Attenuation of Nrf2/Keap1/ARE in Alzheimer’s Disease by Plant Secondary Metabolites: A Mechanistic Review

Multitarget Profiling of a Strigolactone Analogue for Early Events of Alzheimer’s Disease: In Vitro Therapeutic Activities against Neuroinflammation

(2020) Begum Kurt et al.   ACS Chemical Neuroscience

NRF2 as a Therapeutic Target in Neurodegenerative Diseases

(2020) Mikah S. Brandes et al.   ASN Neuro

Combining antioxidant astaxantin and cholinesterase inhibitor huperzine A boosts neuroprotection

(2020) Xin Yang et al.   Molecular Medicine Reports

Synergic Effects of Berberine and Curcumin on Improving Cognitive Function in an Alzheimer’s Disease Mouse Model

(2020) Lin Lin et al.   NEUROCHEMICAL RESEARCH

Protective effects of lycopene in cancer, cardiovascular, and neurodegenerative diseases: An update on epidemiological and mechanistic perspectives

(2020) Ramesh Kumar Saini et al.   PHARMACOLOGICAL RESEARCH

Modulation of dysregulated cancer metabolism by plant secondary metabolites: A mechanistic review

(2020) Sajad Fakhri et al.   SEMINARS IN CANCER BIOLOGY

Neuroprotective Effect of Resveratrol via Activation of Sirt1 Signaling in a Rat Model of Combined Diabetes and Alzheimer’s Disease

(2020) XingRong Ma et al.   Frontiers in Neuroscience

Modulation of Keap1/Nrf2/ARE Signaling Pathway by Curcuma- and Garlic-Derived Hybrids

(2020) Melania Maria Serafini et al.   Frontiers in Pharmacology

Carotenoid research: History and new perspectives for chemistry in biological systems

(2020) George Britton   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Corydalis edulis total alkaloids (CETA) ameliorates cognitive dysfunction in rat model of Alzheimer disease through regulation of the antioxidant stress and MAP2/NF-κB

(2020) Shuai Liang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Intake of Alpha-Linolenic Acid-Rich Perilla frutescens Leaf Powder Decreases Home Blood Pressure and Serum Oxidized Low-Density Lipoprotein in Japanese Adults

(2020) Michio Hashimoto et al.   MOLECULES

Nanoformulations of Herbal Extracts in Treatment of Neurodegenerative Disorders

(2020) Seyed Zachariah Moradi et al.   Frontiers in Bioengineering and Biotechnology

HJ22, a Novel derivative of piperine, Attenuates ibotenic acid-induced cognitive impairment, oxidativestress, apoptosis and inflammation via inhibiting the protein-protein interaction of Keap1-Nrf2

(2020) Xiping Yang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Targeting apoptosis and autophagy following spinal cord injury: Therapeutic approaches to polyphenols and candidate phytochemicals

(2020) Fatemeh Abbaszadeh et al.   PHARMACOLOGICAL RESEARCH

Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases

(2019) Antonio Cuadrado et al.   NATURE REVIEWS DRUG DISCOVERY

Therapeutic Approaches to Alzheimer’s Disease Through Modulation of NRF2

(2019) Gahee Bahn et al.   NEUROMOLECULAR MEDICINE

Levocarnitine Improves AlCl3-Induced Spatial Working Memory Impairment in Swiss albino Mice

(2019) Md. Mamun Al-Amin et al.   Frontiers in Neuroscience

Crocin-protected malathion-induced spatial memory deficits by inhibiting TAU protein hyperphosphorylation and antiapoptotic effects

(2019) Leila Mohammadzadeh et al.   NUTRITIONAL NEUROSCIENCE

Astaxanthin Ameliorates Lipopolysaccharide-Induced Neuroinflammation, Oxidative Stress and Memory Dysfunction through Inactivation of the Signal Transducer and Activator of Transcription 3 Pathway

