stem Cell Research & Therapy

Metabolism and Toxicity of Drugs. Two Decades of Progress in Industrial Drug Metabolism

(2007) Thomas A. Baillie   CHEMICAL RESEARCH IN TOXICOLOGY

Determinants of skin sensitisation potential

(2007) David W. Roberts et al.   JOURNAL OF APPLIED TOXICOLOGY

Prediction of a carcinogenic potential of rat hepatocarcinogens using toxicogenomics analysis of short-term in vivo studies

(2007) Heidrun Ellinger-Ziegelbauer et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Dermal sensitization quantitative risk assessment (QRA) for fragrance ingredients

(2007) Anne Marie Api et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Skin sensitization in chemical risk assessment: Report of a WHO/IPCS international workshop focusing on dose–response assessment

(2007) Henk van Loveren et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Understanding mechanisms of toxicity: Insights from drug discovery research

(2007) Keith A. Houck et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

First steps in establishing a developmental toxicity test method based on human embryonic stem cells

(2007) Sarah Adler et al.   TOXICOLOGY IN VITRO

General approach for the calculation of tissue to plasma partition coefficients

(2007) Walter Schmitt   TOXICOLOGY IN VITRO

Development of a Microscale Cell Culture Analog To Probe Naphthalene Toxicity

(2004) Kwanchanok Viravaidya et al.   BIOTECHNOLOGY PROGRESS

Incorporation of 3T3-L1 Cells To Mimic Bioaccumulation in a Microscale Cell Culture Analog Device for Toxicity Studies

(2004) Kwanchanok Viravaidya et al.   BIOTECHNOLOGY PROGRESS