Controlling coagulation dysregulation in xenotransplantation

Thrombotic Microangiopathy After Kidney Transplantation

(2010) M. Noris et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Transgenic Overexpression of CD39 Protects Against Renal Ischemia-Reperfusion and Transplant Vascular Injury

(2010) S. Crikis et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Recipient Tissue Factor Expression Is Associated With Consumptive Coagulopathy in Pig-to-Primate Kidney Xenotransplantation

(2010) C. C. Lin et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Antiinflammatory and Anticoagulant Effects of Transgenic Expression of Human Thrombomodulin in Mice

(2010) S. Crikis et al.   AMERICAN JOURNAL OF TRANSPLANTATION

The Kunitz-3 domain of TFPI-  is required for protein S-dependent enhancement of factor Xa inhibition

(2010) M. Ndonwi et al.   BLOOD

Transgenic pigs for xenotransplantation: selection of promoter sequences for reliable transgene expression

(2010) Bernhard Aigner et al.   Current Opinion in Organ Transplantation

Coagulation, platelet activation and thrombosis in xenotransplantation

(2010) Moritz Schmelzle et al.   Current Opinion in Organ Transplantation

Overcoming the barriers to xenotransplantation: prospects for the future

(2010) Burcin Ekser et al.   Expert Review of Clinical Immunology

Atorvastatin or transgenic expression of TFPI inhibits coagulation initiated by anti-nonGal IgG binding to porcine aortic endothelial cells

(2010) C. C. LIN et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Complement: a key system for immune surveillance and homeostasis

(2010) Daniel Ricklin et al.   NATURE IMMUNOLOGY

Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases

(2010) Steffen Massberg et al.   NATURE MEDICINE

Reference values for thromboelastometry (ROTEM®) in cynomolgus monkeys (Macaca fascicularis)

(2010) Luca Spiezia et al.   THROMBOSIS RESEARCH

Potential value of human thrombomodulin and DAF expression for coagulation control in pig-to-human xenotransplantation

(2010) Yuko Miwa et al.   XENOTRANSPLANTATION

First experience with heterotopic thoracic pig-to-baboon cardiac xenotransplantation

(2010) Andreas Bauer et al.   XENOTRANSPLANTATION

The fate of human platelets perfused through the pig liver: implications for xenotransplantation

(2010) Christopher Burlak et al.   XENOTRANSPLANTATION

Results of Gal-Knockout Porcine Thymokidney Xenografts

(2009) A. D. Griesemer et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Thrombomodulin Improves Early Outcomes After Intraportal Islet Transplantation

(2009) W Cui et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Endoscopic Gastric Submucosal Transplantation of Islets (ENDO-STI): Technique and Initial Results in Diabetic Pigs

(2009) G. J. Echeverri et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Long-Term Controlled Normoglycemia in Diabetic Non-Human Primates After Transplantation with hCD46 Transgenic Porcine Islets

(2009) D. J. van der Windt et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Renal and Cardiac Endothelial Heterogeneity Impact Acute Vascular Rejection in Pig-to-Baboon Xenotransplantation

(2009) C. Knosalla et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Impact of Thrombocytopenia on Survival of Baboons with Genetically Modified Pig Liver Transplants: Clinical Relevance

(2009) B. Ekser et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Role of tissue factor in a mouse model of thrombotic microangiopathy induced by antiphospholipid antibodies

(2009) S. V. Seshan et al.   BLOOD

The protein C pathway in tissue inflammation and injury: pathogenic role and therapeutic implications

(2009) S. Danese et al.   BLOOD

Coagulation and innate immune responses: can we view them separately?

(2009) M. Delvaeye et al.   BLOOD

Platelet Polyphosphates Are Proinflammatory and Procoagulant Mediators In Vivo

(2009) Felicitas Müller et al.   CELL

Recombinant human soluble thrombomodulin decreases the plasma high-mobility group box-1 protein levels, whereas improving the acute liver injury and survival rates in experimental endotoxemia

(2009) Masaru Nagato et al.   CRITICAL CARE MEDICINE

Pig islets for clinical islet xenotransplantation

(2009) Denis Dufrane et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Regulation of endothelial protein C receptor shedding by cytokines is mediated through differential activation of MAP kinase signaling pathways

(2009) Mario Menschikowski et al.   EXPERIMENTAL CELL RESEARCH

Complement activation and coagulation in xenotransplantation

(2009) Peter J Cowan et al.   IMMUNOLOGY AND CELL BIOLOGY

Soluble Thrombomodulin Protects Ischemic Kidneys

(2009) A. A. Sharfuddin et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Extracellular histones are major mediators of death in sepsis

(2009) Jun Xu et al.   NATURE MEDICINE

The Innate Immune Response and Activation of Coagulation in α1,3-Galactosyltransferase Gene-Knockout Xenograft Recipients

(2009) Mohamed Ezzelarab et al.   TRANSPLANTATION

Long-Term Metabolic Control of Autoimmune Diabetes in Spontaneously Diabetic Nonobese Diabetic Mice by Nonvascularized Microencapsulated Adult Porcine Islets

(2009) Hong Cui et al.   TRANSPLANTATION

Current status of xenotransplantation and prospects for clinical application

(2009) Richard N. Pierson et al.   XENOTRANSPLANTATION

Thrombotic Microangiopathy Associated with Humoral Rejection of Cardiac Xenografts from α1,3-Galactosyltransferase Gene-Knockout Pigs in Baboons

(2008) Akira Shimizu et al.   AMERICAN JOURNAL OF PATHOLOGY

Long-Term Survival of Nonhuman Primate Islets Implanted in an Omental Pouch on a Biodegradable Scaffold

(2008) D. M. Berman et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Pig Thrombomodulin Binds Human Thrombin but Is a Poor Cofactor for Activation of Human Protein C and TAFI

(2008) J. C. Roussel et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Advances in understanding pathogenic mechanisms of thrombophilic disorders

(2008) B. Dahlback   BLOOD

The Choice of Anatomical Site for Islet Transplantation

(2008) Dirk J. Van Der Windt et al.   CELL TRANSPLANTATION

Evidence for non-traditional activation of complement factor C3 during murine liver regeneration

(2008) Amelia Clark et al.   MOLECULAR IMMUNOLOGY

Triggers, targets and treatments for thrombosis

(2008) Nigel Mackman   NATURE

Mechanisms of Thrombus Formation

(2008) Bruce Furie et al.   NEW ENGLAND JOURNAL OF MEDICINE

Coagulation dysregulation as a barrier to xenotransplantation in the primate

(2008) Chih Che Lin et al.   TRANSPLANT IMMUNOLOGY

Expression of Tissue Factor and Initiation of Clotting by Human Platelets and Monocytes After Incubation With Porcine Endothelial Cells

(2008) Chih Che Lin et al.   TRANSPLANTATION

Recombinant pig TFPI efficiently regulates human tissue factor pathways

(2008) K. F. Eddy Lee et al.   XENOTRANSPLANTATION

Effects of pharmacological intervention on coagulopathy and organ function in xenoperfused kidneys

(2008) Wolf Ramackers et al.   XENOTRANSPLANTATION