Roles of Specialized Pro-Resolving Lipid Mediators in Autophagy and Inflammation

Autophagy and microbial pathogenesis

(2020) Matthew D. Keller et al.   CELL DEATH AND DIFFERENTIATION

Role of Resolvins in the Inflammatory Resolution of Neurological Diseases

(2020) Chunrong Li et al.   Frontiers in Pharmacology

Resolvin D1 Reduces Lung Infection and Inflammation Activating Resolution in Cystic Fibrosis

(2020) Elisa Isopi et al.   Frontiers in Immunology

Resolvin E1 protects against doxorubicin-induced cardiotoxicity by inhibiting oxidative stress, autophagy and apoptosis by targeting AKT/mTOR signaling

(2020) Jishou Zhang et al.   BIOCHEMICAL PHARMACOLOGY

Adapting Proteostasis and Autophagy for Controlling the Pathogenesis of Cystic Fibrosis Lung Disease

(2019) Manish Bodas et al.   Frontiers in Pharmacology

Autophagy suppresses the pathogenic immune response to dietary antigens in cystic fibrosis

(2019) Valeria R. Villella et al.   Cell Death & Disease

Crosstalk between Autophagy and Type I Interferon Responses in Innate Antiviral Immunity

(2019) Yu Tian et al.   Viruses-Basel

Mediators of the Resolution of the Inflammatory Response

(2019) Michelle A. Sugimoto et al.   TRENDS IN IMMUNOLOGY

Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease

(2019) Evandro F. Fang et al.   NATURE NEUROSCIENCE

Methylomic correlates of autophagy activity in cystic fibrosis

(2019) Kyle Caution et al.   Journal of Cystic Fibrosis

Regulation of the innate immune system by autophagy: neutrophils, eosinophils, mast cells, NK cells

(2019) Nina Germic et al.   CELL DEATH AND DIFFERENTIATION

Regulation of the innate immune system by autophagy: monocytes, macrophages, dendritic cells and antigen presentation

(2019) Nina Germic et al.   CELL DEATH AND DIFFERENTIATION

The role of macrophages in the resolution of inflammation

(2019) Satoshi Watanabe et al.   JOURNAL OF CLINICAL INVESTIGATION

Roles, Actions, and Therapeutic Potential of Specialized Pro-resolving Lipid Mediators for the Treatment of Inflammation in Cystic Fibrosis

(2019) Antonio Recchiuti et al.   Frontiers in Pharmacology

An update on the interactions between Alzheimer's disease, autophagy and inflammation

(2019) Mehmet Bostancıklıoğlu   GENE

Concise Review: Pro‐Resolving Lipid Mediators and Receptors in Stem Cell Biology

(2019) Mario Romano et al.   Stem Cells Translational Medicine

Maresin 1 activates LGR6 receptor promoting phagocyte immunoresolvent functions

(2019) Nan Chiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Mucus obstruction and inflammation in early cystic fibrosis lung disease: Emerging role of the IL‐1 signaling pathway

(2019) Anita Balázs et al.   PEDIATRIC PULMONOLOGY

Maresin 1 Improves Cognitive Decline and Ameliorates Inflammation in a Mouse Model of Alzheimer’s Disease

(2019) Ping Yin et al.   Frontiers in Cellular Neuroscience

A Comprehensive Review and Update on the Pathogenesis of Inflammatory Bowel Disease

(2019) Qingdong Guan   Journal of Immunology Research

HPV16 drives cancer immune escape via NLRX1-mediated degradation of STING

(2019) Xiaobo Luo et al.   JOURNAL OF CLINICAL INVESTIGATION

GPR101 mediates the pro-resolving actions of RvD5n-3 DPA in arthritis and infections

(2019) Magdalena B. Flak et al.   JOURNAL OF CLINICAL INVESTIGATION

Chronic inflammation in the etiology of disease across the life span

(2019) David Furman et al.   NATURE MEDICINE

Autophagy and Macrophage Functions: Inflammatory Response and Phagocytosis

(2019) Ming-Yue Wu et al.   Cells

Autophagy and Inflammation

(2018) Yu Matsuzawa-Ishimoto et al.   Annual Review of Immunology

Maresin 1 regulates autophagy and inflammation in human periodontal ligament cells through glycogen synthase kinase–3β/β-catenin pathway under inflammatory conditions

