Crocin-protected malathion-induced spatial memory deficits by inhibiting TAU protein hyperphosphorylation and antiapoptotic effects

Crocin improved amyloid beta induced long-term potentiation and memory deficits in the hippocampal CA1 neurons in freely moving rats

(2018) Mohammadmehdi Hadipour et al.   SYNAPSE

Pesticides Induce Spatial Memory Deficits with Synaptic Impairments and an Imbalanced Tau Phosphorylation in Rats

(2018) Ning-Ning Chen et al.   JOURNAL OF ALZHEIMERS DISEASE

Neuroprotective potential of crocin against malathion-induced motor deficit and neurochemical alterations in rats

(2017) Leila Mohammadzadeh et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Protective role of dietary Spirulina platensis against diazinon-induced Oxidative damage in Nile tilapia; Oreochromis niloticus

(2017) Nevien K.M. Abdelkhalek et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Saffron: a promising natural medicine in the treatment of metabolic syndrome

(2017) Bibi Marjan Razavi et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

PP2A Regulates Tau Phosphorylation Directly and also Indirectly via Activating GSK-3β

(2017) Wei Qian et al.   JOURNAL OF ALZHEIMERS DISEASE

Synergistic ameliorative effects of sesame oil and alpha-lipoic acid against subacute diazinon toxicity in rats: hematological, biochemical, and antioxidant studies

(2016) Mohamed M. Abdel-Daim et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Organophosphate pesticide exposure and neurodegeneration

(2016) Fernando Sánchez-Santed et al.   CORTEX

Prooxidant Activity of Polyphenols, Flavonoids, Anthocyanins and Carotenoids: Updated Review of Mechanisms and Catalyzing Metals

(2016) Samira Eghbaliferiz et al.   PHYTOTHERAPY RESEARCH

Long-term and low-dose malathion exposure causes cognitive impairment in adult mice: evidence of hippocampal mitochondrial dysfunction, astrogliosis and apoptotic events

(2015) Alessandra Antunes dos Santos et al.   ARCHIVES OF TOXICOLOGY

Suppressive effects of long-term exposure to P-nitrophenol on gonadal development, hormonal profile with disruption of tissue integrity, and activation of caspase-3 in male Japanese quail (Coturnix japonica)

(2015) Eman Ahmed et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Cross talk between PI3K-AKT-GSK-3β and PP2A pathways determines tau hyperphosphorylation

(2015) Yixuan Wang et al.   NEUROBIOLOGY OF AGING

Determination of the effects on learning and memory performance and related gene expressions of clothianidin in rat models

(2014) Hasan Hüseyin Özdemir et al.   Cognitive Neurodynamics

Synergistic protective role of ceftriaxone and ascorbic acid against subacute diazinon-induced nephrotoxicity in rats

(2014) Mohamed M. Abdel-Daim   CYTOTECHNOLOGY

PTPA activates protein phosphatase-2A through reducing its phosphorylation at tyrosine-307 with upregulation of protein tyrosine phosphatase 1B

(2013) Yu Luo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Protective effect of crocin on diazinon induced cardiotoxicity in rats in subchronic exposure

(2013) Bibi Marjan Razavi et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Understanding the relationship between GSK-3 and Alzheimer’s disease: a focus on how GSK-3 can modulate synaptic plasticity processes

(2013) Miguel Medina et al.   Expert Review of Neurotherapeutics

Bioactivity assessment and toxicity of crocin: A comprehensive review

(2013) Seyedeh Hoda Alavizadeh et al.   FOOD AND CHEMICAL TOXICOLOGY

Dexmedetomidine ameliorates intracerebral hemorrhage-induced memory impairment by inhibiting apoptosis and enhancing brain-derived neurotrophic factor expression in the rat hippocampus

(2013) LAKKYONG HWANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

The NLRP3 Inflammasome in Alzheimer’s Disease

(2013) Meng-Shan Tan et al.   MOLECULAR NEUROBIOLOGY

A role for tau at the synapse in Alzheimer's disease pathogenesis

(2013) Amy M. Pooler et al.   NEUROPHARMACOLOGY

Crocin “saffron” protects against beryllium chloride toxicity in rats through diminution of oxidative stress and enhancing gene expression of antioxidant enzymes

