Transplanting organs from pigs to humans

Infectious disease risks in xenotransplantation

(2018) Jay A. Fishman   AMERICAN JOURNAL OF TRANSPLANTATION

Seven Years of Experiences of Preclinical Experiments of Xeno-Heart Transplantation of Pig to Non-Human Primate (Cynomolgus Monkey)

(2018) S.J. Lee et al.   TRANSPLANTATION PROCEEDINGS

IXA Honorary Member Lecture, 2017: The long and winding road to tolerance

(2018) Megan Sykes   XENOTRANSPLANTATION

Donor-derived infections and infectious risk in xenotransplantation and allotransplantation

(2018) Anoma Nellore et al.   XENOTRANSPLANTATION

Xenoantigen Deletion and Chemical Immunosuppression Can Prolong Renal Xenograft Survival

(2018) Andrew B. Adams et al.   ANNALS OF SURGERY

Consistent success in life-supporting porcine cardiac xenotransplantation

(2018) Matthias Längin et al.   NATURE

Cardiac xenografts show reduced survival in the absence of transgenic human thrombomodulin expression in donor pigs

(2018) Avneesh K. Singh et al.   XENOTRANSPLANTATION

A Comparative Examination of the Clinical Outcome and Histological Appearance of Cryopreserved and Fresh Split-Thickness Skin Grafts

(2017) Paul W. Holzer et al.   Journal of Burn Care & Research

Unexpected mutations after CRISPR–Cas9 editing in vivo

(2017) Kellie A Schaefer et al.   NATURE METHODS

Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9

(2017) Dong Niu et al.   SCIENCE

Humoral Reactivity of Renal Transplant-Waitlisted Patients to Cells From GGTA1/CMAH/B4GalNT2, and SLA Class I Knockout Pigs

(2017) Gregory R. Martens et al.   TRANSPLANTATION

Regulation of Clinical Xenotransplantation—Time for a Reappraisal

(2017) David K.C. Cooper et al.   TRANSPLANTATION

Prolonged Survival of Pig Skin on Baboons After Administration of Pig Cells Expressing Human CD47

(2017) Aseda A. Tena et al.   TRANSPLANTATION

Selection of Patients for Initial Clinical Trials of Solid Organ Xenotransplantation

(2017) David K.C. Cooper et al.   TRANSPLANTATION

Release of pig leukocytes and reduced human NK cell recruitment during ex vivo perfusion of HLA-E/human CD46 double-transgenic pig limbs with human blood

(2017) Gisella Puga Yung et al.   XENOTRANSPLANTATION

Targeted insertion of an anti-CD2 monoclonal antibody transgene into the GGTA1 locus in pigs using FokI-dCas9

(2017) Mark B. Nottle et al.   Scientific Reports

Impact of Mixed Xenogeneic Porcine Hematopoietic Chimerism on Human NK Cell Recognition in a Humanized Mouse Model

(2016) H. W. Li et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Persistence of Indirect but Not Direct T Cell Xenoresponses in Baboon Recipients of Pig Cell and Organ Transplants

(2016) L. Buhler et al.   AMERICAN JOURNAL OF TRANSPLANTATION

The Effects of Exogenous Administration of Human Coagulation Factors Following Pig-to-Baboon Liver Xenotransplantation

(2016) N. Navarro-Alvarez et al.   AMERICAN JOURNAL OF TRANSPLANTATION

A Bridge to Somewhere

(2016) Jigesh A. Shah et al.   ANNALS OF SURGERY

Ubiquitous LEA29Y Expression Blocks T Cell Co-Stimulation but Permits Sexual Reproduction in Genetically Modified Pigs

(2016) Andrea Bähr et al.   PLoS One

The production of multi-transgenic pigs: update and perspectives for xenotransplantation

(2016) Heiner Niemann et al.   TRANSGENIC RESEARCH

Executive Summary of IPITA-TTS Opinion Leaders Report on the Future of β-Cell Replacement

(2016) James F. Markmann et al.   TRANSPLANTATION

First update of the International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes-Executive summary

(2016) Bernhard J. Hering et al.   XENOTRANSPLANTATION

Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft

(2016) Muhammad M. Mohiuddin et al.   Nature Communications

Efficient production of multi-modified pigs for xenotransplantation by ‘combineering’, gene stacking and gene editing

(2016) Konrad Fischer et al.   Scientific Reports

High Incidence of Xenogenic Bone Marrow Engraftment in Pig-to-Baboon Intra-Bone Bone Marrow Transplantation

