Article
Oncology
Xiaofeng Liu, Kunqi Su, Xiaoyan Sun, Yang Jiang, Lijun Wang, Chenyu Hu, Chunfeng Zhang, Min Lu, Xiaojuan Du, Baocai Xing
Summary: In this study, Sec62 was identified as a novel chemoresistance-related target in colorectal cancer, with upregulation associated with poor patient outcomes. Sec62 was found to promote stemness in CRC cells through activating the Wnt signaling pathway. This study provides insights into potential therapeutic targets for improving treatment outcomes in colorectal cancer.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Pathology
Qiken Li, Gang Wang, Jinhua Tao, Weiping Chen
Summary: Overall, RNF6 was found to be upregulated in CRC samples and cell lines. Silencing or overexpressing RNF6 in colorectal cancer cells had significant impacts on cell proliferation, tumorigenicity, invasion, and migration, as well as the expression of p-GSK3ll, GSK3ll, and ll-catenin. The inhibitor IM-12 was able to reverse the effects induced by RNF6 and showed promise in inhibiting the activation of the Wnt/ll-catenin pathway. These findings suggest that RNF6 may serve as a potential therapeutic target for CRC treatment.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Cell Biology
Liyan Wang, Bin Li, Xiaoyuan Yi, Xuhua Xiao, Qinghua Zheng, Lei Ma
Summary: This study revealed that circ_SMAD4 promotes gastric cancer tumorigenesis by activating the CTNNB1-dependent Wnt/beta-catenin pathway. The mechanism involves nuclear circ_SMAD4 recruiting TCF4 to facilitate CTNNB1 transcription, while cytoplasmic circ_SMAD4 sequestering miR-1276 to prevent CTNNB1 mRNA silencing. Rescue experiments confirmed that circ_SMAD4 accelerates GC cell growth through the miR-1276/TCF4-regulated CTNNB1 pathway.
CELL PROLIFERATION
(2021)
Article
Medicine, Research & Experimental
Heyu Song, Ricky A. Sontz, Matthew J. Vance, Julia M. Morris, Sulaiman Sheriff, Songli Zhu, Suzann Duan, Jiping Zeng, Erika Koeppe, Ritu Pandey, Curtis A. Thorne, Elena M. Stoffel, Juanita L. Merchant
Summary: The incidence of early-onset colorectal cancer (EO-CRC) is rising, with lifestyle factors and genetic background playing a potential role. The study found a missense mutation, HNF1AA98V, in the Hepatic Nuclear Factor 1α (HNF1A) gene, which reduces DNA binding ability. In mice, introducing the HNF1AA98V variant and feeding a high-fat or high-sugar diet led to an increased formation of colonic polyps. The study also revealed alterations in gene expression and signaling pathways related to metabolism, immunity, and lipid biogenesis.
Article
Cell Biology
Zimin Xiang, Shuai Zhang, Xiaodong Yao, Libin Xu, Jianwei Hu, Chenghui Yin, Jianmei Chen, Hao Xu
Summary: Resveratrol can promote function recovery and axonal regeneration, improve histological damage, and inhibit apoptosis level after SCI by regulating the Wnt/beta-catenin signaling pathway. This study expanded the regulatory mechanism of resveratrol in SCI injury.
Article
Oncology
Duo Xu, Meirong Li, Longyan Ran, Xiaochen Li, Xingwang Sun, Tao Yin
Summary: This study revealed the involvement of C5aR1 in the development and metastasis of colorectal cancer (CRC). C5aR1 promoted the proliferation, migration, and invasion of CRC cells, and accelerated the process of epithelial-mesenchymal transition (EMT). Furthermore, C5aR1 may regulate CRC through its effects on key proteins in the Wnt/β-catenin pathway.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
Article
Oncology
Yaqi Tang, Xiaoyu Yi, Xinyu Zhang, Baojie Liu, Yongzheng Lu, Zhifang Pan, Tao Yu, Weiguo Feng
Summary: This study aimed to investigate the effect of MC-LR on colorectal cancer cell proliferation and the underlying mechanisms. The results showed that MC-LR promoted CRC cell proliferation by activating the PI3K/Akt/Wnt/beta-catenin pathway. This study provided a novel insight into the toxicological mechanism of MC-LR.
Article
Oncology
Dan Fang, Mu-Ru Wang, Jia-Lun Guan, Ying-Ying Han, Jia-Qi Sheng, De-An Tian, Pei-Yuan Li
Summary: The study found that in HCC, high expression of BRD9 was closely related to malignancy, tumor stage, tumor size, and prognosis. BRD9 promoted cell proliferation and tumor growth, and mediated its effects by activating the Wnt/beta-catenin signaling pathway.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Hongjiao Li, Chenglian Xie, Yurong Lu, Kaijing Chang, Feng Guan, Xiang Li
Summary: This study reveals that plasma exosomal miR92a is significantly upregulated in MDS/AML patients and can interfere with cell resistance to Ara-C by regulating the PTEN and Wnt/β-catenin signaling pathway.
