Autophagy in adipose tissue and the beta cell: implications for obesity and diabetes

LAMP-2: A control step for phagosome and autophagosome maturation

(2014) Paul Saftig et al.   Autophagy

Autophagy is involved in adipogenic differentiation by repressesing proteasome-dependent PPARγ2 degradation

(2013) Chongben Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Autophagy in obesity and atherosclerosis: Interrelationships between cholesterol homeostasis, lipoprotein metabolism and autophagy in macrophages and other systems

(2013) Mireille Ouimet   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The Relationship between Metabolism and the Autophagy Machinery during the Innate Immune Response

(2013) Jennifer Martinez et al.   Cell Metabolism

Metabolic endotoxaemia

(2013) Milan K. Piya et al.   CURRENT OPINION IN LIPIDOLOGY

Evidence for Rapamycin Toxicity in Pancreatic β-Cells and a Review of the Underlying Molecular Mechanisms

(2013) Adam D. Barlow et al.   DIABETES

Reduced Adipose Tissue Macrophage Content Is Associated With Improved Insulin Sensitivity in Thiazolidinedione-Treated Diabetic Humans

(2013) S. Koppaka et al.   DIABETES

The Type 2 Diabetes-Associated Gene Ide Is Required for Insulin Secretion and Suppression of  -Synuclein Levels in  -Cells

(2013) P. Steneberg et al.   DIABETES

Lysosomal acid lipase and lipophagy are constitutive negative regulators of glucose-stimulated insulin secretion from pancreatic beta cells

(2013) Gemma L. Pearson et al.   DIABETOLOGIA

Defective regulation of adipose tissue autophagy in obesity

(2013) C E Nuñez et al.   INTERNATIONAL JOURNAL OF OBESITY

Insulin Signaling in Type 2 Diabetes

(2013) Cecilia Brännmark et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cathepsin B Contributes to Autophagy-related 7 (Atg7)-induced Nod-like Receptor 3 (NLRP3)-dependent Proinflammatory Response and Aggravates Lipotoxicity in Rat Insulinoma Cell Line

(2013) Shali Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of a candidate therapeutic autophagy-inducing peptide

(2013) Sanae Shoji-Kawata et al.   NATURE

Metabolism of inflammation limited by AMPK and pseudo-starvation

(2013) Luke A. J. O'Neill et al.   NATURE

Autophagy in Human Health and Disease

(2013) Augustine M.K. Choi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Autophagy as a crosstalk mediator of metabolic organs in regulation of energy metabolism

(2013) Kook Hwan Kim et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Role of Rapamycin-Induced Autophagy in Pancreatic Islets

(2012) M. Tanemura et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Autophagy plays a protective role in endoplasmic reticulum stress-mediated pancreatic β cell death

(2012) Alberto Bartolome et al.   Autophagy

The end of autophagic cell death?

(2012) Shensi Shen et al.   Autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy

(2012) Daniel J. Klionsky et al.   Autophagy

Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure

(2012) Chutima Talchai et al.   CELL

The Inflammasome Puts Obesity in the Danger Zone

(2012) Rinke Stienstra et al.   Cell Metabolism

Modulation of inflammation by autophagy: consequences for Crohn's disease

(2012) Theo S Plantinga et al.   CURRENT OPINION IN PHARMACOLOGY

Mapping Autophagy on to Your Metabolic Radar

(2012) E. Yamada et al.   DIABETES

Stimulation of Autophagy Improves Endoplasmic Reticulum Stress-Induced Diabetes

(2012) E. Bachar-Wikstrom et al.   DIABETES

Loss of autophagy in hypothalamic POMC neurons impairs lipolysis

(2012) Susmita Kaushik et al.   EMBO REPORTS

Autophagy Activity Is Up-Regulated in Adipose Tissue of Obese Individuals and Modulates Proinflammatory Cytokine Expression

(2012) H. J. Jansen et al.   ENDOCRINOLOGY

Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine

(2012) Kook Hwan Kim et al.   NATURE MEDICINE

Autophagy modulation as a potential therapeutic target for diverse diseases

(2012) David C. Rubinsztein et al.   NATURE REVIEWS DRUG DISCOVERY

Autophagy in Adipose Tissue

(2012) Nitzan Maixner et al.   Obesity Facts

Autophagy in adipose tissue biology

(2012) Yong Zhang et al.   PHARMACOLOGICAL RESEARCH

Palmitate Activates Autophagy in INS-1E β-Cells and in Isolated Rat and Human Pancreatic Islets

(2012) Luisa Martino et al.   PLoS One

Hypothalamic dysfunction in obesity

(2012) Lynda M. Williams   PROCEEDINGS OF THE NUTRITION SOCIETY

The PI3K, Metabolic, and Autophagy Networks: Interactive Partners in Cellular Health and Disease

(2011) Naval P. Shanware et al.   Annual Review of Pharmacology and Toxicology

Liver autophagy contributes to the maintenance of blood glucose and amino acid levels

(2011) Junji Ezaki et al.   Autophagy

Autophagy regulates inflammation in adipocytes

(2011) Takeshi Yoshizaki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SNARE Proteins Are Required for Macroautophagy

(2011) Usha Nair et al.   CELL

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Autophagy deficiency in beta cells leads to compromised unfolded protein response and progression from obesity to diabetes in mice

(2011) W. Quan et al.   DIABETOLOGIA

Autophagy-based unconventional secretory pathway for extracellular delivery of IL-1β

(2011) Nicolas Dupont et al.   EMBO JOURNAL

Defective Hypothalamic Autophagy Directs the Central Pathogenesis of Obesity via the IκB Kinase β (IKKβ)/NF-κB Pathway

