Epigenetics in osteoarthritis and its implication for future therapeutics

Correlation between MMP-13 and HDAC7 expression in human knee osteoarthritis

(2014) Reiji Higashiyama et al.   Modern Rheumatology

MicroRNA in Osteoarthritis

(2013) C Yu et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

DNA methylome signature in rheumatoid arthritis

(2012) Kazuhisa Nakano et al.   ANNALS OF THE RHEUMATIC DISEASES

cAMP response element-binding (CREB) recruitment following a specific CpG demethylation leads to the elevated expression of the matrix metalloproteinase 13 in human articular chondrocytes and osteoarthritis

(2012) Catherine Bui et al.   FASEB JOURNAL

Epigenetic mechanisms in cartilage and osteoarthritis: DNA methylation, histone modifications and microRNAs

(2012) M.J. Barter et al.   OSTEOARTHRITIS AND CARTILAGE

Suppressors of cytokine signalling (SOCS) are reduced in osteoarthritis

(2011) María C. de Andrés et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The epigenetic effect of glucosamine and a nuclear factor-kappa B (NF-kB) inhibitor on primary human chondrocytes – Implications for osteoarthritis

(2011) Kei Imagawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

MicroRNA regulation associated chondrogenesis of mouse MSCs grown on polyhydroxyalkanoates

(2011) Chao Yan et al.   BIOMATERIALS

MicroRNA-146a is linked to pain-related pathophysiology of osteoarthritis

(2011) Xin Li et al.   GENE

Expression of the osteoarthritis-associated gene GDF5 is modulated epigenetically by DNA methylation

(2011) Louise N. Reynard et al.   HUMAN MOLECULAR GENETICS

Genetics and epigenetics of osteoarthritis

(2011) Louise N. Reynard et al.   MATURITAS

Epigenome-wide association studies for common human diseases

(2011) Vardhman K. Rakyan et al.   NATURE REVIEWS GENETICS

Epigenomic and microRNA-mediated regulation in cartilage development, homeostasis, and osteoarthritis

(2011) Mary B. Goldring et al.   TRENDS IN MOLECULAR MEDICINE

DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines

(2011) Jordana T Bell et al.   GENOME BIOLOGY

Superoxide dismutase downregulation in osteoarthritis progression and end-stage disease

(2010) J. L. Scott et al.   ANNALS OF THE RHEUMATIC DISEASES

SirT1 enhances survival of human osteoarthritic chondrocytes by repressing protein tyrosine phosphatase 1B and activating the insulin-like growth factor receptor pathway

(2010) Viktoria Gagarina et al.   ARTHRITIS AND RHEUMATISM

MicroRNA-27b regulates the expression of matrix metalloproteinase 13 in human osteoarthritis chondrocytes

(2010) Nahid Akhtar et al.   ARTHRITIS AND RHEUMATISM

Contribution of H3K4 methylation by SET-1A to interleukin-1-induced cyclooxygenase 2 and inducible nitric oxide synthase expression in human osteoarthritis chondrocytes

(2010) Fatima Ezzahra El Mansouri et al.   ARTHRITIS AND RHEUMATISM

Identification of miR-1 as a micro RNA that supports late-stage differentiation of growth cartilage cells

(2010) Kumi Sumiyoshi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

miR-27a is a negative regulator of adipocyte differentiation via suppressing PPARγ expression

(2010) Sang Yun Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

MicroRNA-140 and the silencing of osteoarthritis

(2010) E. Araldi et al.   GENES & DEVELOPMENT

MicroRNA-140 plays dual roles in both cartilage development and homeostasis

(2010) S. Miyaki et al.   GENES & DEVELOPMENT

Type II Collagen Expression Is Regulated by Tissue-specific miR-675 in Human Articular Chondrocytes

(2010) Katarzyna A. Dudek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Potential involvement of SIRT1 in the pathogenesis of osteoarthritis through the modulation of chondrocyte gene expressions

(2010) Norifumi Fujita et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Alleviation of osteoarthritis by Trichostatin A, a histone deacetylase inhibitor, in experimental osteoarthritis

(2010) Wei-Ping Chen et al.   MOLECULAR BIOLOGY REPORTS

DNA Methylation Mediated by a MicroRNA Pathway

(2010) Liang Wu et al.   MOLECULAR CELL

Epigenomics reveals a functional genome anatomy and a new approach to common disease

(2010) Andrew P Feinberg   NATURE BIOTECHNOLOGY

Epigenetic modifications and human disease

(2010) Anna Portela et al.   NATURE BIOTECHNOLOGY

Hypoxia-inducible factor-2α is a catabolic regulator of osteoarthritic cartilage destruction

(2010) Siyoung Yang et al.   NATURE MEDICINE

Integrated Genetic and Epigenetic Analysis Identifies Haplotype-Specific Methylation in the FTO Type 2 Diabetes and Obesity Susceptibility Locus

(2010) Christopher G. Bell et al.   PLoS One

Plasma and synovial fluid microRNAs as potential biomarkers of rheumatoid arthritis and osteoarthritis

