Transforming growth factor β—at the centre of systemic sclerosis

Immunochip Analysis Identifies Multiple Susceptibility Loci for Systemic Sclerosis

(2014) Maureen D. Mayes et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Role of Lung Pericytes and Resident Fibroblasts in the Pathogenesis of Pulmonary Fibrosis

(2013) Chi Hung et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Endothelial Injury in a Transforming Growth Factor β-Dependent Mouse Model of Scleroderma Induces Pulmonary Arterial Hypertension

(2013) Emma C. Derrett-Smith et al.   ARTHRITIS AND RHEUMATISM

Unchaining the beast; insights from structural and evolutionary studies on TGFβ secretion, sequestration, and activation

(2013) Ian B. Robertson et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Regulation of the Expression of GARP/Latent TGF- 1 Complexes on Mouse T Cells and Their Role in Regulatory T Cell and Th17 Differentiation

(2013) J. P. Edwards et al.   JOURNAL OF IMMUNOLOGY

CTGF Mediates Smad-Dependent Transforming Growth Factor β Signaling To Regulate Mesenchymal Cell Proliferation during Palate Development

(2013) Carolina Parada et al.   MOLECULAR AND CELLULAR BIOLOGY

Integrin-modulating therapy prevents fibrosis and autoimmunity in mouse models of scleroderma

(2013) Elizabeth E. Gerber et al.   NATURE

Identification of human epididymis protein-4 as a fibroblast-derived mediator of fibrosis

(2013) Valerie S LeBleu et al.   NATURE MEDICINE

Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs

(2013) Neil C Henderson et al.   NATURE MEDICINE

The Interaction of Endothelin-1 and TGF-β1 Mediates Vascular Cell Remodeling

(2013) Christopher Lambers et al.   PLoS One

State of the art on nailfold capillaroscopy: a reliable diagnostic tool and putative biomarker in rheumatology?

(2013) M. Cutolo et al.   RHEUMATOLOGY

Therapy for Fibrotic Diseases: Nearing the Starting Line

(2013) S. L. Friedman et al.   Science Translational Medicine

Molecular Basis for the Regulation of Angiogenesis by Thrombospondin-1 and -2

(2013) P. R. Lawler et al.   Cold Spring Harbor Perspectives in Medicine

Identification of Cadherin 11 as a Mediator of Dermal Fibrosis and Possible Role in Systemic Sclerosis

(2013) Minghua Wu et al.   Arthritis & Rheumatology

Association of Interferon- and Transforming Growth Factor β-Regulated Genes and Macrophage Activation With Systemic Sclerosis-Related Progressive Lung Fibrosis

(2013) Romy B. Christmann et al.   Arthritis & Rheumatology

Transforming Growth Factor β-1 Stimulates Profibrotic Epithelial Signaling to Activate Pericyte-Myofibroblast Transition in Obstructive Kidney Fibrosis

(2012) Ching-Fang Wu et al.   AMERICAN JOURNAL OF PATHOLOGY

Modern Age Pathology of Pulmonary Arterial Hypertension

(2012) Elvira Stacher et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

TGFβ receptor gene variants in systemic sclerosis-related pulmonary arterial hypertension: results from a multicentre EUSTAR study of European Caucasian patients

(2012) Eugénie Koumakis et al.   ANNALS OF THE RHEUMATIC DISEASES

Regulation of TGFβ in the immune system: An emerging role for integrins and dendritic cells

(2012) John J. Worthington et al.   IMMUNOBIOLOGY

Specificity of latent TGF-β binding protein (LTBP) incorporation into matrix: Role of fibrillins and fibronectin

(2012) Lior Zilberberg et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Loss-of-function mutations in TGFB2 cause a syndromic presentation of thoracic aortic aneurysm

(2012) Mark E Lindsay et al.   NATURE GENETICS

TGFB2 mutations cause familial thoracic aortic aneurysms and dissections associated with mild systemic features of Marfan syndrome

