mRNA-engineered mesenchymal stem cells for targeted delivery of interleukin-10 to sites of inflammation

The mesenchymal stromal cells dilemma—does a negative phase III trial of random donor mesenchymal stromal cells in steroid-resistant graft-versus-host disease represent a death knell or a bump in the road?

(2013) Jacques Galipeau   CYTOTHERAPY

Harnessing the Mesenchymal Stem Cell Secretome for the Treatment of Cardiovascular Disease

(2012) Sudhir H. Ranganath et al.   Cell Stem Cell

Endogenous Bone Marrow MSCs Are Dynamic, Fate-Restricted Participants in Bone Maintenance and Regeneration

(2012) Dongsu Park et al.   Cell Stem Cell

New insights on translational development of mesenchymal stromal cells for suppressor therapy

(2012) Moïra François et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Therapeutic potential of mesenchymal stem cell-derived microvesicles

(2012) L. Biancone et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Mesenchymal Stem Cells Transmigrate Between and Directly Through Tumor Necrosis Factor-α-Activated Endothelial Cells Via Both Leukocyte-Like and Novel Mechanisms

(2012) Grace S. L. Teo et al.   STEM CELLS

Analysis of Tissues Following Mesenchymal Stromal Cell Therapy in Humans Indicates Limited Long-Term Engraftment and No Ectopic Tissue Formation

(2012) L. von Bahr et al.   STEM CELLS

Regulation and Functions of the IL-10 Family of Cytokines in Inflammation and Disease

(2011) Wenjun Ouyang et al.   Annual Review of Immunology

Mesenchymal Stem Cells: Mechanisms of Inflammation

(2011) Nora G. Singer et al.   Annual Review of Pathology-Mechanisms of Disease

Long-Term Complications, Immunologic Effects, and Role of Passage for Outcome in Mesenchymal Stromal Cell Therapy

(2011) Lena von Bahr et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Engineered cell homing

(2011) D. Sarkar et al.   BLOOD

Expression of therapeutic proteins after delivery of chemically modified mRNA in mice

(2011) Michael S D Kormann et al.   NATURE BIOTECHNOLOGY

Human Mesenchymal Stem Cells Reprogram Adult Cardiomyocytes Toward a Progenitor-Like State Through Partial Cell Fusion and Mitochondria Transfer

(2011) Adrien Acquistapace et al.   STEM CELLS

Co-infusion of ex vivo-expanded, parental MSCs prevents life-threatening acute GVHD, but does not reduce the risk of graft failure in pediatric patients undergoing allogeneic umbilical cord blood transplantation

(2010) M E Bernardo et al.   BONE MARROW TRANSPLANTATION

Highly Efficient Reprogramming to Pluripotency and Directed Differentiation of Human Cells with Synthetic Modified mRNA

(2010) Luigi Warren et al.   Cell Stem Cell

Genetic Modification of Mesenchymal Stem Cells Overexpressing CCR1 Increases Cell Viability, Migration, Engraftment, and Capillary Density in the Injured Myocardium

(2010) Jing Huang et al.   CIRCULATION RESEARCH

The immunomodulatory properties of mesenchymal stem cells and their use for immunotherapy

(2010) Martin J Hoogduijn et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

mRNA as gene therapeutic: How to control protein expression

(2010) Geertrui Tavernier et al.   JOURNAL OF CONTROLLED RELEASE

Targeting Improves MSC Treatment of Inflammatory Bowel Disease

(2010) In Kap Ko et al.   MOLECULAR THERAPY

Incorporation of pseudouridine into mRNA enhances translation by diminishing PKR activation

(2010) Bart R. Anderson et al.   NUCLEIC ACIDS RESEARCH

Innate Immune Suppression Enables Frequent Transfection with RNA Encoding Reprogramming Proteins

(2010) Matthew Angel et al.   PLoS One

Mesenchymal stem cell therapy: Two steps forward, one step back

(2010) James Ankrum et al.   TRENDS IN MOLECULAR MEDICINE

Intravenous hMSCs Improve Myocardial Infarction in Mice because Cells Embolized in Lung Are Activated to Secrete the Anti-inflammatory Protein TSG-6

(2009) Ryang Hwa Lee et al.   Cell Stem Cell

Mesenchymal Stem Cell Homing: The Devil Is in the Details

(2009) Jeffrey M. Karp et al.   Cell Stem Cell

Allogeneic mesenchymal stem cells transplantation in treatment of multiple sclerosis

(2009) J Liang et al.   Multiple Sclerosis Journal

Assessment of therapeutic efficacy and fate of engineered human mesenchymal stem cells for cancer therapy

(2009) L. S. Sasportas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct Evidence of Mesenchymal Stem Cell Tropism for Tumor and Wounding Microenvironments Using In Vivo Bioluminescent Imaging

(2009) Shannon Kidd et al.   STEM CELLS

Mesenchymal stem cells overexpressing interleukin-10 attenuate collagen-induced arthritis in mice

(2008) J.-J. Choi et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Atorvastatin treatment improves survival and effects of implanted mesenchymal stem cells in post-infarct swine hearts

(2008) Y.-J. Yang et al.   EUROPEAN HEART JOURNAL

In Vivo Cell Tracking With Video Rate Multimodality Laser Scanning Microscopy

(2008) I. Veilleux et al.   IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS

Distinct Cytokine Patterns Identified from Multiplex Profiles of Murine DSS and TNBS-Induced Colitis

(2008) Philip Alex et al.   INFLAMMATORY BOWEL DISEASES

Pre-Treatment of Mesenchymal Stem Cells With a Combination of Growth Factors Enhances Gap Junction Formation, Cytoprotective Effect on Cardiomyocytes, and Therapeutic Efficacy for Myocardial Infarction

(2008) Joo-Yong Hahn et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Targeted Migration of Mesenchymal Stem Cells Modified With CXCR4 Gene to Infarcted Myocardium Improves Cardiac Performance

(2008) Zhaokang Cheng et al.   MOLECULAR THERAPY

Incorporation of Pseudouridine Into mRNA Yields Superior Nonimmunogenic Vector With Increased Translational Capacity and Biological Stability

(2008) Katalin Karikó et al.   MOLECULAR THERAPY

Ex vivo glycan engineering of CD44 programs human multipotent mesenchymal stromal cell trafficking to bone

(2008) Robert Sackstein et al.   NATURE MEDICINE

Biodistribution, Long-term Survival, and Safety of Human Adipose Tissue-derived Mesenchymal Stem Cells Transplanted in Nude Mice by High Sensitivity Non-invasive Bioluminescence Imaging

(2008) Marta Vilalta et al.   STEM CELLS AND DEVELOPMENT