The emerging role of Hippo signaling pathway in regulating osteoclast formation

A ROR1–HER3–lncRNA signalling axis modulates the Hippo–YAP pathway to regulate bone metastasis

(2017) Chunlai Li et al.   NATURE CELL BIOLOGY

TAZ promotes cell growth and inhibits Celastrol-induced cell apoptosis

(2016) S. Wang et al.   BIOSCIENCE REPORTS

Melanoma cell adhesion molecule stimulates yes-associated protein transcription by enhancing CREB activity via c-Jun/c-Fos in hepatocellular carcinoma cells

(2016) YONGXIA QIAO et al.   Oncology Letters

Tead and AP1 Coordinate Transcription and Motility

(2016) Xiangfan Liu et al.   Cell Reports

CCN2 enhances RANKL-induced osteoclast differentiation via direct binding to RANK and OPG

(2015) Eriko Aoyama et al.   BONE

A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis

(2015) Toshiro Moroishi et al.   GENES & DEVELOPMENT

Low pH-driven folding of WW45-SARAH domain leads to stabilization of the WW45-Mst2 complex

(2015) Jinsue Song et al.   JOURNAL OF BIOCHEMISTRY

Mst2 Controls Bone Homeostasis by Regulating Osteoclast and Osteoblast Differentiation

(2015) Jongwon Lee et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The Hippo Pathway and YAP/TAZ–TEAD Protein–Protein Interaction as Targets for Regenerative Medicine and Cancer Treatment

(2015) Matteo Santucci et al.   JOURNAL OF MEDICINAL CHEMISTRY

Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth

(2015) Francesca Zanconato et al.   NATURE CELL BIOLOGY

Decoding the regulatory landscape of melanoma reveals TEADS as regulators of the invasive cell state

(2015) Annelien Verfaillie et al.   Nature Communications

MDP, a database linking drug response data to genomic information, identifies dasatinib and statins as a combinatorial strategy to inhibit YAP/TAZ in cancer cells

(2015) Cristian Taccioli et al.   Oncotarget

Inhibition of ERK1/2 down-regulates the Hippo/YAP signaling pathway in human NSCLC cells

(2015) Bin You et al.   Oncotarget

GRM7 Regulates Embryonic Neurogenesis via CREB and YAP

(2015) Wenlong Xia et al.   Stem Cell Reports

A Review: Molecular Aberrations within Hippo Signaling in Bone and Soft-Tissue Sarcomas

(2015) Michael D. Deel et al.   Frontiers in Oncology

Extracellular Matrix Stiffness Regulates Osteogenic Differentiation through MAPK Activation

(2015) Jun-Ha Hwang et al.   PLoS One

Canonical Wnt signalling activates TAZ through PP1A during osteogenic differentiation

(2014) M R Byun et al.   CELL DEATH AND DIFFERENTIATION

(−)-Epicatechin Gallate (ECG) Stimulates Osteoblast Differentiation via Runt-related Transcription Factor 2 (RUNX2) and Transcriptional Coactivator with PDZ-binding Motif (TAZ)-mediated Transcriptional Activation

(2014) Mi Ran Byun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mevalonates Restore Zoledronic Acid–induced Osteoclastogenesis Inhibition

(2014) Y. Nagaoka et al.   JOURNAL OF DENTAL RESEARCH

Establishment of transgenic lines to monitor and manipulate Yap/Taz-Tead activity in zebrafish reveals both evolutionarily conserved and divergent functions of the Hippo pathway

(2014) Joel B. Miesfeld et al.   MECHANISMS OF DEVELOPMENT

Metabolic control of YAP and TAZ by the mevalonate pathway

(2014) Giovanni Sorrentino et al.   NATURE CELL BIOLOGY

Osteoblast-derived WNT16 represses osteoclastogenesis and prevents cortical bone fragility fractures

(2014) Sofia Movérare-Skrtic et al.   NATURE MEDICINE

Genetic Deletion of Mst1 Alters T Cell Function and Protects against Autoimmunity

(2014) Konstantin V. Salojin et al.   PLoS One

FGF2 stimulates osteogenic differentiation through ERK induced TAZ expression

(2013) Mi Ran Byun et al.   BONE

Spatial Organization of Hippo Signaling at the Plasma Membrane Mediated by the Tumor Suppressor Merlin/NF2

(2013) Feng Yin et al.   CELL

Zinc inhibits osteoclast differentiation by suppression of Ca2+-Calcineurin-NFATc1 signaling pathway

(2013) Kwang Park et al.   Cell Communication and Signaling

Regulation of Hippo Signaling by EGFR-MAPK Signaling through Ajuba Family Proteins

(2013) B.V.V.G. Reddy et al.   DEVELOPMENTAL CELL

Mutual interaction between YAP and CREB promotes tumorigenesis in liver cancer

(2013) Jiayi Wang et al.   HEPATOLOGY

Genetic Deletion of Catalytic Subunits of AMP-activated Protein Kinase Increases Osteoclasts and Reduces Bone Mass in Young Adult Mice