Article
Oncology
Fei Song, Fei-Yu Chen, Sui-Yi Wu, Bo Hu, Xiao-liang Liang, Hao-Qin Yang, Jian-Wen Cheng, Peng-Xiang Wang, Wei Guo, Jian Zhou, Jia Fan, Zhong Chen, Xin-Rong Yang
Summary: This study revealed that the expression of MUC1 is significantly up-regulated in ICC, and is associated with the aggressiveness of tumors and patient prognosis. Further investigations showed that MUC1 promotes ICC progression by activating the Wnt/beta-catenin pathway.
Article
Biotechnology & Applied Microbiology
Wenping Song, Xuan Wu, Cheng Cheng, Ding Li, Jinhua Chen, Wenzhou Zhang
Summary: This study investigates the impact of ARHGAP9 on lung adenocarcinoma (LUAD) metastasis and sheds light on its molecular mechanism. The findings demonstrate that downregulated ARHGAP9 is correlated with poor prognosis in LUAD patients. ARHGAP9 knockdown enhances LUAD cell proliferation, migration, and invasion while suppressing cell apoptosis and G0G1 cell cycle arrest. RNA sequencing analysis indicates that ARHGAP9 knockdown reduces the expression of DKK2. Silencing ARHGAP9 and overexpressing DKK2 reverses the promoted effects on LUAD cell proliferation, migration, and invasion, and reduces the activity of the Wnt/beta-catenin signaling pathway. Thus, ARHGAP9 knockdown promotes LUAD metastasis by activating the Wnt/beta-catenin signaling pathway through suppressing DKK2, offering a potential strategy for LUAD treatment.
Article
Oncology
Junhao Zhou, Hu Tian, Xi Zhi, Zhuoyu Xiao, Taoyi Chen, Haoyu Yuan, Qi Chen, Mingkun Chen, Jiankun Yang, Qizhao Zhou, Kangyi Xue, Wenbin Guo, Ming Xia, Jiming Bao, Cheng Yang, Haifeng Duan, Hongyi Wang, Zhipeng Huang, Ting Zhu, Cundong Liu
Summary: The study found that ATF5 is elevated in bladder urothelial cancer tissues, especially in recurrent cases, which is associated with a poor prognosis. Overexpression of ATF5 significantly enhances tumor sphere formation in bladder cancer cells, while silencing ATF5 inhibits this capability. Mechanistically, ATF5 can directly bind to and stimulate the promoter of the DVL I gene, leading to activation of the Wnt/β-catenin pathway.
CANCER CELL INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Shi-lei Liu, Chen Cai, Zi-yi Yang, Zi-you Wu, Xiang-song Wu, Xue-feng Wang, Ping Dong, Wei Gong
Summary: DGCR5 is highly expressed in pancreatic cancer tissues and associated with poor prognosis, its depletion can inhibit cell proliferation, migration, and invasion, while xenograft assay validated its role in promoting tumor growth. Mechanistically, DGCR5 acts as a ceRNA regulating TOP2A via miR-3163 and inhibiting the Wnt/β-catenin pathway, and downregulation enhances cell sensitivity to gemcitabine. Additionally, PAX5 can bind to DGCR5 promoter region and increase transcription, suggesting its potential as a diagnostic biomarker and therapeutic target for pancreatic cancer.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Zheng Zhang, Weiwei Jiang, Miao Hu, Rui Gao, Xuhui Zhou
Summary: Dysfunction in osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) is regulated by miR-486-3p/CTNNBIP1 axis, where miR-486-3p promotes osteogenesis through activating the Wnt/beta-catenin signaling pathway, while overexpression of CTNNBIP1 inhibits osteogenic differentiation.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Cell Biology
Bei Tao, Yi Song, Yao Wu, Xiaobo Yang, Tangming Peng, Lilei Peng, Kaiguo Xia, Xiangguo Xia, Ligang Chen, Chuanhong Zhong
Summary: This study found that a stiffer matrix can promote the stemness of glioma cells by activating the BCL9L/Wnt/beta-catenin signaling pathway. Additionally, gigantol can enhance the effectiveness of traditional chemotherapy and radiotherapy by inhibiting Wnt/beta-catenin signaling, providing a potential strategy for clinical treatment of gliomas.
