Therapeutic and pathological roles of fibroblast growth factors in pulmonary diseases

FGF9 and FGF18 in idiopathic pulmonary fibrosis promote survival and migration and inhibit myofibroblast differentiation of human lung fibroblasts in vitro

(2016) Audrey Joannes et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

On the evolution of the pulmonary alveolar lipofibroblast

(2016) John S. Torday et al.   EXPERIMENTAL CELL RESEARCH

Ponatinib attenuates experimental pulmonary arterial hypertension by modulating Wnt signaling and vasohibin-2/vasohibin-1

(2016) Zechun Kang et al.   LIFE SCIENCES

Role of fibroblast growth factors in organ regeneration and repair

(2016) Elie El Agha et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Keratinocyte Growth Factor Gene Electroporation into Skeletal Muscle as a Novel Gene Therapeutic Approach for Elastase-Induced Pulmonary Emphysema in Mice

(2015) Shuichi Tobinaga et al.   ACTA HISTOCHEMICA ET CYTOCHEMICA

Attenuating endogenous Fgfr2b ligands during bleomycin-induced lung fibrosis does not compromise murine lung repair

(2015) BreAnne MacKenzie et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Fibroblast Growth Factor 2 Is Required for Epithelial Recovery, but Not for Pulmonary Fibrosis, in Response to Bleomycin

(2015) Robert D. Guzy et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Evidence for the involvement of fibroblast growth factor 10 in lipofibroblast formation during embryonic lung development

(2015) D. Al Alam et al.   DEVELOPMENT

Mode of action of nintedanib in the treatment of idiopathic pulmonary fibrosis

(2015) Lutz Wollin et al.   EUROPEAN RESPIRATORY JOURNAL

Inhibition of FGFR Signaling With PD173074 Ameliorates Monocrotaline-induced Pulmonary Arterial Hypertension and Rescues BMPR-II Expression

(2015) Yaguo Zheng et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Ponatinib ameliorates pulmonary fibrosis by suppressing TGF-β1/Smad3 pathway

(2015) Yubei Qu et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Validated prediction of pro-invasive growth factors using a transcriptome-wide invasion signature derived from a complex 3D invasion assay

(2015) Bettina Oehrle et al.   Scientific Reports

The Fibroblast Growth Factor signaling pathway

(2015) David M. Ornitz et al.   Wiley Interdisciplinary Reviews-Developmental Biology

Increased Pericyte Coverage Mediated by Endothelial-Derived Fibroblast Growth Factor-2 and Interleukin-6 Is a Source of Smooth Muscle–Like Cells in Pulmonary Hypertension

(2014) Nicolas Ricard et al.   CIRCULATION

Characterization of the cell of origin and propagation potential of the fibroblast growth factor 9-induced mouse model of lung adenocarcinoma

(2014) Daisuke Arai et al.   JOURNAL OF PATHOLOGY

Docetaxel plus nintedanib versus docetaxel plus placebo in patients with previously treated non-small-cell lung cancer (LUME-Lung 1): a phase 3, double-blind, randomised controlled trial

(2014) Martin Reck et al.   LANCET ONCOLOGY

FGFR1 amplification is associated with poor prognosis and smoking in non-small-cell lung cancer

(2014) An Na Seo et al.   VIRCHOWS ARCHIV

Recent advances in late lung development and the pathogenesis of bronchopulmonary dysplasia

(2013) Alicia Madurga et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Inhibitor-Sensitive FGFR2 and FGFR3 Mutations in Lung Squamous Cell Carcinoma

(2013) R. G. Liao et al.   CANCER RESEARCH

Rapid Induction of Lung Adenocarcinoma by Fibroblast Growth Factor 9 Signaling through FGF Receptor 3

(2013) Y. Yin et al.   CANCER RESEARCH

Fgf10-positive cells represent a progenitor cell population during lung development and postnatally

(2013) E. El Agha et al.   DEVELOPMENT

Fibroblast growth factor-2 is a sputum remodeling biomarker of severe asthma

(2013) Élyse Y. Bissonnette et al.   JOURNAL OF ASTHMA

Expression of Fibroblast Growth Factor 9 in Normal Human Lung and Idiopathic Pulmonary Fibrosis

(2013) Emily Coffey et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Expression of fibroblast growth factor 9 is associated with poor prognosis in patients with resected non-small cell lung cancer

(2013) Keiko Ohgino et al.   LUNG CANCER

The Beneficial Effect of Suramin on Monocrotaline-Induced Pulmonary Hypertension in Rats

(2013) Mohamed Izikki et al.   PLoS One

Long-term pulmonary outcomes of patients with bronchopulmonary dysplasia

(2013) Anita Bhandari et al.   SEMINARS IN PERINATOLOGY

A mechanism of resistance to gefitinib mediated by cellular reprogramming and the acquisition of an FGF2-FGFR1 autocrine growth loop

(2013) K E Ware et al.   Oncogenesis

Dynamic Regulation of Platelet-Derived Growth Factor Receptor α Expression in Alveolar Fibroblasts during Realveolarization

