The Epigenomic Landscape in Osteoarthritis

Intra-articular Delivery of Antago-miR-483-5p Inhibits Osteoarthritis by Modulating Matrilin 3 and Tissue Inhibitor of Metalloproteinase 2

(2017) Hua Wang et al.   MOLECULAR THERAPY

Utility of circulating serum miRNAs as biomarkers of early cartilage degeneration in animal models of post-traumatic osteoarthritis and inflammatory arthritis

(2017) L.H.W. Kung et al.   OSTEOARTHRITIS AND CARTILAGE

Analysis of genetics and DNA methylation in osteoarthritis: What have we learnt about the disease?

(2017) Louise N. Reynard   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Genome-wide DNA methylation profile implicates potential cartilage regeneration at the late stage of knee osteoarthritis

(2016) Y. Zhang et al.   OSTEOARTHRITIS AND CARTILAGE

Identification of synovial fluid microRNA signature in knee osteoarthritis: differentiating early- and late-stage knee osteoarthritis

(2016) Y.-H. Li et al.   OSTEOARTHRITIS AND CARTILAGE

Genome-Wide DNA Methylation Study Identifies Significant Epigenomic Changes in Osteoarthritic Subchondral Bone and Similarity to Overlying Cartilage

(2016) Matlock A. Jeffries et al.   Arthritis & Rheumatology

microRNA-140 Inhibits Inflammation and Stimulates Chondrogenesis in a Model of Interleukin 1β-induced Osteoarthritis

(2016) Tommy A Karlsen et al.   Molecular Therapy-Nucleic Acids

Identification of DNA methylation changes associated with disease progression in subchondral bone with site-matched cartilage in knee osteoarthritis

(2016) Yanfei Zhang et al.   Scientific Reports

Genome-wide DNA methylation study of hip and knee cartilage reveals embryonic organ and skeletal system morphogenesis as major pathways involved in osteoarthritis

(2015) Erfan Aref-Eshghi et al.   BMC MUSCULOSKELETAL DISORDERS

DNA Methylation in Osteoarthritis

(2015) Wouter Hollander et al.   CURRENT GENOMICS

Methylation quantitative trait locus analysis of osteoarthritis links epigenetics with genetic risk

(2015) Michael D. Rushton et al.   HUMAN MOLECULAR GENETICS

Differential DNA methylation and reduced expression of critical transcription factors in human oa cartilage

(2015) O. Alvarez-Garcia et al.   OSTEOARTHRITIS AND CARTILAGE

Epigenetic regulation of interleukin-8, an inflammatory chemokine, in osteoarthritis

(2015) A. Takahashi et al.   OSTEOARTHRITIS AND CARTILAGE

DNA methylation regulates sclerostin (SOST) expression in osteoarthritic chondrocytes by bone morphogenetic protein 2 (BMP-2) induced changes in Smads binding affinity to the CpG region of SOST promoter

(2015) Ioanna Papathanasiou et al.   ARTHRITIS RESEARCH & THERAPY

Transcriptional Associations of Osteoarthritis-Mediated Loss of Epigenetic Control in Articular Cartilage

(2015) Wouter den Hollander et al.   Arthritis & Rheumatology

The effect of forced exercise on knee joints in Dio2−/−mice: type II iodothyronine deiodinase-deficient mice are less prone to develop OA-like cartilage damage upon excessive mechanical stress

(2014) Nils Bomer et al.   ANNALS OF THE RHEUMATIC DISEASES

Knee and hip articular cartilage have distinct epigenomic landscapes: implications for future cartilage regeneration approaches

(2014) W den Hollander et al.   ANNALS OF THE RHEUMATIC DISEASES

Underlying molecular mechanisms ofDIO2susceptibility in symptomatic osteoarthritis

(2014) Nils Bomer et al.   ANNALS OF THE RHEUMATIC DISEASES

The epidemiology of osteoarthritis

(2014) Victoria L. Johnson et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

