Article
Agriculture, Multidisciplinary
Zhiming Zhu, Ziwen Xiong, Wenjin Zou, Zhiwen Shi, Shanying Li, Xinze Zhang, Shicheng Liu, Yi Liu, Xunguang Luo, Jie Ren, Zhenglin Zhu, Pan Dong
Summary: This study demonstrates the inhibitory effect of scopolamine on Phytophthora infestans, suggesting its potential as an eco-friendly option for controlling late blight in the future.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Biology
Garrett J. Blair, Changliang Guo, Shiyun Wang, Michael S. Fanselow, Peyman Golshani, Daniel Aharoni, Hugh T. Blair
Summary: This study found that place cells in the hippocampus of rats undergo remapping during the memory of aversive events, indicating that reorganization of hippocampal population codes may play a role in storing memories for aversive events.
Article
Nutrition & Dietetics
Ji-Hye Choi, Eun-Byeol Lee, Hwan-Hee Jang, Youn-Soo Cha, Yong-Soon Park, Sung-Hyen Lee
Summary: Allium hookeri (AH) is a medicinal food used in Southeast Asia with positive effects in relieving memory impairment induced by scopolamine, especially the root extracts. AH improves cognitive effects by enhancing the cholinergic system, inhibiting neuroinflammation, and providing neuroprotective effects.
Article
Chemistry, Multidisciplinary
Xinxin Pang, Li Mao, Danyang Ye, Wenqi Wang, Hongliu Yang, Xiaoxiao Fan, Yuping Yang, Zhijun Su, Tao Ma, Mingqian Sun, Yonggang Liu
Summary: In this study, 12 magnolol derivatives were obtained by structural modification, and one derivative M27 showed significantly superior anti-aging effect compared to the original compound. Further investigation revealed that M27 prolonged the lifespan of C. elegans through improving physiological parameters, stress resistance, and regulating the IIS pathway.
FRONTIERS IN CHEMISTRY
(2023)
Article
Agriculture, Multidisciplinary
Zhiqiang Lu, Xiaomeng Xu, Dongmei Li, Na Sun, Songyi Lin
Summary: The study found that SCP improved behavioral performance and regulated the disorder of the cholinergic system in mouse models in a dose-dependent manner. High-dose SCP repaired damaged neuronal cells, enhanced the Nissl body number, increased the unsaturated lipid level, and activated the long-term potentiation (LTP) pathway in both mouse and rat hippocampus.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Wei Qiao, Meng Zha, Yun Yang, Guangzhi Hu, Ligang Feng
Summary: The electron-deficient effect of Pd in the Pd17Se15 catalyst weakens the adsorption of CO poisoning species and enhances the electrocatalytic performance of alcohol electrooxidation in an alkaline medium.
CHEMICAL COMMUNICATIONS
(2022)
Article
Pharmacology & Pharmacy
K. Venkatesan
Summary: This study found that alpha-asarone isolated from Acorus calamus has anti-amnesic and anti-cholinesterase activities. Administration of alpha-asarone improved scopolamine-induced memory impairments and reduced acetylcholinesterase activity in different brain regions. These findings suggest that alpha-asarone may be useful for the management of Alzheimer's disease.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Computer Science, Theory & Methods
Xiaoyan Hu, Hao Chen, Miao Li, Guang Cheng, Ruidong Li, Hua Wu, Yali Yuan
Summary: This paper proposes ReplaceDGA, an adversarial DGA method based on BiLSTM network, with high anti-detection ability. ReplaceDGA does not require knowledge of the targeted DGA classifiers and builds a prediction model for benign domain names using BiLSTM network. It replaces two characters of each input benign domain name based on the prediction model to maximize the similarity between the benign and generated domain names. Experimental results demonstrate that ReplaceDGA successfully evades various character-level DGA classifiers, even after they are retrained by domain names generated by ReplaceDGA, and outperforms existing adversarial DGAs in anti-detection ability, repetition rate, and collision rate. Our study of ReplaceDGA highlights the need for developing more comprehensive and robust DGA classifiers that consider other factors besides character-level information of domain names.
