Inhibition of the sterol regulatory element-binding protein pathway suppresses hepatocellular carcinoma by repressing inflammation in mice

IL6-mediated inflammatory loop reprograms normal to epithelial-mesenchymal transition+ metastatic cancer stem cells in preneoplastic liver of transforming growth factor beta-deficient β2-spectrin+/− mice

(2017) Abhisek Mitra et al.   HEPATOLOGY

Hepatocellular carcinoma repression by TNFα-mediated synergistic lethal effect of mitosis defect-induced senescence and cell death sensitization

(2016) Dan Li et al.   HEPATOLOGY

Acetyl-coenzyme A carboxylase alpha promotion of glucose-mediated fatty acid synthesis enhances survival of hepatocellular carcinoma in mice and patients

(2016) Ming-Da Wang et al.   HEPATOLOGY

Gp78, an E3 Ubiquitin Ligase Acts as a Gatekeeper Suppressing Nonalcoholic Steatohepatitis (NASH) and Liver Cancer

(2015) Tianpeng Zhang et al.   PLoS One

Leptin promotes a proinflammatory lipid profile and induces inflammatory pathways in human SZ95 sebocytes

(2014) D. Törőcsik et al.   BRITISH JOURNAL OF DERMATOLOGY

ER Stress Cooperates with Hypernutrition to Trigger TNF-Dependent Spontaneous HCC Development

(2014) Hayato Nakagawa et al.   CANCER CELL

SREBP-1 Has a Prognostic Role and Contributes to Invasion and Metastasis in Human Hepatocellular Carcinoma

(2014) Chao Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

An Essential Requirement for the SCAP/SREBP Signaling Axis to Protect Cancer Cells from Lipotoxicity

(2013) K. J. Williams et al.   CANCER RESEARCH

Hepatic loss of survivin impairs postnatal liver development and promotes expansion of hepatic progenitor cells in mice

(2013) Dan Li et al.   HEPATOLOGY

Toll-like receptor 4 activity protects against hepatocellular tumorigenesis and progression by regulating expression of DNA repair protein Ku70 in mice

(2013) Ziyan Wang et al.   HEPATOLOGY

Ablation of gp78 in Liver Improves Hyperlipidemia and Insulin Resistance by Inhibiting SREBP to Decrease Lipid Biosynthesis

(2012) Tong-Fei Liu et al.   Cell Metabolism

The Scap/SREBP Pathway Is Essential for Developing Diabetic Fatty Liver and Carbohydrate-Induced Hypertriglyceridemia in Animals

(2012) Young-Ah Moon et al.   Cell Metabolism

Effects of glycine on phagocytosis and secretion by Kupffer cellsin vitro

(2012) Hui-Wen Wu   WORLD JOURNAL OF GASTROENTEROLOGY

Novel Theranostic Opportunities Offered by Characterization of Altered Membrane Lipid Metabolism in Breast Cancer Progression

(2011) M. Hilvo et al.   CANCER RESEARCH

Inhibition of SREBP by a Small Molecule, Betulin, Improves Hyperlipidemia and Insulin Resistance and Reduces Atherosclerotic Plaques

(2011) Jing-Jie Tang et al.   Cell Metabolism

Ubiquitination regulates the assembly of VLDL in HepG2 cells and is the committing step of the apoB-100 ERAD pathway

(2011) Eric A. Fisher et al.   JOURNAL OF LIPID RESEARCH

Activation of Androgen Receptor, Lipogenesis, and Oxidative Stress Converged by SREBP-1 Is Responsible for Regulating Growth and Progression of Prostate Cancer Cells

(2011) W.-C. Huang et al.   MOLECULAR CANCER RESEARCH

Dietary and Genetic Obesity Promote Liver Inflammation and Tumorigenesis by Enhancing IL-6 and TNF Expression

(2010) Eek Joong Park et al.   CELL

Coinfection of hepatitis B and C viruses and risk of hepatocellular carcinoma: Systematic review and meta-analysis

(2010) Lisa Y. Cho et al.   INTERNATIONAL JOURNAL OF CANCER

A Role for KAI1 in Promotion of Cell Proliferation and Mammary Gland Hyperplasia by the gp78 Ubiquitin Ligase

(2010) Bharat Joshi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

EGFR Signaling Through an Akt-SREBP-1-Dependent, Rapamycin-Resistant Pathway Sensitizes Glioblastomas to Antilipogenic Therapy

(2009) D. Guo et al.   Science Signaling

Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet

(2008) Kelly A. Posey et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Hepatocyte Necrosis Induced by Oxidative Stress and IL-1α Release Mediate Carcinogen-Induced Compensatory Proliferation and Liver Tumorigenesis

(2008) Toshiharu Sakurai et al.   CANCER CELL

Liver X receptor mediates hepatitis B virus X protein-induced lipogenesis in hepatitis B virus-associated hepatocellular carcinoma

(2008) Tae-Young Na et al.   HEPATOLOGY

A reproducible and well-tolerated method for 2/3 partial hepatectomy in mice

(2008) Claudia Mitchell et al.   Nature Protocols