(2019) Ji Han et al.   Marine Drugs

p-Hydroxybenzyl Alcohol Prevents Memory Deficits by Increasing Neurotrophic Factors and Decreasing Inflammatory Factors in a Mice Model of Alzheimer’s Disease

(2019) Yanfei Ding et al.   JOURNAL OF ALZHEIMERS DISEASE

Curcumin analogues attenuate Aβ25-35-induced oxidative stress in PC12 cells via Keap1/Nrf2/HO-1 signaling pathways

(2019) Jialin Xu et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Non-conventional compounds with potential therapeutic effects against Alzheimer’s disease

(2019) Alexandre A. de Castro et al.   Expert Review of Neurotherapeutics

Natural Compounds for Alzheimer’s Disease Therapy: A Systematic Review of Preclinical and Clinical Studies

(2019) Stephanie Andrade et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gedunin Inhibits Oligomeric Aβ1–42-Induced Microglia Activation Via Modulation of Nrf2-NF-κB Signaling

(2019) Sara Tom et al.   MOLECULAR NEUROBIOLOGY

Neuroprotective Effect of Natural Alkaloid Fangchinoline Against Oxidative Glutamate Toxicity: Involvement of Keap1-Nrf2 Axis Regulation

(2019) Fengxia Bao et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Activation of Nrf2 signaling by sitagliptin and quercetin combination against β‐amyloid induced Alzheimer's disease in rats

(2019) Yuping Li et al.   DRUG DEVELOPMENT RESEARCH

Perspectives of medicinally privileged chalcone based metal coordination compounds for biomedical applications

(2019) Debarshi Kar Mahapatra et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Inonotus obliquus polysaccharides protect against Alzheimer's disease by regulating Nrf2 signaling and exerting antioxidative and antiapoptotic effects

(2019) Yanqiu Han et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Neuroprotective Potential of Curcumin-Loaded Nanostructured Lipid Carrier in an Animal Model of Alzheimer’s Disease: Behavioral and Biochemical Evidence

(2019) Soroor Sadegh Malvajerd et al.   JOURNAL OF ALZHEIMERS DISEASE

The Neuroprotective Effects of Astaxanthin: Therapeutic Targets and Clinical Perspective

(2019) Fakhri et al.   MOLECULES

Ginsenoside Re Inhibits ROS/ASK-1 Dependent Mitochondrial Apoptosis Pathway and Activation of Nrf2-Antioxidant Response in Beta-Amyloid-Challenged SH-SY5Y Cells

(2019) Meichen Liu et al.   MOLECULES

Shaping the Nrf2-ARE-related pathways in Alzheimer’s and Parkinson’s diseases

(2019) Lígia Fão et al.   AGEING RESEARCH REVIEWS

Pharmacological properties and derivatives of shikonin—A review in recent years

(2019) Chuanjie Guo et al.   PHARMACOLOGICAL RESEARCH

β-Carotene: A Natural Compound Improves Cognitive Impairment and Oxidative Stress in a Mouse Model of Streptozotocin-Induced Alzheimer’s Disease

(2019) Sundas Hira et al.   Biomolecules

Protective Effect of Green Perilla-Derived Chalcone Derivative DDC on Amyloid β Protein-Induced Neurotoxicity in Primary Cortical Neurons

(2019) Mami Iwasaki et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Norcepharadione B attenuates H2O2-induced neuronal injury by upregulating cellular antioxidants and inhibiting volume-sensitive Cl− channel

(2019) Xin Jia et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Effects of Astaxanthin from Shrimp Shell on Oxidative Stress and Behavior in Animal Model of Alzheimer’s Disease

(2019) Takunrat Taksima et al.   Marine Drugs

Artemether Activation of AMPK/GSK3β(ser9)/Nrf2 Signaling Confers Neuroprotection towards β-Amyloid-Induced Neurotoxicity in 3xTg Alzheimer’s Mouse Model

(2019) Shuai Li et al.   Oxidative Medicine and Cellular Longevity

Ameliorative effect of deoxyvasicine on scopolamine-induced cognitive dysfunction by restoration of cholinergic function in mice