(2018) Li Du et al.   ARCHIVES OF ORAL BIOLOGY

Autophagy and inflammation in chronic respiratory disease

(2018) Alexandra C. Racanelli et al.   Autophagy

Three Distinct Types of Microautophagy Based on Membrane Dynamics and Molecular Machineries

(2018) Masahide Oku et al.   BIOESSAYS

Mitigating SOX2-potentiated Immune Escape of Head and Neck Squamous Cell Carcinoma with a STING-inducing Nanosatellite Vaccine

(2018) Yee Sun Tan et al.   CLINICAL CANCER RESEARCH

Resolvin D1 Resolve Inflammation in Experimental Acute Pancreatitis by Restoring Autophagic Flux

(2018) Bingbing Wang et al.   DIGESTIVE DISEASES AND SCIENCES

Human Papilloma Virus and Autophagy

(2018) Domenico Mattoscio et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

GPR37 regulates macrophage phagocytosis and resolution of inflammatory pain

(2018) Sangsu Bang et al.   JOURNAL OF CLINICAL INVESTIGATION

Resolvins in inflammation: emergence of the pro-resolving superfamily of mediators

(2018) Charles N. Serhan et al.   JOURNAL OF CLINICAL INVESTIGATION

Cargo recognition and degradation by selective autophagy

(2018) Damián Gatica et al.   NATURE CELL BIOLOGY

The coming of age of chaperone-mediated autophagy

(2018) Susmita Kaushik et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Evaluation of autophagy inducers in epithelial cells carrying the ΔF508 mutation of the cystic fibrosis transmembrane conductance regulator CFTR

(2018) Shaoyi Zhang et al.   Cell Death & Disease

An autophagy assay reveals the ESCRT-III component CHMP2A as a regulator of phagophore closure

(2018) Yoshinori Takahashi et al.   Nature Communications

The role of mitochondria in NLRP3 inflammasome activation

(2018) Qiuyun Liu et al.   MOLECULAR IMMUNOLOGY

Resolution of chronic inflammatory disease: universal and tissue-specific concepts

(2018) Georg Schett et al.   Nature Communications

Resolution of sickle cell disease–associated inflammation and tissue damage with 17R-resolvin D1

(2018) Alessandro Matte et al.   BLOOD

Treating inflammation and infection in the 21st century: new hints from decoding resolution mediators and mechanisms

(2017) Charles N. Serhan   FASEB JOURNAL

New insights into autophagosome–lysosome fusion

(2017) Shuhei Nakamura et al.   JOURNAL OF CELL SCIENCE

Maresin 1 inhibits TNF-alpha-induced lipolysis and autophagy in 3T3-L1 adipocytes

(2017) Laura M Laiglesia et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Myeloid ATG16L1 Facilitates Host–Bacteria Interactions in Maintaining Intestinal Homeostasis

(2017) Hong Zhang et al.   JOURNAL OF IMMUNOLOGY

LC3-Associated Phagocytosis and Inflammation

(2017) Bradlee L. Heckmann et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural elucidation and physiologic functions of specialized pro-resolving mediators and their receptors

(2017) Nan Chiang et al.   MOLECULAR ASPECTS OF MEDICINE

Inflammasome and Autophagy Regulation: A Two-way Street

(2017) Qian Sun et al.   MOLECULAR MEDICINE

Resolvin D1 enhances the resolution of lung inflammation caused by long-term Pseudomonas aeruginosa infection

(2017) M Codagnone et al.   Mucosal Immunology

Dual role of autophagy in hallmarks of cancer

(2017) Shikha Satendra Singh et al.   ONCOGENE

Pilot application of lipoxin A4 analog and lipoxin A4 receptor agonist in asthmatic children with acute episodes

(2017) Xia Kong et al.   Experimental and Therapeutic Medicine

ANGPTL8 negatively regulates NF-κB activation by facilitating selective autophagic degradation of IKKγ

(2017) Yu Zhang et al.   Nature Communications

Autophagy regulates UBC9 levels during viral-mediated tumorigenesis

(2017) Domenico Mattoscio et al.   PLoS Pathogens

Elevated Mirc1/Mir17-92 cluster expression negatively regulates autophagy and CFTR (cystic fibrosis transmembrane conductance regulator) function in CF macrophages

(2016) Mia F. Tazi et al.   Autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

A novel treatment of cystic fibrosis acting on-target: cysteamine plus epigallocatechin gallate for the autophagy-dependent rescue of class II-mutated CFTR

(2016) A Tosco et al.   CELL DEATH AND DIFFERENTIATION

Novel Resolvin D2 Receptor Axis in Infectious Inflammation

(2016) Nan Chiang et al.   JOURNAL OF IMMUNOLOGY

Resolvin D3 Is Dysregulated in Arthritis and Reduces Arthritic Inflammation

(2016) Hildur H. Arnardottir et al.   JOURNAL OF IMMUNOLOGY

Resolvin E1 Reverses Experimental Periodontitis and Dysbiosis

(2016) Chun-Teh Lee et al.   JOURNAL OF IMMUNOLOGY

Spautin-1 Ameliorates Acute Pancreatitis via Inhibiting Impaired Autophagy and Alleviating Calcium Overload

(2016) Juan Xiao et al.   MOLECULAR MEDICINE

Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages

(2016) Jesmond Dalli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism and Regulation of NLRP3 Inflammasome Activation

(2016) Yuan He et al.   TRENDS IN BIOCHEMICAL SCIENCES

IL-1 receptor antagonist ameliorates inflammasome-dependent inflammation in murine and human cystic fibrosis

(2016) Rossana G. Iannitti et al.   Nature Communications

Autophagy Inhibition Dysregulates TBK1 Signaling and Promotes Pancreatic Inflammation

(2016) S. Yang et al.   Cancer Immunology Research

Activation of autophagy in macrophages by pro-resolving lipid mediators

(2015) Patricia Prieto et al.   Autophagy

Modulation of inflammation by autophagy: Consequences for human disease

(2015) Romana T. Netea-Maier et al.   Autophagy

Protectins and maresins: New pro-resolving families of mediators in acute inflammation and resolution bioactive metabolome

(2015) Charles N. Serhan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Lipoxin A4 Attenuates Obesity-Induced Adipose Inflammation and Associated Liver and Kidney Disease

(2015) Emma Börgeson et al.   Cell Metabolism

Mitophagy programs: mechanisms and physiological implications of mitochondrial targeting by autophagy

(2015) Anne Hamacher-Brady et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Lipoxins and aspirin-triggered lipoxins in resolution of inflammation

(2015) Mario Romano et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Novel proresolving and tissue-regenerative resolvin and protectin sulfido-conjugated pathways

(2015) Jesmond Dalli et al.   FASEB JOURNAL

mTOR: a pharmacologic target for autophagy regulation

(2015) Young Chul Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Inflammation in cystic fibrosis lung disease: Pathogenesis and therapy

(2015) André M. Cantin et al.   Journal of Cystic Fibrosis

Identification of resolvin D2 receptor mediating resolution of infections and organ protection

(2015) Nan Chiang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Enhancement of neutrophil autophagy by an IVIG preparation against multidrug-resistant bacteria as well as drug-sensitive strains

(2015) Hiroshi Itoh et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Elucidation of novel 13-series resolvins that increase with atorvastatin and clear infections

(2015) Jesmond Dalli et al.   NATURE MEDICINE

Immune attack: the role of inflammation in Alzheimer disease

(2015) Frank L. Heppner et al.   NATURE REVIEWS NEUROSCIENCE

Pyruvate prevents the development of age-dependent cognitive deficits in a mouse model of Alzheimer's disease without reducing amyloid and tau pathology

(2015) Elisa Isopi et al.   NEUROBIOLOGY OF DISEASE

The resolution code of acute inflammation: Novel pro-resolving lipid mediators in resolution

(2015) Charles N. Serhan et al.   SEMINARS IN IMMUNOLOGY

Autophagy Is Required for Neutrophil-Mediated Inflammation

(2015) Abhisek Bhattacharya et al.   Cell Reports

Restoration of CFTR function in patients with cystic fibrosis carrying the F508del-CFTR mutation