DNA demethylation, Tet proteins and 5-hydroxymethylcytosine in epigenetic reprogramming: An emerging complex story

(2014) Peter W.S. Hill et al.   GENOMICS

Correlation between MMP-13 and HDAC7 expression in human knee osteoarthritis

(2014) Reiji Higashiyama et al.   Modern Rheumatology

Functional interactions among microRNAs and long noncoding RNAs

(2014) Je-Hyun Yoon et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Lysine-specific demethylase 1-mediated demethylation of histone H3 lysine 9 contributes to interleukin 1β-induced microsomal prostaglandin E synthase 1 expression in human osteoarthritic chondrocytes

(2014) Fatima El Mansouri et al.   ARTHRITIS RESEARCH & THERAPY

Intra-articular injection of synthetic microRNA-210 accelerates avascular meniscal healing in rat medial meniscal injured model

(2014) Yoshitaka Kawanishi et al.   ARTHRITIS RESEARCH & THERAPY

Association of Reduced Type IX Collagen Gene Expression in Human Osteoarthritic Chondrocytes With Epigenetic Silencing by DNA Hypermethylation

(2014) Kei Imagawa et al.   Arthritis & Rheumatology

Genome-Wide DNA Methylation Study Identifies Significant Epigenomic Changes in Osteoarthritic Cartilage

(2014) Matlock A. Jeffries et al.   Arthritis & Rheumatology

Characterization of the Cartilage DNA Methylome in Knee and Hip Osteoarthritis

(2014) Michael D. Rushton et al.   Arthritis & Rheumatology

Genome-wide DNA methylation analysis of articular chondrocytes reveals a cluster of osteoarthritic patients

(2013) Juan Fernández-Tajes et al.   ANNALS OF THE RHEUMATIC DISEASES

Class I Histone Deacetylase Inhibition Modulates Metalloproteinase Expression and Blocks Cytokine-Induced Cartilage Degradation

(2013) Kirsty L. Culley et al.   ARTHRITIS AND RHEUMATISM

Vorinostat, a HDAC inhibitor, showed anti-osteoarthritic activities through inhibition of iNOS and MMP expression, p38 and ERK phosphorylation and blocking NF-κB nuclear translocation

(2013) Hui-ming Zhong et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Regulated Transcription of Human Matrix Metalloproteinase 13 (MMP13) and Interleukin-1β (IL1B) Genes in Chondrocytes Depends on Methylation of Specific Proximal Promoter CpG Sites

(2013) Ko Hashimoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Set7/9 ImpactsCOL2A1Expression Through Binding and Repression of SirT1 Histone Deacetylation

(2013) Hanna Oppenheimer et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Osteoarthritis: A disease of the joint as an organ

(2012) Richard F. Loeser et al.   ARTHRITIS AND RHEUMATISM

Loss of methylation in CpG sites in the NF-κB enhancer elements of inducible nitric oxide synthase is responsible for gene induction in human articular chondrocytes

(2012) María C. de Andrés et al.   ARTHRITIS AND RHEUMATISM

Characterization of microRNA expression profiles in normal and osteoarthritic human chondrocytes

(2012) Silvia Díaz-Prado et al.   BMC MUSCULOSKELETAL DISORDERS

cAMP response element-binding (CREB) recruitment following a specific CpG demethylation leads to the elevated expression of the matrix metalloproteinase 13 in human articular chondrocytes and osteoarthritis

(2012) Catherine Bui et al.   FASEB JOURNAL

Changes in the epigenetic status of theSOX-9promoter in human osteoarthritic cartilage

(2012) Kyung-Il Kim et al.   JOURNAL OF BONE AND MINERAL RESEARCH

MicroRNA-199a-3p, microRNA-193b, and microRNA-320c are correlated to aging and regulate human cartilage metabolism

(2012) Taku Ukai et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Wnt5a-Ror2 signaling between osteoblast-lineage cells and osteoclast precursors enhances osteoclastogenesis

