Probing the mechanical landscape – new insights into podosome architecture and mechanics

Membrane trafficking in osteoclasts and implications for osteoporosis

(2019) Pei Ying Ng et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

A mechano-signalling network linking microtubules, myosin IIA filaments and integrin-based adhesions

(2019) Nisha Bte Mohd Rafiq et al.   NATURE MATERIALS

Filamin A mediates isotropic distribution of applied force across the actin network

(2019) Abhishek Kumar et al.   JOURNAL OF CELL BIOLOGY

Forces and constraints controlling podosome assembly and disassembly

(2019) Nisha Bte Mohd Rafiq et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

DNA mechanotechnology reveals that integrin receptors apply pN forces in podosomes on fluid substrates

(2019) Roxanne Glazier et al.   Nature Communications

Modular actin nano-architecture enables podosome protrusion and mechanosensing

(2019) Koen van den Dries et al.   Nature Communications

Lymphocyte-specific protein 1 regulates mechanosensory oscillation of podosomes and actin isoform-based actomyosin symmetry breaking

(2018) Pasquale Cervero et al.   Nature Communications

Combining laser capture microdissection and proteomics reveals an active translation machinery controlling invadosome formation

(2018) Zakaria Ezzoukhry et al.   Nature Communications

Podosomes, But Not the Maturation Status, Determine the Protease-Dependent 3D Migration in Human Dendritic Cells

(2018) Céline Cougoule et al.   Frontiers in Immunology

Talin as a mechanosensitive signaling hub

(2018) Benjamin T. Goult et al.   JOURNAL OF CELL BIOLOGY

Super-Resolution Correlative Light and Electron Microscopy (SR-CLEM) Reveals Novel Ultrastructural Insights Into Dendritic Cell Podosomes

(2018) Ben Joosten et al.   Frontiers in Immunology

Assembling actin filaments for protrusion

(2018) Klemens Rottner et al.   CURRENT OPINION IN CELL BIOLOGY

Actin assembly mechanisms at a glance

(2017) Klemens Rottner et al.   JOURNAL OF CELL SCIENCE

Feel the force: Podosomes in mechanosensing

(2016) Stefan Linder et al.   EXPERIMENTAL CELL RESEARCH

Podosome assembly is controlled by the GTPase ARF1 and its nucleotide exchange factor ARNO

(2016) Nisha Bte Mohd Rafiq et al.   JOURNAL OF CELL BIOLOGY

Evaluation of the force and spatial dynamics of macrophage podosomes by multi-particle tracking

(2016) Amsha Proag et al.   METHODS

Actomyosin-dependent dynamic spatial patterns of cytoskeletal components drive mesoscale podosome organization

(2016) Marjolein B. M. Meddens et al.   Nature Communications

Fascin actin bundling controls podosome turnover and disassembly while cortactin is involved in podosome assembly by its SH3 domain in THP-1 macrophages and dendritic cells

(2015) Isabel Van Audenhove et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Regulation of ECM degradation and axon guidance by growth cone invadosomes

(2015) M. Santiago-Medina et al.   DEVELOPMENT

The formins FHOD1 and INF2 regulate inter- and intra-structural contractility of podosomes

(2015) Linda Panzer et al.   JOURNAL OF CELL SCIENCE

Molecular mechanism of vinculin activation and nanoscale spatial organization in focal adhesions

(2015) Lindsay B. Case et al.   NATURE CELL BIOLOGY

Direct optical nanoscopy with axially localized detection

(2015) N. Bourg et al.   Nature Photonics

Vinculin controls talin engagement with the actomyosin machinery

(2015) Paul Atherton et al.   Nature Communications

Mechanical interplay between invadopodia and the nucleus in cultured cancer cells

(2015) Or-Yam Revach et al.   Scientific Reports

A crucial role for  2 integrins in podosome formation, dynamics and Toll-like-receptor-signaled disassembly in dendritic cells

(2014) C. Gawden-Bone et al.   JOURNAL OF CELL SCIENCE

Endothelial podosome rosettes regulate vascular branching in tumour angiogenesis

(2014) Giorgio Seano et al.   NATURE CELL BIOLOGY

Protrusion force microscopy reveals oscillatory force generation and mechanosensing activity of human macrophage podosomes

(2014) Anna Labernadie et al.   Nature Communications

Actomyosin-dependent formation of the mechanosensitive talin–vinculin complex reinforces actin anchoring

(2014) Corina Ciobanasu et al.   Nature Communications

Spatiotemporal organization and mechanosensory function of podosomes

(2014) Koen van den Dries et al.   Cell Adhesion & Migration

Podosomes in space

(2014) Christiane Wiesner et al.   Cell Adhesion & Migration

Mechanical activation of vinculin binding to talin locks talin in an unfolded conformation

(2014) Mingxi Yao et al.   Scientific Reports

Megakaryocytes assemble podosomes that degrade matrix and protrude through basement membrane

(2013) H. Schachtner et al.   BLOOD

A specific subset of RabGTPases controls cell surface exposure of MT1-MMP, extracellular matrix degradation and three-dimensional invasion of macrophages

(2013) C. Wiesner et al.   JOURNAL OF CELL SCIENCE

Dual-color superresolution microscopy reveals nanoscale organization of mechanosensory podosomes