IEEE TRANSACTIONS ON INFORMATION FORENSICS AND SECURITY
(2023)
Article
Integrative & Complementary Medicine
Qianqian Huang, Chen Zhang, Shi Dong, Junwen Han, Sihao Qu, Tianshu Xie, Haibin Zhao, Yuanyuan Shi
Summary: This study revealed for the first time the significant neuroprotective effect of asafoetida in treating Alzheimer's disease, and elucidated its underlying mechanisms through a series of experiments.
Article
Biochemistry & Molecular Biology
Moumita Kundu, Subhayan Das, Suvendu Nandi, Dibakar Dhara, Mahitosh Mandal
Summary: The study found that magnolol (MGN) enhances the therapeutic effect of temozolomide (TMZ) on glioma. MGN promotes glioma cell apoptosis induced by TMZ by inhibiting NF-xB pathway-mediated MGMT activation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Environmental Sciences
Ali H. Abu Almaaty, Rehab M. Mosaad, Mohamed K. Hassan, Elham H. A. Ali, Ghada A. Mahmoud, Hassan Ahmed, Nahla Anber, Saad Alkahtani, Mohamed M. Abdel-Daim, Lotfi Aleya, Seddik Hammad
Summary: The study evaluated the therapeutic effects of Urtica dioica extracts on memory dysfunction, amnesia, and oxidative stress induced by scopolamine. The results demonstrated that Urtica dioica extracts, particularly nettle root, significantly improved memory deficits and monoamine levels, showing antioxidative stress effects.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Plant Sciences
Razvan Stefan Boiangiu, Eyup Bagci, Gabriela Dumitru, Lucian Hritcu, Elena Todirascu-Ciornea
Summary: This study investigates the protective effect of Angelica purpurascens essential oil (APO) on memory impairments induced by scopolamine in zebrafish. The results show that APO can restore cholinergic system function and improve brain antioxidant state, thereby alleviating the memory deficits.
Article
Pharmacology & Pharmacy
Funan Ning, Lvyi Chen, Linlin Chen, Xin Liu, Yao Zhu, Jiayi Hu, Guangjing Xie, Jiaxuan Xia, Kun Shi, Zhou Lan, Ping Wang
Summary: The study identified the major components of Polygoni Multiflori Radix Praeparata and Acori Tatarinowii Rhizoma, and found that their traditional combination has a protective effect on cognitive function by increasing neurotransmitter levels in the hippocampus and activating related proteins.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiao-Long Sun, Mei-Lin Zhu, Yi-Qun Dai, Hong-Mei Li, Bo-Han Li, Hui Ma, Chang-Hao Zhang, Cheng-Zhu Wu
Summary: In this study, 15 semi-synthesized MAG derivatives were evaluated for their in vitro anticancer activities, and compound 6a showed the best cytotoxic activity against four human cancer cell lines. Furthermore, compound 6a was found to significantly inhibit the migration and invasion of MDA-MB-231 cells, and downregulate the expression of HIF-1 alpha, MMP-2, and MMP-9 in a concentration-dependent manner in Western blot experiments. These results suggest that substituting a benzyl group having F atoms at the C2 position on MAG is a viable strategy for optimizing MAG derivatives as anticancer agents.
Article
Biochemistry & Molecular Biology
Jiachen Ma, Tian Yuan, Yuqi Gao, Xiaoming Zeng, Zhigang Liu, Jinming Gao
Summary: The oil of Torreya grandis (TGO) has been found to have neuroprotective effects, preventing memory loss and cognitive impairment. TGO can rebalance the cholinergic system, inhibit neuroinflammation and oxidative stress, and regulate gut microbiota. Additionally, it increases the production of short-chain fatty acids and decreases the content of lipopolysaccharides in the serum.
Article
Urology & Nephrology
Manjula Kurella Tamura, Sarah Gaussoin, Nicholas M. Pajewski, Greg Zaharchuk, Barry Freedman, Stephen R. Rapp, Alexander P. Auchus, William E. Haley, Suzanne Oparil, Jessica Kendrick, Christianne L. Roumie, Srinivasan Beddhu, Alfred K. Cheung, Jeff D. Williamson, John A. Detre, Sudipto Dolui, R. Nick Bryan, Ilya M. Nasrallah
Summary: This study aimed to investigate the effects of intensive blood pressure control on cerebral perfusion and structure in individuals with and without chronic kidney disease (CKD). The findings suggest that intensive blood pressure treatment in adults with early kidney disease does not appear to have a detrimental effect on brain perfusion or structure.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2022)
Article
Public, Environmental & Occupational Health
Yuhan Zang, Zhengbao Zhu, Mengyao Shi, Aili Wang, Xuewei Xie, Tan Xu, Yanbo Peng, Pinni Yang, Qunwei Li, Zhong Ju, Deqin Geng, Jing Chen, Liping Liu, Yonghong Zhang, Jiang He
Summary: This study investigated the association between annual household income and prognosis of ischaemic stroke. The findings indicated that low annual household income was significantly associated with increased risks of adverse clinical outcomes after ischaemic stroke. Further studies are needed to replicate these findings in other samples.
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
(2022)
Article
Clinical Neurology
Kaixin Zhang, Zhengbao Zhu, Bizhong Che, Xiaoqing Bu, Tian Xu, Chongke Zhong, Aili Wang, Hao Peng, Daoxia Guo, Xiaowei Zheng, Tan Xu, Jing Chen, Yonghong Zhang, Jiang He
Summary: The study found that among Chinese patients with ischemic stroke, the ASTRAL score had the best accuracy for predicting 2-year prognosis. The ASTRAL score showed good fit and higher efficacy compared to other prognostic scores such as SPAN-100 and THRIVE, making it a valuable risk assessment tool for the 2-year prognosis of these patients.
NEUROLOGICAL RESEARCH
(2022)
Article
Nutrition & Dietetics
M. Kyla Shea, Kathryn Barger, Sarah L. Booth, Jifan Wang, Harold Feldman, Raymond R. Townsend, Jing Chen, John Flack, Jiang He, Bernard G. Jaar, Mayank Kansal, Sylvia E. Rosas, Daniel E. Weiner
Summary: The study found that individuals with better vitamin K status in chronic kidney disease have a lower risk of all-cause mortality, but there is no significant difference in the risk of atherosclerotic cardiovascular disease events.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Genetics & Heredity
George Hindy, Peter Dornbos, Mark D. Chaffin, Dajiang J. Liu, Minxian Wang, Margaret Sunitha Selvaraj, David Zhang, Joseph Park, Carlos A. Aguilar-Salinas, Lucinda Antonacci-Fulton, Diego Ardissino, Donna K. Arnett, Stella Aslibekyan, Gil Atzmon, Christie M. Ballantyne, Francisco Barajas-Olmos, Nir Barzilai, Lewis C. Becker, Lawrence F. Bielak, Joshua C. Bis, John Blangero, Eric Boerwinkle, Lori L. Bonnycastle, Erwin Bottinger, Donald W. Bowden, Matthew J. Bown, Jennifer A. Brody, Jai G. Broome, Noel P. Burtt, Brian E. Cade, Federico Centeno-Cruz, Edmund