Actin assembly mechanisms at a glance

The bacterial virulence factors VopL and VopF nucleate actin from the pointed end

(2017) Thomas A. Burke et al.   JOURNAL OF CELL BIOLOGY

Cellular functions of WASP family proteins at a glance

(2017) Olga Alekhina et al.   JOURNAL OF CELL SCIENCE

Efficiency of lamellipodia protrusion is determined by the extent of cytosolic actin assembly

(2017) Georgi Dimchev et al.   MOLECULAR BIOLOGY OF THE CELL

Distinct VASP tetramers synergize in the processive elongation of individual actin filaments from clustered arrays

(2017) Stefan Brühmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FMNL formins boost lamellipodial force generation

(2017) Frieda Kage et al.   Nature Communications

Endosome-ER Contacts Control Actin Nucleation and Retromer Function through VAP-Dependent Regulation of PI4P

(2016) Rui Dong et al.   CELL

Focal adhesions, stress fibers and mechanical tension

(2016) Keith Burridge et al.   EXPERIMENTAL CELL RESEARCH

Feel the force: Podosomes in mechanosensing

(2016) Stefan Linder et al.   EXPERIMENTAL CELL RESEARCH

Cellular functions of the ADF/cofilin family at a glance

(2016) Georgios Kanellos et al.   JOURNAL OF CELL SCIENCE

DrosophilaWASH is required for integrin-mediated cell adhesion, cell motility and lysosomal neutralization

(2016) Benedikt M. Nagel et al.   JOURNAL OF CELL SCIENCE

Retromer- and WASH-dependent sorting of nutrient transporters requires a multivalent interaction network with ANKRD50

(2016) Arunas Kvainickas et al.   JOURNAL OF CELL SCIENCE

The inner workings of stress fibers − from contractile machinery to focal adhesions and back

(2016) Ariel Livne et al.   JOURNAL OF CELL SCIENCE

Diversified actin protrusions promote environmental exploration but are dispensable for locomotion of leukocytes

(2016) Alexander Leithner et al.   NATURE CELL BIOLOGY

The WH2 Domain and Actin Nucleation: Necessary but Insufficient

(2016) Roberto Dominguez   TRENDS IN BIOCHEMICAL SCIENCES

Coordinated recruitment of Spir actin nucleators and myosin V motors to Rab11 vesicle membranes

(2016) Olena Pylypenko et al.   eLife

Specification of Architecture and Function of Actin Structures by Actin Nucleation Factors

(2015) Colleen T. Skau et al.   Annual Review of Biophysics

Virulent Burkholderia Species Mimic Host Actin Polymerases to Drive Actin-Based Motility

(2015) Erin L. Benanti et al.   CELL

WHAMM Directs the Arp2/3 Complex to the ER for Autophagosome Biogenesis through an Actin Comet Tail Mechanism

(2015) David J. Kast et al.   CURRENT BIOLOGY

Filopodia in cell adhesion, 3D migration and cancer cell invasion

(2015) Guillaume Jacquemet et al.   CURRENT OPINION IN CELL BIOLOGY

Membrane Targeting of the Spir·Formin Actin Nucleator Complex Requires a Sequential Handshake of Polar Interactions

(2015) Janine Tittel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Initiation of lamellipodia and ruffles involves cooperation between mDia1 and the Arp2/3 complex

(2015) T. Isogai et al.   JOURNAL OF CELL SCIENCE

The formins FHOD1 and INF2 regulate inter- and intra-structural contractility of podosomes

(2015) Linda Panzer et al.   JOURNAL OF CELL SCIENCE

Membrane tension and cytoskeleton organization in cell motility

(2015) Pierre Sens et al.   JOURNAL OF PHYSICS-CONDENSED MATTER

The formin FMNL3 assembles plasma membrane protrusions that participate in cell–cell adhesion

