Activity and structure of human acetyl-CoA carboxylase targeted by a specific inhibitor

Acetyl-coenzyme A carboxylase inhibition reduces de novo lipogenesis in overweight male subjects: A randomized, double-blind, crossover study

(2017) Kathryn Stiede et al.   HEPATOLOGY

Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models

(2016) Robert U Svensson et al.   NATURE MEDICINE

Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats

(2016) Geraldine Harriman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AMPK: An Energy-Sensing Pathway with Multiple Inputs and Outputs

(2016) D. Grahame Hardie et al.   TRENDS IN CELL BIOLOGY

The dynamic organization of fungal acetyl-CoA carboxylase

(2016) Moritz Hunkeler et al.   Nature Communications

A unified molecular mechanism for the regulation of acetyl-CoA carboxylase by phosphorylation

(2016) Jia Wei et al.   Cell Discovery

Discovery of spirocyclic-diamine inhibitors of mammalian acetyl CoA-carboxylase

(2015) Daniel W. Kung et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Beyond Energy Homeostasis: the Expanding Role of AMP-Activated Protein Kinase in Regulating Metabolism

(2015) David Carling et al.   Cell Metabolism

Crystal structure of the 500-kDa yeast acetyl-CoA carboxylase holoenzyme dimer

(2015) Jia Wei et al.   NATURE

Human acetyl-CoA carboxylase 2 expressed in silkworm Bombyx mori exhibits posttranslational biotinylation and phosphorylation

(2014) In-Wook Hwang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

AMPK-Dependent Inhibitory Phosphorylation of ACC Is Not Essential for Maintaining Myocardial Fatty Acid Oxidation

(2014) Beshay N.M. Zordoky et al.   CIRCULATION RESEARCH

AMPK phosphorylation of ACC2 is required for skeletal muscle fatty acid oxidation and insulin sensitivity in mice

(2014) Hayley M. O’Neill et al.   DIABETOLOGIA

Decreasing the Rate of Metabolic Ketone Reduction in the Discovery of a Clinical Acetyl-CoA Carboxylase Inhibitor for the Treatment of Diabetes

(2014) David A. Griffith et al.   JOURNAL OF MEDICINAL CHEMISTRY

Recent Advances in the Development of Acetyl-CoA Carboxylase (ACC) Inhibitors for the Treatment of Metabolic Disease

(2014) Matthew P. Bourbeau et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural Insights into the Regulation of ACC2 by Citrate

(2013) Seong Jung Kwon et al.   BULLETIN OF THE KOREAN CHEMICAL SOCIETY

Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin

(2013) Morgan D Fullerton et al.   NATURE MEDICINE

Resistance to herbicides caused by single amino acid mutations in acetyl-CoA carboxylase in resistant populations of grassy weeds

(2013) SoRi Jang et al.   NEW PHYTOLOGIST

Structure and function of biotin-dependent carboxylases

(2012) Liang Tong   CELLULAR AND MOLECULAR LIFE SCIENCES

Acetyl-CoA Carboxylase 2−/−Mutant Mice are Protected against Fatty Liver under High-fat, High-carbohydrate Dietary andde NovoLipogenic Conditions

(2012) Lutfi Abu-Elheiga et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Lipogenesis Pathway as a Cancer Target

(2011) Hanley N. Abramson   JOURNAL OF MEDICINAL CHEMISTRY

Maximizing Lipophilic Efficiency: The Use of Free-Wilson Analysis in the Design of Inhibitors of Acetyl-CoA Carboxylase

(2011) Kevin D. Freeman-Cook et al.   JOURNAL OF MEDICINAL CHEMISTRY

AMPK Is a Direct Adenylate Charge-Regulated Protein Kinase

(2011) J. S. Oakhill et al.   SCIENCE

Recombinant yeast screen for new inhibitors of human acetyl-CoA carboxylase 2 identifies potential drugs to treat obesity

(2010) J. Marjanovic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induced polymerization of mammalian acetyl-CoA carboxylase by MIG12 provides a tertiary level of regulation of fatty acid synthesis

(2010) C.-W. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular mechanism for the regulation of human ACC2 through phosphorylation by AMPK

(2009) Yong Soon Cho et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Potent biphenyl- and 3-phenyl pyridine-based inhibitors of acetyl-CoA carboxylase

(2009) Tasir S. Haque et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of small molecule isozyme non-specific inhibitors of mammalian acetyl-CoA carboxylase 1 and 2

(2009) Jeffrey W. Corbett et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Differential activation of recombinant human acetyl-CoA carboxylases 1 and 2 by citrate

(2008) Gregory A. Locke et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Cell cycle regulation of the BRCA1/acetyl-CoA-carboxylase complex

(2008) H. Ray et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Structural Evidence for Direct Interactions between the BRCT Domains of Human BRCA1 and a Phospho-peptide from Human ACC1†

(2008) Yang Shen et al.   BIOCHEMISTRY

Synthesis of spiro[chroman-2,4′-piperidin]-4-one derivatives as acetyl-CoA carboxylase inhibitors

(2008) Pundlik Shinde et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Fatty acid metabolism: target for metabolic syndrome

(2008) Salih J. Wakil et al.   JOURNAL OF LIPID RESEARCH

BRCA1 and acetyl-CoA carboxylase: The metabolic syndrome of breast cancer

(2007) Joan Brunet et al.   MOLECULAR CARCINOGENESIS