Letter
Gastroenterology & Hepatology
Qi Su, Raphaela Iris Lau, Qin Liu, Francis Ka Leung Chan, Siew Chien Ng
Article
Gastroenterology & Hepatology
Yi Bao, Jianning Zhai, Huarong Chen, Chi Chun Wong, Cong Liang, Yanqiang Ding, Dan Huang, Hongyan Gou, Danyu Chen, Yasi Pan, Wei Kang, Ka Fai To, Jun Yu
Summary: YTHDF1 plays a crucial role in the tumour immune microenvironment of colorectal cancer by regulating the m(6)A-p65-CXCL1/CXCR2 pathway, affecting anti-tumour immune response, and serving as a potential target for immune checkpoint blockade therapy.
Article
Gastroenterology & Hepatology
Minako Nagai, Michael J. Wright, Ding Ding, Elizabeth D. Thompson, Ammar A. Javed, Matthew J. Weiss, Ralph H. Hruban, Jun Yu, Richard A. Burkhart, Jin He, John L. Cameron, Christopher L. Wolfgang, William R. Burns
Summary: Patients with pancreatic ductal adenocarcinoma (PDAC) and liver metastasis usually undergo palliative chemotherapy, while those with metastatic colorectal cancer are often considered for aggressive surgery. This study found that in select patients, curative-intent surgery for isolated liver metastasis in PDAC can result in meaningful survival, especially in those who received induction chemotherapy.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2023)
Article
Oncology
Jinglin Zhang, Bonan Chen, Hui Li, Yifei Wang, Xiaoli Liu, Kit Yee Wong, Wai Nok Chan, Aden K. Y. Chan, Alvin H. k Cheung, Kam Tong Leung, Yujuan Dong, Yi Pan, Huixing Ke, Li Liang, Zhaocai Zhou, Jianyong Xiao, Chi Chun Wong, William K. K. Wu, Alfred S. L. Cheng, Brigette B. Y. Ma, Jun Yu, Kwok Wai Lo, Wei Kang, Ka Fai To
Summary: Colorectal cancer (CRC) is a common cancer worldwide, and the tumor microenvironment, specifically cancer-associated fibroblasts (CAFs), plays a crucial role in promoting CRC progression.
JOURNAL OF PATHOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Feiyu Shi, Gaixia Liu, Yufeng Lin, Cosmos Liutao Guo, Jing Han, Eagle S. H. Chu, Chengxin Shi, Yaguang Li, Haowei Zhang, Chenhao Hu, Ruihan Liu, Shuixiang He, Gang Guo, Yinnan Chen, Xiang Zhang, Olabisi Oluwabukola Coker, Sunny Hei Wong, Jun Yu, Junjun She
Summary: Appendectomy is associated with an increased risk of colorectal cancer (CRC) due to gut microbial dysbiosis. A longitudinal study (cohort 1, n = 129,155) showed a 73.0% increase in CRC risk among appendectomy cases during a 20-year follow-up period. Fecal samples from another cohort (n = 314) revealed dysbiosis in the gut microbiome of appendectomy subjects, with enrichment of CRC-promoting bacteria and depletion of beneficial commensals. Microbial network analysis indicated stronger correlations and enriched oncogenic pathways among bacteria in appendectomy subjects compared to controls. Appendectomy was also found to promote colorectal tumorigenesis in mice through microbial dysbiosis and impaired intestinal barrier function. This study highlights the importance of the gut microbiome in CRC development following appendectomy.
Article
Biochemistry & Molecular Biology
Yun Qian, Lianxin Zhou, Simson Tsz Yat Luk, Jiaying Xu, Weilin Li, Hongyan Gou, Huarong Chen, Wei Kang, Jun Yu, Chi Chun Wong
Summary: The incidence of colorectal cancer (CRC) is increasing globally. We identified SCNN1B as a down-regulated gene in CRC that acts as a tumor suppressor. SCNN1B mRNA and protein expression levels were decreased in primary CRC and CRC cells. In a cohort study, SCNN1B protein was an independent prognostic factor associated with favorable outcomes in CRC. Overexpression of SCNN1B in CRC cell lines inhibited cell proliferation, induced apoptosis and cell cycle arrest, and suppressed cell migration. Xenograft models confirmed the tumor suppressive function of SCNN1B in vivo. Mechanistically, SCNN1B suppressed the MAPK signaling pathway by inhibiting the activation of c-Raf, a downstream target of KRAS.
Review
Oncology
Huan Yan, Jing-Ling Zhang, Kam-Tong Leung, Kwok-Wai Lo, Jun Yu, Ka-Fai To, Wei Kang
Summary: Gastric cancer is a highly life-threatening malignancy, particularly in Asian countries. Aberrant activation of G-protein-coupled receptors (GPCRs) and G proteins promotes the progression of gastric cancer. These activated GPCRs/G proteins can potentially serve as valuable biomarkers for early diagnosis and prognostic prediction, as well as therapeutic targets. This review summarizes the recent research progress of GPCRs and highlights their mechanisms in tumorigenesis, specifically in gastric cancer initiation and progression.
