Proteomic characterization of endogenous substrates of mammalian ubiquitin ligase Hrd1

Hypothalamic ER–associated degradation regulates POMC maturation, feeding, and age-associated obesity

(2018) Geun Hyang Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Characterization of protein complexes of the endoplasmic reticulum-associated degradation E3 ubiquitin ligase Hrd1

(2017) Jiwon Hwang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ER-associated degradation is required for vasopressin prohormone processing and systemic water homeostasis

(2017) Guojun Shi et al.   JOURNAL OF CLINICAL INVESTIGATION

Cryo-EM structure of the protein-conducting ERAD channel Hrd1 in complex with Hrd3

(2017) Stefan Schoebel et al.   NATURE

Autoubiquitination of the Hrd1 Ligase Triggers Protein Retrotranslocation in ERAD

(2016) Ryan D. Baldridge et al.   CELL

Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery

(2016) Fiorenza Fumagalli et al.   NATURE CELL BIOLOGY

The HECT domain ubiquitin ligase HUWE1 targets unassembled soluble proteins for degradation

(2016) Yue Xu et al.   Cell Discovery

gp78 functions downstream of Hrd1 to promote degradation of misfolded proteins of the endoplasmic reticulum

(2015) Ting Zhang et al.   MOLECULAR BIOLOGY OF THE CELL

IRE1α is an endogenous substrate of endoplasmic-reticulum-associated degradation

(2015) Shengyi Sun et al.   NATURE CELL BIOLOGY

ER-associated degradation: Protein quality control and beyond

(2014) Annamaria Ruggiano et al.   JOURNAL OF CELL BIOLOGY

Cleaning up in the endoplasmic reticulum: ubiquitin in charge

(2014) John C Christianson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival

(2014) Shengyi Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of HERP and a HERP-related Protein in HRD1-dependent Protein Degradation at the Endoplasmic Reticulum

(2013) Chih-Hsiang Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death

(2013) Paola Magnaghi et al.   Nature Chemical Biology

MHC class I molecules are preferentially ubiquitinated on endoplasmic reticulum luminal residues during HRD1 ubiquitin E3 ligase-mediated dislocation

(2013) M. L. Burr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unassembled CD147 is an endogenous endoplasmic reticulum–associated degradation substrate

(2012) Ryan E. Tyler et al.   MOLECULAR BIOLOGY OF THE CELL

Ubiquitin Ligase Substrate Identification through Quantitative Proteomics at Both the Protein and Peptide Levels

(2011) Kimberly A. Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dual Regulation of the Transcriptional Activity of Nrf1 by  -TrCP- and Hrd1-Dependent Degradation Mechanisms

(2011) Y. Tsuchiya et al.   MOLECULAR AND CELLULAR BIOLOGY

Road to Ruin: Targeting Proteins for Degradation in the Endoplasmic Reticulum

(2011) M. H. Smith et al.   SCIENCE

Retrotranslocation of a Misfolded Luminal ER Protein by the Ubiquitin-Ligase Hrd1p

(2010) Pedro Carvalho et al.   CELL

ERAD and ERAD tuning: disposal of cargo and of ERAD regulators from the mammalian ER

(2010) Riccardo Bernasconi et al.   CURRENT OPINION IN CELL BIOLOGY

Defining the Glycan Destruction Signal for Endoplasmic Reticulum-Associated Degradation

(2008) Erin M. Quan et al.   MOLECULAR CELL

OS-9 and GRP94 deliver mutant α1-antitrypsin to the Hrd1–SEL1L ubiquitin ligase complex for ERAD

(2008) John C. Christianson et al.   NATURE CELL BIOLOGY