Enhancing Chondrogenic Phenotype for Cartilage Tissue Engineering: Monoculture and Coculture of Articular Chondrocytes and Mesenchymal Stem Cells

Articular Chondrocyte Redifferentiation in 3D Co-cultures with Mesenchymal Stem Cells

(2014) Ville V. Meretoja et al.   TISSUE ENGINEERING PART C-METHODS

Direct and indirect co-culture of chondrocytes and mesenchymal stem cells for the generation of polymer/extracellular matrix hybrid constructs

(2013) Erica J. Levorson et al.   Acta Biomaterialia

Single-Stage Cell-Based Cartilage Regeneration Using a Combination of Chondrons and Mesenchymal Stromal Cells

(2013) Joris E.J. Bekkers et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

The effect of hypoxia on the chondrogenic differentiation of co-cultured articular chondrocytes and mesenchymal stem cells in scaffolds

(2013) Ville V. Meretoja et al.   BIOMATERIALS

TGF-β3-induced chondrogenesis in co-cultures of chondrocytes and mesenchymal stem cells on biodegradable scaffolds

(2013) Rebecca L. Dahlin et al.   BIOMATERIALS

Co-cultivated mesenchymal stem cells support chondrocytic differentiation of articular chondrocytes

(2013) Qiang Zuo et al.   INTERNATIONAL ORTHOPAEDICS

Chondrocyte redifferentiation and construct mechanical property development in single-component photocrosslinkable hydrogels

(2013) Peter A. Levett et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Gene expression profiling of dedifferentiated human articular chondrocytes in monolayer culture

(2013) B. Ma et al.   OSTEOARTHRITIS AND CARTILAGE

Mesenchymal Stem Cells Downregulate Articular Chondrocyte Differentiation in Noncontact Coculture Systems: Implications in Cartilage Tissue Regeneration

(2013) Lei Xu et al.   STEM CELLS AND DEVELOPMENT

Cell-Derived Polymer/Extracellular Matrix Composite Scaffolds for Cartilage Regeneration, Part 1: Investigation of Cocultures and Seeding Densities for Improved Extracellular Matrix Deposition

(2013) Erica J. Levorson et al.   TISSUE ENGINEERING PART C-METHODS

Cell-Derived Polymer/Extracellular Matrix Composite Scaffolds for Cartilage Regeneration, Part 2: Construct Devitalization and Determination of Chondroinductive Capacity

(2013) Erica J. Levorson et al.   TISSUE ENGINEERING PART C-METHODS

Hypoxia Enhances Chondrogenesis and Prevents Terminal Differentiation through PI3K/Akt/FoxO Dependent Anti-Apoptotic Effect

(2013) Hsieh-Hsing Lee et al.   Scientific Reports

Mesenchymal chondroprogenitor cell origin and therapeutic potential

(2013) Janice O'Sullivan et al.   Stem Cell Research & Therapy

Hypoxia and flow perfusion modulate proliferation and gene expression of articular chondrocytes on porous scaffolds

(2012) Rebecca L. Dahlin et al.   AICHE JOURNAL

Inducing ossification in an engineered 3D scaffold-free living cartilage template

(2012) Ting Ting Lau et al.   BIOMATERIALS

Enhanced chondrogenesis in co-cultures with articular chondrocytes and mesenchymal stem cells

(2012) Ville V. Meretoja et al.   BIOMATERIALS

Cartilage graft engineering by co-culturing primary human articular chondrocytes with human bone marrow stromal cells

(2012) Maria Antonietta Sabatino et al.   Journal of Tissue Engineering and Regenerative Medicine

Unlike Bone, Cartilage Regeneration Remains Elusive

(2012) D. J. Huey et al.   SCIENCE

Culture of Primary Bovine Chondrocytes on a Continuously Expanding Surface Inhibits Dedifferentiation

(2012) Derek H. Rosenzweig et al.   TISSUE ENGINEERING PART A

Trophic Effects of Mesenchymal Stem Cells in Chondrocyte Co-Cultures are Independent of Culture Conditions and Cell Sources

(2012) Ling Wu et al.   TISSUE ENGINEERING PART A

Dedifferentiation and Redifferentiation of Articular Chondrocytes from Surface and Middle Zones: Changes in MicroRNAs-221/-222, -140, and -143/145 Expression

(2012) Eunmee Hong et al.   TISSUE ENGINEERING PART A

Combined 3D and hypoxic culture improves cartilage-specific gene expression in human chondrocytes

(2011) Casper B Foldager et al.   Acta Orthopaedica

Clinical and Magnetic Resonance Imaging–Based Outcomes to 5 Years After Matrix-Induced Autologous Chondrocyte Implantation to Address Articular Cartilage Defects in the Knee

(2011) Jay R. Ebert et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

Enhanced MSC chondrogenesis following delivery of TGF-β3 from alginate microspheres within hyaluronic acid hydrogels in vitro and in vivo

(2011) Liming Bian et al.   BIOMATERIALS

Effects of oxygen and culture system on in vitro propagation and redifferentiation of osteoarthritic human articular chondrocytes

(2011) Karsten Schrobback et al.   CELL AND TISSUE RESEARCH

Chondrocytes or adult stem cells for cartilage repair: The indisputable role of growth factors

(2011) Anne-Marie Freyria et al.   INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED

Enhanced chondrocyte proliferation and mesenchymal stromal cells chondrogenesis in coculture pellets mediate improved cartilage formation

(2011) Chitrangada Acharya et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Extracellular matrix deposited by synovium-derived stem cells delays replicative senescent chondrocyte dedifferentiation and enhances redifferentiation

(2011) Ming Pei et al.   JOURNAL OF CELLULAR PHYSIOLOGY

State of the art and future perspectives of articular cartilage regeneration: a focus on adipose-derived stem cells and platelet-derived products

(2011) F. Hildner et al.   Journal of Tissue Engineering and Regenerative Medicine

Gene expression and cell differentiation in matrix-associated chondrocyte transplantation grafts: a comparative study

(2011) C. Albrecht et al.   OSTEOARTHRITIS AND CARTILAGE

Structured three-dimensional co-culture of mesenchymal stem cells with chondrocytes promotes chondrogenic differentiation without hypertrophy

(2011) M.E. Cooke et al.   OSTEOARTHRITIS AND CARTILAGE

Trophic Effects of Mesenchymal Stem Cells Increase Chondrocyte Proliferation and Matrix Formation

(2011) Ling Wu et al.   TISSUE ENGINEERING PART A

The Response of Bone Marrow-Derived Mesenchymal Stem Cells to Dynamic Compression Following TGF-β3 Induced Chondrogenic Differentiation

(2010) Stephen D. Thorpe et al.   ANNALS OF BIOMEDICAL ENGINEERING

Human articular chondrocytes secrete parathyroid hormone-related protein and inhibit hypertrophy of mesenchymal stem cells in coculture during chondrogenesis

(2010) J. Fischer et al.   ARTHRITIS AND RHEUMATISM

Osteoarthritic chondrocyte-secreted morphogens induce chondrogenic differentiation of human mesenchymal stem cells

(2010) Aereas Aung et al.   ARTHRITIS AND RHEUMATISM

Bioactive polymer/extracellular matrix scaffolds fabricated with a flow perfusion bioreactor for cartilage tissue engineering

(2010) Jiehong Liao et al.   BIOMATERIALS

Evaluating osteochondral defect repair potential of autologous rabbit bone marrow cells on type II collagen scaffold

(2010) Wei-Chuan Chen et al.   CYTOTECHNOLOGY

Gene expression profiling of primary human articular chondrocytes in high-density micromasses reveals patterns of recovery, maintenance, re- and dedifferentiation

(2010) Tilo Dehne et al.   GENE

Treatment of articular cartilage lesions of the knee

(2010) Mazen Falah et al.   INTERNATIONAL ORTHOPAEDICS

Low oxygen tension is a more potent promoter of chondrogenic differentiation than dynamic compression

(2010) Eric G. Meyer et al.   JOURNAL OF BIOMECHANICS

Matrix-induced autologous chondrocyte implantation versus microfracture in the treatment of cartilage defects of the knee: a 2-year randomised study

(2010) Erhan Basad et al.   KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY

Recapitulation of endochondral bone formation using human adult mesenchymal stem cells as a paradigm for developmental engineering

(2010) C. Scotti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Primary chondrocytes enhance cartilage tissue formation upon co-culture with a range of cell types

(2010) Jeanine A. A. Hendriks et al.   Soft Matter

Mesenchymal Stem Cell Stimulation of Tissue Growth Depends on Differentiation State

(2010) Ashley R. Rothenberg et al.   STEM CELLS AND DEVELOPMENT

Improving Chondrogenesis: Potential and Limitations of SOX9 Gene Transfer and Mechanical Stimulation for Cartilage Tissue Engineering

(2010) Laszlo Kupcsik et al.   TISSUE ENGINEERING PART A

Coculture of Human Mesenchymal Stem Cells and Articular Chondrocytes Reduces Hypertrophy and Enhances Functional Properties of Engineered Cartilage

(2010) Liming Bian et al.   TISSUE ENGINEERING PART A

Comparative Review of Growth Factors for Induction of Three-Dimensional In Vitro Chondrogenesis in Human Mesenchymal Stem Cells Isolated from Bone Marrow and Adipose Tissue

(2010) Jennifer L. Puetzer et al.   TISSUE ENGINEERING PART B-REVIEWS

Anabolic and catabolic responses of human articular chondrocytes to varying oxygen percentages

(2010) Simon Ströbel et al.   ARTHRITIS RESEARCH & THERAPY

Activation and dedifferentiation of chondrocytes: Implications in cartilage injury and repair

(2009) Gundula Schulze-Tanzil   ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER

In vitro stage-specific chondrogenesis of mesenchymal stem cells committed to chondrocytes

(2009) Wei-Hong Chen et al.   ARTHRITIS AND RHEUMATISM

The use of green fluorescence gene (GFP)-modified rabbit mesenchymal stem cells (rMSCs) co-cultured with chondrocytes in hydrogel constructs to reveal the chondrogenesis of MSCs

(2009) Han N. Yang et al.   BIOMATERIALS

Population doublings and percentage of S100-positive cells as predictors of in vitro chondrogenicity of expanded human articular chondrocytes

(2009) Samoa Giovannini et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Transient Exposure to Transforming Growth Factor Beta 3 Improves the Mechanical Properties of Mesenchymal Stem Cell–Laden Cartilage Constructs in a Density-Dependent Manner

(2009) Alice H. Huang et al.   TISSUE ENGINEERING PART A

Variations in the ratios of co-cultured mesenchymal stem cells and chondrocytes regulate the expression of cartilaginous and osseous phenotype in alginate constructs

(2008) Xiang-tao Mo et al.   BONE

Hypoxia promotes chondrogenesis in rat mesenchymal stem cells: A role for AKT and hypoxia‐inducible factor (HIF)‐1α

(2008) Manoj Kanichai et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Hypoxic expansion promotes the chondrogenic potential of articular chondrocytes

(2008) Rainer J. Egli et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Why are MSCs therapeutic? New data: new insight

(2008) AI Caplan   JOURNAL OF PATHOLOGY

Cellular methods in cartilage research: Primary human chondrocytes in culture and chondrogenesis in human bone marrow stem cells

(2008) Simon R. Tew et al.   METHODS

Transient Exposure to Transforming Growth Factor Beta 3 Under Serum-Free Conditions Enhances the Biomechanical and Biochemical Maturation of Tissue-Engineered Cartilage

(2008) Benjamin A. Byers et al.   TISSUE ENGINEERING PART A

Comparison of Chondrogenic Potential in Equine Mesenchymal Stromal Cells Derived from Adipose Tissue and Bone Marrow

(2008) MARTIN A. VIDAL et al.   VETERINARY SURGERY