(2015) Timothy J. Gauvin et al.   MOLECULAR BIOLOGY OF THE CELL

Cell type–dependent mechanisms for formin-mediated assembly of filopodia

(2015) Lorna E. Young et al.   MOLECULAR BIOLOGY OF THE CELL

Innate control of actin nucleation determines two distinct migration behaviours in dendritic cells

(2015) Pablo Vargas et al.   NATURE CELL BIOLOGY

Inverted formin 2 in focal adhesions promotes dorsal stress fiber and fibrillar adhesion formation to drive extracellular matrix assembly

(2015) Colleen T. Skau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of signalling and the cytoskeleton during Vaccinia Virus egress

(2015) Flavia Leite et al.   VIRUS RESEARCH

A resilient formin-derived cortical actin meshwork in the rear drives actomyosin-based motility in 2D confinement

(2015) Nagendran Ramalingam et al.   Nature Communications

Platelet actin nodules are podosome-like structures dependent on Wiskott–Aldrich syndrome protein and ARP2/3 complex

(2015) Natalie S. Poulter et al.   Nature Communications

The structure of FMNL2–Cdc42 yields insights into the mechanism of lamellipodia and filopodia formation

(2015) Sonja Kühn et al.   Nature Communications

Actin nucleation by WH2 domains at the autophagosome

(2015) Amanda S. Coutts et al.   Nature Communications

Lamellipodin promotes actin assembly by clustering Ena/VASP proteins and tethering them to actin filaments

(2015) Scott D Hansen et al.   eLife

A mitochondria-anchored isoform of the actin-nucleating spire protein regulates mitochondrial division

(2015) Uri Manor et al.   eLife

Biallelic Truncating Mutations in FMN2, Encoding the Actin-Regulatory Protein Formin 2, Cause Nonsyndromic Autosomal-Recessive Intellectual Disability

(2014) Rosalind Law et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The Value of Mechanistic Biophysical Information for Systems-Level Understanding of Complex Biological Processes Such as Cytokinesis

(2014) Thomas D. Pollard   BIOPHYSICAL JOURNAL

RNF2 is recruited by WASH to ubiquitinate AMBRA1 leading to downregulation of autophagy

(2014) Pengyan Xia et al.   CELL RESEARCH

Cellular Control of Cortical Actin Nucleation

(2014) Miia Bovellan et al.   CURRENT BIOLOGY

The Drosophila FHOD1-like formin Knittrig acts through Rok to promote stress fiber formation and directed macrophage migration during the cellular immune response

(2014) U. Lammel et al.   DEVELOPMENT

Actomyosin networks and tissue morphogenesis

(2014) Akankshi Munjal et al.   DEVELOPMENT

JMY is involved in anterograde vesicle trafficking from the trans-Golgi network

(2014) Kai Schlüter et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Requirements for and consequences of Rac-dependent protrusion

(2014) Anika Steffen et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Homozygous loss of DIAPH1 is a novel cause of microcephaly in humans

(2014) A Gulhan Ercan-Sencicek et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Daam1 is a regulator of filopodia formation and phagocytic uptake of Borrelia burgdorferi by primary human macrophages

(2014) Ann-Kathrin Hoffmann et al.   FASEB JOURNAL

FHOD1 regulates stress fiber organization by controlling the dynamics of transverse arcs and dorsal fibers

(2014) N. Schulze et al.   JOURNAL OF CELL SCIENCE

Steering cell migration: lamellipodium dynamics and the regulation of directional persistence

(2014) Matthias Krause et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Actin Dynamics, Architecture, and Mechanics in Cell Motility

(2014) Laurent Blanchoin et al.   PHYSIOLOGICAL REVIEWS

Ena/VASP Enabled is a highly processive actin polymerase tailored to self-assemble parallel-bundled F-actin networks with Fascin

(2014) J. D. Winkelman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Function and Regulation of the Endosomal Fusion and Fission Machineries

