Dissecting fibrosis: therapeutic insights from the small-molecule toolbox

Orphan nuclear receptor NR4A1 regulates transforming growth factor-β signaling and fibrosis

(2015) Katrin Palumbo-Zerr et al.   NATURE MEDICINE

The α v β 1 integrin plays a critical in vivo role in tissue fibrosis

(2015) Nilgun I. Reed et al.   Science Translational Medicine

Strategic management of keloid disease in ethnic skin: a structured approach supported by the emerging literature

(2015) S. Ud-Din et al.   BRITISH JOURNAL OF DERMATOLOGY

Identification of a Cell-of-Origin for Fibroblasts Comprising the Fibrotic Reticulum in Idiopathic Pulmonary Fibrosis

(2014) Hong Xia et al.   AMERICAN JOURNAL OF PATHOLOGY

FRI0496 An Open-Label Study to Evaluate Biomarkers and Safety in Systemic Sclerosis (SSC) Patients Treated with Paquinimod (ABR-215757)

(2014) R. Hesselstrand et al.   ANNALS OF THE RHEUMATIC DISEASES

Maraviroc, a CCR5 antagonist, ameliorates the development of hepatic steatosis in a mouse model of non-alcoholic fatty liver disease (NAFLD)

(2014) L. Perez-Martinez et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

MMI-0100 inhibits cardiac fibrosis in myocardial infarction by direct actions on cardiomyocytes and fibroblasts via MK2 inhibition

(2014) Lei Xu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Genetic Targeting or Pharmacologic Inhibition of NADPH Oxidase Nox4 Provides Renoprotection in Long-Term Diabetic Nephropathy

(2014) J. C. Jha et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Phenotypic screening in cancer drug discovery — past, present and future

(2014) John G. Moffat et al.   NATURE REVIEWS DRUG DISCOVERY

Molecular mechanisms of epithelial–mesenchymal transition

(2014) Samy Lamouille et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Therapeutic approaches to diabetic nephropathy—beyond the RAS

(2014) Beatriz Fernandez-Fernandez et al.   Nature Reviews Nephrology

A Phase 3 Trial of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis

(2014) Talmadge E. King et al.   NEW ENGLAND JOURNAL OF MEDICINE

Efficacy and Safety of Nintedanib in Idiopathic Pulmonary Fibrosis

(2014) Luca Richeldi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Randomized Trial of Acetylcysteine in Idiopathic Pulmonary Fibrosis

(2014)   NEW ENGLAND JOURNAL OF MEDICINE

Reversal of Persistent Fibrosis in Aging by Targeting Nox4-Nrf2 Redox Imbalance

(2014) L. Hecker et al.   Science Translational Medicine

Understanding CT patterns in idiopathic pulmonary fibrosis

(2014) Simon P Hart   Lancet Respiratory Medicine

Assessment of Brd4 Inhibition in Idiopathic Pulmonary Fibrosis Lung Fibroblasts and in Vivo Models of Lung Fibrosis

(2013) Xiaoyan Tang et al.   AMERICAN JOURNAL OF PATHOLOGY

Always cleave up your mess: targeting collagen degradation to treat tissue fibrosis

(2013) William McKleroy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Role of Lung Pericytes and Resident Fibroblasts in the Pathogenesis of Pulmonary Fibrosis

(2013) Chi Hung et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Peptide-Mediated Inhibition of Mitogen-Activated Protein Kinase–Activated Protein Kinase–2 Ameliorates Bleomycin-Induced Pulmonary Fibrosis

(2013) Ragini Vittal et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Treatment of Idiopathic Pulmonary Fibrosis With Ambrisentan

(2013) Ganesh Raghu   ANNALS OF INTERNAL MEDICINE

Blockade of canonical Wnt signalling ameliorates experimental dermal fibrosis

(2013) Christian Beyer et al.   ANNALS OF THE RHEUMATIC DISEASES

Identification of steroid sensitive responders versus non-responders in the treatment of keloid disease

(2013) Sara Ud-Din et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

The chemistry and biological activities of N-acetylcysteine

(2013) Yuval Samuni et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Synthesis and biological evaluation of the pirfenidone derivatives as antifibrotic agents

(2013) Zhen Ma et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Pharmacokinetics, Safety, and Tolerability of Saroglitazar (ZYH1), a Predominantly PPARα Agonist with Moderate PPARγ Agonist Activity in Healthy Human Subjects

(2013) Rajendra H. Jani et al.   CLINICAL DRUG INVESTIGATION

Blockade of KCa3.1 Ameliorates Renal Fibrosis Through the TGF-β1/Smad Pathway in Diabetic Mice

(2013) Chunling Huang et al.   DIABETES

Dual Peroxisome Proliferator-Activated Receptor  /  Agonist GFT505 Improves Hepatic and Peripheral Insulin Sensitivity in Abdominally Obese Subjects

(2013) B. Cariou et al.   DIABETES CARE

Macitentan for the treatment of idiopathic pulmonary fibrosis: the randomised controlled MUSIC trial

(2013) Ganesh Raghu et al.   EUROPEAN RESPIRATORY JOURNAL

Efficacy and Safety of the Farnesoid X Receptor Agonist Obeticholic Acid in Patients With Type 2 Diabetes and Nonalcoholic Fatty Liver Disease

(2013) Sunder Mudaliar et al.   GASTROENTEROLOGY

Hepatoprotective effects of the dual peroxisome proliferator-activated receptor alpha/delta agonist, GFT505, in rodent models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis

(2013) Bart Staels et al.   HEPATOLOGY

BML-11, A Lipoxin Receptor Agonist, Protected Carbon Tetrachloride-Induced Hepatic Fibrosis in Rats

(2013) Xiao-Yan Zhou et al.   INFLAMMATION

Protease-Activated Receptor 1 Inhibition by SCH79797 Attenuates Left Ventricular Remodeling and Profibrotic Activities of Cardiac Fibroblasts

(2013) Dmitry L. Sonin et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS

Tocopherol Activity Correlates with Its Location in a Membrane: A New Perspective on the Antioxidant Vitamin E

(2013) Drew Marquardt et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

5-HT2Areceptor antagonists inhibit hepatic stellate cell activation and facilitate apoptosis

(2013) Dong Chan Kim et al.   LIVER INTERNATIONAL

Large FK506-Binding Proteins Shape the Pharmacology of Rapamycin

(2013) A. M. Marz et al.   MOLECULAR AND CELLULAR BIOLOGY

The why and how of phenotypic small-molecule screens

(2013) Ulrike S Eggert   Nature Chemical Biology

Heavy drugs draw heavy interest from pharma backers

(2013) Alla Katsnelson   NATURE MEDICINE

Identification of human epididymis protein-4 as a fibroblast-derived mediator of fibrosis

(2013) Valerie S LeBleu et al.   NATURE MEDICINE

Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs

(2013) Neil C Henderson et al.   NATURE MEDICINE

Bardoxolone Methyl in Type 2 Diabetes and Stage 4 Chronic Kidney Disease

(2013) Dick de Zeeuw et al.   NEW ENGLAND JOURNAL OF MEDICINE

PKCδ as a Regulator for TGFβ1-Induced α-SMA Production in a Murine Nonalcoholic Steatohepatitis Model

(2013) Su Jin Lee et al.   PLoS One

Maraviroc, a CCR5 Antagonist, Prevents Development of Hepatocellular Carcinoma in a Mouse Model

(2013) Laura Ochoa-Callejero et al.   PLoS One

Pulmonary Autotaxin Expression Contributes to the Pathogenesis of Pulmonary Fibrosis

(2012) Nikos Oikonomou et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Jun N-terminal kinase as a potential molecular target for prevention and treatment of dermal fibrosis

(2012) Nicole Reich et al.   ANNALS OF THE RHEUMATIC DISEASES

Targeted delivery of cytokine therapy to rheumatoid tissue by a synovial targeting peptide

(2012) Sarah E Wythe et al.   ANNALS OF THE RHEUMATIC DISEASES

Pomalidomide is effective for prevention and treatment of experimental skin fibrosis

(2012) Simon Weingärtner et al.   ANNALS OF THE RHEUMATIC DISEASES

Inactivation of tankyrases reduces experimental fibrosis by inhibiting canonical Wnt signalling

(2012) Alfiya Distler et al.   ANNALS OF THE RHEUMATIC DISEASES

Development of Focal Adhesion Kinase Inhibitors in Cancer Therapy

(2012) Wen Wee Ma   Anti-Cancer Agents in Medicinal Chemistry

JAK-2 as a novel mediator of the profibrotic effects of transforming growth factor β in systemic sclerosis

(2012) Clara Dees et al.   ARTHRITIS AND RHEUMATISM

Binding and activity of the prostacyclin receptor (IP) agonists, treprostinil and iloprost, at human prostanoid receptors: Treprostinil is a potent DP1 and EP2 agonist

(2012) Brendan J. Whittle et al.   BIOCHEMICAL PHARMACOLOGY

Synthesis and biological evaluation of analogues of the kinase inhibitor nilotinib as Abl and Kit inhibitors

(2012) Damien Y. Duveau et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Isosteric analogs of lenalidomide and pomalidomide: Synthesis and biological activity

(2012) Alexander L. Ruchelman et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Imatinib mesylate in scleroderma-associated diffuse skin fibrosis: a phase II multicentre randomized double-blinded controlled trial

(2012) S. Prey et al.   BRITISH JOURNAL OF DERMATOLOGY

Urinary Proteomics for Early Diagnosis in Diabetic Nephropathy

(2012) P. Zurbig et al.   DIABETES

Corticosteroid Plus Pentoxifylline Is Not Better than Corticosteroid Alone for Improving Survival in Severe Alcoholic Hepatitis (COPE Trial)

(2012) Sandeep Singh Sidhu et al.   DIGESTIVE DISEASES AND SCIENCES

Evaluation of the antifibrotic effect of fenofibrate and rosiglitazone on bleomycin-induced pulmonary fibrosis in rats

(2012) M. Samah et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

A neutrophil elastase inhibitor prevents bleomycin-induced pulmonary fibrosis in mice

(2012) Akihiro Takemasa et al.   EUROPEAN RESPIRATORY JOURNAL

Liver fibrosis and hepatocyte apoptosis are attenuated by GKT137831, a novel NOX4/NOX1 inhibitor in vivo

(2012) Joy X. Jiang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent

(2012) Tomonori Aoyama et al.   HEPATOLOGY

Prostaglandin F2α facilitates collagen synthesis in cardiac fibroblasts via an F-prostanoid receptor/protein kinase C/Rho kinase pathway independent of transforming growth factor β1

(2012) Wen-yuan Ding et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Bardoxolone Methyl Decreases Megalin and Activates Nrf2 in the Kidney

(2012) S. A. Reisman et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Chemical genetic discovery of targets and anti-targets for cancer polypharmacology

(2012) Arvin C. Dar et al.   NATURE

Automated design of ligands to polypharmacological profiles

(2012) Jérémy Besnard et al.   NATURE

Stromedix acquisition signals growing interest in fibrosis

(2012) Malorye Allison   NATURE BIOTECHNOLOGY

Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase

(2012) Tracy L Keller et al.   Nature Chemical Biology

Multigenerational epigenetic adaptation of the hepatic wound-healing response

(2012) Müjdat Zeybel et al.   NATURE MEDICINE

A systems approach identifies HIPK2 as a key regulator of kidney fibrosis

(2012) Yuanmeng Jin et al.   NATURE MEDICINE

Ruxolitinib

(2012) Ruben A. Mesa et al.   NATURE REVIEWS DRUG DISCOVERY

Targeting the TGFβ signalling pathway in disease

(2012) Rosemary J. Akhurst et al.   NATURE REVIEWS DRUG DISCOVERY

Prednisone, Azathioprine, andN-Acetylcysteine for Pulmonary Fibrosis

(2012)   NEW ENGLAND JOURNAL OF MEDICINE

Protection from liver fibrosis by a peroxisome proliferator-activated receptor   agonist

(2012) K. Iwaisako et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteasome inhibition improves diaphragm function in an animal model for COPD

(2011) Hieronymus van Hees et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Delayed stress fiber formation mediates pulmonary myofibroblast differentiation in response to TGF-β

(2011) Nathan Sandbo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Transglutaminase 2 and Its Role in Pulmonary Fibrosis

(2011) Keith C. Olsen et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

BUILD-3: A Randomized, Controlled Trial of Bosentan in Idiopathic Pulmonary Fibrosis

(2011) Talmadge E. King et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Regulation of Transforming Growth Factor-β1–driven Lung Fibrosis by Galectin-3

(2011) Alison C. MacKinnon et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Therapeutic Value of Small Molecule Inhibitor to Plasminogen Activator Inhibitor–1 for Lung Fibrosis

(2011) Wen-Tan Huang et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Inhibition of focal adhesion kinase prevents experimental lung fibrosis and myofibroblast formation

(2011) David Lagares et al.   ARTHRITIS AND RHEUMATISM

Aromatic phosphonates inhibit the lysophospholipase D activity of autotaxin

(2011) Guowei Jiang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of CC-930, an orally active anti-fibrotic JNK inhibitor

(2011) Véronique Plantevin Krenitsky et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Novel therapeutic approaches for pulmonary fibrosis

(2011) Arnab Datta et al.   BRITISH JOURNAL OF PHARMACOLOGY

Sorafenib inhibits transforming growth factor β1-Mediated Epithelial-Mesenchymal Transition and apoptosis in mouse hepatocytes

(2011) Yue-Lei Chen et al.   HEPATOLOGY

P2X7 receptor antagonism attenuates the hypertension and renal injury in Dahl salt-sensitive rats

(2011) Xu Ji et al.   HYPERTENSION RESEARCH

Inhibition of PDGF, TGF-β, and Abl signaling and reduction of liver fibrosis by the small molecule Bcr-Abl tyrosine kinase antagonist Nilotinib

(2011) Yuqing Liu et al.   JOURNAL OF HEPATOLOGY

Peptide Inhibitors of MK2 Show Promise for Inhibition of Abdominal Adhesions

(2011) Brian C. Ward et al.   JOURNAL OF SURGICAL RESEARCH

Nilotinib Attenuates Renal Injury and Prolongs Survival in Chronic Kidney Disease

(2011) M. Iyoda et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Addition of Atrasentan to Renin-Angiotensin System Blockade Reduces Albuminuria in Diabetic Nephropathy

(2011) D. E. Kohan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Pirfenidone for Diabetic Nephropathy

(2011) K. Sharma et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Pirfenidone in patients with idiopathic pulmonary fibrosis (CAPACITY): two randomised trials

(2011) Paul W Noble et al.   LANCET

How were new medicines discovered?

(2011) David C. Swinney et al.   NATURE REVIEWS DRUG DISCOVERY

Bardoxolone Methyl and Kidney Function in CKD with Type 2 Diabetes

(2011) Pablo E. Pergola et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Multiwell Platform for Studying Stiffness-Dependent Cell Biology

(2011) Justin D. Mih et al.   PLoS One

Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition

(2011) J. R. Rock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of Nilotinib on Bleomycin-Induced Acute Lung Injury and Pulmonary Fibrosis in Mice

(2011) Chin Kook Rhee et al.   RESPIRATION

An investigator-driven study of everolimus in surgical lung biopsy confirmed idiopathic pulmonary fibrosis

(2011) MONIQUE A. MALOUF et al.   RESPIROLOGY

Induction of Heart Valve Lesions by Small-Molecule ALK5 Inhibitors

(2011) Mark J. Anderton et al.   TOXICOLOGIC PATHOLOGY

Inhibition of Mitogen Activated Protein Kinase Activated Protein Kinase II with MMI-0100 reduces intimal hyperplasia ex vivo and in vivo

(2011) Akihito Muto et al.   VASCULAR PHARMACOLOGY

Hypermethylation of PTGER2 Confers Prostaglandin E2 Resistance in Fibrotic Fibroblasts from Humans and Mice

(2010) Steven K. Huang et al.   AMERICAN JOURNAL OF PATHOLOGY

Diminished Prostaglandin E2Contributes to the Apoptosis Paradox in Idiopathic Pulmonary Fibrosis

(2010) Toby M. Maher et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Reply

(2010) James R. Seibold et al.   ARTHRITIS AND RHEUMATISM

Prevention of diabetic nephropathy in Ins2+/−AkitaJmice by the mitochondria-targeted therapy MitoQ

(2010) Balu K. Chacko et al.   BIOCHEMICAL JOURNAL

A novel, orally active LPA1 receptor antagonist inhibits lung fibrosis in the mouse bleomycin model

(2010) JS Swaney et al.   BRITISH JOURNAL OF PHARMACOLOGY

Blockade of Endothelial-Mesenchymal Transition by a Smad3 Inhibitor Delays the Early Development of Streptozotocin-Induced Diabetic Nephropathy

(2010) J. Li et al.   DIABETES

Inhibitory effect of CXC chemokine receptor 4 antagonist AMD3100 on bleomycin induced murine pulmonary fibrosis

(2010) Jeong Sup Song et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Modulation of Lysyl Oxidase-like 2 Enzymatic Activity by an Allosteric Antibody Inhibitor

(2010) Hector M. Rodriguez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression

(2010) Fei Liu et al.   JOURNAL OF CELL BIOLOGY

A Novel Inhibitor of Plasminogen Activator Inhibitor-1 Provides Antithrombotic Benefits Devoid of Bleeding Effect in Nonhuman Primates

(2010) Yuko Izuhara et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

New insights into the antifibrotic effects of sorafenib on hepatic stellate cells and liver fibrosis

(2010) Yan Wang et al.   JOURNAL OF HEPATOLOGY

The chemokine monocyte chemoattractant protein-1 contributes to renal dysfunction in swine renovascular hypertension

(2010) Xiang-Yang Zhu et al.   JOURNAL OF HYPERTENSION

Selective Inhibition of JAK1 and JAK2 Is Efficacious in Rodent Models of Arthritis: Preclinical Characterization of INCB028050

(2010) J. S. Fridman et al.   JOURNAL OF IMMUNOLOGY

First in Class, Potent, and Orally Bioavailable NADPH Oxidase Isoform 4 (Nox4) Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis

(2010) Benoı̂t Laleu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Prevention of Bleomycin-Induced Pulmonary Fibrosis by a Novel Antifibrotic Peptide with Relaxin-Like Activity

(2010) A. Pini et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Selective inhibition of BET bromodomains

(2010) Panagis Filippakopoulos et al.   NATURE

Methylation determines fibroblast activation and fibrogenesis in the kidney

(2010) Wibke Bechtel et al.   NATURE MEDICINE

Allosteric inhibition of lysyl oxidase–like-2 impedes the development of a pathologic microenvironment

(2010) Vivian Barry-Hamilton et al.   NATURE MEDICINE

Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis

(2010) Arun J. Sanyal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inhibition of Wnt/ -catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis

(2010) W. R. Henderson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fate Tracing Reveals the Pericyte and Not Epithelial Origin of Myofibroblasts in Kidney Fibrosis

(2009) Benjamin D. Humphreys et al.   AMERICAN JOURNAL OF PATHOLOGY

Endothelin antagonism in portal hypertensive mice: implications for endothelin receptor-specific signaling in liver disease

(2009) Hong-Qiang Feng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Effects of losartan on hepatic expression of nonphagocytic NADPH oxidase and fibrogenic genes in patients with chronic hepatitis C

(2009) Jordi Colmenero et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Imatinib Treatment for Idiopathic Pulmonary Fibrosis

(2009) Craig E. Daniels et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Rapamycin Prevents Transforming Growth Factor-α–Induced Pulmonary Fibrosis

(2009) Thomas R. Korfhagen et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

MeCP2 Controls an Epigenetic Pathway That Promotes Myofibroblast Transdifferentiation and Fibrosis

(2009) Jelena Mann et al.   GASTROENTEROLOGY

Long-term efficacy of rosiglitazone in nonalcoholic steatohepatitis: Results of the fatty liver improvement by rosiglitazone therapy (FLIRT 2) extension trial

(2009) Vlad Ratziu et al.   HEPATOLOGY

CCR2 promotes hepatic fibrosis in mice

(2009) Ekihiro Seki et al.   HEPATOLOGY

Anti-fibrotic effect of thalidomide through inhibiting TGF-β-induced ERK1/2 pathways in bleomycin-induced lung fibrosis in mice

(2009) Jung-Yoon Choe et al.   INFLAMMATION RESEARCH

Increased TG2 Expression Can Result in Induction of Transforming Growth Factor β1, Causing Increased Synthesis and Deposition of Matrix Proteins, Which Can Be Regulated by Nitric Oxide

(2009) Dilek Telci et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transglutaminase inhibition ameliorates experimental diabetic nephropathy

(2009) Linghong Huang et al.   KIDNEY INTERNATIONAL

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

(2009) Shih-Min A. Huang et al.   NATURE

Open access chemical and clinical probes to support drug discovery

(2009) Aled M Edwards et al.   Nature Chemical Biology

Renal fibrosis is attenuated by targeted disruption of KCa3.1 potassium channels

(2009) I. Grgic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of beraprost sodium (BPS) in a new rat partial unilateral ureteral obstruction model

(2009) Masahiko Takenaka et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Halofuginone Inhibits TH17 Cell Differentiation by Activating the Amino Acid Starvation Response

(2009) M. S. Sundrud et al.   SCIENCE

Identification of Human S100A9 as a Novel Target for Treatment of Autoimmune Disease via Binding to Quinoline-3-Carboxamides

(2009) Per Björk et al.   PLOS BIOLOGY

Tissue stiffness, latent TGF-β1 Activation, and mechanical signal transduction: Implications for the pathogenesis and treatment of fibrosis

(2009) Boris Hinz   Current Rheumatology Reports

Adenoviral Overexpression and Small Interfering RNA Suppression Demonstrate That Plasminogen Activator Inhibitor-1 Produces Elevated Collagen Accumulation in Normal and Keloid Fibroblasts

(2008) Tai-Lan Tuan et al.   AMERICAN JOURNAL OF PATHOLOGY

c-Jun N-Terminal Kinase 1 Is Required for the Development of Pulmonary Fibrosis

(2008) John F. Alcorn et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Superoxide scavenging activity of pirfenidone–iron complex

(2008) Yoshihiro Mitani et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

BIBF 1120: Triple Angiokinase Inhibitor with Sustained Receptor Blockade and Good Antitumor Efficacy

(2008) F. Hilberg et al.   CANCER RESEARCH

A synthetic peptide from transforming growth factor- 1 type III receptor prevents myocardial fibrosis in spontaneously hypertensive rats

(2008) N. Hermida et al.   CARDIOVASCULAR RESEARCH

Dual inhibition of c-abl and PDGF receptor signaling by dasatinib and nilotinib for the treatment of dermal fibrosis

(2008) Alfiya Akhmetshina et al.   FASEB JOURNAL

Inhibition of Integrin αvβ6 on Cholangiocytes Blocks Transforming Growth Factor-β Activation and Retards Biliary Fibrosis Progression

(2008) Eleonora Patsenker et al.   GASTROENTEROLOGY

Mechanisms of Hepatic Fibrogenesis

(2008) Scott L. Friedman   GASTROENTEROLOGY

Fibrocytes are a potential source of lung fibroblasts in idiopathic pulmonary fibrosis

(2008) Annika Andersson-Sjöland et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Pharmacology of Macitentan, an Orally Active Tissue-Targeting Dual Endothelin Receptor Antagonist

(2008) M. Iglarz et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

T-type calcium channel blockade as a therapeutic strategy against renal injury in rats with subtotal nephrectomy

(2008) N. Sugano et al.   KIDNEY INTERNATIONAL

Liver cirrhosis

(2008) Detlef Schuppan et al.   LANCET

Cytosporone B is an agonist for nuclear orphan receptor Nur77

(2008) Yanyan Zhan et al.   Nature Chemical Biology

Network pharmacology: the next paradigm in drug discovery

(2008) Andrew L Hopkins   Nature Chemical Biology

Aliskiren Combined with Losartan in Type 2 Diabetes and Nephropathy

(2008) Hans-Henrik Parving et al.   NEW ENGLAND JOURNAL OF MEDICINE

Functional Wnt Signaling Is Increased in Idiopathic Pulmonary Fibrosis

(2008) Melanie Königshoff et al.   PLoS One

Cross-talk between PDGF and S1P signalling elucidates the inhibitory effect and potential antifibrotic action of the immunomodulator FTY720 in activated HSC-cultures

(2007) Anna Maria Brunati et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The bleomycin animal model: A useful tool to investigate treatment options for idiopathic pulmonary fibrosis?

(2007) Antje Moeller et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Pirfenidone inhibits the expression of HSP47 in TGF-β1-stimulated human lung fibroblasts

(2007) Seiko Nakayama et al.   LIFE SCIENCES