Fibroblast growth factor receptor 3 activates a network of profibrotic signaling pathways to promote fibrosis in systemic sclerosis

The Akt/FoxO/p27 Kip1 axis contributes to the anti‐proliferation of pentoxifylline in hypertrophic scars

(2019) Fangfang Yang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Shared and distinct mechanisms of fibrosis

(2019) Jörg H. W. Distler et al.   Nature Reviews Rheumatology

Targeting TGF-β signaling for the treatment of fibrosis

(2018) Andrea Hermina Györfi et al.   MATRIX BIOLOGY

Gene Profiling in Patients with Systemic Sclerosis Reveals the Presence of Oncogenic Gene Signatures

(2018) Marzia Dolcino et al.   Frontiers in Immunology

Targeting of cadherin-11 decreases skin fibrosis in the tight skin-1 mouse model

(2017) Mesias Pedroza et al.   PLoS One

Review: Frontiers of Antifibrotic Therapy in Systemic Sclerosis

(2017) Jörg H. W. Distler et al.   Arthritis & Rheumatology

Regulation of CREB Activation by P38 Mitogen Activated Protein Kinase during Human Primary Erythroblast Differentiation

(2017) V. Di Giacomo et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Involvement of ER stress, PI3K/AKT activation, and lung fibroblast proliferation in bleomycin-induced pulmonary fibrosis

(2017) Han-Shui Hsu et al.   Scientific Reports

Composition of TWIST1 dimers regulates fibroblast activation and tissue fibrosis

(2016) Katrin Palumbo-Zerr et al.   ANNALS OF THE RHEUMATIC DISEASES

Therapeutic and pathological roles of fibroblast growth factors in pulmonary diseases

(2016) Elie El Agha et al.   DEVELOPMENTAL DYNAMICS

Fine-tuning vascular fate during endothelial-mesenchymal transition

(2016) Lin Xiao et al.   JOURNAL OF PATHOLOGY

Fibroblast growth factor-1 attenuates TGF-β1-induced lung fibrosis

(2016) Chiko Shimbori et al.   JOURNAL OF PATHOLOGY

The harmonizome: a collection of processed datasets gathered to serve and mine knowledge about genes and proteins

(2016) Andrew D. Rouillard et al.   Database-The Journal of Biological Databases and Curation

Identification of Optimal Mouse Models of Systemic Sclerosis by Interspecies Comparative Genomics

(2016) Jennifer L. Sargent et al.   Arthritis & Rheumatology

Nintedanib inhibits fibroblast activation and ameliorates fibrosis in preclinical models of systemic sclerosis

(2015) Jingang Huang et al.   ANNALS OF THE RHEUMATIC DISEASES

Orphan nuclear receptor NR4A1 regulates transforming growth factor-β signaling and fibrosis

(2015) Katrin Palumbo-Zerr et al.   NATURE MEDICINE

Dissecting fibrosis: therapeutic insights from the small-molecule toolbox

(2015) Carmel B. Nanthakumar et al.   NATURE REVIEWS DRUG DISCOVERY

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Cytokines in the immunopathology of systemic sclerosis

(2015) Jasmin Raja et al.   Seminars in Immunopathology

The Fibroblast Growth Factor signaling pathway

(2015) David M. Ornitz et al.   Wiley Interdisciplinary Reviews-Developmental Biology

Transforming growth factor β—at the centre of systemic sclerosis

(2014) Robert Lafyatis   Nature Reviews Rheumatology

Up-regulation of fibroblast growth factor (FGF) 9 expression and FGF-WNT/β-catenin signaling in laser-induced wound healing

(2014) Zhenlong Zheng et al.   WOUND REPAIR AND REGENERATION

Integrated mechanisms of CaMKII-dependent ventricular remodeling

(2014) Michael M. Kreusser et al.   Frontiers in Pharmacology

2013 Classification Criteria for Systemic Sclerosis: An American College of Rheumatology/European League Against Rheumatism Collaborative Initiative

(2013) Frank van den Hoogen et al.   ARTHRITIS AND RHEUMATISM

Causal analysis approaches in Ingenuity Pathway Analysis

(2013) Andreas Krämer et al.   BIOINFORMATICS

Molecular Signatures in Skin Associated with Clinical Improvement during Mycophenolate Treatment in Systemic Sclerosis

