Article
Biotechnology & Applied Microbiology
Wenwen Ding, Danhua Zhou, Shimeng Zhang, Jiaping Qian, Lingxia Yang, Lei Tang
Summary: This study demonstrates that Trimetazidine (TMZ) can inhibit liver fibrosis and hepatic stellate cell proliferation induced by CCl4 and TGF-beta. TMZ exerts its effects by blocking the activation of TGF beta/Smad signaling pathway. These findings provide new insights into the potential application of TMZ in the treatment of liver fibrosis.
Article
Biochemistry & Molecular Biology
Xinyue Li, Navneet Kaur, Mustafa Albahrani, Adam R. Karpf, Adrian R. Black, Jennifer D. Black
Summary: This study identified a novel crosstalk between PKC alpha and TGF beta signaling, which regulates the expression of TGF beta receptor 1 and affects intestinal epithelial cell proliferation and tumor development. The crosstalk between PKC alpha and TGF beta signaling is not only present in the intestine, but also in other epithelial tissues.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Review
Immunology
Joshua M. Moreau, Maria Velegraki, Chelsea Bolyard, Michael D. Rosenblum, Zihai Li
Summary: TGF-beta 1 plays a crucial role in the development and function of T-reg, although its pleiotropic and context-dependent activity makes it complicated.
SCIENCE IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Angelica Mastandrea Amanso, Archana Kamalakar, Sara Bitarafan, Shelly Abramowicz, Hicham Drissi, Joey Victor Barnett, Levi Benjamin Wood, S. L. Goudy
Summary: Our study demonstrates the crucial role of TGF beta receptor 3 in inducing mineralization in bone cells through noncanonical targets of TGF beta signaling. Treatment with soluble TGF beta R3 increased mineralization in human pediatric bone-derived osteoblast-like cells, showing potential for bone inductive therapy. Further research will focus on utilizing sR3 to induce bone regeneration in vivo using animal models.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Karan Singh, Nalani Sachan, Taylor Ene, Branka Dabovic, Daniel Rifkin
Summary: LTBP3 plays a crucial role in adipogenesis, and its deficiency inhibits adipocyte differentiation, which is regulated by TGF beta. Understanding the control of mesenchymal stem cell fate is essential for the potential use of these cells for regenerative medicine.
Article
Biology
Elisa Ceccherini, Nicoletta Di Giorgi, Elena Michelucci, Giovanni Signore, Lorena Tedeschi, Federico Vozzi, Silvia Rocchiccioli, Antonella Cecchettini
Summary: The study revealed that human cholangiocytes exhibit reduced proliferation and cell cycle arrest in G0/G1 phase following TGF-beta treatment. Proteomic analysis identified four downregulated proteins related to Ca2+ homeostasis.
Article
Orthopedics
Riza Mert Cetik, Samiye Yabanoglu Ciftci, Betul Arica, Ipek Baysal, Saadet Ozen Akarca Dizakar, Fatma Kubra Erbay Elibol, Ayse Gencer, Teyfik Demir, Mehmet Ayvaz
Summary: Application of TGF-beta 3 enhances healing of Achilles tendon midsubstance injuries, and the use of nanoparticle form improves outcomes, specifically accelerating the remodeling process.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Zhuo Chen, Hanjie Yu, Xiangqin Chen, Wentian Chen, Wanghua Song, Zheng Li
Summary: TGF-beta superfamily members play important roles in various diseases, and glycosylation modification is involved in the regulation of TGF-beta signaling pathway. There is a complex mutual regulation between glycosylation and TGF-beta signaling, which affects biological processes.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Medicinal
Baocheng Xie, Huan Zhou, Hongyu Liu, Shiyi Liao, Chenhui Zhou, Daohua Xu
Summary: This study aimed to investigate the protective effect and mechanism of salidroside on dexamethasone-induced osteogenic differentiation and bone formation in MC3T3-E1 cells and zebrafish. The results showed that salidroside had no harmful impact on MC3T3-E1 cells; it significantly relieved dexamethasone-induced inhibition of ALP activity and mineralization in the cells, and promoted osteogenic differentiation. Salidroside alleviated dexamethasone-induced inhibition of osteogenic differentiation and bone formation via TGF-beta /Smad2/3 signaling pathway.
PHYTOTHERAPY RESEARCH
(2023)
Article
Medicine, Research & Experimental
Jose Alvaro Lomeli-Nieto, Jose Francisco Munoz-Valle, Christian Johana Banos-Hernandez, Jose Eduardo Navarro-Zarza, Juliana Marisol Godinez-Rubi, Samuel Garcia-Arellano, Maria Guadalupe Ramirez-Duenas, Isela Parra-Rojas, Arisbeth Villanueva-Perez, Jorge Hernandez-Bello
Summary: This study demonstrates a joint decrease of the three active TGF-beta isoforms in SSc patients. However, TGF-beta 1, TGF-beta R1, and TGF-beta R2 are possibly increased in clinically involved skin.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Oncology
Cai-Xia Li, Li-Hua Cui, Lan-Qiu Zhang, Lei Yang, Yu-Zhen Zhuo, Nai-Qiang Cui, Shu-Kun Zhang
Summary: Activation of the NLRP3 inflammasome is directly involved in the activation of Pancreatic stellate cells in vivo and in vitro, and inhibiting NLRP3 suppresses the activation of PSCs through the TGF-β1/Smad3 pathway.
EXPERIMENTAL CELL RESEARCH
(2021)
Review
Gastroenterology & Hepatology
Yujia Li, Weiguo Fan, Frederik Link, Sai Wang, Steven Dooley
Summary: Transforming growth factor-beta (TGF-beta) is an important factor in the liver that plays a role in various processes initiated by liver injury. It affects different types of liver cells and the response depends on the specific context. In the healthy liver, TGF-beta is stored in the extracellular matrix as latent TGF-beta (L-TGF-beta), and the protein ECM1 is critical for maintaining its latency. Activation of L-TGF-beta has detrimental effects on liver structure and function. This review article presents current knowledge on the formation, secretion, matrix deposition, and activation of L-TGF-beta, and highlights the potential therapeutic benefits of reducing L-TGF-beta activation in liver fibrosis and liver cancer.
Article
Medicine, Research & Experimental
Alex Boye
Summary: Early detection of cancer is crucial for cancer management and limited survival. Understanding cancer biology and key factors in cancer progression plays a significant role in cancer treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Soonjae Hwang, Sangbin Park, Uzma Yaseen, Ho-Jae Lee, Ji-Young Cha
Summary: Liver fibrosis is a progressive and debilitating disease characterized by excessive deposition of extracellular matrix proteins. Our study reveals that KLF10 acts as a negative regulator of TGF-beta signaling pathway, suppressing hepatic stellate cell activation and fibrogenesis through modulation of ATF3 expression. Targeting the KLF10-ATF3 axis may have therapeutic implications for liver fibrosis treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Meifang Zheng, Hongyan Li, Yanhang Gao, David R. Brigstock, Runping Gao
Summary: This study evaluated the inhibitory effect of vitamin D3 analogue calcipotriol (Cal) on the fibrosis of pancreatic stellate cells (PSCs) induced by TGF-B1 and the rationality of Cal use in alcoholic chronic pancreatitis (ACP). The results showed enhanced expression of VDR in ACP patients and ACP-induced PSCs. Through a VDR-dependent mechanism, Cal antagonized 16 profibrotic proteins in TGF-B1-induced RP-2 cells.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