(2012) Leiling Chen et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Transforming Growth Factor–β–Induced Differentiation of Airway Smooth Muscle Cells Is Inhibited by Fibroblast Growth Factor–2

(2012) Michael Schuliga et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Mutant Soluble Ectodomain of Fibroblast Growth Factor Receptor-2 IIIc Attenuates Bleomycin-Induced Pulmonary Fibrosis in Mice

(2012) Zhi-hong Yu et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Thyroid hormone is highly permissive in angioproliferative pulmonary hypertension in rats

(2012) A. Al Husseini et al.   EUROPEAN RESPIRATORY JOURNAL

Loss of Shp2 in alveoli epithelia induces deregulated surfactant homeostasis, resulting in spontaneous pulmonary fibrosis

(2012) Xue Zhang et al.   FASEB JOURNAL

TGF-beta 1 induced fibroblast proliferation is mediated by the FGF-2/ERK pathway

(2012) Li Xiao   Frontiers in Bioscience-Landmark

FGFR1 Amplification in Squamous Cell Carcinoma of The Lung

(2012) Rebecca S. Heist et al.   Journal of Thoracic Oncology

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(2012) Wang Ju et al.   MOLECULAR MEDICINE

Comprehensive genomic characterization of squamous cell lung cancers

(2012)   NATURE

An endothelial apelin-FGF link mediated by miR-424 and miR-503 is disrupted in pulmonary arterial hypertension

(2012) Jongmin Kim et al.   NATURE MEDICINE

Endothelial-Derived Angiocrine Signals Induce and Sustain Regenerative Lung Alveolarization

(2011) Bi-Sen Ding et al.   CELL

Fibroblast growth factor 10 haploinsufficiency causes chronic obstructive pulmonary disease

(2011) J. Klar et al.   JOURNAL OF MEDICAL GENETICS

Mechanisms of disease: pulmonary arterial hypertension

(2011) Ralph T. Schermuly et al.   Nature Reviews Cardiology

Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition

(2011) J. R. Rock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of FGF7 as a novel susceptibility locus for chronic obstructive pulmonary disease

(2011) J. M. Brehm et al.   THORAX

FGF-1 reverts epithelial-mesenchymal transition induced by TGF-β1 through MAPK/ERK kinase pathway

(2010) Carlos Ramos et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Fibroblast Growth Factor Receptors Control Epithelial–Mesenchymal Interactions Necessary for Alveolar Elastogenesis

(2010) Sorachai Srisuma et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Transient Overexpression of Gremlin Results in Epithelial Activation and Reversible Fibrosis in Rat Lungs

(2010) Laszlo Farkas et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Keratinocyte Growth Factor Gene Transduction Ameliorates Pulmonary Fibrosis Induced by Bleomycin in Mice

(2010) Seiko Sakamoto et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Autocrine Fibroblast Growth Factor-2 Signaling Contributes to Altered Endothelial Phenotype in Pulmonary Hypertension

(2010) Ly Tu et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Serum Eosinophil Cationic Protein and 27 Cytokines/Chemokines in Acute Exacerbation of Childhood Asthma

(2010) Masahiko Kato et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Allergen-Induced Coexpression of bFGF and TGF-β1 by Macrophages in a Mouse Model of Airway Remodeling: bFGF Induces Macrophage TGF-β1 Expression in vitro

(2010) Hye Young Yum et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Research Resource: Comprehensive Expression Atlas of the Fibroblast Growth Factor System in Adult Mouse

(2010) Klementina Fon Tacer et al.   MOLECULAR ENDOCRINOLOGY

Frequent and Focal FGFR1 Amplification Associates with Therapeutically Tractable FGFR1 Dependency in Squamous Cell Lung Cancer

(2010) J. Weiss et al.   Science Translational Medicine

Overexpression of Fibroblast Growth Factor-10 during Both Inflammatory and Fibrotic Phases Attenuates Bleomycin-induced Pulmonary Fibrosis in Mice

(2009) Varsha V. Gupte et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Palifermin Induces Alveolar Maintenance Programs in Emphysematous Mice

(2009) Ali Ö. Yildirim et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Fibroblast Growth Factor Receptor Inhibitor PD173074 Blocks Small Cell Lung Cancer Growth In vitro and In vivo

(2009) O. E. Pardo et al.   CANCER RESEARCH

Molecular pathology of the fibroblast growth factor family

(2009) Pavel Krejci et al.   HUMAN MUTATION

Endothelial-derived FGF2 contributes to the progression of pulmonary hypertension in humans and rodents

(2009) Mohamed Izikki et al.   JOURNAL OF CLINICAL INVESTIGATION

The FGF family: biology, pathophysiology and therapy

(2009) Andrew Beenken et al.   NATURE REVIEWS DRUG DISCOVERY

Identification of Keratinocyte Growth Factor as a Target of microRNA-155 in Lung Fibroblasts: Implication in Epithelial-Mesenchymal Interactions

(2009) Nicolas Pottier et al.   PLoS One

Bone Marrow Stem Cells Expressing Keratinocyte Growth Factor via an Inducible Lentivirus Protects against Bleomycin-Induced Pulmonary Fibrosis

(2009) Susana Aguilar et al.   PLoS One