(2012) Kazuhiro Maeda et al.   NATURE MEDICINE

Macro view of microRNA function in osteoarthritis

(2012) Shigeru Miyaki et al.   Nature Reviews Rheumatology

DNA methylation status predicts cell type-specific enhancer activity

(2011) Malgorzata Wiench et al.   EMBO JOURNAL

MicroRNA-146a is linked to pain-related pathophysiology of osteoarthritis

(2011) Xin Li et al.   GENE

Expression of the osteoarthritis-associated gene GDF5 is modulated epigenetically by DNA methylation

(2011) Louise N. Reynard et al.   HUMAN MOLECULAR GENETICS

Regulation of Human Chondrocyte Function through Direct Inhibition of Cartilage Master Regulator SOX9 by MicroRNA-145 (miRNA-145)

(2011) Aida Martinez-Sanchez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nfat1 regulates adult articular chondrocyte function through its age-dependent expression mediated by epigenetic histone methylation

(2011) Marianna Rodova et al.   JOURNAL OF BONE AND MINERAL RESEARCH

MicroRNA-27b regulates the expression of matrix metalloproteinase 13 in human osteoarthritis chondrocytes

(2010) Nahid Akhtar et al.   ARTHRITIS AND RHEUMATISM

miR-27a is a negative regulator of adipocyte differentiation via suppressing PPARγ expression

(2010) Sang Yun Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

MicroRNA-140 and the silencing of osteoarthritis

(2010) E. Araldi et al.   GENES & DEVELOPMENT

MicroRNA-140 plays dual roles in both cartilage development and homeostasis

(2010) S. Miyaki et al.   GENES & DEVELOPMENT

Genetic epidemiology of hip and knee osteoarthritis

(2010) Ana M. Valdes et al.   Nature Reviews Rheumatology

DNA demethylation at specific CpG sites in theIL1Bpromoter in response to inflammatory cytokines in human articular chondrocytes

(2009) Ko Hashimoto et al.   ARTHRITIS AND RHEUMATISM

MicroRNA-140 is expressed in differentiated human articular chondrocytes and modulates interleukin-1 responses

(2009) Shigeru Miyaki et al.   ARTHRITIS AND RHEUMATISM

Regulation of the IGFBP-5 and MMP-13 genes by the microRNAs miR-140 and miR-27a in human osteoarthritic chondrocytes

(2009) Ginette Tardif et al.   BMC MUSCULOSKELETAL DISORDERS

Epigenetic Histone Code and Autoimmunity

(2009) Jürgen Dieker et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

A novel domain in histone deacetylase 1 and 2 mediates repression of cartilage-specific genes in human chondrocytes

(2009) Sohee Hong et al.   FASEB JOURNAL

Inhibition of histone deacetylases antagonized FGF2 and IL-1β effects on MMP expression in human articular chondrocytes

(2009) Xibin Wang et al.   GROWTH FACTORS

The RNA-induced Silencing Complex: A Versatile Gene-silencing Machine

(2009) Ashley J. Pratt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Cartilage-specific Gene Expression in Human Chondrocytes by SirT1 and Nicotinamide Phosphoribosyltransferase

(2008) Mona Dvir-Ginzberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation

(2008) Yutaka Kondo et al.   NATURE GENETICS

Trichostatin A, a histone deacetylase inhibitor, suppresses synovial inflammation and subsequent cartilage destruction in a collagen antibody-induced arthritis mouse model

(2008) Y. Nasu et al.   OSTEOARTHRITIS AND CARTILAGE

The identification of differentially expressed microRNA in osteoarthritic tissue that modulate the production of TNF-α and MMP13

(2008) S.W. Jones et al.   OSTEOARTHRITIS AND CARTILAGE

Integrative MicroRNA and Proteomic Approaches Identify Novel Osteoarthritis Genes and Their Collaborative Metabolic and Inflammatory Networks

(2008) Dimitrios Iliopoulos et al.   PLoS One