NASH, Fibrosis and Hepatocellular Carcinoma: Lipid Synthesis and Glutamine/Acetate Signaling

Inhibition of the mitochondrial citrate carrier, Slc25a1, reverts steatosis, glucose intolerance, and inflammation in preclinical models of NAFLD/NASH

(2020) Mingjun Tan et al.   CELL DEATH AND DIFFERENTIATION

The IKKβ-USP30-ACLY Axis Controls Lipogenesis and Tumorigenesis

(2020) Li Gu et al.   HEPATOLOGY

Dietary fructose feeds hepatic lipogenesis via microbiota-derived acetate

(2020) Steven Zhao et al.   NATURE

Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity

(2019) Kim Vriens et al.   NATURE

ETC-1002 (Bempedoic acid) for the management of hyperlipidemia: from preclinical studies to phase 3 trials

(2019) M. Ruscica et al.   EXPERT OPINION ON PHARMACOTHERAPY

Cholesterol biosynthesis supports the growth of hepatocarcinoma lesions depleted of fatty acid synthase in mice and humans

(2019) Li Che et al.   GUT

Hepatocyte Deletion of Triglyceride‐Synthesis Enzyme DGAT 2 Reduces Steatosis without Increasing Inflammation or Fibrosis

(2019) Nina L. Gluchowski et al.   HEPATOLOGY

Therapeutic targeting of glutaminolysis as an essential strategy to combat cancer

(2019) José M. Matés et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Betulin and betulinic acid: triterpenoids derivatives with a powerful biological potential

(2019) Anna Hordyjewska et al.   PHYTOCHEMISTRY REVIEWS

ATP-citrate lyase (ACLY) in lipid metabolism and atherosclerosis: An updated review

(2019) Xiaojun Feng et al.   PROGRESS IN LIPID RESEARCH

SREBP-1 inhibitor Betulin enhances the antitumor effect of Sorafenib on hepatocellular carcinoma via restricting cellular glycolytic activity

(2019) Fan Yin et al.   Cell Death & Disease

First‐in‐class fatty acid synthase inhibitor TVB‐2640 reduces hepatic de novo lipogenesis in males with metabolic abnormalities

(2019) Majid M. Syed‐Abdul et al.   HEPATOLOGY

Targeting diacylglycerol acyltransferase 2 for the treatment of nonalcoholic steatohepatitis

(2019) Neeta B. Amin et al.   Science Translational Medicine

ASPP2 inhibits tumor growth by repressing the mevalonate pathway in hepatocellular carcinoma

(2019) Beibei Liang et al.   Cell Death & Disease

Safe use of proton pump inhibitors in patients with cirrhosis

(2018) Rianne A. Weersink et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Acetyl-CoA Carboxylase Inhibitor GS-0976 for 12 Weeks Reduces Hepatic De Novo Lipogenesis and Steatosis in Patients With Nonalcoholic Steatohepatitis

(2018) Eric J. Lawitz et al.   Clinical Gastroenterology and Hepatology

Activity and structure of human acetyl-CoA carboxylase targeted by a specific inhibitor

(2018) SoRi Jang et al.   FEBS LETTERS

Hedgehog-YAP Signaling Pathway Regulates Glutaminolysis to Control Activation of Hepatic Stellate Cells

(2018) Kuo Du et al.   GASTROENTEROLOGY

Stearoyl-CoA desaturase-1 promotes colorectal cancer metastasis in response to glucose by suppressing PTEN

(2018) Hui Ran et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Lansoprazole prevents the progression of liver fibrosis in non-alcoholic steatohepatitis model rats

(2018) Toshio Nishi et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Regulation of Acetate Utilization by Monocarboxylate Transporter 1 (MCT1) in Hepatocellular Carcinoma (HCC)

(2018) Jeong Yong Jeon et al.   ONCOLOGY RESEARCH

CD24 regulates sorafenib resistance via activating autophagy in hepatocellular carcinoma

(2018) Shuai Lu et al.   Cell Death & Disease

Preclinical evaluation of novel fatty acid synthase inhibitors in primary colorectal cancer cells and a patient-derived xenograft model of colorectal cancer

(2018) Yekaterina Y. Zaytseva et al.   Oncotarget

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Inhibition of Acetyl-CoA Carboxylase by Phosphorylation or the Inhibitor ND-654 Suppresses Lipogenesis and Hepatocellular Carcinoma

(2018) James S.V. Lally et al.   Cell Metabolism

ACSS2 promotes systemic fat storage and utilization through selective regulation of genes involved in lipid metabolism

(2018) Zhiguang Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deletion of Stearoyl-CoA Desaturase-1 From the Intestinal Epithelium Promotes Inflammation and Tumorigenesis, Reversed by Dietary Oleate