(2012) Catherine Boileau et al.   NATURE GENETICS

Lineage tracing and genetic ablation of ADAM12+ perivascular cells identify a major source of profibrotic cells during acute tissue injury

(2012) Sophie Dulauroy et al.   NATURE MEDICINE

BUILD-3: A Randomized, Controlled Trial of Bosentan in Idiopathic Pulmonary Fibrosis

(2011) Talmadge E. King et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Therapeutic Value of Small Molecule Inhibitor to Plasminogen Activator Inhibitor–1 for Lung Fibrosis

(2011) Wen-Tan Huang et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Overexpression of VEGF 165 b, an Inhibitory Splice Variant of Vascular Endothelial Growth Factor, Leads to Insufficient Angiogenesis in Patients With Systemic Sclerosis

(2011) Mirko Manetti et al.   CIRCULATION RESEARCH

Cadherin-11 contributes to pulmonary fibrosis: potential role in TGF-β production and epithelial to mesenchymal transition

(2011) Daniel J. Schneider et al.   FASEB JOURNAL

Interleukin-1β Induces Increased Transcriptional Activation of the Transforming Growth Factor-β-activating Integrin Subunit β8 through Altering Chromatin Architecture

(2011) Jennifer A. Markovics et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endoglin promotes TGF-β/Smad1 signaling in scleroderma fibroblasts

(2011) Erin Morris et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Mouse and human lung fibroblasts regulate dendritic cell trafficking, airway inflammation, and fibrosis through integrin αvβ8–mediated activation of TGF-β

(2011) Hideya Kitamura et al.   JOURNAL OF CLINICAL INVESTIGATION

Binding of Anti-SSA Antibodies to Apoptotic Fetal Cardiocytes Stimulates Urokinase Plasminogen Activator (uPA)/uPA Receptor-Dependent Activation of TGF-β and Potentiates Fibrosis

(2011) Paraskevi Briassouli et al.   JOURNAL OF IMMUNOLOGY

CCN2 Is Required for the TGF-β Induced Activation of Smad1 - Erk1/2 Signaling Network

(2011) Sashidhar S. Nakerakanti et al.   PLoS One

A Pericyte Origin of Spinal Cord Scar Tissue

(2011) C. Goritz et al.   SCIENCE

Modulation of Macrophage Efferocytosis in Inflammation

(2011) Darlynn Korns et al.   Frontiers in Immunology

A four-gene biomarker predicts skin disease in patients with diffuse cutaneous systemic sclerosis

(2010) G. Farina et al.   ARTHRITIS AND RHEUMATISM

Selective expression of connective tissue growth factor in fibroblasts in vivo promotes systemic tissue fibrosis

(2010) Sonali Sonnylal et al.   ARTHRITIS AND RHEUMATISM

Genetic Deficiency of Plasminogen Activator Inhibitor-1 Promotes Cardiac Fibrosis in Aged Mice

(2010) Asish K. Ghosh et al.   CIRCULATION

BMP signaling in vascular development and disease

(2010) Jonathan W. Lowery et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Expression of integrin  1 by fibroblasts is required for tissue repair in vivo

(2010) S. Liu et al.   JOURNAL OF CELL SCIENCE

Assembly of fibrillin microfibrils governs extracellular deposition of latent TGF 

(2010) T. Massam-Wu et al.   JOURNAL OF CELL SCIENCE

CTGF directs fibroblast differentiation from human mesenchymal stem/stromal cells and defines connective tissue healing in a rodent injury model

(2010) Chang H. Lee et al.   JOURNAL OF CLINICAL INVESTIGATION

Roles of epithelial cell-derived periostin in TGF-  activation, collagen production, and collagen gel elasticity in asthma

(2010) S. S. Sidhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulation of collagen type I, fibronectin and dermal fibroblast function and activity, in systemic sclerosis by the antioxidant epigallocatechin-3-gallate

(2010) A. Dooley et al.   RHEUMATOLOGY

Mutations in Fibrillin-1 Cause Congenital Scleroderma: Stiff Skin Syndrome

(2010) B. L. Loeys et al.   Science Translational Medicine

Essential Roles for Early Growth Response Transcription Factor Egr-1 in Tissue Fibrosis and Wound Healing

(2009) Minghua Wu et al.   AMERICAN JOURNAL OF PATHOLOGY

Fate Tracing Reveals the Pericyte and Not Epithelial Origin of Myofibroblasts in Kidney Fibrosis

(2009) Benjamin D. Humphreys et al.   AMERICAN JOURNAL OF PATHOLOGY

Loss of β1 integrin in mouse fibroblasts results in resistance to skin scleroderma in a mouse model

(2009) Shangxi Liu et al.   ARTHRITIS AND RHEUMATISM

Noncanonical transforming growth factor β signaling in scleroderma fibrosis

(2009) Maria Trojanowska   CURRENT OPINION IN RHEUMATOLOGY

Mice that lack activity of  v 6- and  v 8-integrins reproduce the abnormalities of Tgfb1- and Tgfb3-null mice

(2009) P. Aluwihare et al.   JOURNAL OF CELL SCIENCE

Inflammatory Skin Disease in K5.hTGF-β1 Transgenic Mice Is Not Dependent on the IL-23/Th17 Inflammatory Pathway

(2009) Erin L. Fitch et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Abnormalities in the Regulators of Angiogenesis in Patients with Scleroderma

(2009) L. K. HUMMERS et al.   JOURNAL OF RHEUMATOLOGY

A non-Smad mechanism of fibroblast activation by transforming growth factor-β via c-Abl and Egr-1: selective modulation by imatinib mesylate

(2009) S Bhattacharyya et al.   ONCOGENE

The Pronounced Th17 Profile in Systemic Sclerosis (SSc) Together with Intracellular Expression of TGFβ and IFNγ Distinguishes SSc Phenotypes

(2009) Timothy R. D. J. Radstake et al.   PLoS One

Increased Frequency and Compromised Function of T Regulatory Cells in Systemic Sclerosis (SSc) Is Related to a Diminished CD69 and TGFβ Expression

(2009) Timothy R. D. J. Radstake et al.   PLoS One

Smad-Independent Transforming Growth Factor-β Regulation of Early Growth Response-1 and Sustained Expression in Fibrosis

(2008) Swati Bhattacharyya et al.   AMERICAN JOURNAL OF PATHOLOGY

Connective tissue growth factor inhibits adipocyte differentiation

(2008) Joanne T. M. Tan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Cartilage oligomeric matrix protein expression in systemic sclerosis reveals heterogeneity of dermal fibroblast responses to transforming growth factor  

(2008) G Farina et al.   ANNALS OF THE RHEUMATIC DISEASES

PGE2 induces angiogenesis via MT1-MMP-mediated activation of the TGF /Alk5 signaling pathway

(2008) A. Alfranca et al.   BLOOD

Genetic Ablation of the Bmpr2 Gene in Pulmonary Endothelium Is Sufficient to Predispose to Pulmonary Arterial Hypertension

(2008) Kwon-Ho Hong et al.   CIRCULATION

Integrins and the activation of latent transforming growth factor β1 – An intimate relationship

(2008) P WIPFF et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

The role of proteases in transforming growth factor-β activation

(2008) G JENKINS   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Fibrillin-1 microfibril deposition is dependent on fibronectin assembly

(2008) R. Kinsey et al.   JOURNAL OF CELL SCIENCE

TGFβ1 and TGFβ3 are partially redundant effectors in brain vascular morphogenesis

(2008) Zhenyu Mu et al.   MECHANISMS OF DEVELOPMENT

Inhibition of Integrin αvβ6, an Activator of Latent Transforming Growth Factor-β, Prevents Radiation-induced Lung Fibrosis

(2007) Khalid Puthawala et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Partial Inhibition of Integrin αvβ6 Prevents Pulmonary Fibrosis without Exacerbating Inflammation

(2007) Gerald S. Horan et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE