Heterogeneity and Actin Cytoskeleton in Osteoclast and Macrophage Multinucleation

YAP/TAZ functions and their regulation at a glance

(2020) Arianna Pocaterra et al.   JOURNAL OF CELL SCIENCE

Integrin‐associated molecules and signalling cross talking in osteoclast cytoskeleton regulation

(2020) Lingbo Kong et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Erythromyeloid progenitors give rise to a population of osteoclasts that contribute to bone homeostasis and repair

(2020) Yasuhito Yahara et al.   NATURE CELL BIOLOGY

Multinucleated giant cell phenotype in response to stimulation

(2020) Kevin L. Trout et al.   IMMUNOBIOLOGY

Dynamin regulates the dynamics and mechanical strength of the actin cytoskeleton as a multifilament actin-bundling protein

(2020) Ruihui Zhang et al.   NATURE CELL BIOLOGY

Switch of macrophage fusion competency by 3D matrices

(2020) Josephine Y. Fang et al.   Scientific Reports

Overview of RAW264.7 for osteoclastogensis study: Phenotype and stimuli

(2019) Lingbo Kong et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Tks5 and Dynamin-2 enhance actin bundle rigidity in invadosomes to promote myoblast fusion

(2019) Mei-Chun Chuang et al.   JOURNAL OF CELL BIOLOGY

Interaction between the integrin Mac-1 and signal regulatory protein α (SIRPα) mediates fusion in heterologous cells

(2019) Nataly P. Podolnikova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Overview of the Derivation and Function of Multinucleated Giant Cells and Their Role in Pathological Processes

(2019) Patricia Joyce Brooks et al.   AMERICAN JOURNAL OF PATHOLOGY

Integrin signaling and mechanotransduction in regulation of somatic stem cells

(2019) Aleksi Isomursu et al.   EXPERIMENTAL CELL RESEARCH

How cells fuse

(2019) Nicolas G. Brukman et al.   JOURNAL OF CELL BIOLOGY

Developmental origin, functional maintenance and genetic rescue of osteoclasts

(2019) Christian E. Jacome-Galarza et al.   NATURE

Coordination of Fusion and Trafficking of Pre-osteoclasts at the Marrow–Bone Interface

(2019) Kent Søe et al.   CALCIFIED TISSUE INTERNATIONAL

Immune Function and Diversity of Osteoclasts in Normal and Pathological Conditions

(2019) Maria-Bernadette Madel et al.   Frontiers in Immunology

The fusogenic synapse at a glance

(2019) Ji Hoon Kim et al.   JOURNAL OF CELL SCIENCE

Tunneling nanotubes mediate intercellular communication between endothelial progenitor cells and osteoclast precursors

(2019) Rui-Fang Li et al.   JOURNAL OF MOLECULAR HISTOLOGY

An actin-based protrusion originating from a podosome-enriched region initiates macrophage fusion

(2019) James J. Faust et al.   MOLECULAR BIOLOGY OF THE CELL

The Mononuclear Phagocytic System. Generation of Diversity

(2019) Siamon Gordon et al.   Frontiers in Immunology

Insight into Mechanobiology: How Stem Cells Feel Mechanical Forces and Orchestrate Biological Functions

(2019) Chiara Argentati et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Probing the mechanical landscape – new insights into podosome architecture and mechanics

(2019) Koen van den Dries et al.   JOURNAL OF CELL SCIENCE

Filopodia and their links with membrane traffic and cell adhesion

(2019) J.L. Gallop   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Digestive exophagy: Phagocyte digestion of objects too large for phagocytosis

(2019) Frederick R. Maxfield et al.   TRAFFIC

1-α,25-dihydroxyvitamin D 3 potentiates avian osteoclast activation by increasing the formation of zipper-like structure via Src/Rac1 signaling

(2018) Dong Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Membrane re-modelling by BAR domain superfamily proteins via molecular and non-molecular factors

(2018) Tamako Nishimura et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

YAP1 is essential for osteoclastogenesis through a TEADs-dependent mechanism

(2018) Liming Zhao et al.   BONE

Extracellular calcium regulates the adhesion and migration of osteoclast via integrin αv β3 / Rho A/Cytoskeleton signaling

(2018) Bilu Xiang et al.   CELL BIOLOGY INTERNATIONAL

Niche signals and transcription factors involved in tissue-resident macrophage development

(2018) Wouter T'Jonck et al.   CELLULAR IMMUNOLOGY

Origin and development of septoclasts in endochondral ossification of mice

(2018) Yasuhiko Bando et al.   HISTOCHEMISTRY AND CELL BIOLOGY

The Sealing Zone in Osteoclasts: A Self-Organized Structure on the Bone

(2018) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

IL1β and TNFα promote RANKL-dependent adseverin expression and osteoclastogenesis

(2018) Yongqiang Wang et al.   JOURNAL OF CELL SCIENCE

Common signalling pathways in macrophage and osteoclast multinucleation

(2018) Marie Pereira et al.   JOURNAL OF CELL SCIENCE

The actin cortex at a glance

(2018) Priyamvada Chugh et al.   JOURNAL OF CELL SCIENCE

The emerging role of Hippo signaling pathway in regulating osteoclast formation

(2018) Wanlei Yang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Actin binding LIM 1 (abLIM1) negatively controls osteoclastogenesis by regulating cell migration and fusion

(2018) Haruna Narahara et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Emerging views of the nucleus as a cellular mechanosensor

(2018) Tyler J. Kirby et al.   NATURE CELL BIOLOGY

Crosstalk between YAP/TAZ and Notch Signaling

(2018) Antonio Totaro et al.   TRENDS IN CELL BIOLOGY

Systematic Nanoscale Analysis of Endocytosis Links Efficient Vesicle Formation to Patterned Actin Nucleation

(2018) Markus Mund et al.   CELL

Non-canonical Wnt signals regulate cytoskeletal remodeling in osteoclasts

(2018) Shunsuke Uehara et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Talin as a mechanosensitive signaling hub

(2018) Benjamin T. Goult et al.   JOURNAL OF CELL BIOLOGY

Cell fusion potentiates tumor heterogeneity and reveals circulating hybrid cells that correlate with stage and survival

(2018) Charles E. Gast et al.   Science Advances

Developmental and Functional Heterogeneity of Monocytes

(2018) Martin Guilliams et al.   IMMUNITY

Orthodontic compressive force modulates Ets-1/Tks5 pathway to promote the formation of circumferential invadopodia and the fusion of osteoclast precursors

(2018) Yifan Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Evaluation of efficacy on RANKL induced osteoclast from RAW264.7 cells

(2018) Chengchao Song et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Integrin activation by talin, kindlin and mechanical forces

(2018) Zhiqi Sun et al.   NATURE CELL BIOLOGY

Variations on the theme of podosomes: A matter of context

(2018) Florian Alonso et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The role of CR3 (CD11b/CD18) and CR4 (CD11c/CD18) in complement-mediated phagocytosis and podosome formation by human phagocytes

(2017) Szilvia Lukácsi et al.   IMMUNOLOGY LETTERS

Transcriptional control of monocyte and macrophage development

(2017) Daisuke Kurotaki et al.   INTERNATIONAL IMMUNOLOGY

Cell-surface phosphatidylserine regulates osteoclast precursor fusion

(2017) Santosh K. Verma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rho GTPase signaling complexes in cell migration and invasion

(2017) Campbell D. Lawson et al.   JOURNAL OF CELL BIOLOGY

Actin assembly mechanisms at a glance

(2017) Klemens Rottner et al.   JOURNAL OF CELL SCIENCE

Diversity of actin architecture in human osteoclasts: network of curved and branched actin supporting cell shape and intercellular micrometer-level tubes

(2017) Paula Pennanen et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Network based subcellular proteomics in monocyte membrane revealed novel candidate genes involved in osteoporosis

(2017) Y. Zeng et al.   OSTEOPOROSIS INTERNATIONAL

SNARE proteins in membrane trafficking

(2017) Tuanlao Wang et al.   TRAFFIC

Symmetrical retrograde actin flow in the actin fusion structure is involved in osteoclast fusion

(2017) Jiro Takito et al.   Biology Open

Phosphatidylethanolamine dynamics are required for osteoclast fusion

(2017) Atsushi Irie et al.   Scientific Reports

Regulation of Osteoclast Differentiation by Myosin X

(2017) Amy Tasca et al.   Scientific Reports

Diversity of multinucleated giant cells by microstructures of hydroxyapatite and plasma components in extraskeletal implantation model

(2016) Kota Morishita et al.   Acta Biomaterialia

Macrophage reaction against biomaterials in the mouse model – Phenotypes, functions and markers

(2016) R. Klopfleisch   Acta Biomaterialia

The Role of Integrins α M β 2 (Mac-1, CD11b/CD18) and α D β 2 (CD11d/CD18) in Macrophage Fusion

(2016) Nataly P. Podolnikova et al.   AMERICAN JOURNAL OF PATHOLOGY

E-cadherin is important for cell differentiation during osteoclastogenesis

(2016) Cara Fiorino et al.   BONE

The cast of clasts: catabolism and vascular invasion during bone growth, repair, and disease by osteoclasts, chondroclasts, and septoclasts

(2016) Paul R. Odgren et al.   CONNECTIVE TISSUE RESEARCH

Diffusion Barriers, Mechanical Forces, and the Biophysics of Phagocytosis

(2016) Philip P. Ostrowski et al.   DEVELOPMENTAL CELL

United we stand: Adhesion and molecular mechanisms driving cell fusion across species

(2016) Francesca Zito et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Feel the force: Podosomes in mechanosensing

(2016) Stefan Linder et al.   EXPERIMENTAL CELL RESEARCH

Role of YAP/TAZ in cell-matrix adhesion-mediated signalling and mechanotransduction

(2016) Sirio Dupont   EXPERIMENTAL CELL RESEARCH

Osteoclast Fusion: Time-Lapse Reveals Involvement of CD47 and Syncytin-1 at Different Stages of Nuclearity

(2016) Anaïs Marie Julie Møller et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Ultrastructural aspects of foreign body giant cells generated on different substrates

(2016) Bas ten Harkel et al.   JOURNAL OF STRUCTURAL BIOLOGY

Osteoclast fusion is initiated by a small subset of RANKL-stimulated monocyte progenitors, which can fuse to RANKL-unstimulated progenitors

(2015) Noam Levaot et al.   BONE

The elementary fusion modalities of osteoclasts

(2015) Kent Søe et al.   BONE

Proliferation-coupled osteoclast differentiation by RANKL: Cell density as a determinant of osteoclast formation

(2015) M. Motiur Rahman et al.   BONE

Three steps forward, two steps back: mechanistic insights into the assembly and disassembly of the SNARE complex

(2015) Jeffrey P Bombardier et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

The role of osteoclast differentiation and function in skeletal homeostasis

(2015) Kyoji Ikeda et al.   JOURNAL OF BIOCHEMISTRY

Surface apposition and multiple cell contacts promote myoblast fusion inDrosophilaflight muscles

(2015) Nagaraju Dhanyasi et al.   JOURNAL OF CELL BIOLOGY

Oxysterols and EBI2 promote osteoclast precursor migration to bone surfaces and regulate bone mass homeostasis

(2015) Erin Nevius et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Multinucleated Giant Cells Are Specialized for Complement-Mediated Phagocytosis and Large Target Destruction

(2015) Ronny Milde et al.   Cell Reports

The Foreign Body Giant Cell Cannot Resorb Bone, But Dissolves Hydroxyapatite Like Osteoclasts

(2015) Bas ten Harkel et al.   PLoS One

Global epigenomic analysis indicates protocadherin-7 activates osteoclastogenesis by promoting cell–cell fusion

(2014) Haruhiko Nakamura et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Late stages of the synchronized macrophage fusion in osteoclast formation depend on dynamin

(2014) Santosh K. Verma et al.   BIOCHEMICAL JOURNAL

The F-BAR protein PSTPIP1 controls extracellular matrix degradation and filopodia formation in macrophages

(2014) T. W. Starnes et al.   BLOOD

Osteoclast Fusion is Based on Heterogeneity Between Fusion Partners

(2014) Anne-Sofie Hobolt-Pedersen et al.   CALCIFIED TISSUE INTERNATIONAL

Tools of the trade: podosomes as multipurpose organelles of monocytic cells

(2014) Stefan Linder et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

New roles of filopodia and podosomes in the differentiation and fusion process of osteoclasts

(2014) R.L. Song et al.   GENETICS AND MOLECULAR RESEARCH

Vinculin Regulates Osteoclast Function

(2014) Tomohiro Fukunaga et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamin and endocytosis are required for the fusion of osteoclasts and myoblasts

(2014) Nah-Young Shin et al.   JOURNAL OF CELL BIOLOGY

Regulation of Osteoclast Multinucleation by the Actin Cytoskeleton Signaling Network

(2014) Jiro Takito et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Protrusion force microscopy reveals oscillatory force generation and mechanosensing activity of human macrophage podosomes

(2014) Anna Labernadie et al.   Nature Communications

Osteoclast Fusion and Fission

(2012) Ineke D. C. Jansen et al.   CALCIFIED TISSUE INTERNATIONAL

An Essential Role for STAT6-STAT1 Protein Signaling in Promoting Macrophage Cell-Cell Fusion

(2012) Hiroya Miyamoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Osteoclast stimulatory transmembrane protein and dendritic cell-specific transmembrane protein cooperatively modulate cell-cell fusion to form osteoclasts and foreign body giant cells

(2012) Hiroya Miyamoto et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Tks5-dependent formation of circumferential podosomes/invadopodia mediates cell–cell fusion

(2012) Tsukasa Oikawa et al.   JOURNAL OF CELL BIOLOGY

The transient appearance of zipper-like actin superstructures during the fusion of osteoclasts

(2012) J. Takito et al.   JOURNAL OF CELL SCIENCE

Involvement of actin polymerization in podosome dynamics

(2012) C. Luxenburg et al.   JOURNAL OF CELL SCIENCE

Tunneling nanotube formation is essential for the regulation of osteoclastogenesis

(2012) Akira Takahashi et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

c-Src Links a RANK/ v 3 Integrin Complex to the Osteoclast Cytoskeleton

(2012) T. Izawa et al.   MOLECULAR AND CELLULAR BIOLOGY

The CD40-CD40L axis and IFN-  play critical roles in Langhans giant cell formation

(2011) H. Sakai et al.   INTERNATIONAL IMMUNOLOGY

Kindlin-3–mediated signaling from multiple integrin classes is required for osteoclast-mediated bone resorption

(2011) Sarah Schmidt et al.   JOURNAL OF CELL BIOLOGY

Integrins, growth factors, and the osteoclast cytoskeleton

(2010) Wei Zou et al.   Annals of the New York Academy of Sciences

Involvement of human endogenous retroviral syncytin-1 in human osteoclast fusion

(2010) Kent Søe et al.   BONE

Chemorepulsion by blood S1P regulates osteoclast precursor mobilization and bone remodeling in vivo

(2010) Masaru Ishii et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Osteoclast heterogeneity:

(2009) Vincent Everts et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Filamin A Regulates Monocyte Migration Through Rho Small GTPases During Osteoclastogenesis

(2009) Roland Leung et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Identification of cell cycle–arrested quiescent osteoclast precursors in vivo

(2009) Toshihide Mizoguchi et al.   JOURNAL OF CELL BIOLOGY

Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis

(2009) Masaru Ishii et al.   NATURE

Molecular mediators of macrophage fusion

(2009) Laura Helming et al.   TRENDS IN CELL BIOLOGY

The molecular basis of macrophage fusion

(2007) Laura Helming et al.   IMMUNOBIOLOGY

Bone-Resorbing Osteoclasts Contain Gap-Junctional Connexin-43

(2006) Joanna Ilvesaro et al.   JOURNAL OF BONE AND MINERAL RESEARCH