(2013) Monique Hinchcliff et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Fgf9 from dermal γδ T cells induces hair follicle neogenesis after wounding

(2013) Denise Gay et al.   NATURE MEDICINE

Overexpression of FGF9 in colon cancer cells is mediated by hypoxia-induced translational activation

(2013) T.-M. Chen et al.   NUCLEIC ACIDS RESEARCH

The Next Generation of Transcription Factor Binding Site Prediction

(2013) Anthony Mathelier et al.   PLoS Computational Biology

Cutaneous Features of Crouzon Syndrome With Acanthosis Nigricans

(2013) Adnan Mir et al.   JAMA Dermatology

Jun N-terminal kinase as a potential molecular target for prevention and treatment of dermal fibrosis

(2012) Nicole Reich et al.   ANNALS OF THE RHEUMATIC DISEASES

JAK-2 as a novel mediator of the profibrotic effects of transforming growth factor β in systemic sclerosis

(2012) Clara Dees et al.   ARTHRITIS AND RHEUMATISM

Phase II, Open-Label Study of Brivanib as Second-Line Therapy in Patients with Advanced Hepatocellular Carcinoma

(2012) R. S. Finn et al.   CLINICAL CANCER RESEARCH

Mechanisms of fibrosis: therapeutic translation for fibrotic disease

(2012) Thomas A Wynn et al.   NATURE MEDICINE

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

(2012) Guangchuang Yu et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Periostin Facilitates Skin Sclerosis via PI3K/Akt Dependent Mechanism in a Mouse Model of Scleroderma

(2012) Lingli Yang et al.   PLoS One

FIMO: scanning for occurrences of a given motif

(2011) Charles E. Grant et al.   BIOINFORMATICS

Bayesian probit regression model for the diagnosis of pulmonary fibrosis: proof-of-principle

(2011) Eric B Meltzer et al.   BMC Medical Genomics

Sixteen years and counting: The current understanding of fibroblast growth factor receptor 3 (FGFR3) signaling in skeletal dysplasias

(2011) Silvie Foldynova-Trantirkova et al.   HUMAN MUTATION

Effects of p-CREB-1 on transforming growth factor-β3 auto-regulation in hepatic stellate cells

(2011) Liang Deng et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Animal models of systemic sclerosis: Prospects and limitations

(2010) Christian Beyer et al.   ARTHRITIS AND RHEUMATISM

Small molecule FGF receptor inhibitors block FGFR-dependent urothelial carcinoma growth in vitro and in vivo

(2010) F R Lamont et al.   BRITISH JOURNAL OF CANCER

Prostacyclin receptor suppresses cardiac fibrosis: Role of CREB phosphorylation

(2010) Elsa C. Chan et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Overexpression of Fibroblast Growth Factor-10 during Both Inflammatory and Fibrotic Phases Attenuates Bleomycin-induced Pulmonary Fibrosis in Mice

(2009) Varsha V. Gupte et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

FGFR2-related pathogenesis and FGFR2-targeted therapeutics (Review)

(2009) Katoh   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

A TGFβ-Responsive Gene Signature Is Associated with a Subset of Diffuse Scleroderma with Increased Disease Severity

(2009) Jennifer L. Sargent et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

1-tert-Butyl-3-[6-(3,5-dimethoxy-phenyl)-2-(4-diethylamino-butylamino)-pyrido[2,3-d]pyrimidin-7-yl]-urea (PD173074), a Selective Tyrosine Kinase Inhibitor of Fibroblast Growth Factor Receptor-3 (FGFR3), Inhibits Cell Proliferation of Bladder Cancer Carrying the FGFR3 Gene Mutation along with Up-Regulation of p27/Kip1 and G1/G0 Arrest

(2009) M. Miyake et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Scleroderma

(2009) Armando Gabrielli et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hypoxia. Hypoxia in the pathogenesis of systemic sclerosis

(2009) Christian Beyer et al.   ARTHRITIS RESEARCH & THERAPY

Rho-associated kinases are crucial for myofibroblast differentiation and production of extracellular matrix in scleroderma fibroblasts

(2008) Alfiya Akhmetshina et al.   ARTHRITIS AND RHEUMATISM

Dual inhibition of c-abl and PDGF receptor signaling by dasatinib and nilotinib for the treatment of dermal fibrosis

(2008) Alfiya Akhmetshina et al.   FASEB JOURNAL