(2013) Heeseog Kang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts

(2013) Fernando Calvo et al.   NATURE CELL BIOLOGY

MST1 functions as a key modulator of neurodegeneration in a mouse model of ALS

(2013) J. K. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ajuba Family Proteins Link JNK to Hippo Signaling

(2013) G. Sun et al.   Science Signaling

Ablation of Rassf2 induces bone defects and subsequent haematopoietic anomalies in mice

(2012) Hoogeun Song et al.   EMBO JOURNAL

Src controls tumorigenesis via JNK-dependent regulation of the Hippo pathway in Drosophila

(2012) Masato Enomoto et al.   EMBO REPORTS

Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice

(2012) Miki Nishio et al.   JOURNAL OF CLINICAL INVESTIGATION

TM-25659 enhances osteogenic differentiation and suppresses adipogenic differentiation by modulating the transcriptional co-activator TAZ

(2011) EJ Jang et al.   BRITISH JOURNAL OF PHARMACOLOGY

N-terminal RASSF family

(2011) Nicholas Underhill-Day et al.   Epigenetics

Coactivation of GR and NFKB alters the repertoire of their binding sites and target genes

(2011) N. A. S. Rao et al.   GENOME RESEARCH

The V-ATPase a3 subunit mutation R740S is dominant negative and results in osteopetrosis in mice

(2011) Noelle Ochotny et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

YAP and TAZ feel the force

(2011) Katharine H. Wrighton   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ajuba LIM Proteins Are Negative Regulators of the Hippo Signaling Pathway

(2010) Meghna Das Thakur et al.   CURRENT BIOLOGY

Regulation of Hippo signaling by Jun kinase signaling during compensatory cell proliferation and regeneration, and in neoplastic tumors

(2010) Gongping Sun et al.   DEVELOPMENTAL BIOLOGY

The NF2 Tumor Suppressor, Merlin, Regulates Epidermal Development through the Establishment of a Junctional Polarity Complex

(2010) Andrew B. Gladden et al.   DEVELOPMENTAL CELL

CCN family 2/connective tissue growth factor (CCN2/CTGF) promotes osteoclastogenesis via induction of and interaction with dendritic cell-specific transmembrane protein (DC-STAMP)

(2010) Takashi Nishida et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The hippo pathway in biological control and cancer development

(2010) Siew Wee Chan et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Proapoptotic Rassf1A/Mst1 signaling in cardiac fibroblasts is protective against pressure overload in mice

(2010) Dominic P. Del Re et al.   JOURNAL OF CLINICAL INVESTIGATION

The RASSF8 candidate tumor suppressor inhibits cell growth and regulates the Wnt and NF-κB signaling pathways

(2010) F E Lock et al.   ONCOGENE

Structure-based development of a receptor activator of nuclear factor- B ligand (RANKL) inhibitor peptide and molecular basis for osteopetrosis

(2010) H. M. Ta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of the tumor suppressor RASSF2 in regulation of MST1 kinase activity

(2009) Hoogeun Song et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Both TEAD-Binding and WW Domains Are Required for the Growth Stimulation and Oncogenic Transformation Activity of Yes-Associated Protein

(2009) B. Zhao et al.   CANCER RESEARCH

Anti-apoptotic Molecule Bcl-2 Regulates the Differentiation, Activation, and Survival of Both Osteoblasts and Osteoclasts

(2009) Yuichi Nagase et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TEAD Transcription Factors Mediate the Function of TAZ in Cell Growth and Epithelial-Mesenchymal Transition

(2009) Heng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Osteoclasts and the immune system

(2009) Tomoki Nakashima et al.   JOURNAL OF BONE AND MINERAL METABOLISM

Crucial Role for Mst1 and Mst2 Kinases in Early Embryonic Development of the Mouse

(2009) S. Oh et al.   MOLECULAR AND CELLULAR BIOLOGY

RASSF2 associates with and stabilizes the proapoptotic kinase MST2

(2009) W N Cooper et al.   ONCOGENE

Cytoplasmic RASSF2A is a proapoptotic mediator whose expression is epigenetically silenced in gastric cancer

(2008) Reo Maruyama et al.   CARCINOGENESIS

Nf2/Merlin Regulates Hematopoietic Stem Cell Behavior by Altering Microenvironmental Architecture

(2008) Jonas Larsson et al.   Cell Stem Cell

A crucial role of WW45 in developing epithelial tissues in the mouse

(2008) Joo-Hyeon Lee et al.   EMBO JOURNAL

TEAD mediates YAP-dependent gene induction and growth control

(2008) B. Zhao et al.   GENES & DEVELOPMENT

Overexpression of TEAD-1 in Transgenic Mouse Striated Muscles Produces a Slower Skeletal Muscle Contractile Phenotype

(2008) Richard W. Tsika et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rassf Family of Tumor Suppressor Polypeptides

(2008) Joseph Avruch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PAK1 is a novel MEK-independent raf target controlling expression of the IAP survivin in M-CSF-mediated osteoclast survival

(2008) Elizabeth W. Bradley et al.   JOURNAL OF CELLULAR PHYSIOLOGY