Chan, Yi-Cheng Chang, Yii-Der I. Chen, Ching-Yu Cheng, Won Jung Choi, Rajiv Chowdhury, Cecilia Contreras-Cubas, Emilio J. Cordova, Adolfo Correa, L. Adrienne Cupples, Joanne E. Curran, John Danesh, Paul S. de Vries, Ralph A. DeFronzo, Harsha Doddapaneni, Ravindranath Duggirala, Susan K. Dutcher, Patrick T. Ellinor, Leslie S. Emery, Jose C. Florez, Myriam Fornage, Barry I. Freedman, Valentin Fuster, Ma. Eugenia Garay-Sevilla, Humberto Garcia-Ortiz, Soren Germer, Richard A. Gibbs, Christian Gieger, Benjamin Glaser, Clicerio Gonzalez, Maria Elena Gonzalez-Villalpando, Mariaelisa Graff, Sarah E. Graham, Niels Grarup, Leif C. Groop, Xiuqing Guo, Namrata Gupta, Sohee Han, Craig L. Hanis, Torben Hansen, Jiang He, Nancy L. Heard-Costa, Yi-Jen Hung, Mi Yeong Hwang, Marguerite R. Irvin, Sergio Islas-Andrade, Gail P. Jarvik, Hyun Min Kang, Sharon L. R. Kardia, Tanika Kelly, Eimear E. Kenny, Alyna T. Khan, Bong-Jo Kim, Ryan W. Kim, Young Jin Kim, Heikki A. Koistinen, Charles Kooperberg, Johanna Kuusisto, Soo Heon Kwak, Markku Laakso, Leslie A. Lange, Jiwon Lee, Juyoung Lee, Seonwook Lee, Donna M. Lehman, Rozenn N. Lemaitre, Allan Linneberg, Jianjun Liu, Ruth J. F. Loos, Steven A. Lubitz, Valeriya Lyssenko, Ronald C. W. Ma, Lisa Warsinger Martin, Angelica Martinez-Hernandez, Rasika A. Mathias, Stephen T. McGarvey, Ruth McPherson, James B. Meigs, Thomas Meitinger, Olle Melander, Elvia Mendoza-Caamal, Ginger A. Metcalf, Xuenan Mi, Karen L. Mohlke, May E. Montasser, Jee-Young Moon, Hortensia Moreno-Macias, Alanna C. Morrison, Donna M. Muzny, Sarah C. Nelson, Peter M. Nilsson, Jeffrey R. O'Connell, Marju Orho-Melander, Lorena Orozco, Colin N. A. Palmer, Nicholette D. Palmer, Cheol Joo Park, Kyong Soo Park, Oluf Pedersen, Juan M. Peralta, Patricia A. Peyser, Wendy S. Post, Michael Preuss, Bruce M. Psatsy, Qibin Qi, D. C. Rao, Susan Redline, Alexander P. Reiner, Cristina Revilla-Monsalve, Stephen S. Rich, Nilesh Samani, Heribert Schunkert, Claudia Schurmann, Daekwan Seo, Jeong-Sun Seo, Xueling Sim, Rob Sladek, Kerrin S. Small, Wing Yee So, Adrienne M. Stilp, E. Shyong Tai, Claudia H. T. Tam, Kent D. Taylor, Yik Ying Teo, Farook Thameem, Brian Tomlinson, Michael Y. Tsai, Tiinamaij Tuomi, Jaakko Tuomilehto, Teresa Tusie-Luna, Miriam S. Udler, Rob M. van Dam, Ramachandran S. Vasan, Karine A. Viaud Martinez, Fei Fei Wang, Xuzhi Wang, Hugh Watkins, Daniel E. Weeks, James G. Wilson, Daniel R. Witte, Tien-Yin Wong, Lisa R. Yanek, Sekar Kathiresan, Daniel J. Rader, Jerome I. Rotter, Michael Boehnke, Mark I. McCarthy, Cristen J. Willer, Pradeep Natarajan, Jason A. Flannick, Amit V. Khera, Gina M. Peloso
Summary: Large-scale gene sequencing studies have the potential to identify causal genes for therapeutic purposes. This study identified gene associations with blood lipid levels using rare coding variants and found new genes not previously associated with lipid levels. The findings suggest the utility of gene-based associations for drug development and indicate that the gene closest to the array-based GWAS index SNP is often the functional gene for blood lipid levels.
AMERICAN JOURNAL OF HUMAN GENETICS
(2022)
Article
Cardiac & Cardiovascular Systems
Kirsten S. Dorans, Lydia A. Bazzano, Xingyan Li, Joshua D. Bundy, Ling Tian, Jiang He
Summary: This study compared cardiometabolic risk factors among parous women aged 20-44 in the United States with and without a history of gestational diabetes mellitus (GDM). The results showed that women with a history of GDM had less favorable cardiometabolic risk factor profiles, highlighting the importance of developing interventions to improve cardiovascular health in women with a history of GDM.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Article
Cardiac & Cardiovascular Systems
Yuhan Zang, Zhengbao Zhu, Yi Xie, Zhen Liu, Jieyun Yin, Pinni Yang, Kaixin Zhang, Xiaoqing Bu, Aili Wang, Jing Chen, Yonghong Zhang, Jiang He
Summary: This study found that elevated serum GDF-15 levels in the acute phase of ischemic stroke were independently associated with PSD, suggesting that GDF-15 may be a valuable prognostic biomarker for PSD.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Urology & Nephrology
Leila R. Zelnick, Michael G. Shlipak, Elsayed Z. Soliman, Amanda Anderson, Robert Christenson, Mayank Kansal, Rajat Deo, Jiang He, Bernard G. Jaar, Matthew R. Weir, Panduranga Rao, Debbie L. Cohen, Jordana B. Cohen, Harold Feldman, Alan Go, Nisha Bansal
Summary: This study evaluated the prognostic value of cardiac biomarkers and echocardiographic variables in predicting heart failure (HF) in patients with chronic kidney disease (CKD). The results showed that NT-proBNP and hsTnT had better discrimination than the current HF prediction model. HF clinical prediction models tailored to CKD patients are needed.
KIDNEY INTERNATIONAL REPORTS
(2022)
Review
Cardiac & Cardiovascular Systems
Yaqin Wang, Keyong Huang, Fangchao Liu, Xiangfeng Lu, Jianfeng Huang, Dongfeng Gu
Summary: This systematic review and meta-analysis found that elevated concentrations of circulating branched-chain amino acids (BCAA), particularly Isoleucine, were associated with an increased risk of cardiovascular disease (CVD), independent of traditional risk factors.
Article
Neurosciences
Yue-Liang Yao, Yan-Xia Wang, Fei-Cheng Yang, Chuan Wang, Min Mao, Qu-Jing Gai, Jiang He, Yan Qin, Xiao-Xue Yao, Xi Lan, Jiang Zhu, Hui-Min Lu, Hui Zeng, Xiao-Hong Yao, Xiu-Wu Bian, Yan Wang
Summary: This study investigated the resistance mechanism of Sonic hedgehog subtype medulloblastoma (MB) to SMO inhibitors through the analysis of transcriptomes, methylomes, and interactomes. The findings identified CK2 and AKT as potential therapeutic targets for SHH-subtype MB cells with SMO inhibitor resistance.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Cardiac & Cardiovascular Systems
Mengyao Shi, Jiang He, Changwei Li, Xiangfeng Lu, William J. He, Jie Cao, Jing Chen, Ji-Chun Chen, Lydia A. Bazzano, Jian-Xin Li, Hua He, Dongfeng Gu, Tanika N. Kelly
Summary: The study identified metabolite associations with salt sensitivity and hypertension, with 15 metabolites linked to hypertension. Changes in these metabolites predicted the occurrence of hypertension, providing insights into the biological mechanisms underlying salt-sensitive hypertension.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Article
Cardiac & Cardiovascular Systems
Pinni Yang, Zhengbao Zhu, Mengyao Shi, Jieyun Yin, Yuhan Zang, Chongke Zhong, Aili Wang, Hao Peng, Tian Xu, Daoxia Guo, Tan Xu, Jing Chen, Yonghong Zhang, Jiang He
Summary: The association between GDF-15 levels and stroke prognosis differs based on diabetes status, with a significant association found in patients with diabetes but not in those without diabetes. Elevated serum GDF-15 levels may serve as an important prognostic factor for ischemic stroke in patients with diabetes.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Article
Endocrinology & Metabolism
Ruiyuan Zhang, Xiao Sun, Zhijie Huang, Yang Pan, Adrianna Westbrook, Shengxu Li, Lydia Bazzano, Wei Chen, Jiang He, Tanika Kelly, Changwei Li
Summary: This study identified plasma metabolites altered by cigarette smoking and found five metabolites that partially mediated the association between current smoking and BMI.