(2010) Koichi Murata et al.   ARTHRITIS RESEARCH & THERAPY

Extensive sequence-influenced DNA methylation polymorphism in the human genome

(2010) Asaf Hellman et al.   Epigenetics & Chromatin

DNA demethylation at specific CpG sites in theIL1Bpromoter in response to inflammatory cytokines in human articular chondrocytes

(2009) Ko Hashimoto et al.   ARTHRITIS AND RHEUMATISM

Methylation status of CpG islands in the promoter regions of signature genes during chondrogenesis of human synovium-derived mesenchymal stem cells

(2009) Yoichi Ezura et al.   ARTHRITIS AND RHEUMATISM

SIRT1 regulation of apoptosis of human chondrocytes

(2009) Koji Takayama et al.   ARTHRITIS AND RHEUMATISM

MicroRNA-140 is expressed in differentiated human articular chondrocytes and modulates interleukin-1 responses

(2009) Shigeru Miyaki et al.   ARTHRITIS AND RHEUMATISM

Profiling microRNA expression in bovine articular cartilage and implications for mechanotransduction

(2009) Walter Dunn et al.   ARTHRITIS AND RHEUMATISM

Expression of MicroRNA-146a in osteoarthritis cartilage

(2009) Keiichiro Yamasaki et al.   ARTHRITIS AND RHEUMATISM

Regulation of the IGFBP-5 and MMP-13 genes by the microRNAs miR-140 and miR-27a in human osteoarthritic chondrocytes

(2009) Ginette Tardif et al.   BMC MUSCULOSKELETAL DISORDERS

A novel domain in histone deacetylase 1 and 2 mediates repression of cartilage-specific genes in human chondrocytes

(2009) Sohee Hong et al.   FASEB JOURNAL

Regulation of chondrocytic phenotype by micro RNA 18a: Involvement ofCcn2/Ctgfas a major target gene

(2009) Toshihiro Ohgawara et al.   FEBS LETTERS

Inhibition of histone deacetylases antagonized FGF2 and IL-1β effects on MMP expression in human articular chondrocytes

(2009) Xibin Wang et al.   GROWTH FACTORS

Ionizing Radiation Induces Cellular Senescence of Articular Chondrocytes via Negative Regulation of SIRT1 by p38 Kinase

(2009) Eun-Hee Hong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

miR-199a*, a Bone Morphogenic Protein 2-responsive MicroRNA, Regulates Chondrogenesis via Direct Targeting to Smad1

(2009) Edward A. Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Induction and regulatory function of miR-9 in human monocytes and neutrophils exposed to proinflammatory signals

(2009) F. Bazzoni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Hypoxia-Inducible Factor 2  Signaling by the Stress-Responsive Deacetylase Sirtuin 1

(2009) E. M. Dioum et al.   SCIENCE

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

(2009) C. Choudhary et al.   SCIENCE

Isolation and characterization of CD146+ multipotent mesenchymal stromal cells

(2008) Antonio Sorrentino et al.   EXPERIMENTAL HEMATOLOGY

Regulation of Cartilage-specific Gene Expression in Human Chondrocytes by SirT1 and Nicotinamide Phosphoribosyltransferase

(2008) Mona Dvir-Ginzberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cellular and epigenetic features of a young healthy and a young osteoarthritic cartilage compared with aged control and OA cartilage

(2008) Marco A. da Silva et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Histone deacetylase inhibitors suppress interleukin-1β-induced nitric oxide and prostaglandin E2 production in human chondrocytes

(2008) N. Chabane et al.   OSTEOARTHRITIS AND CARTILAGE

Methylation of the OP-1 promoter: potential role in the age-related decline in OP-1 expression in cartilage

(2008) R.F. Loeser et al.   OSTEOARTHRITIS AND CARTILAGE

DNA methylation is not responsible for p21WAF1/CIP1 down-regulation in osteoarthritic chondrocytes

(2008) S. Sesselmann et al.   OSTEOARTHRITIS AND CARTILAGE

The identification of differentially expressed microRNA in osteoarthritic tissue that modulate the production of TNF-α and MMP13

(2008) S.W. Jones et al.   OSTEOARTHRITIS AND CARTILAGE

Integrative MicroRNA and Proteomic Approaches Identify Novel Osteoarthritis Genes and Their Collaborative Metabolic and Inflammatory Networks

(2008) Dimitrios Iliopoulos et al.   PLoS One

Dicer-dependent pathways regulate chondrocyte proliferation and differentiation

(2008) T. Kobayashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Etiopathogenesis of Osteoarthritis

(2008) Kenneth D. Brandt et al.   RHEUMATIC DISEASE CLINICS OF NORTH AMERICA

Expression of ADAMTS-4 by chondrocytes in the surface zone of human osteoarthritic cartilage is regulated by epigenetic DNA de-methylation

(2008) Kelvin S. C. Cheung et al.   RHEUMATOLOGY INTERNATIONAL