(2018) Simon Ducheix et al.   GASTROENTEROLOGY

GS-0976 Reduces Hepatic Steatosis and Fibrosis Markers in Patients With Nonalcoholic Fatty Liver Disease

(2018) Rohit Loomba et al.   GASTROENTEROLOGY

Inhibition of de novo lipogenesis targets androgen receptor signaling in castration-resistant prostate cancer

(2018) Giorgia Zadra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of a potent HMG-CoA reductase degrader that eliminates statin-induced reductase accumulation and lowers cholesterol

(2018) Shi-You Jiang et al.   Nature Communications

Dual Inhibition of the Lactate Transporters MCT1 and MCT4 Is Synthetic Lethal with Metformin due to NAD+ Depletion in Cancer Cells

(2018) Don Benjamin et al.   Cell Reports

Aberrant MCT4 and GLUT1 expression is correlated with early recurrence and poor prognosis of hepatocellular carcinoma after hepatectomy

(2018) Hai-Long Chen et al.   Cancer Medicine

Targeting glutaminase 1 attenuates stemness properties in hepatocellular carcinoma by increasing reactive oxygen species and suppressing Wnt/beta-catenin pathway

(2018) Binghua Li et al.   EBioMedicine

A tale of two glutaminases: homologous enzymes with distinct roles in tumorigenesis

(2017) William P Katt et al.   Future Medicinal Chemistry

Stearoyl-CoA Desaturase Promotes Liver Fibrosis and Tumor Development in Mice via a Wnt Positive-Signaling Loop by Stabilization of Low-Density Lipoprotein-Receptor-Related Proteins 5 and 6

(2017) Keane K.Y. Lai et al.   GASTROENTEROLOGY

Proton Pump Inhibitors Increase Risk for Hepatic Encephalopathy in Patients With Cirrhosis in A Population Study

(2017) Chia-Fen Tsai et al.   GASTROENTEROLOGY

Liver Cancer Cell of Origin, Molecular Class, and Effects on Patient Prognosis

(2017) Daniela Sia et al.   GASTROENTEROLOGY

Inhibition of the sterol regulatory element-binding protein pathway suppresses hepatocellular carcinoma by repressing inflammation in mice

(2017) Na Li et al.   HEPATOLOGY

Stearoyl-CoA desaturase regulates sorafenib resistance via modulation of ER stress-induced differentiation

(2017) Mark Kin Fai Ma et al.   JOURNAL OF HEPATOLOGY

PPARδ Reprograms Glutamine Metabolism in Sorafenib-Resistant HCC

(2017) Mi-Jin Kim et al.   MOLECULAR CANCER RESEARCH

Compensatory metabolic networks in pancreatic cancers upon perturbation of glutamine metabolism

(2017) Douglas E. Biancur et al.   Nature Communications

Lipid Metabolism and Lipid Droplets in Pancreatic Cancer and Stellate Cells

(2017) Yoshiaki Sunami et al.   Cancers

Liver Cancer: Connections with Obesity, Fatty Liver, and Cirrhosis

(2016) Andrea Marengo et al.   Annual Review of Medicine

Lipid desaturation - the next step in targeting lipogenesis in cancer?

(2016) Barrie Peck et al.   FEBS Journal

Atorvastatin and fluvastatin are associated with dose-dependent reductions in cirrhosis and hepatocellular carcinoma, among patients with hepatitis C virus: Results from ERCHIVES

(2016) Tracey G. Simon et al.   HEPATOLOGY

Statins increase hepatic cholesterol synthesis and stimulate fecal cholesterol elimination in mice

(2016) Marleen Schonewille et al.   JOURNAL OF LIPID RESEARCH

Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats

(2016) Geraldine Harriman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis

(2016) Stephen L. Pinkosky et al.   Nature Communications

SCD1 is associated with tumor promotion, late stage and poor survival in lung adenocarcinoma

(2016) Jun Huang et al.   Oncotarget

Syrosingopine sensitizes cancer cells to killing by metformin

(2016) Don Benjamin et al.   Science Advances

Co-activation of AKT and c-Met triggers rapid hepatocellular carcinoma development via the mTORC1/FASN pathway in mice

(2016) Junjie Hu et al.   Scientific Reports

Glutamate Dehydrogenase 1 Signals through Antioxidant Glutathione Peroxidase 1 to Regulate Redox Homeostasis and Tumor Growth

(2015) Lingtao Jin et al.   CANCER CELL

Acetyl Coenzyme A: A Central Metabolite and Second Messenger

(2015) Federico Pietrocola et al.   Cell Metabolism

Molecular Pathways: Fatty Acid Synthase

(2015) S. F. Jones et al.   CLINICAL CANCER RESEARCH

Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis

(2015) Yan Xiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Functional screening identifies MCT4 as a key regulator of breast cancer cell metabolism and survival