(2011) Qingyuan Meng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fatty Acids Suppress Autophagic Turnover in β-Cells

(2011) Guy Las et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inflammation of the Hypothalamus Leads to Defective Pancreatic Islet Function

(2011) Vivian C. Calegari et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy Controls IL-1β Secretion by Targeting Pro-IL-1β for Degradation

(2011) James Harris et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy in immunity and inflammation

(2011) Beth Levine et al.   NATURE

Yin and Yang of hypothalamic insulin and leptin signaling in regulating white adipose tissue metabolism

(2011) Thomas Scherer et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Autophagy in health and disease. 4. The role of pancreatic β-cell autophagy in health and diabetes

(2010) Yoshio Fujitani et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Mitochondrial degradation by autophagy (mitophagy) in GFP-LC3 transgenic hepatocytes during nutrient deprivation

(2010) Insil Kim et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The double-edged effect of autophagy in pancreatic beta cells and diabetes

(2010) Ze-fang Chen et al.   Autophagy

The emerging role of autophagy in the pathophysiology of diabetes mellitus

(2010) Claudio D. Gonzalez et al.   Autophagy

Human-IAPP disrupts the autophagy/lysosomal pathway in pancreatic β-cells: protective role of p62-positive cytoplasmic inclusions

(2010) J F Rivera et al.   CELL DEATH AND DIFFERENTIATION

Relation between human LPIN1, hypoxia and endoplasmic reticulum stress genes in subcutaneous and visceral adipose tissue

(2010) M Miranda et al.   INTERNATIONAL JOURNAL OF OBESITY

Altered Autophagy in Human Adipose Tissues in Obesity

(2010) Julia Kovsan et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Substrate Fate in Activated Macrophages: A Comparison between Innate, Classic, and Alternative Activation

(2010) J.-C. Rodriguez-Prados et al.   JOURNAL OF IMMUNOLOGY

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

Mutant INS-Gene Induced Diabetes of Youth: Proinsulin Cysteine Residues Impose Dominant-Negative Inhibition on Wild-Type Proinsulin Transport

(2010) Ming Liu et al.   PLoS One

Innate immunity and adipose tissue biology

(2010) Andreas Schäffler et al.   TRENDS IN IMMUNOLOGY

Targeted deletion ofautophagy-related 5(atg5) impairs adipogenesis in a cellular model and in mice

(2009) Rebecca Baerga et al.   Autophagy

Activation of autophagy through modulation of 5′-AMP-activated protein kinase protects pancreatic β-cells from high glucose

(2009) Diana Han et al.   BIOCHEMICAL JOURNAL

Balancing needs and means: the dilemma of the β-cell in the modern world

(2009) G. Leibowitz et al.   DIABETES OBESITY & METABOLISM

Autophagy in human type 2 diabetes pancreatic beta cells

(2009) M. Masini et al.   DIABETOLOGIA

Misfolded Proinsulin Affects Bystander Proinsulin in Neonatal Diabetes

(2009) Israel Hodish et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy Regulates Pancreatic Beta Cell Death in Response to Pdx1 Deficiency and Nutrient Deprivation

(2009) Kei Fujimoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential roles of NHERF1, NHERF2, and PDZK1 in regulating CFTR-mediated intestinal anion secretion in mice

(2009) Anurag Kumar Singh et al.   JOURNAL OF CLINICAL INVESTIGATION

Density functional computational studies on (E)-2-[(2-Hydroxy-5-nitrophenyl)-iminiomethyl]-4-nitrophenolate

(2009) Hasan Tanak et al.   JOURNAL OF MOLECULAR MODELING

ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery

(2009) Chang Hwa Jung et al.   MOLECULAR BIOLOGY OF THE CELL

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

Glucose Amplifies Fatty Acid-Induced Endoplasmic Reticulum Stress in Pancreatic β-Cells via Activation of mTORC1

(2009) Etti Bachar et al.   PLoS One

Adipose-specific deletion of autophagy-related gene 7 (atg7) in mice reveals a role in adipogenesis

(2009) Y. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity

(2008) Xiaoqing Zhang et al.   CELL

Loss of Autophagy Diminishes Pancreatic β Cell Mass and Function with Resultant Hyperglycemia

(2008) Hye Seung Jung et al.   Cell Metabolism

Autophagy Is Important in Islet Homeostasis and Compensatory Increase of Beta Cell Mass in Response to High-Fat Diet

(2008) Chie Ebato et al.   Cell Metabolism

mTOR Inhibition by Rapamycin Prevents  -Cell Adaptation to Hyperglycemia and Exacerbates the Metabolic State in Type 2 Diabetes

(2008) M. Fraenkel et al.   DIABETES

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

(2008) Gilad Twig et al.   EMBO JOURNAL

The Role for Endoplasmic Reticulum Stress in Diabetes Mellitus

(2008) Décio L. Eizirik et al.   ENDOCRINE REVIEWS

The Unfolded Protein Response: A Pathway That Links Insulin Demand with β-Cell Failure and Diabetes

(2008) Donalyn Scheuner et al.   ENDOCRINE REVIEWS

Glucolipotoxicity: Fuel Excess and β-Cell Dysfunction

(2008) Vincent Poitout et al.   ENDOCRINE REVIEWS

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

(2008) Ken Cadwell et al.   NATURE

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

(2008) Tatsuya Saitoh et al.   NATURE

Munc 18-1 and Granuphilin Collaborate During Insulin Granule Exocytosis

(2008) Alejandra Tomas et al.   TRAFFIC