Fine-tuning vascular fate during endothelial-mesenchymal transition

HSPB1 Inhibits the Endothelial-to-Mesenchymal Transition to Suppress Pulmonary Fibrosis and Lung Tumorigenesis

(2016) S.-H. Choi et al.   CANCER RESEARCH

FGF2 inhibits endothelial–mesenchymal transition through microRNA-20a-mediated repression of canonical TGF-β signaling

(2016) Ana C. P. Correia et al.   JOURNAL OF CELL SCIENCE

c-Met–mediated endothelial plasticity drives aberrant vascularization and chemoresistance in glioblastoma

(2016) Menggui Huang et al.   JOURNAL OF CLINICAL INVESTIGATION

In Brief: Endothelial-to-mesenchymal transition

(2016) Gonzalo Sanchez-Duffhues et al.   JOURNAL OF PATHOLOGY

Endothelial to mesenchymal transition (EndoMT) in the pathogenesis of Systemic Sclerosis-associated pulmonary fibrosis and pulmonary arterial hypertension. Myth or reality?

(2016) Sergio A. Jimenez et al.   MATRIX BIOLOGY

Endothelial cells are progenitors of cardiac pericytes and vascular smooth muscle cells

(2016) Qi Chen et al.   Nature Communications

Endothelial to mesenchymal transition is common in atherosclerotic lesions and is associated with plaque instability

(2016) Solene M. Evrard et al.   Nature Communications

Fibroblast growth factor signaling in myofibroblasts differs from lipofibroblasts during alveolar septation in mice

(2015) Stephen E. McGowan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

SLUG Is Expressed in Endothelial Cells Lacking Primary Cilia to Promote Cellular CalcificationSignificance

(2015) Gonzalo Sánchez-Duffhues et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

High-throughput investigation of endothelial-to-mesenchymal transformation (EndMT) with combinatorial cellular microarrays

(2015) Zongjie Wang et al.   BIOTECHNOLOGY AND BIOENGINEERING

Tumor Endothelial Cells with Distinct Patterns of TGF -Driven Endothelial-to-Mesenchymal Transition

(2015) L. Xiao et al.   CANCER RESEARCH

Endothelial-to-Mesenchymal Transition in Pulmonary Hypertension

(2015) B. Ranchoux et al.   CIRCULATION

A Hypoxia-Induced Vascular Endothelial-to-Mesenchymal Transition in Development of Radiation-Induced Pulmonary Fibrosis

(2015) S.-H. Choi et al.   CLINICAL CANCER RESEARCH

miR-200b Mediates Endothelial-to-Mesenchymal Transition in Diabetic Cardiomyopathy

(2015) Biao Feng et al.   DIABETES

When endothelial cells go rogue

(2015) P.-Y. Chen et al.   EMBO Molecular Medicine

Endothelial-to-mesenchymal transition drives atherosclerosis progression

(2015) Pei-Yu Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Expression of α-Smooth Muscle Actin Determines the Fate of Mesenchymal Stromal Cells

(2015) Nilesh P. Talele et al.   Stem Cell Reports

Nintedanib: First Global Approval

(2014) Paul L. McCormack   DRUGS

Activation of RhoA-ROCK-BMP signaling reprograms adult human corneal endothelial cells

(2014) Ying-Ting Zhu et al.   JOURNAL OF CELL BIOLOGY

Generation of the epicardial lineage from human pluripotent stem cells

(2014) Alec D Witty et al.   NATURE BIOTECHNOLOGY

Reversible Modulation of Myofibroblast Differentiation in Adipose-Derived Mesenchymal Stem Cells

(2014) Vivek D. Desai et al.   PLoS One

Endothelial cell FGF signaling is required for injury response but not for vascular homeostasis

(2014) Sunday S. Oladipupo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fibroblast growth factor receptor 1 is a key inhibitor of TGF  signaling in the endothelium

(2014) P.-Y. Chen et al.   Science Signaling

TGF-  Signaling Mediates Endothelial-to-Mesenchymal Transition (EndMT) During Vein Graft Remodeling

(2014) B. C. Cooley et al.   Science Translational Medicine

Cancer-Associated Fibroblasts as Another Polarized Cell Type of the Tumor Microenvironment

(2014) Martin Augsten   Frontiers in Oncology

FGF2-induced Ras–MAPK signalling maintains lymphatic endothelial cell identity by upregulating endothelial-cell-specific gene expression and suppressing TGFβ signalling through Smad2

(2013) Taeko Ichise et al.   JOURNAL OF CELL SCIENCE

Deficiency for endoglin in tumor vasculature weakens the endothelial barrier to metastatic dissemination

(2013) Charlotte Anderberg et al.   JOURNAL OF EXPERIMENTAL MEDICINE

EndMT contributes to the onset and progression of cerebral cavernous malformations

(2013) Luigi Maddaluno et al.   NATURE

The epigenetics of epithelial-mesenchymal plasticity in cancer

(2013) Wai Leong Tam et al.   NATURE MEDICINE

‘Cancer associated fibroblasts’ – more than meets the eye

(2013) Shalom Madar et al.   TRENDS IN MOLECULAR MEDICINE

Co-ordinating Notch, BMP, and TGF-β signaling during heart valve development

(2012) Victoria C. Garside et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Identification of novel molecular markers through transcriptomic analysis in human fetal and adult corneal endothelial cells

(2012) Yinyin Chen et al.   HUMAN MOLECULAR GENETICS

IL-1β and TGFβ2 synergistically induce endothelial to mesenchymal transition in an NFκB-dependent manner

