The resurgent landscape of xenotransplantation of pig organs in nonhuman primates

Cas9 activates the p53 pathway and selects for p53-inactivating mutations

(2020) Oana M. Enache et al.   NATURE GENETICS

CRISPR-Cas9 genome editing induces megabase-scale chromosomal truncations

(2019) Grégoire Cullot et al.   Nature Communications

Xenotransplantation in China: Present status

(2019) Yi Wang et al.   XENOTRANSPLANTATION

Progress in multiple genetically modified minipigs for xenotransplantation in China

(2019) Dengke Pan et al.   XENOTRANSPLANTATION

Identification of preexisting adaptive immunity to Cas9 proteins in humans

(2019) Carsten T. Charlesworth et al.   NATURE MEDICINE

Long-Term Survival of Pig-to-Rhesus Macaque Renal Xenografts is Dependent on CD4 T cell Depletion

(2019) S C Kim et al.   AMERICAN JOURNAL OF TRANSPLANTATION

31 Day Xeno Lung Recipient Survival - Progress towards the Clinic

(2019) L. Burdorf et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

CRISPR/Cas9-based epigenome editing: An overview of dCas9-based tools with special emphasis on off-target activity

(2019) Vanja Tadić et al.   METHODS

Third WHO Global Consultation on Regulatory Requirements for Xenotransplantation Clinical Trials, Changsha, Hunan, China December 12–14, 2018

(2019) Wayne J. Hawthorne et al.   XENOTRANSPLANTATION

Intra‐bone bone marrow transplantation from hCD47 transgenic pigs to baboons prolongs chimerism to >60 days and promotes increased porcine lung transplant survival

(2019) Hironosuke Watanabe et al.   XENOTRANSPLANTATION

Transplanting organs from pigs to humans

(2019) Megan Sykes et al.   Science Immunology

Tissue Factor at the crossroad of coagulation and cell signaling

(2018) Hortensia Zelaya et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

CRISPR–Cas9 genome editing induces a p53-mediated DNA damage response

(2018) Emma Haapaniemi et al.   NATURE MEDICINE

Why was PERV not transmitted during preclinical and clinical xenotransplantation trials and after inoculation of animals?

(2018) Joachim Denner   Retrovirology

Xenotransplantation: back to the future?

(2018) Raphael P. H. Meier et al.   TRANSPLANT INTERNATIONAL

Overcoming Coagulation Dysregulation in Pig Solid Organ Transplantation in Nonhuman Primates

(2018) Liaoran Wang et al.   TRANSPLANTATION

Viral pathogens: What are they and do they matter?

(2018) Linda Scobie et al.   XENOTRANSPLANTATION

Growth hormone receptor-deficient pigs resemble the pathophysiology of human Laron syndrome and reveal altered activation of signaling cascades in the liver

(2018) Arne Hinrichs et al.   Molecular Metabolism

Physiologic Aspects of Pig Kidney Transplantation in Nonhuman Primates

(2018) Hayato Iwase et al.   COMPARATIVE MEDICINE

Progress and challenges in Lung xenotransplantation

(2018) Lars Burdorf et al.   Current Opinion in Organ Transplantation

Perspectives on the Optimal Genetically-Engineered pig in 2018 for Initial Clinical Trials of Kidney or Heart Xenotransplantation

(2018) David K.C. Cooper et al.   TRANSPLANTATION

Porcine endogenous retroviruses: Quantification of the copy number in cell lines, pig breeds, and organs

(2018) Uwe Fiebig et al.   XENOTRANSPLANTATION

PERVading strategies and infectious risk for clinical xenotransplantation

(2018) Christopher G. A. McGregor et al.   XENOTRANSPLANTATION

Xenoantigen Deletion and Chemical Immunosuppression Can Prolong Renal Xenograft Survival

(2018) Andrew B. Adams et al.   ANNALS OF SURGERY

Consistent success in life-supporting porcine cardiac xenotransplantation

(2018) Matthias Längin et al.   NATURE

Renal xenotransplantation: experimental progress and clinical prospects

(2017) Martin Wijkstrom et al.   KIDNEY INTERNATIONAL

Genetically Modified Pigs as Organ Donors for Xenotransplantation

(2017) Magdalena Hryhorowicz et al.   MOLECULAR BIOTECHNOLOGY

Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9

(2017) Dong Niu et al.   SCIENCE

The role of sialic acids in the immune recognition of xenografts

(2017) Beth M. French et al.   XENOTRANSPLANTATION

Cytokine profiles in Tibetan macaques following α-1,3-galactosyltransferase-knockout pig liver xenotransplantation