(2015) M. Tasaki et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Genome-wide inactivation of porcine endogenous retroviruses (PERVs)

(2015) L. Yang et al.   SCIENCE

Pig kidney graft survival in a baboon for 136 days: longest life-supporting organ graft survival to date

(2015) Hayato Iwase et al.   XENOTRANSPLANTATION

Pre-transplant antibody screening and anti-CD154 costimulation blockade promote long-term xenograft survival in a pig-to-primate kidney transplant model

(2015) Laura Higginbotham et al.   XENOTRANSPLANTATION

Evaluation of human and non-human primate antibody binding to pig cells lacking GGTA1/CMAH/β4GalNT2 genes

(2015) Jose L. Estrada et al.   XENOTRANSPLANTATION

Pig-to-Monkey Islet Xenotransplantation Using Multi-Transgenic Pigs

(2014) R. Bottino et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Reduced Binding of Human Antibodies to Cells From GGTA1/CMAH KO Pigs

(2014) C. Burlak et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Development and Applications of CRISPR-Cas9 for Genome Engineering

(2014) Patrick D. Hsu et al.   CELL

Xenotransplantation: immunological hurdles and progress toward tolerance

(2014) Adam Griesemer et al.   IMMUNOLOGICAL REVIEWS

Xenograft Tolerance and Immune Function of Human T Cells Developing in Pig Thymus Xenografts

(2014) H. Kalscheuer et al.   JOURNAL OF IMMUNOLOGY

Rituximab Treatment Prevents the Early Development of Proteinuria following Pig-to-Baboon Xeno-Kidney Transplantation

(2014) M. Tasaki et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

hCTLA4-Ig transgene expression in keratocytes modulates rejection of corneal xenografts in a pig to non-human primate anterior lamellar keratoplasty model

(2014) Bertrand Vabres et al.   XENOTRANSPLANTATION

Double knockout pigs deficient in N-glycolylneuraminic acid and Galactose α-1,3-Galactose reduce the humoral barrier to xenotransplantation

(2013) Andrew J. Lutz et al.   XENOTRANSPLANTATION

Innate cellular immunity and xenotransplantation

(2012) Hui Wang et al.   Current Opinion in Organ Transplantation

Xenografted Islet Cell Clusters From INSLEA29Y Transgenic Pigs Rescue Diabetes and Prevent Immune Rejection in Humanized Mice

(2012) N. Klymiuk et al.   DIABETES

Improvement in Outcomes of Clinical Islet Transplantation: 1999-2010

(2012) F. B. Barton et al.   DIABETES CARE

Heme Oxygenase, Inflammation, and Fibrosis: The Good, the Bad, and the Ugly?

(2012) Ditte M. S. Lundvig et al.   Frontiers in Pharmacology

Multiplex high resolution melting assay for estimation of Porcine Endogenous Retrovirus (PERV) relative gene dosage in pigs and detection of PERV infection in xenograft recipients

(2011) Shaun Wynyard et al.   JOURNAL OF VIROLOGICAL METHODS

Species incompatibilities in the pig-to-macaque islet xenotransplant model affect transplant outcome: a comparison with allotransplantation

(2011) Melanie L. Graham et al.   XENOTRANSPLANTATION

Identification of New Carbohydrate and Membrane Protein Antigens in Cardiac Xenotransplantation

(2010) Guerard W. Byrne et al.   TRANSPLANTATION

The Epidemiology and Prevention of Donor-Derived Infections

(2009) Michael G. Ison   ADVANCES IN CHRONIC KIDNEY DISEASE

Results of Gal-Knockout Porcine Thymokidney Xenografts

(2009) A. D. Griesemer et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Pig-to-nonhuman primate islet xenotransplantation

(2009) Bernhard J. Hering et al.   TRANSPLANT IMMUNOLOGY

Hematopoietic Cell Transplantation for Tolerance Induction: Animal Models to Clinical Trials

(2009) Megan Sykes   TRANSPLANTATION

HLA-E/Human β2-Microglobulin Transgenic Pigs: Protection Against Xenogeneic Human Anti-Pig Natural Killer Cell Cytotoxicity

(2009) Elisabeth H. Weiss et al.   TRANSPLANTATION

Comparison of Human T Cell Repertoire Generated in Xenogeneic Porcine and Human Thymus Grafts

(2008) Ichiro Shimizu et al.   TRANSPLANTATION

Knockdown of porcine endogenous retrovirus (PERV) expression by PERV-specific shRNA in transgenic pigs

(2008) Britta Dieckhoff et al.   XENOTRANSPLANTATION