(2015) Franziska Baenke et al.   JOURNAL OF PATHOLOGY

Oncogenic PI3K and K-Ras stimulate de novo lipid synthesis through mTORC1 and SREBP

(2015) S J H Ricoult et al.   ONCOGENE

Targeting SREBPs for treatment of the metabolic syndrome

(2015) Selma M. Soyal et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Stratification of Hepatocellular Carcinoma Patients Based on Acetate Utilization

(2015) Elias Björnson et al.   Cell Reports

Acetate Dependence of Tumors

(2014) Sarah A. Comerford et al.   CELL

SREBP-1 Has a Prognostic Role and Contributes to Invasion and Metastasis in Human Hepatocellular Carcinoma

(2014) Chao Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Monocarboxylate transporter 4 predicts poor prognosis in hepatocellular carcinoma and is associated with cell proliferation and migration

(2014) Heng-Jun Gao et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Repositioning Proton Pump Inhibitors as Anticancer Drugs by Targeting the Thioesterase Domain of Human Fatty Acid Synthase

(2014) Valerie E. Fako et al.   JOURNAL OF MEDICINAL CHEMISTRY

A human fatty acid synthase inhibitor binds β-ketoacyl reductase in the keto-substrate site

(2014) Mary Ann Hardwicke et al.   Nature Chemical Biology

The growing landscape of lysine acetylation links metabolism and cell signalling

(2014) Chunaram Choudhary et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hepatic triacylglycerol synthesis and secretion: DGAT2 as the link between glycaemia and triglyceridaemia

(2013) Victor A. Zammit   BIOCHEMICAL JOURNAL

A Novel Inhibitor of Stearoyl-CoA Desaturase-1 Attenuates Hepatic Lipid Accumulation, Liver Injury and Inflammation in Model of Nonalcoholic Steatohepatitis

(2013) Nobuya Kurikawa et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Hooked on fat: the role of lipid synthesis in cancer metabolism and tumour development

(2013) F. Baenke et al.   Disease Models & Mechanisms

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

(2013) Jaekyoung Son et al.   NATURE

Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin

(2013) Morgan D Fullerton et al.   NATURE MEDICINE

SCD1 Expression Is Dispensable for Hepatocarcinogenesis Induced by AKT and Ras Oncogenes in Mice

(2013) Lei Li et al.   PLoS One

Transcriptional Control of Hepatic Lipid Metabolism by SREBP and ChREBP

(2013) Xu Xu et al.   SEMINARS IN LIVER DISEASE

High stearoyl-CoA desaturase 1 expression is associated with shorter survival in breast cancer patients

(2012) Ashley M. Holder et al.   BREAST CANCER RESEARCH AND TREATMENT

Breathless cancer cells get fat on glutamine

(2012) Dimitrios Anastasiou et al.   CELL RESEARCH

Significance of Short Chain Fatty Acid Transport by Members of the Monocarboxylate Transporter Family (MCT)

(2012) Ivano Moschen et al.   NEUROCHEMICAL RESEARCH

Plasma Fatty Acid Composition in Patients with Pancreatic Cancer: Correlations to Clinical Parameters

(2012) Jaroslav Macášek et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Inhibition of SREBP by a Small Molecule, Betulin, Improves Hyperlipidemia and Insulin Resistance and Reduces Atherosclerotic Plaques

(2011) Jing-Jie Tang et al.   Cell Metabolism

Development of a Liver-Targeted Stearoyl-CoA Desaturase (SCD) Inhibitor (MK-8245) to Establish a Therapeutic Window for the Treatment of Diabetes and Dyslipidemia

(2011) Renata M. Oballa et al.   JOURNAL OF MEDICINAL CHEMISTRY

Reductive carboxylation supports growth in tumour cells with defective mitochondria

(2011) Andrew R. Mullen et al.   NATURE

Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

(2011) Christian M. Metallo et al.   NATURE

Increased Lipogenesis, Induced by AKT-mTORC1-RPS6 Signaling, Promotes Development of Human Hepatocellular Carcinoma

(2010) Diego F. Calvisi et al.   GASTROENTEROLOGY

Stem Cells in Hepatocarcinogenesis: Evidence from Genomic Data

(2010) Jens Marquardt et al.   SEMINARS IN LIVER DISEASE

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

(2009) Ping Gao et al.   NATURE

Hepatic Stearoyl-CoA Desaturase (SCD)-1 Activity and Diacylglycerol but Not Ceramide Concentrations Are Increased in the Nonalcoholic Human Fatty Liver

(2008) A. Kotronen et al.   DIABETES

Cellular cholesterol trafficking and compartmentalization

(2008) Elina Ikonen   NATURE REVIEWS MOLECULAR CELL BIOLOGY