Article
Cardiac & Cardiovascular Systems
Anna Jovanovich, Xuan Cai, Rebecca Frazier, Josh D. Bundy, Jiang He, Panduranga Rao, Claudia Lora, Mirela Dobre, Alan Go, Tariq Shafi, Harold Feldman, Eugene P. Rhee, Makoto Miyazaki, Tamara Isakova, Michel Chonchol
Summary: Through the CRIC study, it was found that there was no association between DCA and CAC in participants. DCA was not associated with prevalent, incident, or progression of CAC in the CRIC study participants.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Multidisciplinary Sciences
Tetsushi Nakao, Alexander G. Bick, Margaret A. Taub, Seyedeh M. Zekavat, Md M. Uddin, Abhishek Niroula, Cara L. Carty, John Lane, Michael C. Honigberg, Joshua S. Weinstock, Akhil Pampana, Christopher J. Gibson, Gabriel K. Griffin, Shoa L. Clarke, Romit Bhattacharya, Themistocles L. Assimes, Leslie S. Emery, Adrienne M. Stilp, Quenna Wong, Jai Broome, Cecelia A. Laurie, Alyna T. Khan, Albert Smith, Thomas W. Blackwell, Veryan Codd, Christopher P. Nelson, Zachary T. Yoneda, Juan M. Peralta, Donald W. Bowden, Marguerite R. Irvin, Meher Boorgula, Wei Zhao, Lisa R. Yanek, Kerri L. Wiggins, James E. Hixson, C. Charles Gu, Gina M. Peloso, Dan M. Roden, Muagututi'a S. Reupena, Chii-Min Hwu, Dawn L. DeMeo, Kari E. North, Shannon Kelly, Solomon K. Musani, Joshua C. Bis, Donald M. Lloyd-Jones, Jill M. Johnsen, Michael Preuss, Russell P. Tracy, Patricia A. Peyser, Dandi Qiao, Pinkal Desai, Joanne E. Curran, Barry Freedman, Hemant K. Tiwari, Sameer Chavan, Jennifer A. Smith, Nicholas L. Smith, Tanika N. Kelly, Bertha Hidalgo, L. Adrienne Cupples, Daniel E. Weeks, Nicola L. Hawley, Ryan L. Minster, Ranjan Deka, Take T. Naseri, Lisa de Las Fuentes, Laura M. Raffield, Alanna C. Morrison, Paul S. Vries, Christie M. Ballantyne, Eimear E. Kenny, Stephen S. Rich, Eric A. Whitsel, Michael H. Cho, M. Benjamin Shoemaker, Betty S. Pace, John Blangero, Nicholette D. Palmer, Braxton D. Mitchell, Alan R. Shuldiner, Kathleen C. Barnes, Susan Redline, Sharon L. R. Kardia, Goncalo R. Abecasis, Lewis C. Becker, Susan R. Heckbert, Jiang He, Wendy Post, Donna K. Arnett, Ramachandran S. Vasan, Dawood Darbar, Scott T. Weiss, Stephen T. McGarvey, Mariza de Andrade, Yii-Der Ida Chen, Robert C. Kaplan, Deborah A. Meyers, Brian S. Custer, Adolfo Correa, Bruce M. Psaty, Myriam Fornage, JoAnn E. Manson, Eric Boerwinkle, Barbara A. Konkle, Ruth J. F. Loos, Jerome Rotter, Edwin K. Silverman, Charles Kooperberg, John Danesh, Nilesh J. Samani, Siddhartha Jaiswal, Peter Libby, Patrick T. Ellinor, Nathan Pankratz, Benjamin L. Ebert, Alexander P. Reiner, Rasika A. Mathias, Ron Do, Pradeep Natarajan
Summary: This study investigated the relationship between CHIP, LTL, and CAD using data from the Trans-Omics for Precision Medicine (TOPMed) program and UK Biobank. The results showed that genetically imputed longer LTL increased the risk of developing CHIP, which then hastened the shortening of measured LTL. There was also evidence of mediation between CHIP and CAD through LTL.