(2014) Daniela De Stefano et al.   Autophagy

The generation of neutrophils in the bone marrow is controlled by autophagy

(2014) S Rožman et al.   CELL DEATH AND DIFFERENTIATION

Crosstalk between the cGAS DNA Sensor and Beclin-1 Autophagy Protein Shapes Innate Antimicrobial Immune Responses

(2014) Qiming Liang et al.   Cell Host & Microbe

Autophagy in adipose tissue and the beta cell: implications for obesity and diabetes

(2014) Rinke Stienstra et al.   DIABETOLOGIA

FPR2/ALXR Agonists and the Resolution of Inflammation

(2014) Olivier Corminboeuf et al.   JOURNAL OF MEDICINAL CHEMISTRY

The HOPS complex mediates autophagosome–lysosome fusion through interaction with syntaxin 17

(2014) Peidu Jiang et al.   MOLECULAR BIOLOGY OF THE CELL

Functional Role of Autophagy-Mediated Proteome Remodeling in Cell Survival Signaling and Innate Immunity

(2014) Robin Mathew et al.   MOLECULAR CELL

WIPI2 Links LC3 Conjugation with PI3P, Autophagosome Formation, and Pathogen Clearance by Recruiting Atg12–5-16L1

(2014) Hannah C. Dooley et al.   MOLECULAR CELL

Pro-resolving lipid mediators are leads for resolution physiology

(2014) Charles N. Serhan   NATURE

Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense

(2014) K. G. Lassen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of soluble epoxide hydrolase modulates inflammation and autophagy in obese adipose tissue and liver: Role for omega-3 epoxides

(2014) Cristina López-Vicario et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A dual role for autophagy in a murine model of lung cancer

(2014) Shuan Rao et al.   Nature Communications

Cyclic Dinucleotides Trigger ULK1 (ATG1) Phosphorylation of STING to Prevent Sustained Innate Immune Signaling

(2013) Hiroyasu Konno et al.   CELL

The machinery of macroautophagy

(2013) Yuchen Feng et al.   CELL RESEARCH

Resolvin D3 and Aspirin-Triggered Resolvin D3 Are Potent Immunoresolvents

(2013) Jesmond Dalli et al.   CHEMISTRY & BIOLOGY

Resolution of inflammation: an integrated view

(2013) Almudena Ortega-Gómez et al.   EMBO Molecular Medicine

Understanding Resolvin Signaling Pathways to Improve Oral Health

(2013) David Keinan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Autophagy Enhances Bacterial Clearance during P. aeruginosa Lung Infection

(2013) Robert D. Junkins et al.   PLoS One

Novel n-3 Immunoresolvents: Structures and Actions

(2013) Jesmond Dalli et al.   Scientific Reports

Resolvin D1 Receptor Stereoselectivity and Regulation of Inflammation and Proresolving MicroRNAs

(2012) Sriram Krishnamoorthy et al.   AMERICAN JOURNAL OF PATHOLOGY

Autophagy is required for CSF-1-induced macrophagic differentiation and acquisition of phagocytic functions

(2012) A. Jacquel et al.   BLOOD

Induction of autophagy is essential for monocyte-macrophage differentiation

(2012) Y. Zhang et al.   BLOOD

Efficacy and safety of 15(R/S)-methyl-lipoxin A4in topical treatment of infantile eczema

(2012) S.-H. Wu et al.   BRITISH JOURNAL OF DERMATOLOGY

Depletion of the Ubiquitin-binding Adaptor Molecule SQSTM1/p62 from Macrophages HarboringcftrΔF508 Mutation Improves the Delivery ofBurkholderia cenocepaciato the Autophagic Machinery

(2012) Basant A. Abdulrahman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rescue of Dysfunctional Autophagy Attenuates Hyperinflammatory Responses from Cystic Fibrosis Cells

(2012) M. L. Mayer et al.   JOURNAL OF IMMUNOLOGY

Infection regulates pro-resolving mediators that lower antibiotic requirements

(2012) Nan Chiang et al.   NATURE

Resolvin D1 attenuates inflammation in lipopolysaccharide-induced acute lung injury through a process involving the PPARγ/NF-κB pathway