(2019) Gang Deng et al.   PHYTOMEDICINE

Emerging promise of sulforaphane-mediated Nrf2 signaling cascade against neurological disorders

(2019) Md. Sahab Uddin et al.   SCIENCE OF THE TOTAL ENVIRONMENT

The Biological Activity of Natural Alkaloids against Herbivores, Cancerous Cells and Pathogens

(2019) Amin Thawabteh et al.   Toxins

7-O-Esters of taxifolin with pronounced and overadditive effects in neuroprotection, anti-neuroinflammation, and amelioration of short-term memory impairment in vivo

(2019) Sandra Gunesch et al.   Redox Biology

α-Tocopherol Modulates Non-Amyloidogenic Pathway and Autophagy in an In Vitro Model of Alzheimer’s Disease: A Transcriptional Study

(2019) Agnese Gugliandolo et al.   Brain Sciences

A novel chalcone derivative as Nrf2 activator attenuates learning and memory impairment in a scopolamine-induced mouse model

(2019) Hyeon Jeong Kim et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Nootropic effect of neferine on aluminium chloride–induced Alzheimer's disease in experimental models

(2019) Shuaizeng Yin et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Antioxidative and antiapoptosis: Neuroprotective effects of dauricine in Alzheimer's disease models

(2019) Lingfeng Wang et al.   LIFE SCIENCES

Future Therapeutic Perspectives into the Alzheimer’s Disease Targeting the Oxidative Stress Hypothesis

(2019) Jéssika P. Teixeira et al.   MOLECULES

FA-97, a New Synthetic Caffeic Acid Phenethyl Ester Derivative, Protects against Oxidative Stress-Mediated Neuronal Cell Apoptosis and Scopolamine-Induced Cognitive Impairment by Activating Nrf2/HO-1 Signaling

(2019) Ting Wan et al.   Oxidative Medicine and Cellular Longevity

Pharmacological activation of the Nrf2 pathway by 3H-1, 2-dithiole-3-thione is neuroprotective in a mouse model of Alzheimer disease

(2018) YuanBo Cui et al.   BEHAVIOURAL BRAIN RESEARCH

Plumbagin ameliorates memory dysfunction in streptozotocin induced Alzheimer’s disease via activation of Nrf2/ARE pathway and inhibition of β-secretase

(2018) Kartik T. Nakhate et al.   BIOMEDICINE & PHARMACOTHERAPY

Curcumin provides neuroprotection in model of traumatic brain injury via the Nrf2-ARE signaling pathway

(2018) Wei Dai et al.   BRAIN RESEARCH BULLETIN

20(S)-protopanaxadiol (PPD) alleviates scopolamine-induced memory impairment via regulation of cholinergic and antioxidant systems, and expression of Egr-1, c-Fos and c-Jun in mice

(2018) Cong Lu et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Epigenetic modification of Nrf2 by sulforaphane increases the antioxidative and anti-inflammatory capacity in a cellular model of Alzheimer's disease

(2018) Fangfang Zhao et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Protective Effects of 6-(Methylsulfinyl)hexyl Isothiocyanate on Aβ1-42-Induced Cognitive Deficit, Oxidative Stress, Inflammation, and Apoptosis in Mice

(2018) Fabiana Morroni et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Schisanhenol improves learning and memory in scopolamine-treated mice by reducing acetylcholinesterase activity and attenuating oxidative damage through SIRT1-PGC-1α-Tau signaling pathway

(2018) Yunfeng Han et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Neuroprotective Effect of Alpha-Linolenic Acid against Aβ-Mediated Inflammatory Responses in C6 Glial Cell

(2018) Ah Young Lee et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Supplemental Retinal Carotenoids Enhance Memory in Healthy Individuals with Low Levels of Macular Pigment in A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

(2018) Rebecca Power et al.   JOURNAL OF ALZHEIMERS DISEASE

Supplementation of lycopene attenuates lipopolysaccharide-induced amyloidogenesis and cognitive impairments via mediating neuroinflammation and oxidative stress

(2018) Jia Wang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Protective Effects of Sulforaphane on Cognitive Impairments and AD-like Lesions in Diabetic Mice are Associated with the Upregulation of Nrf2 Transcription Activity

(2018) Die Pu et al.   NEUROSCIENCE

Transcription Factor NRF2 as a Therapeutic Target for Chronic Diseases: A Systems Medicine Approach

(2018) Antonio Cuadrado et al.   PHARMACOLOGICAL REVIEWS

Neuroprotective effects of 20(S)-protopanaxatriol (PPT) on scopolamine-induced cognitive deficits in mice

(2018) Cong Lu et al.   PHYTOTHERAPY RESEARCH

Astaxanthin prevents the methotrexate-induced reproductive toxicity by targeting oxidative stress in male mice

(2018) Heidar Heidari Khoei et al.   Toxin Reviews

α-Cyperone inhibits LPS-induced inflammation in BV-2 cells through activation of Akt/Nrf2/HO-1 and suppression of the NF-κB pathway

(2018) Bingxu Huang et al.   Food & Function

Shikonin Protects PC12 Cells Against β-amyloid Peptide-Induced Cell Injury Through Antioxidant and Antiapoptotic Activities

(2018) Yuna Tong et al.   Scientific Reports

Strigolactone Levels in Dicot Roots Are Determined by an Ancestral Symbiosis-Regulated Clade of the PHYTOENE SYNTHASE Gene Family

(2018) Ron Stauder et al.   Frontiers in Plant Science

Analogous β-Carboline Alkaloids Harmaline and Harmine Ameliorate Scopolamine-Induced Cognition Dysfunction by Attenuating Acetylcholinesterase Activity, Oxidative Stress, and Inflammation in Mice

(2018) Shu-Ping Li et al.   Frontiers in Pharmacology

Amelioration of Cognitive Deficit by Embelin in a Scopolamine-Induced Alzheimer’s Disease-Like Condition in a Rat Model

(2018) Saatheeyavaane Bhuvanendran et al.   Frontiers in Pharmacology

Neuroprotection against 6-OHDA toxicity in PC12 cells and mice through the Nrf2 pathway by a sesquiterpenoid from Tussilago farfara

(2018) Joohee Lee et al.   Redox Biology

The signaling pathways underlying BDNF-induced Nrf2 hippocampal nuclear translocation involve ROS, RyR-Mediated Ca2+ signals, ERK and PI3K

(2018) Bárbara Bruna et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Neuro-protective effects of aloperine in an Alzheimer’s disease cellular model

(2018) Jing Zhao et al.   BIOMEDICINE & PHARMACOTHERAPY

Astaxanthin attenuates neuroinflammation contributed to the neuropathic pain and motor dysfunction following compression spinal cord injury

(2018) Sajad Fakhri et al.   BRAIN RESEARCH BULLETIN

Sulfur-containing secondary metabolites as neuroprotective agents

(2018) Alessandro Venditti et al.   CURRENT MEDICINAL CHEMISTRY

Andrographolide Protects PC12 Cells Against β-Amyloid-Induced Autophagy-Associated Cell Death Through Activation of the Nrf2-Mediated p62 Signaling Pathway

(2018) Lili Gu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neuroprotective and Neurorescue Effects of a Novel Polymeric Nanoparticle Formulation of Curcumin (NanoCurc™) in the Neuronal Cell Culture and Animal Model: Implications for Alzheimer's disease

(2018) Balmiki Ray et al.   JOURNAL OF ALZHEIMERS DISEASE

Astaxanthin: A mechanistic review on its biological activities and health benefits

(2018) Sajad Fakhri et al.   PHARMACOLOGICAL RESEARCH

Neuroprotective Effect of Caffeic Acid Phenethyl Ester in A Mouse Model of Alzheimer’s Disease Involves Nrf2/HO-1 Pathway

(2018) Fabiana Morroni et al.   Aging and Disease

Crosstalk of toll-like receptors signaling and Nrf2 pathway for regulation of inflammation

(2018) Shikha Mohan et al.   BIOMEDICINE & PHARMACOTHERAPY

Farrerol attenuates β-amyloid-induced oxidative stress and inflammation through Nrf2/Keap1 pathway in a microglia cell line

(2018) Bei Cui et al.   BIOMEDICINE & PHARMACOTHERAPY

Effects of astaxanthin on sensory‐motor function in a compression model of spinal cord injury: Involvement of ERK and AKT signalling pathway

(2018) Sajad Fakhri et al.   EUROPEAN JOURNAL OF PAIN

Protective roles of Amanita caesarea polysaccharides against Alzheimer's disease via Nrf2 pathway

(2018) Zhiping Li et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Investigation of the neuroprotective effects of crocin via antioxidant activities in HT22 cells and in mice with Alzheimer's disease

(2018) Chunyue Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Ginsenoside Compound K Regulates Amyloid β via the Nrf2/Keap1 Signaling Pathway in Mice with Scopolamine Hydrobromide-Induced Memory Impairments

(2018) Qing Yang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Neuroprotective effects of matrine on scopolamine-induced amnesia via inhibition of AChE/BuChE and oxidative stress

(2018) Kaiyue Sun et al.   METABOLIC BRAIN DISEASE

Trigonelline protects hippocampus against intracerebral Aβ(1–40) as a model of Alzheimer’s disease in the rat: insights into underlying mechanisms

(2018) Javad Fahanik-Babaei et al.   METABOLIC BRAIN DISEASE

Berberine ameliorates lipopolysaccharide-induced learning and memory deficit in the rat: insights into underlying molecular mechanisms

(2018) Sepideh Sadraie et al.   METABOLIC BRAIN DISEASE

Several targets involved in Alzheimer’s disease amyloidogenesis are affected by morin and isoquercitrin

(2018) Vanesa Carmona et al.   NUTRITIONAL NEUROSCIENCE

Neuroprotective effects of berberine on recognition memory impairment, oxidative stress, and damage to the purinergic system in rats submitted to intracerebroventricular injection of streptozotocin

(2018) Juliana Sorraila de Oliveira et al.   PSYCHOPHARMACOLOGY

Synthesis and evaluation of isoprenylation-resveratrol dimer derivatives against Alzheimer's disease

(2018) Yan-Wei Tang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Astaxanthin ameliorates scopolamine-induced spatial memory deficit via reduced cortical-striato-hippocampal oxidative stress

(2018) Md. Mamun Al-Amin et al.   BRAIN RESEARCH

The Protective Effect of Lavender Essential Oil and Its Main Component Linalool against the Cognitive Deficits Induced by D-Galactose and Aluminum Trichloride in Mice

(2017) Pan Xu et al.   Evidence-based Complementary and Alternative Medicine

Examining the impact of grape consumption on brain metabolism and cognitive function in patients with mild decline in cognition: A double-blinded placebo controlled pilot study

(2017) Jooyeon Lee et al.   EXPERIMENTAL GERONTOLOGY

Petasites japonicus bakkenolide B inhibits lipopolysaccharide‑induced pro‑inflammatory cytokines via AMPK/Nrf2 induction in microglia

(2017) Sun Park et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Protective effect of naringin against the LPS-induced apoptosis of PC12 cells: Implications for the treatment of neurodegenerative disorders

(2017) Hui Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Naringenin reduces oxidative stress and improves mitochondrial dysfunction via activation of the Nrf2/ARE signaling pathway in neurons

(2017) Kaihua Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Can Co-Activation of Nrf2 and Neurotrophic Signaling Pathway Slow Alzheimer’s Disease?

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Quercetin Attenuates Manganese-Induced Neuroinflammation by Alleviating Oxidative Stress through Regulation of Apoptosis, iNOS/NF-κB and HO-1/Nrf2 Pathways

(2017) Entaz Bahar et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dietary Lycopene Supplementation Improves Cognitive Performances in Tau Transgenic Mice Expressing P301L Mutation via Inhibiting Oxidative Stress and Tau Hyperphosphorylation

(2017) Lixia Yu et al.   JOURNAL OF ALZHEIMERS DISEASE

Andrographolide Activates Keap1/Nrf2/ARE/HO-1 Pathway in HT22 Cells and Suppresses Microglial Activation by Aβ42 through Nrf2-Related Inflammatory Response

(2017) Ji Yeon Seo et al.   MEDIATORS OF INFLAMMATION

Trigonelline insulates against oxidative stress, proinflammatory cytokines and restores BDNF levels in lipopolysaccharide induced cognitive impairment in adult mice

(2017) Amrita A. Chowdhury et al.   METABOLIC BRAIN DISEASE

Curcumin revitalizes Amyloid beta (25–35)-induced and organophosphate pesticides pestered neurotoxicity in SH-SY5Y and IMR-32 cells via activation of APE1 and Nrf2

(2017) Bibekananda Sarkar et al.   METABOLIC BRAIN DISEASE

The Neuroprotective Effects of Carvacrol on Ethanol-Induced Hippocampal Neurons Impairment via the Antioxidative and Antiapoptotic Pathways

(2017) Peng Wang et al.   Oxidative Medicine and Cellular Longevity

Vincamine alleviates amyloid-β 25-35 peptides-induced cytotoxicity in PC12 cells

(2017) Jianfeng Han et al.   Pharmacognosy Magazine

Lycium barbarum polysaccharide protects against neurotoxicity via the Nrf2‑HO‑1 pathway

(2017) Shumei Cao et al.   Experimental and Therapeutic Medicine

Carotenoids Database: structures, chemical fingerprints and distribution among organisms

(2017) Junko Yabuzaki   Database-The Journal of Biological Databases and Curation

PLGA nanoparticles modified with a BBB-penetrating peptide co-delivering Aβ generation inhibitor and curcumin attenuate memory deficits and neuropathology in Alzheimer’s disease mice

(2017) Na Huang et al.   Oncotarget

Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer’s disease

(2017) Fiona Kerr et al.   PLoS Genetics

Oral administration of methysticin improves cognitive deficits in a mouse model of Alzheimer's disease

(2017) Athanassios Fragoulis et al.   Redox Biology

Effects of a mixed berry beverage on cognitive functions and cardiometabolic risk markers; A randomized cross-over study in healthy older adults

(2017) Anne Nilsson et al.   PLoS One

Alpha-tocopherol quinine ameliorates spatial memory deficits by reducing beta-amyloid oligomers, neuroinflammation and oxidative stress in transgenic mice with Alzheimer's disease

(2016) Shao-wei Wang et al.   BEHAVIOURAL BRAIN RESEARCH

Melatonin Stimulates the SIRT1/Nrf2 Signaling Pathway Counteracting Lipopolysaccharide (LPS)-Induced Oxidative Stress to Rescue Postnatal Rat Brain

(2016) Shahid Ali Shah et al.   CNS Neuroscience & Therapeutics

Alkaloids Pharmacological Activities - Prospects for the Development of Phytopharmaceuticals for Neurodegenerative Diseases

(2016) Soane K.M. Chaves et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Quercetin phospholipid complex significantly protects against oxidative injury in ARPE-19 cells associated with activation of Nrf2 pathway

(2016) Xin-Rong Xu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

S-allyl-l-cysteine and isoliquiritigenin improve mitochondrial function in cellular models of oxidative and nitrosative stress

(2016) Isabel Denzer et al.   FOOD CHEMISTRY

Neuroprotective and Cognition-Enhancing Effects of Compound K Isolated from Red Ginseng

(2016) Ji Yeon Seo et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Inhibition of beta-amyloid-induced neurotoxicity by pinocembrin through Nrf2/HO-1 pathway in SH-SY5Y cells

(2016) Yumin Wang et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Simultaneous activation of Nrf2 and elevation of antioxidant compounds for reducing oxidative stress and chronic inflammation in human Alzheimer's disease

(2016) Kedar N. Prasad   MECHANISMS OF AGEING AND DEVELOPMENT

Thymol improves high-fat diet-induced cognitive deficits in mice via ameliorating brain insulin resistance and upregulating NRF2/HO-1 pathway

(2016) FangFang et al.   METABOLIC BRAIN DISEASE

Timosaponin B-II ameliorates scopolamine-induced cognition deficits by attenuating acetylcholinesterase activity and brain oxidative damage in mice

(2016) Xu Zhao et al.   METABOLIC BRAIN DISEASE

Allicin attenuates H2O2-induced cytotoxicity in retinal pigmented epithelial cells by regulating the levels of reactive oxygen species

(2016) GERILE TU et al.   Molecular Medicine Reports

Quercetin Exerts Differential Neuroprotective Effects Against H2O2 and Aβ Aggregates in Hippocampal Neurons: the Role of Mitochondria

(2016) Juan A. Godoy et al.   MOLECULAR NEUROBIOLOGY

Sulforaphane exerts its anti-inflammatory effect against amyloid-β peptide via STAT-1 dephosphorylation and activation of Nrf2/HO-1 cascade in human THP-1 macrophages

(2016) Ye Won An et al.   NEUROBIOLOGY OF AGING

Lactucopicrin ameliorates oxidative stress mediated by scopolamine-induced neurotoxicity through activation of the NRF2 pathway

(2016) Ramu Venkatesan et al.   NEUROCHEMISTRY INTERNATIONAL

Nrf2–ARE pathway: An emerging target against oxidative stress and neuroinflammation in neurodegenerative diseases

(2016) Izaskun Buendia et al.   PHARMACOLOGY & THERAPEUTICS

Nrf2 mitigates LRRK2- and α-synuclein–induced neurodegeneration by modulating proteostasis

(2016) Gaia Skibinski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vitro neuroprotective potential of the monoterpenes α-pinene and 1,8-cineole against H2O2-induced oxidative stress in PC12 cells

(2016) María Porres-Martínez et al.   ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES

Sulforaphane protects against rotenone-induced neurotoxicity in vivo: Involvement of the mTOR, Nrf2 and autophagy pathways

(2016) Qian Zhou et al.   Scientific Reports

Nrf2 regulates ROS production by mitochondria and NADPH oxidase

(2015) Stjepana Kovac et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Ginsenoside Rd attenuates Aβ25–35-induced oxidative stress and apoptosis in primary cultured hippocampal neurons

(2015) Juan-fang Liu et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Role for the PI3K/Akt/Nrf2 signaling pathway in the protective effects of carnosic acid against methylglyoxal-induced neurotoxicity in SH-SY5Y neuroblastoma cells

(2015) Marcos Roberto de Oliveira et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Allicin improves endoplasmic reticulum stress-related cognitive deficits via PERK/Nrf2 antioxidative signaling pathway

(2015) Yao-Feng Zhu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Naringenin improves learning and memory in an Alzheimer's disease rat model: Insights into the underlying mechanisms

(2015) Saeed Ghofrani et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Tetramethylpyrazine inhibits CoCl2-induced neurotoxicity through enhancement of Nrf2/GCLc/GSH and suppression of HIF1α/NOX2/ROS pathways

(2015) Dongsheng Guan et al.   JOURNAL OF NEUROCHEMISTRY

S-allyl cysteine activates the Nrf2-dependent antioxidant response and protects neurons against ischemic injuryin vitroandin vivo

(2015) Huanying Shi et al.   JOURNAL OF NEUROCHEMISTRY

Methyl jasmonate enhances memory performance through inhibition of oxidative stress and acetylcholinesterase activity in mice