(2013) K. van den Dries et al.   MOLECULAR BIOLOGY OF THE CELL

Talins and kindlins: partners in integrin-mediated adhesion

(2013) David A. Calderwood et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Interplay between myosin IIA-mediated contractility and actin network integrity orchestrates podosome composition and oscillations

(2013) K. van den Dries et al.   Nature Communications

Force Fluctuations within Focal Adhesions Mediate ECM-Rigidity Sensing to Guide Directed Cell Migration

(2012) Sergey V. Plotnikov et al.   CELL

Proteomic analysis of podosome fractions from macrophages reveals similarities to spreading initiation centres

(2012) Pasquale Cervero et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Macrophage Mesenchymal Migration Requires Podosome Stabilization by Filamin A

(2012) Romain Guiet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Involvement of actin polymerization in podosome dynamics

(2012) C. Luxenburg et al.   JOURNAL OF CELL SCIENCE

Supervillin couples myosin-dependent contractility to podosomes and enables their turnover

(2012) R. Bhuwania et al.   JOURNAL OF CELL SCIENCE

United we stand – integrating the actin cytoskeleton and cell–matrix adhesions in cellular mechanotransduction

(2012) Ulrich S. Schwarz et al.   JOURNAL OF CELL SCIENCE

Adhesion rings surround invadopodia and promote maturation

(2012) K. M. Branch et al.   Biology Open

Degrading Devices: Invadosomes in Proteolytic Cell Invasion

(2011) Stefan Linder et al.   Annual Review of Cell and Developmental Biology

Geometry sensing by dendritic cells dictates spatial organization and PGE2-induced dissolution of podosomes

(2011) Koen van den Dries et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

(2011) Jean-Cheng Kuo et al.   NATURE CELL BIOLOGY

Bayesian localization microscopy reveals nanoscale podosome dynamics

(2011) Susan Cox et al.   NATURE METHODS

The 'ins' and 'outs' of podosomes and invadopodia: characteristics, formation and function

(2011) Danielle A. Murphy et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

KIF5B and KIF3A/KIF3B kinesins drive MT1-MMP surface exposure, CD44 shedding, and extracellular matrix degradation in primary macrophages

(2010) C. Wiesner et al.   BLOOD

The formin FRL1 (FMNL1) is an essential component of macrophage podosomes

(2010) Akos T. Mersich et al.   Cytoskeleton

Macrophage podosomes go 3D

(2010) Emeline Van Goethem et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Ion-dependent Polymerization Differences between Mammalian β- and γ-Nonmuscle Actin Isoforms

(2010) Sarah E. Bergeron et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The distribution of podosomes in osteoclasts cultured on bone laminae: Effect of retinol

(2010) Alberta Zambonin-Zallone et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Dendritic cell podosomes are protrusive and invade the extracellular matrix using metalloproteinase MMP-14

(2010) C. Gawden-Bone et al.   JOURNAL OF CELL SCIENCE

Nanoscale architecture of integrin-based cell adhesions

(2010) Pakorn Kanchanawong et al.   NATURE

Dynamics of podosome stiffness revealed by atomic force microscopy

(2010) A. Labernadie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Actin machinery and mechanosensitivity in invadopodia, podosomes and focal adhesions

(2009) C. Albiges-Rizo et al.   JOURNAL OF CELL SCIENCE

Matrix Architecture Dictates Three-Dimensional Migration Modes of Human Macrophages: Differential Involvement of Proteases and Podosome-Like Structures

(2009) E. Van Goethem et al.   JOURNAL OF IMMUNOLOGY

p53 Suppresses Src-Induced Podosome and Rosette Formation and Cellular Invasiveness through the Upregulation of Caldesmon

(2009) U. K. Mukhopadhyay et al.   MOLECULAR AND CELLULAR BIOLOGY

Stretching Single Talin Rod Molecules Activates Vinculin Binding

(2009) A. del Rio et al.   SCIENCE

Proteomic Analysis of Integrin-Associated Complexes Identifies RCC2 as a Dual Regulator of Rac1 and Arf6

(2009) J. D. Humphries et al.   Science Signaling

Surface-Induced Regulation of Podosome Organization and Dynamics in Cultured Osteoclasts

(2008) Dafna Geblinger et al.   CHEMBIOCHEM

Extracellular Matrix Rigidity Promotes Invadopodia Activity

(2008) Nelson R. Alexander et al.   CURRENT BIOLOGY

Self-Organized Podosomes Are Dynamic Mechanosensors

(2008) Olivier Collin et al.   CURRENT BIOLOGY

PGE2-mediated podosome loss in dendritic cells is dependent on actomyosin contraction downstream of the RhoA-Rho-kinase axis

(2008) S. F. G. van Helden et al.   JOURNAL OF CELL SCIENCE

Talin depletion reveals independence of initial cell spreading from integrin activation and traction

(2008) Xian Zhang et al.   NATURE CELL BIOLOGY

The Tyrosine Kinase Activity of c-Src Regulates Actin Dynamics and Organization of Podosomes in Osteoclasts

(2007) Olivier Destaing et al.   MOLECULAR BIOLOGY OF THE CELL