(2012) Monika Maleszewska et al.   IMMUNOBIOLOGY

Nuclear p120 catenin unlocks mitotic block of contact-inhibited human corneal endothelial monolayers without disrupting adherent junctions

(2012) Y.-T. Zhu et al.   JOURNAL OF CELL SCIENCE

Targeting the TGFβ signalling pathway in disease

(2012) Rosemary J. Akhurst et al.   NATURE REVIEWS DRUG DISCOVERY

TGFβ signalling in context

(2012) Joan Massagué   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Endothelial–mesenchymal transition and its contribution to the emergence of stem cell phenotype

(2012) Damian Medici et al.   SEMINARS IN CANCER BIOLOGY

FGF Regulates TGF-β Signaling and Endothelial-to-Mesenchymal Transition via Control of let-7 miRNA Expression

(2012) Pei-Yu Chen et al.   Cell Reports

Transforming Growth Factor-β–Induced Endothelial-to-Mesenchymal Transition Is Partly Mediated by MicroRNA-21

(2011) Regalla Kumarswamy et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Transforming growth factor-β2 promotes Snail-mediated endothelial–mesenchymal transition through convergence of Smad-dependent and Smad-independent signalling

(2011) Damian Medici et al.   BIOCHEMICAL JOURNAL

Experimental myocardial infarction triggers canonical Wnt signaling and endothelial-to-mesenchymal transition

(2011) O. Aisagbonhi et al.   Disease Models & Mechanisms

TGF-β regulates isoform switching of FGF receptors and epithelial-mesenchymal transition

(2011) Takuya Shirakihara et al.   EMBO JOURNAL

Endothelial mesenchymal transformation mediated by IL-1β-induced FGF-2 in corneal endothelial cells

(2011) Jeong Goo Lee et al.   EXPERIMENTAL EYE RESEARCH

The impact of pericytes on the blood–brain barrier integrity depends critically on the pericyte differentiation stage

(2011) Gokulan Thanabalasundaram et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Therapeutic potential of fibroblast growth factor-2 for hypertrophic scars: upregulation of MMP-1 and HGF expression

(2011) Hitomi Eto et al.   LABORATORY INVESTIGATION

Stromal Endothelial Cells Directly Influence Cancer Progression

(2011) J. W. Franses et al.   Science Translational Medicine

Epigenetic Regulation of Myofibroblast Differentiation by DNA Methylation

(2010) Biao Hu et al.   AMERICAN JOURNAL OF PATHOLOGY

FGF-1 reverts epithelial-mesenchymal transition induced by TGF-β1 through MAPK/ERK kinase pathway

(2010) Carlos Ramos et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Cardiac fibroblast to myofibroblast differentiation in vivo and in vitro: Expression of focal adhesion components in neonatal and adult rat ventricular myofibroblasts

(2010) Jon-Jon Santiago et al.   DEVELOPMENTAL DYNAMICS

Fate-determining mechanisms in epithelial–myofibroblast transition: major inhibitory role for Smad3

(2010) András Masszi et al.   JOURNAL OF CELL BIOLOGY

Conversion of vascular endothelial cells into multipotent stem-like cells

(2010) Damian Medici et al.   NATURE MEDICINE

Embryonic vasculogenesis and hematopoietic specification

(2010) Lauren C. Goldie et al.   Organogenesis

Endothelial to Mesenchymal Transition via Transforming Growth Factor-β1/Smad Activation Is Associated with Portal Venous Stenosis in Idiopathic Portal Hypertension

(2009) Azusa Kitao et al.   AMERICAN JOURNAL OF PATHOLOGY

Endothelial-Myofibroblast Transition Contributes to the Early Development of Diabetic Renal Interstitial Fibrosis in Streptozotocin-Induced Diabetic Mice

(2009) Jinhua Li et al.   AMERICAN JOURNAL OF PATHOLOGY

FGF signaling is required for myofibroblast differentiation during alveolar regeneration

(2009) Anne-Karina T. Perl et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Endothelial–Mesenchymal Transition in Bleomycin-Induced Pulmonary Fibrosis

(2009) Naozumi Hashimoto et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN

(2009) Zvi G. Fridlender et al.   CANCER CELL

The basics of epithelial-mesenchymal transition

(2009) Raghu Kalluri et al.   JOURNAL OF CLINICAL INVESTIGATION

Transplantation of basic fibroblast growth factor-pretreated adipose tissue-derived stromal cells enhances regression of liver fibrosis in mice

(2008) Yoshihiro Kamada et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Opposing actions of Notch1 and VEGF in post-natal cardiac valve endothelial cells

(2008) Jeong-Hee Yang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Calcification of Multipotent Prostate Tumor Endothelium

(2008) Andrew C. Dudley et al.   CANCER CELL

Fibroblast growth factor represses Smad-mediated myofibroblast activation in aortic valvular interstitial cells

(2008) Melinda C. Cushing et al.   FASEB JOURNAL

Fibroblasts in Kidney Fibrosis Emerge via Endothelial-to-Mesenchymal Transition

(2008) E. M. Zeisberg et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Basic fibroblast growth factor (bFGF) alleviates the scar of the rabbit ear model in wound healing

(2008) Ju Lin Xie et al.   WOUND REPAIR AND REGENERATION

Basic fibroblast growth factor accelerates and improves second-degree burn wound healing

(2008) Sadanori Akita et al.   WOUND REPAIR AND REGENERATION