(2015) Anthony T. Eduviere et al.   LIFE SCIENCES

An Overview of the Pharmacological Properties and Potential Applications of Natural Monoterpenes

(2015) Agata Koziol et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Neuroprotective efficacy of naringin on 3-nitropropionic acid-induced mitochondrial dysfunction through the modulation of Nrf2 signaling pathway in PC12 cells

(2015) Gopinath Kulasekaran et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Thiacremonone Potentiates Anti-Oxidant Effects to Improve Memory Dysfunction in an APP/PS1 Transgenic Mice Model

(2015) Hyung-Mun Yun et al.   MOLECULAR NEUROBIOLOGY

Neuroprotective effect of astaxanthin against glutamate-induced cytotoxicity in HT22 cells: Involvement of the Akt/GSK-3β pathway

(2015) X. Wen et al.   NEUROSCIENCE

Association of Neuroprotective Effect of Di-O-Demethylcurcumin on Aβ25–35-Induced Neurotoxicity with Suppression of NF-κB and Activation of Nrf2

(2015) Decha Pinkaew et al.   NEUROTOXICITY RESEARCH

Nootropic, neuroprotective and neurotrophic effects of phloretin in scopolamine induced amnesia in mice

(2015) Priya J. Ghumatkar et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Naringin mitigate okadaic acid-induced cognitive impairment in an experimental paradigm of Alzheimer's disease

(2015) Anand Kamal Sachdeva et al.   Journal of Functional Foods

Deaths in the United States among persons with Alzheimer's disease (2010–2050)

(2014) Jennifer Weuve et al.   Alzheimers & Dementia

Oxidative damage and the Nrf2-ARE pathway in neurodegenerative diseases

(2014) Li Gan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Protective effects of aloe-emodin on scopolamine-induced memory impairment in mice and H2O2-induced cytotoxicity in PC12 cells

(2014) Li Tao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Biological Activities of Plant Pigments Betalains

(2014) Fernando Gandía-Herrero et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

In vitroneuroprotective activity of sesquiterpenoids from the flower buds ofTussilago farfara

(2014) Hyo Jin Lim et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Berberine protects homocysteic acid-induced HT-22 cell death: involvement of Akt pathway

(2014) Meihui Chen et al.   METABOLIC BRAIN DISEASE

Is There a Correlation Between In Vitro Antioxidant Potential and In Vivo Effect of Carvacryl Acetate Against Oxidative Stress in Mice Hippocampus?

(2014) Lúcio Fernandes Pires et al.   NEUROCHEMICAL RESEARCH

Evaluation ofp-cymene, a natural antioxidant

(2014) Talita Mendes de Oliveira et al.   PHARMACEUTICAL BIOLOGY

Protective effects of ginsenoside Rg1 on chronic restraint stress induced learning and memory impairments in male mice

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Long-term naringin consumption reverses a glucose uptake defect and improves cognitive deficits in a mouse model of Alzheimer's disease

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S-allyl cysteine attenuates oxidative stress associated cognitive impairment and neurodegeneration in mouse model of streptozotocin-induced experimental dementia of Alzheimer's type

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After cellular internalization, quercetin causes Nrf2 nuclear translocation, increases glutathione levels, and prevents neuronal death against an oxidative insult

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Coadministration of huperzine A and ligustrazine phosphate effectively reverses scopolamine-induced amnesia in rats

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Sulforaphane as an inducer of glutathione prevents oxidative stress-induced cell death in a dopaminergic-like neuroblastoma cell line

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Sulforaphane protects immature hippocampal neurons against death caused by exposure to hemin or to oxygen and glucose deprivation

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Chitosan prevents oxidative stress-induced amyloid β formation and cytotoxicity in NT2 neurons: involvement of transcription factors Nrf2 and NF-κB

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Carnosic acid, acatechol-typeelectrophilic compound, protects neurons bothin vitroandin vivothrough activation of the Keap1/Nrf2 pathway viaS-alkylation of targeted cysteines on Keap1

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