(2012) Hesham A. El-Beshbishy et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Dietary Crocin Inhibits Colitis and Colitis-Associated Colorectal Carcinogenesis in Male ICR Mice

(2012) Kunihiro Kawabata et al.   Evidence-based Complementary and Alternative Medicine

Repeated exposures to chlorpyrifos lead to spatial memory retrieval impairment and motor activity alteration

(2012) Changhui Yan et al.   NEUROTOXICOLOGY AND TERATOLOGY

Functional consequences of repeated organophosphate exposure: Potential non-cholinergic mechanisms

(2012) A.V. Terry   PHARMACOLOGY & THERAPEUTICS

Glycogen synthase kinase-3β regulates Tyr307phosphorylation of protein phosphatase-2A via protein tyrosine phosphatase 1B but not Src

(2011) Xiu-Qing Yao et al.   BIOCHEMICAL JOURNAL

Neuroprotective Effect of Crocin on Acrylamide-induced Cytotoxicity in PC12 cells

(2011) Soghra Mehri et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Amyloid β Peptide Levels Increase in Brain of AβPP Swedish Mice after Exposure to Chlorpyrifos

(2011) Jose G. Salazar et al.   Current Alzheimer Research

Protective effects of saffron extract and its active constituent crocin against oxidative stress and spatial learning and memory deficits induced by chronic stress in rats

(2011) Behshid Ghadrdoost et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The Many Faces of Tau

(2011) Meaghan Morris et al.   NEURON

Association between environmental exposure to pesticides and neurodegenerative diseases

(2011) Tesifón Parrón et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Anti-inflammatory effects of crocin and crocetin in rat brain microglial cells

(2010) Kyong Nyon Nam et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Sub-acute effects of diazinon on biochemical indices and specific biomarkers in rats: Protective effects of crocin and safranal

(2010) Alireza Timcheh Hariri et al.   FOOD AND CHEMICAL TOXICOLOGY

Molecular mechanisms of neurodegeneration in Alzheimer's disease

(2010) L. Crews et al.   HUMAN MOLECULAR GENETICS

Icariin attenuates β-amyloid-induced neurotoxicity by inhibition of tau protein hyperphosphorylation in PC12 cells

(2010) Ke-Wu Zeng et al.   NEUROPHARMACOLOGY

Repeated exposures to low-level chlorpyrifos results in impairments in sustained attention and increased impulsivity in rats

(2010) M.L. Middlemore-Risher et al.   NEUROTOXICOLOGY AND TERATOLOGY

The effect of crocin and safranal, constituents of saffron, against subacute effect of diazinon on hematological and genotoxicity indices in rats

(2010) Alireza Timcheh Hariri et al.   PHYTOMEDICINE

Role of HSP27 and reduced glutathione in modulating malathion-induced apoptosis of human peripheral blood mononuclear cells: Ameliorating effect of N-acetylcysteine and curcumin

(2009) Tanzeel Ahmed et al.   TOXICOLOGY IN VITRO

Essential roles of caspases and their upstream regulators in rotenone-induced apoptosis

(2008) Jihjong Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Biochemical evaluation of hepatic damage in subchronic exposure to malathion in rats: Effect on superoxide dismutase and catalase activities using native PAGE

(2008) Raja Rezg et al.   COMPTES RENDUS BIOLOGIES

Opposing effects of PSD-93 and PSD-95 on long-term potentiation and spike timing-dependent plasticity

(2008) Holly J. Carlisle et al.   JOURNAL OF PHYSIOLOGY-LONDON

Tau-based treatment strategies in neurodegenerative diseases

(2008) Anja Schneider et al.   Neurotherapeutics

Dendritic morphology on neurons from prefrontal cortex, hippocampus, and nucleus accumbens is altered in adult male mice exposed to repeated low dose of malathion

(2008) Alba Delia Campaña et al.   SYNAPSE

Memory impairment, oxidative damage and apoptosis induced by space radiation: Ameliorative potential of α-lipoic acid

(2007) K MANDA et al.   BEHAVIOURAL BRAIN RESEARCH

Crocus sativusL. (Saffron) Extract and its Active Constituents (Crocin and Safranal) on Ischemia-Reperfusion in Rat Skeletal Muscle

(2007) Hossein Hosseinzadeh et al.   Evidence-based Complementary and Alternative Medicine