(2014) A. Gautreau et al.   Cold Spring Harbor Perspectives in Biology

Structural and functional insights into the Spir/formin actin nucleator complex

(2013) Susanne Dietrich et al.   BIOLOGICAL CHEMISTRY

Megakaryocytes assemble podosomes that degrade matrix and protrude through basement membrane

(2013) H. Schachtner et al.   BLOOD

The Formin Daam1 and Fascin Directly Collaborate to Promote Filopodia Formation

(2013) Richa Jaiswal et al.   CURRENT BIOLOGY

WASH inhibits autophagy through suppression of Beclin 1 ubiquitination

(2013) Pengyan Xia et al.   EMBO JOURNAL

CDC42 switches IRSp53 from inhibition of actin growth to elongation by clustering of VASP

(2013) Andrea Disanza et al.   EMBO JOURNAL

Guardians of the actin monomer

(2013) Bo Xue et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Lamellipodin and the Scar/WAVE complex cooperate to promote cell migration in vivo

(2013) Ah-Lai Law et al.   JOURNAL OF CELL BIOLOGY

FHOD1 is a combined actin filament capping and bundling factor that selectively associates with actin arcs and stress fibers

(2013) A. Schonichen et al.   JOURNAL OF CELL SCIENCE

Rac function is crucial for cell migration but is not required for spreading and focal adhesion formation

(2013) A. Steffen et al.   JOURNAL OF CELL SCIENCE

WASH is required for lysosomal recycling and efficient autophagic and phagocytic digestion

(2013) Jason S. King et al.   MOLECULAR BIOLOGY OF THE CELL

Inhibitory signalling to the Arp2/3 complex steers cell migration

(2013) Irene Dang et al.   NATURE

Dimeric WH2 domains in Vibrio VopF promote actin filament barbed-end uncapping and assisted elongation

(2013) Julien Pernier et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Diaphanous homolog 3 (Diap3) Overexpression Causes Progressive Hearing Loss and Inner Hair Cell Defects in a Transgenic Mouse Model of Human Deafness

(2013) Cynthia J. Schoen et al.   PLoS One

FHOD1, a Formin Upregulated in Epithelial-Mesenchymal Transition, Participates in Cancer Cell Migration and Invasion

(2013) Maria Gardberg et al.   PLoS One

Interplay between myosin IIA-mediated contractility and actin network integrity orchestrates podosome composition and oscillations

(2013) K. van den Dries et al.   Nature Communications

Arp2/3 Is Critical for Lamellipodia and Response to Extracellular Matrix Cues but Is Dispensable for Chemotaxis

(2012) Congying Wu et al.   CELL

FMNL2 Drives Actin-Based Protrusion and Migration Downstream of Cdc42

(2012) Jennifer Block et al.   CURRENT BIOLOGY

The Arp2/3 complex is required for lamellipodia extension and directional fibroblast cell migration

(2012) Praveen Suraneni et al.   JOURNAL OF CELL BIOLOGY

Supervillin couples myosin-dependent contractility to podosomes and enables their turnover

(2012) R. Bhuwania et al.   JOURNAL OF CELL SCIENCE

N-WASP-mediated invadopodium formation is involved in intravasation and lung metastasis of mammary tumors

(2012) B. Gligorijevic et al.   JOURNAL OF CELL SCIENCE

WASH Knockout T Cells Demonstrate Defective Receptor Trafficking, Proliferation, and Effector Function

(2012) J. T. Piotrowski et al.   MOLECULAR AND CELLULAR BIOLOGY

Myosin 1E coordinates actin assembly and cargo trafficking during clathrin-mediated endocytosis

(2012) Jackie Cheng et al.   MOLECULAR BIOLOGY OF THE CELL

Cell mechanics control rapid transitions between blebs and lamellipodia during migration

(2012) M. Bergert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Actin cortex mechanics and cellular morphogenesis

(2012) Guillaume Salbreux et al.   TRENDS IN CELL BIOLOGY

Adhesion rings surround invadopodia and promote maturation

(2012) K. M. Branch et al.   Biology Open

Recruitment of the endosomal WASH complex is mediated by the extended ‘tail’ of Fam21 binding to the retromer protein Vps35

(2011) Michael E. Harbour et al.   BIOCHEMICAL JOURNAL

Spire-Type Actin Nucleators Cooperate with Formin-2 to Drive Asymmetric Oocyte Division

(2011) Sybille Pfender et al.   CURRENT BIOLOGY

Actin dynamics and turnover in cell motility

(2011) Klemens Rottner et al.   CURRENT OPINION IN CELL BIOLOGY

Membrane extensions are associated with proper anterior migration of muscle cells during Caenorhabditis elegans embryogenesis

(2011) Ryan Viveiros et al.   DEVELOPMENTAL BIOLOGY

Actin polymerization driven by WASH causes V-ATPase retrieval and vesicle neutralization before exocytosis

(2011) Michael Carnell et al.   JOURNAL OF CELL BIOLOGY

The Arp2/3 activator WASH regulates  5 1-integrin-mediated invasive migration

(2011) T. Zech et al.   JOURNAL OF CELL SCIENCE

Cofilin cooperates with fascin to disassemble filopodial actin filaments

(2011) D. Breitsprecher et al.   JOURNAL OF CELL SCIENCE

The roles of fascins in health and disease

(2011) Yosuke Hashimoto et al.   JOURNAL OF PATHOLOGY

An actin-dependent mechanism for long-range vesicle transport

(2011) Melina Schuh   NATURE CELL BIOLOGY

INF2Mutations in Charcot–Marie–Tooth Disease with Glomerulopathy

(2011) Olivia Boyer et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Src-Tks5 Pathway Is Required for Neural Crest Cell Migration during Embryonic Development

(2011) Danielle A. Murphy et al.   PLoS One

Filopodia initiation

(2011) Changsong Yang et al.   Cell Adhesion & Migration

Sequence-Dependent Sorting of Recycling Proteins by Actin-Stabilized Endosomal Microdomains

(2010) Manojkumar A. Puthenveedu et al.   CELL

The formin FRL1 (FMNL1) is an essential component of macrophage podosomes

(2010) Akos T. Mersich et al.   Cytoskeleton

Actin dynamics at intracellular membranes: The Spir/formin nucleator complex

(2010) Eugen Kerkhoff   EUROPEAN JOURNAL OF CELL BIOLOGY

Cytoskeleton-modulating effectors of enteropathogenic and enterohaemorrhagic Escherichia coli: Tir, EspFU and actin pedestal assembly

(2010) Kenneth G. Campellone   FEBS Journal

Actin, microtubules, and vimentin intermediate filaments cooperate for elongation of invadopodia

(2010) Marie Schoumacher et al.   JOURNAL OF CELL BIOLOGY

Structure and control of the actin regulatory WAVE complex

(2010) Zhucheng Chen et al.   NATURE

Direct visualization of secondary structures of F-actin by electron cryomicroscopy

(2010) Takashi Fujii et al.   NATURE

Hydrostatic pressure and the actomyosin cortex drive mitotic cell rounding

(2010) Martin P. Stewart et al.   NATURE

Rickettsia Sca2 is a bacterial formin-like mediator of actin-based motility

(2010) Cat M. Haglund et al.   NATURE CELL BIOLOGY

Increased activity of Diaphanous homolog 3 (DIAPH3)/diaphanous causes hearing defects in humans with auditory neuropathy and in Drosophila

(2010) C. J. Schoen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

WASH and WAVE actin regulators of the Wiskott-Aldrich syndrome protein (WASP) family are controlled by analogous structurally related complexes

(2010) D. Jia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

WASH, WHAMM and JMY: regulation of Arp2/3 complex and beyond

(2010) Klemens Rottner et al.   TRENDS IN CELL BIOLOGY

The role of formins in filopodia formation

(2009) Harry Mellor   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Diaphanous-Related Formins Are Required for Invadopodia Formation and Invasion of Breast Tumor Cells

(2009) F. Lizarraga et al.   CANCER RESEARCH

Drosophila Cip4/Toca-1 Integrates Membrane Trafficking and Actin Dynamics through WASP and SCAR/WAVE

(2009) Robert Fricke et al.   CURRENT BIOLOGY

Actin and endocytosis: mechanisms and phylogeny

(2009) Brian J Galletta et al.   CURRENT OPINION IN CELL BIOLOGY

The Arp2/3 Activator WASH Controls the Fission of Endosomes through a Large Multiprotein Complex

(2009) Emmanuel Derivery et al.   DEVELOPMENTAL CELL

A FAM21-Containing WASH Complex Regulates Retromer-Dependent Sorting

(2009) Timothy S. Gomez et al.   DEVELOPMENTAL CELL

Wiskott–Aldrich Syndrome: Immunodeficiency resulting from defective cell migration and impaired immunostimulatory activation

(2009) Gerben Bouma et al.   IMMUNOBIOLOGY

Filopodia: Complex models for simple rods

(2009) Jan Faix et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Cortactin Promotes Migration and Platelet-derived Growth Factor-induced Actin Reorganization by Signaling to Rho-GTPases

(2009) Frank P.L. Lai et al.   MOLECULAR BIOLOGY OF THE CELL

Activation of the WAVE Complex by Coincident Signals Controls Actin Assembly

(2009) Andres M. Lebensohn et al.   MOLECULAR CELL

The nature of the globular- to fibrous-actin transition

(2009) Toshiro Oda et al.   NATURE

Actin, a Central Player in Cell Shape and Movement

(2009) T. D. Pollard et al.   SCIENCE

Fascin1 is dispensable for mouse development but is favorable for neonatal survival

(2009) Yoshihiko Yamakita et al.   CELL MOTILITY AND THE CYTOSKELETON

Coronin 1B Antagonizes Cortactin and Remodels Arp2/3-Containing Actin Branches in Lamellipodia

(2008) Liang Cai et al.   CELL

Dynamic analysis of filopodial interactions during the zippering phase of Drosophila dorsal closure

(2008) T. H. Millard et al.   DEVELOPMENT

Arp2/3 complex interactions and actin network turnover in lamellipodia

(2008) Frank PL Lai et al.   EMBO JOURNAL

Clustering of VASP actively drives processive, WH2 domain-mediated actin filament elongation

(2008) Dennis Breitsprecher et al.   EMBO JOURNAL

EFC/F-BAR proteins and the N-WASP–WIP complex induce membrane curvature-dependent actin polymerization

(2008) Kazunari Takano et al.   EMBO JOURNAL

Actin in the endocytic pathway: From yeast to mammals

(2008) Henrique Girao et al.   FEBS LETTERS

WASP family members and formin proteins coordinate regulation of cell protrusions in carcinoma cells

(2008) Corina Sarmiento et al.   JOURNAL OF CELL BIOLOGY

Filopodia formation induced by active mDia2/Drf3

(2008) J. BLOCK et al.   JOURNAL OF MICROSCOPY

Arp2/3 Complex Is Important for Filopodia Formation, Growth Cone Motility, and Neuritogenesis in Neuronal Cells

(2008) Farida Korobova et al.   MOLECULAR BIOLOGY OF THE CELL

Actin nucleation: bacteria get in-Spired

(2008) Margot E. Quinlan et al.   NATURE CELL BIOLOGY

Filopodia: molecular architecture and cellular functions

(2008) Pieta K. Mattila et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Blebs lead the way: how to migrate without lamellipodia

(2008) Guillaume Charras et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Leiomodin Is an Actin Filament Nucleator in Muscle Cells

(2008) D. Chereau et al.   SCIENCE

Arp2 depletion inhibits sheet-like protrusions but not linear protrusions of fibroblasts and lymphocytes

(2008) Susan M. Nicholson-Dykstra et al.   CELL MOTILITY AND THE CYTOSKELETON