Article
Gastroenterology & Hepatology
Jianning Zhai, Huarong Chen, Chi Chun Wong, Yao Peng, Hongyan Gou, Jingwan Zhang, Yasi Pan, Danyu Chen, Yufeng Lin, Shiyan Wang, Wei Kang, Ka Fai To, Zhiwei Chen, Yuqiang Nie, Housheng Hansen He, Joseph Jao-Yiu Sung, Jun Yu
Summary: This study identified the ALKBH5-N6-methyladenosine-AXIN2-Wnt-DKK1 axis in colorectal cancer (CRC), which drives immune suppression and facilitates tumorigenesis. Targeting ALKBH5 or DKK1 can enhance the efficacy of immunotherapy in CRC.
Article
Biochemistry & Molecular Biology
Xin-yue Zhang, Ze-xian Liu, Yi-fan Zhang, Li-xia Xu, Meng-ke Chen, Yu-feng Zhou, Jun Yu, Xiao-xing Li, Ning Zhang
Summary: Crotonylation plays a role in regulating HCC metastasis and invasion. Crotonylated SEPT2-K74-P85 alpha-AKT pathway facilitates cell invasion. High SEPT2-K74 crotonylation predicts poor prognosis and high recurrence rate in HCC patients.
CELL AND BIOSCIENCE
(2023)
Review
Oncology
Wing Sum Shin, Fuda Xie, Bonan Chen, Peiyao Yu, Jun Yu, Ka Fai To, Wei Kang
Summary: Despite declining rates, gastric cancer remains a major cause of cancer deaths worldwide, particularly in Asia due to high H. pylori infection rates and lifestyle factors. Variations in H. pylori strains and prevalence contribute to differences in incidence and mortality. Large-scale eradication efforts have been effective, but the 5-year survival rate for advanced cases remains low. More focus is needed on screening, early diagnosis, precision medicine, and understanding the interplay between cancer cells and microenvironments for better treatment outcomes.
Article
Cell Biology
Jessie Qiaoyi Liang, Yao Zeng, Effie Yin Tung Lau, Yuting Sun, Yao Huang, Tingyu Zhou, Zhilu Xu, Jun Yu, Siew Chien Ng, Francis Ka Leung Chan
Summary: A newly developed probiotic formula was found to modulate the dysbiosis of gut microbiota associated with colorectal cancer by inhibiting the growth of pathogenic bacteria.
Article
Biochemistry & Molecular Biology
Yanqiang Ding, Liuyang Zhao, Guoping Wang, Yu Shi, Gang Guo, Changan Liu, Zigui Chen, Olabisi Oluwabukola Coker, Junjun She, Jun Yu
Summary: This study used PacBio sequencing to reveal the DNA methylation landscape of gut phages. The research found that methylation plays an important role in the taxonomy and interaction with hosts of phages, and also discovered the presence of restriction-modification systems in some phage genomes, which aid in evading clearance by the host.
NUCLEIC ACIDS RESEARCH
(2023)
Review
Oncology
Wing Sum Shin, Fuda Xie, Bonan Chen, Jun Yu, Kwok Wai Lo, Gary M. K. Tse, Ka Fai To, Wei Kang
Summary: Microbial influences, including viral and fungal infections, may contribute to gastric cancer development. Established players such as H. pylori and EBV, as well as gut bacteria like Lactobacillus and Streptococcus, and viruses like hepatitis B and C, and fungi like Candida albicans, have been shown to have potential impacts on gastric cancer. Advanced sequencing technologies provide insights into the complexities of the gastric microbiome and offer potential diagnostic and therapeutic applications for gastric cancer.
Review
Biochemistry & Molecular Biology
Yang Lyu, Fuda Xie, Bonan Chen, Wing Sum Shin, Wei Chen, Yulong He, Kam Tong Leung, Gary M. K. Tse, Jun Yu, Ka Fai To, Wei Kang
Summary: This review focuses on the complex interaction between the nervous system and gastrointestinal (GI) cancer, exploring the mechanisms of GI cancer development. It discusses the intricate relationship between the nervous system and GI tract development and tumor progression, as well as the feedback regulation of tumor cells on the nervous system. The review also highlights the influence of various components within the tumor microenvironment on GI cancer occurrence and progression. Furthermore, it emphasizes the transformation relationship between non-neuronal cells and neuronal cells, inspiring the development of nervous system-guided anti-tumor drugs.
Letter
Surgery
Sami Shoucair, Jun Yu