(2017) Zhuochao Zhang et al.   XENOTRANSPLANTATION

Immunological and physiological observations in baboons with life-supporting genetically engineered pig kidney grafts

(2017) Hayato Iwase et al.   XENOTRANSPLANTATION

Cell Therapy for Parkinson's Disease: A Translational Approach to Assess the Role of Local and Systemic Immunosuppression

(2016) R. Aron Badin et al.   AMERICAN JOURNAL OF TRANSPLANTATION

A Bridge to Somewhere

(2016) Jigesh A. Shah et al.   ANNALS OF SURGERY

Contact system revisited: an interface between inflammation, coagulation, and innate immunity

(2016) A. T. Long et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Progress in Clinical Encapsulated Islet Xenotransplantation

(2016) David K.C. Cooper et al.   TRANSPLANTATION

Susceptibility of porcine endogenous retrovirus to anti-retroviral inhibitors

(2016) Takele Argaw et al.   XENOTRANSPLANTATION

Failure of transplantation tolerance induction by autologous regulatory T cells in the pig-to-non-human primate islet xenotransplantation model

(2016) Jun-Seop Shin et al.   XENOTRANSPLANTATION

Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft

(2016) Muhammad M. Mohiuddin et al.   Nature Communications

The role of endothelial cells on islet function and revascularization after islet transplantation

(2016) Alicia Del Toro-Arreola et al.   Organogenesis

Blockade of CD40-CD154 Costimulatory Pathway Promotes Long-Term Survival of Full-Thickness Porcine Corneal Grafts in Nonhuman Primates: Clinically Applicable Xenocorneal Transplantation

(2015) H. J. Choi et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Endothelial cell control of thrombosis

(2015) Jonathan W. Yau et al.   BMC Cardiovascular Disorders

Pig BMSCs Transfected with Human TFPI Combat Species Incompatibility and Regulate the Human TF Pathway in Vitro and in a Rodent Model

(2015) Hongchen Ji et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

The role of genetically engineered pigs in xenotransplantation research

(2015) David KC Cooper et al.   JOURNAL OF PATHOLOGY

Pig kidney graft survival in a baboon for 136 days: longest life-supporting organ graft survival to date

(2015) Hayato Iwase et al.   XENOTRANSPLANTATION

Pre-transplant antibody screening and anti-CD154 costimulation blockade promote long-term xenograft survival in a pig-to-primate kidney transplant model

(2015) Laura Higginbotham et al.   XENOTRANSPLANTATION

Current status of pig kidney xenotransplantation

(2015) Hayato Iwase et al.   International Journal of Surgery

Species-specific regulation of fibrinogen synthesis with implications for porcine hepatocyte xenotransplantation

(2014) Wolf Ramackers et al.   XENOTRANSPLANTATION

One-Year Heterotopic Cardiac Xenograft Survival in a Pig to Baboon Model

(2013) M. M. Mohiuddin et al.   AMERICAN JOURNAL OF TRANSPLANTATION

The Interaction Between Signal Regulatory Protein Alpha (SIRPα) and CD47: Structure, Function, and Therapeutic Target

(2013) A. Neil Barclay et al.   Annual Review of Immunology

Clinical Islet Xenotransplantation: How Close Are We?

(2012) D. J. van der Windt et al.   DIABETES

Potential factors influencing the development of thrombocytopenia and consumptive coagulopathy after genetically modified pig liver xenotransplantation

(2012) Burcin Ekser et al.   TRANSPLANT INTERNATIONAL

Human T-cell proliferation in response to thrombin-activated GTKO pig endothelial cells

(2012) Corin Ezzelarab et al.   XENOTRANSPLANTATION

Controlling coagulation dysregulation in xenotransplantation

(2011) Peter J Cowan et al.   Current Opinion in Organ Transplantation

Clinical xenotransplantation: the next medical revolution?

(2011) Burcin Ekser et al.   LANCET

Genetic modifications of pigs for medicine and agriculture

(2011) Jeffrey J. Whyte et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Changes in cardiac gene expression after pig-to-primate orthotopic xenotransplantation

(2011) Guerard W. Byrne et al.   XENOTRANSPLANTATION

Atorvastatin or transgenic expression of TFPI inhibits coagulation initiated by anti-nonGal IgG binding to porcine aortic endothelial cells

(2010) C. C. LIN et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Renal and Cardiac Endothelial Heterogeneity Impact Acute Vascular Rejection in Pig-to-Baboon Xenotransplantation

(2009) C. Knosalla et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Organ Shortage Crisis: Problems and Possible Solutions

(2008) G.M. Abouna   TRANSPLANTATION PROCEEDINGS