(2012) Zenglin Liao et al.   RESPIRATORY RESEARCH

p47 negatively regulates IKK activation by inducing the lysosomal degradation of polyubiquitinated NEMO

(2012) Yuri Shibata et al.   Nature Communications

Pro-Resolving Lipid Mediators (SPMs) and Their Actions in Regulating miRNA in Novel Resolution Circuits in Inflammation

(2012) Antonio Recchiuti et al.   Frontiers in Immunology

The Role of Atg Proteins in Autophagosome Formation

(2011) Noboru Mizushima et al.   Annual Review of Cell and Developmental Biology

Autophagy stimulation by rapamycin suppresses lung inflammation and infection byBurkholderia cenocepaciain a model of cystic fibrosis

(2011) Basant A. Abdulrahman et al.   Autophagy

Transcriptional regulation of the human FPR2/ALX gene: evidence of a heritable genetic variant that impairs promoter activity

(2011) Felice Simiele et al.   FASEB JOURNAL

Azithromycin blocks autophagy and may predispose cystic fibrosis patients to mycobacterial infection

(2011) Maurizio Renna et al.   JOURNAL OF CLINICAL INVESTIGATION

Autophagy-Dependent Anticancer Immune Responses Induced by Chemotherapeutic Agents in Mice

(2011) M. Michaud et al.   SCIENCE

Mitochondria and the Autophagy-Inflammation-Cell Death Axis in Organismal Aging

(2011) D. R. Green et al.   SCIENCE

Inflammation 2010: New Adventures of an Old Flame

(2010) Ruslan Medzhitov   CELL

Neutrophil extracellular trap cell death requires both autophagy and superoxide generation

(2010) Quinten Remijsen et al.   CELL RESEARCH

LC3 and GATE-16/GABARAP subfamilies are both essential yet act differently in autophagosome biogenesis

(2010) Hilla Weidberg et al.   EMBO JOURNAL

Cystic fibrosis transmembrane conductance regulator (CFTR) expression in human platelets: impact on mediators and mechanisms of the inflammatory response

(2010) Domenico Mattoscio et al.   FASEB JOURNAL

MicroRNAs in resolution of acute inflammation: identification of novel resolvin D1-miRNA circuits

(2010) Antonio Recchiuti et al.   FASEB JOURNAL

Regulation of autophagy by phosphatidylinositol 3-phosphate

(2010) Chloe Burman et al.   FEBS LETTERS

Autophagy and adaptive immunity

(2010) Victoria L. Crotzer et al.   IMMUNOLOGY

FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end–directed vesicle transport

(2010) Serhiy Pankiv et al.   JOURNAL OF CELL BIOLOGY

Anti-Inflammatory Role of the Murine Formyl-Peptide Receptor 2: Ligand-Specific Effects on Leukocyte Responses and Experimental Inflammation

(2010) Neil Dufton et al.   JOURNAL OF IMMUNOLOGY

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Defective CFTR induces aggresome formation and lung inflammation in cystic fibrosis through ROS-mediated autophagy inhibition

(2010) Alessandro Luciani et al.   NATURE CELL BIOLOGY

Resolvin D1 binds human phagocytes with evidence for proresolving receptors

(2010) S. Krishnamoorthy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resolvin E1 Receptor Activation Signals Phosphorylation and Phagocytosis

(2009) Taisuke Ohira et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response

(2009) T. Saitoh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling

(2009) Michal Caspi Tal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The IKK Complex, a Central Regulator of NF- B Activation

(2009) A. Israel   Cold Spring Harbor Perspectives in Biology

Dynein-dependent Movement of Autophagosomes Mediates Efficient Encounters with Lysosomes

(2008) Shunsuke Kimura et al.   CELL STRUCTURE AND FUNCTION

Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum

(2008) Elizabeth L. Axe et al.   JOURNAL OF CELL BIOLOGY

Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions

(2008) Charles N. Serhan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

(2008) Ken Cadwell et al.   NATURE

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

(2008) Tatsuya Saitoh et al.   NATURE

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE