Emerging Gene-Editing Modalities for Osteoarthritis

Knee osteoarthritis and its association with mental health and health‐related quality of life: A nationwide cross‐sectional study

(2020) Hye‐Min Park et al.   Geriatrics & Gerontology International

Physical Therapy versus Glucocorticoid Injection for Osteoarthritis of the Knee

(2020) Gail D. Deyle et al.   NEW ENGLAND JOURNAL OF MEDICINE

Extracellular nanovesicles for packaging of CRISPR-Cas9 protein and sgRNA to induce therapeutic exon skipping

(2020) Peter Gee et al.   Nature Communications

Engineered cartilage utilizing fetal cartilage-derived progenitor cells for cartilage repair

(2020) Do Young Park et al.   Scientific Reports

Articular fibrocartilage - Why does hyaline cartilage fail to repair?

(2019) Angela R. Armiento et al.   ADVANCED DRUG DELIVERY REVIEWS

Genome Engineering for Osteoarthritis: From Designer Cells to Disease-Modifying Drugs

(2019) Yun-Rak Choi et al.   Tissue Engineering and Regenerative Medicine

Maintenance of Nucleolar Homeostasis by CBX4 Alleviates Senescence and Osteoarthritis

(2019) Xiaoqing Ren et al.   Cell Reports

CRISPR/Cas9 technology as a potent molecular tool for gene therapy

(2019) Ansar Karimian et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Re-examining osteoarthritis therapy from a developmental biologist’s perspective

(2019) Akrit Pran Jaswal et al.   BIOCHEMICAL PHARMACOLOGY

Exploration of CRISPR/Cas9-based gene editing as therapy for osteoarthritis

(2019) Lan Zhao et al.   ANNALS OF THE RHEUMATIC DISEASES

Safety of Topical Non-steroidal Anti-Inflammatory Drugs in Osteoarthritis: Outcomes of a Systematic Review and Meta-Analysis

(2019) Germain Honvo et al.   DRUGS & AGING

Designer Stem Cells: Genome Engineering and the Next Generation of Cell‐Based Therapies

(2019) Farshid Guilak et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

CRISPR/Cas system for genome editing: progress and prospects as a therapeutic tool

(2019) Deepak Kumar Sahel et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

A small molecule promotes cartilage extracellular matrix generation and inhibits osteoarthritis development

(2019) Yuanyuan Shi et al.   Nature Communications

Up-regulation of FOXD1 by YAP alleviates senescence and osteoarthritis

(2019) Lina Fu et al.   PLOS BIOLOGY

Emerging Trend in the Pharmacotherapy of Osteoarthritis

(2019) Wei Zhang et al.   Frontiers in Endocrinology

Refixation of Large Osteochondral Fractures After Patella Dislocation Shows Better Mid- to Long-Term Outcome Compared With Debridement

(2019) Markus Gesslein et al.   Cartilage

Targeting the Immune System With Mesenchymal Stromal Cell-Derived Extracellular Vesicles: What Is the Cargo's Mechanism of Action?

(2019) Jorge Diego Martin-Rufino et al.   Frontiers in Bioengineering and Biotechnology

Non-operative treatment options for knee osteoarthritis

(2019) Michael DeRogatis et al.   Annals of Translational Medicine

Engineered exosomes: A new promise for the management of musculoskeletal diseases

(2018) D. Bellavia et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Stem cell-based therapeutic strategies for cartilage defects and osteoarthritis

(2018) Cosimo De Bari et al.   CURRENT OPINION IN PHARMACOLOGY

Identification of a novel, methylation-dependent, RUNX2 regulatory region associated with osteoarthritis risk

(2018) Sarah J Rice et al.   HUMAN MOLECULAR GENETICS

Adipose-Derived Mesenchymal Stem Cells: Are They a Good Therapeutic Strategy for Osteoarthritis?

(2018) Elena Damia et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Cost of Joint Replacement

(2018) John A. Palsis et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Emerging role of extracellular vesicles in musculoskeletal diseases

(2018) Cameron Murphy et al.   MOLECULAR ASPECTS OF MEDICINE

Effect of electric stimulation on human chondrocytes and mesenchymal stem cells under normoxia and hypoxia

(2018) Bettina Hiemer et al.   Molecular Medicine Reports

Mesenchymal stem cells produced exosomes and microparticles that exert a similar chondroprotective effect in osteoarthritis

(2018) S. Cosenza et al.   OSTEOARTHRITIS AND CARTILAGE

Medical Expenditures and Earnings Losses Among US Adults With Arthritis in 2013

(2018) Louise B. Murphy et al.   ARTHRITIS CARE & RESEARCH

The CRISPR tool kit for genome editing and beyond

(2018) Mazhar Adli   Nature Communications

Stem Cells for Cartilage Repair: Preclinical Studies and Insights in Translational Animal Models and Outcome Measures

(2018) Melissa Lo Monaco et al.   Stem Cells International

Repair of Damaged Articular Cartilage: Current Approaches and Future Directions

(2018) Ekaterina Medvedeva et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

CRISPR-Cas9 targeting of MMP13 in human chondrocytes leads to significantly reduced levels of the metalloproteinase and enhanced type II collagen accumulation

(2018) C.I. Seidl et al.   OSTEOARTHRITIS AND CARTILAGE

Pre-existing technological core and roots for the CRISPR breakthrough

(2018) Christopher L. Magee et al.   PLoS One

Engineered CRISPR-Cas9 nuclease with expanded targeting space

(2018) Hiroshi Nishimasu et al.   SCIENCE

Proteomic characterization of endogenous substrates of mammalian ubiquitin ligase Hrd1

(2018) Yilin Ye et al.   Cell and Bioscience

Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation

(2018) Jacob O'Brien et al.   Frontiers in Endocrinology

Mesenchymal stem cell-based therapy of osteoarthritis: Current knowledge and future perspectives

(2018) C. Randall Harrell et al.   BIOMEDICINE & PHARMACOTHERAPY

Gesicle-Mediated Delivery of CRISPR/Cas9 Ribonucleoprotein Complex for Inactivating the HIV Provirus

(2018) Lee A. Campbell et al.   MOLECULAR THERAPY

Osteoarthritis year in review 2018: mechanics

(2018) L.E. DeFrate et al.   OSTEOARTHRITIS AND CARTILAGE

Human Synovial Mesenchymal Stem Cells Good Manufacturing Practices for Articular Cartilage Regeneration

(2018) Tiago Lazzaretti Fernandes et al.   TISSUE ENGINEERING PART C-METHODS

Targeting of chondrocyte plasticity via connexin43 modulation attenuates cellular senescence and fosters a pro-regenerative environment in osteoarthritis

(2018) Marta Varela-Eirín et al.   Cell Death & Disease

Bone Marrow Fat and Hematopoiesis

(2018) Huifang Wang et al.   Frontiers in Endocrinology

Native joint-resident mesenchymal stem cells for cartilage repair in osteoarthritis

(2017) Dennis McGonagle et al.   Nature Reviews Rheumatology

Extracellular Vesicle-Shuttled mRNA in Mesenchymal Stem Cell Communication

(2017) Enrico Ragni et al.   STEM CELLS

CRISPR-Based Epigenome Editing of Cytokine Receptors for the Promotion of Cell Survival and Tissue Deposition in Inflammatory Environments

(2017) Niloofar Farhang et al.   TISSUE ENGINEERING PART A

Genome Engineering for Personalized Arthritis Therapeutics

(2017) Shaunak S. Adkar et al.   TRENDS IN MOLECULAR MEDICINE

Mesenchymal stem cells derived exosomes and microparticles protect cartilage and bone from degradation in osteoarthritis

(2017) Stella Cosenza et al.   Scientific Reports

Exosomes from embryonic mesenchymal stem cells alleviate osteoarthritis through balancing synthesis and degradation of cartilage extracellular matrix

(2017) Yafei Wang et al.   Stem Cell Research & Therapy

The Epigenomic Landscape in Osteoarthritis

(2017) Tommie C. Simon et al.   Current Rheumatology Reports

Genome Engineering of Stem Cells for Autonomously Regulated, Closed-Loop Delivery of Biologic Drugs

(2017) Jonathan M. Brunger et al.   Stem Cell Reports

Cartilage repair by mesenchymal stem cells: Clinical trial update and perspectives

(2017) Wayne Yuk-wai Lee et al.   Journal of Orthopaedic Translation

Vital Signs: Prevalence of Doctor-Diagnosed Arthritis and Arthritis-Attributable Activity Limitation — United States, 2013–2015

(2017) Kamil E. Barbour et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Fetal Cartilage-Derived Cells Have Stem Cell Properties and Are a Highly Potent Cell Source for Cartilage Regeneration

(2016) Woo Hee Choi et al.   CELL TRANSPLANTATION

The cast of clasts: catabolism and vascular invasion during bone growth, repair, and disease by osteoclasts, chondroclasts, and septoclasts

(2016) Paul R. Odgren et al.   CONNECTIVE TISSUE RESEARCH

Inflammation and epigenetic regulation in osteoarthritis

(2016) Jie Shen et al.   CONNECTIVE TISSUE RESEARCH

Increased trabecular bone and improved biomechanics in an osteocalcin-null rat model created by CRISPR/Cas9 technology

(2016) Laura J. Lambert et al.   Disease Models & Mechanisms

High seeding density of human chondrocytes in agarose produces tissue-engineered cartilage approaching native mechanical and biochemical properties

(2016) Alexander D. Cigan et al.   JOURNAL OF BIOMECHANICS

Recent Progress in CRISPR/Cas9 Technology

(2016) Yue Mei et al.   Journal of Genetics and Genomics

CRISPR/Cas9 knockout of HAS2 in rat chondrosarcoma chondrocytes demonstrates the requirement of hyaluronan for aggrecan retention

(2016) Yi Huang et al.   MATRIX BIOLOGY

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9

(2016) John G Doench et al.   NATURE BIOTECHNOLOGY

Generation of IL1β-resistant chondrocytes using CRISPR-CAS genome editing

(2016) T.A. Karlsen et al.   OSTEOARTHRITIS AND CARTILAGE

Updated Projected Prevalence of Self-Reported Doctor-Diagnosed Arthritis and Arthritis-Attributable Activity Limitation Among US Adults, 2015-2040

(2016) Jennifer M. Hootman et al.   Arthritis & Rheumatology

Adipose, Bone Marrow and Synovial Joint-Derived Mesenchymal Stem Cells for Cartilage Repair

(2016) Christopher R. Fellows et al.   Frontiers in Genetics

Osteoarthritis in the XXIst Century: Risk Factors and Behaviours that Influence Disease Onset and Progression

(2015) Giuseppe Musumeci et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Supramolecular synergy in the boundary lubrication of synovial joints

(2015) Jasmine Seror et al.   Nature Communications

Toward regeneration of articular cartilage

(2015) Masahiro Iwamoto et al.   BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS

Incidence, Prevalence, Costs, and Impact on Disability of Common Conditions Requiring Rehabilitation in the United States: Stroke, Spinal Cord Injury, Traumatic Brain Injury, Multiple Sclerosis, Osteoarthritis, Rheumatoid Arthritis, Limb Loss, and Back Pain

(2014) Vincent Y. Ma et al.   ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION

Origin and function of cartilage stem/progenitor cells in osteoarthritis

(2014) Yangzi Jiang et al.   Nature Reviews Rheumatology

Intra-Articular Injection of Mesenchymal Stem Cells for the Treatment of Osteoarthritis of the Knee: A Proof-of-Concept Clinical Trial

(2014) Chris Hyunchul Jo et al.   STEM CELLS

Enhancing Chondrogenic Phenotype for Cartilage Tissue Engineering: Monoculture and Coculture of Articular Chondrocytes and Mesenchymal Stem Cells

(2014) Kelsea M. Hubka et al.   TISSUE ENGINEERING PART B-REVIEWS

The ECM-Cell Interaction of Cartilage Extracellular Matrix on Chondrocytes

(2014) Yue Gao et al.   Biomed Research International

Evolution of Autologous Chondrocyte Repair and Comparison to Other Cartilage Repair Techniques

(2014) Ashvin K. Dewan et al.   Biomed Research International

Impact of Obesity and Knee Osteoarthritis on Morbidity and Mortality in Older Americans

(2013) Elena Losina et al.   ANNALS OF INTERNAL MEDICINE

mRNA-engineered mesenchymal stem cells for targeted delivery of interleukin-10 to sites of inflammation

(2013) O. Levy et al.   BLOOD

Epigenetics in osteoarthritis and its implication for future therapeutics

(2013) Gun-Il Im et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Contribution of genetic and epigenetic mechanisms to Wnt pathway activity in prevalent skeletal disorders

(2013) Carmen García-Ibarbia et al.   GENE

Cas9 as a versatile tool for engineering biology

(2013) Prashant Mali et al.   NATURE METHODS

Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!)

(2012) F. Berenbaum   OSTEOARTHRITIS AND CARTILAGE

Advances in the Surgical Management of Articular Cartilage Defects

(2012) Spencer Stein et al.   Cartilage

Specific Armadillo Repeat Sequences Facilitate β-Catenin Nuclear Transport in Live Cells via Direct Binding to Nucleoporins Nup62, Nup153, and RanBP2/Nup358

(2011) Manisha Sharma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chondrogenic differentiation in femoral bone marrow-derived mesenchymal cells (MSC) from elderly patients suffering osteoarthritis or femoral fracture

(2010) Felícito García-Álvarez et al.   ARCHIVES OF GERONTOLOGY AND GERIATRICS

Current evidence for osteoarthritis treatments

(2010) Ananthila Anandacoomarasamy et al.   Therapeutic Advances in Musculoskeletal Disease

Aging and osteoarthritis: the role of chondrocyte senescence and aging changes in the cartilage matrix

(2009) R.F. Loeser   OSTEOARTHRITIS AND CARTILAGE

The Basic Science of Articular Cartilage: Structure, Composition, and Function

(2009) Alice J. Sophia Fox et al.   Sports Health-A Multidisciplinary Approach

Intramedullary pressure and matrix strain induced by oscillatory skeletal muscle stimulation and its potential in adaptation

(2008) Yi-Xian Qin et al.   JOURNAL OF BIOMECHANICS